KeratitisNCT07316244
Pattern of Microbial Keratitis in Assiut University Hospital
An observational study of Keratitis and Microbial Keratitis, run by Assiut University.
Trial summary
The aim of the study is to explore the epidemiology, including risk factors, causative microorganisms, complications and clinical outcomes of microbial keratitis among patients attending cornea clinic at Assiut University Hospital. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Keratitis, Microbial Keratitis
- What is being tested?
- corneal scraping including direct smear, culture and sensitivity
- How many people
- 100 participants
- Where
- No sites listed yet
- Study dates
- Jan 2026to Mar 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Child, Adult, Older adult
Study population: 1. Full history taking: age, gender, residency ( urbn or rural ), literacy, present or past medical and surgical histories 2. Full ophthalmological examination,visual acuity at presentation and after healing. 3. Slit-lamp biomicroscopy 3. outcome of corneal scraping including direct smear, culture and sensitivity
Who may be able to join
- All cases presented with Microbial keratitis at cornea clinic , Assiut university hospital during the study period.
Who cannot join
- Non-microbial keratitis including Moorens ulcers, chemical burns, and Shield ulcers.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
The aim of the study is to explore the epidemiology, including risk factors, causative microorganisms, complications and clinical outcomes of microbial keratitis among patients attending cornea clinic at Assiut University Hospital.
Read the detailed description
Microbial keratitis (MK) is a potentially-serious, sight-threatening infection that may cause significant visual impairment or even blindness if not diagnosed and treated promptly.It can be caused by a range of pathogens including bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae), viruses(herpes viruses), parasites (e.g., Acanthamoeba), and fungi (yeasts, and filaments).
Bacterial keratitis (BK) is the most common cause of microbial keratitis Incidence, risk factors and impact of disease, vary widely according to region, access to health care, socioeconomic and environmental factors, predisposing conditions and causative organisms.The frequency and severity of keratitis are significantly higher in low-income countries.
The history of contact lens (CL) wear, ocular trauma, ocular surface disease (e.g. blepharitis, and dry eye), and systemic diseases (diabetes, and rheumatoid arthritis) are common risk factors associated with MK.
Early treatment reduces the risk of corneal scarring, vascularization, or perforation.Treatment with different anti-microbial agents depend on the presenting clinical picture, initiated with broad spectrum empirical antibiotics in suspected bacterial keratitis, prior to targeted treatment guided by corneal scraping for gram-stain, culture and sensitivity.
The diagnosis of MK is made on the clinical basis together with microbiological evaluation. The microbiological profile of microbial keratitis has shown great differences worldwide. Due to the continuous shifting in microbiological profile and antibiotics resistance profiles reported in several studies, microbiological investigations and antibiotic susceptibility are mandatory to provide an effective treatment.
- Conditions
- Keratitis, Microbial Keratitis
- Being tested
- corneal scraping including direct smear, culture and sensitivity
- Keywords
- Mk
- Medical subject headings
- Keratitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
corneal scraping including direct smear, culture and sensitivityDiagnostic test
corneal scraping including direct smear, culture and sensitivity
What is being measured
The primary outcome is the main question the study is designed to answer.
pattern of microbial keratitis in Assiut university hospital.
Identification of different causative microbial agents of microbial keratitis among patients presenting to Assiut University Hospital.
Measured: At initial presentation ( baseline)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Jan 2026
- Study startJan 2026 (estimated)
- Primary completionDec 2026 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for KeratitisStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Liza Mamdouh, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07316244
- Sponsor's protocol ID
- Pattern Mk in A.U.H
- Status last verified
- Dec 2025
- First submitted
- 16 Dec 2025
- Last updated
- 5 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pattern of Microbial Keratitis in Assiut University Hospital
- ClinicalTrials.gov ID
- NCT07316244
- Acronym / sponsor ID
- Pattern Mk in A.U.H
- Conditions
- Keratitis, Microbial Keratitis
- Keywords
- Mk
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- Jan 2026 (estimated)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 5 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the study is to explore the epidemiology, including risk factors, causative microorganisms, complications and clinical outcomes of microbial keratitis among patients attending cornea clinic at Assiut University Hospital.
Detailed description
Microbial keratitis (MK) is a potentially-serious, sight-threatening infection that may cause significant visual impairment or even blindness if not diagnosed and treated promptly.It can be caused by a range of pathogens including bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae), viruses(herpes viruses), parasites (e.g., Acanthamoeba), and fungi (yeasts, and filaments).
Bacterial keratitis (BK) is the most common cause of microbial keratitis Incidence, risk factors and impact of disease, vary widely according to region, access to health care, socioeconomic and environmental factors, predisposing conditions and causative organisms.The frequency and severity of keratitis are significantly higher in low-income countries.
The history of contact lens (CL) wear, ocular trauma, ocular surface disease (e.g. blepharitis, and dry eye), and systemic diseases (diabetes, and rheumatoid arthritis) are common risk factors associated with MK.
Early treatment reduces the risk of corneal scarring, vascularization, or perforation.Treatment with different anti-microbial agents depend on the presenting clinical picture, initiated with broad spectrum empirical antibiotics in suspected bacterial keratitis, prior to targeted treatment guided by corneal scraping for gram-stain, culture and sensitivity.
The diagnosis of MK is made on the clinical basis together with microbiological evaluation. The microbiological profile of microbial keratitis has shown great differences worldwide. Due to the continuous shifting in microbiological profile and antibiotics resistance profiles reported in several studies, microbiological investigations and antibiotic susceptibility are mandatory to provide an effective treatment.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
Who may qualify
- Sex
- All
- Age groups
- Child, Adult, Older adult
- Study population
- 1. Full history taking: age, gender, residency ( urbn or rural ), literacy, present or past medical and surgical histories 2. Full ophthalmological examination,visual acuity at presentation and after healing. 3. Slit-lamp biomicroscopy 3. outcome of corneal scraping including direct smear, culture and sensitivity
Key inclusion criteria (1 listed)
- All cases presented with Microbial keratitis at cornea clinic , Assiut university hospital during the study period.
Key exclusion criteria (1 listed)
- Non-microbial keratitis including Moorens ulcers, chemical burns, and Shield ulcers.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| corneal scraping including direct smear, culture and sensitivitycorneal scraping including direct smear, culture and sensitivity | Diagnostic test | – |
Primary outcome
pattern of microbial keratitis in Assiut university hospital.
Time frame: At initial presentation ( baseline)
Identification of different causative microbial agents of microbial keratitis among patients presenting to Assiut University Hospital.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Jan 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Keratitis and Microbial Keratitis, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Liza Mamdouh Mamdouh (01099972360, liza.wissa@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
pattern of microbial keratitis in Assiut university hospital. (time frame: At initial presentation ( baseline)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Jan 2026; AzTrials last refreshed its copy on 7 Nov 2026.