HIV/AIDSNCT07298785

Peer-led Dynamic Choice HIV Prevention for Women: The Peer-led DCP Pilot Study

A study testing Peer-led Dynamic Choice HIV Prevention (DCP) intervention in people with HIV/AIDS, run by University of California, San Francisco at 1 site in Uganda.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

This study will refine and pilot test the Peer-led Dynamic Choice HIV Prevention (DCP) intervention in a single-arm pilot trial. The study will test the hypothesis that the Peer-led Dynamic Choice HIV Prevention intervention will be feasible and increase biomedical HIV prevention coverage in the 6 months after receipt… Read more about this study

Who is it for?: Ages 15 years and older, women onlyHealthy volunteers can take part
Conditions the study is for: HIV/AIDS
What is being tested?: Peer-led Dynamic Choice HIV Prevention (DCP) intervention
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 60 participants
Where: 1 siteUganda
Study dates: 27 Jan 2026to 14 Aug 2026
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 15 years and older
Women only
Healthy volunteers accepted
Child, Adult, Older adult

Who may be able to join

Age >=18 years or mature or mature minor >=15 years;
Female sex at birth;
HIV negative by country-standard testing algorithm
Elevated risk of HIV exposure, defined as at least 1 of the following: a) eligible for PrEP based on Uganda Ministry of Health Guidelines; b) exchange of sex for goods or money in last 6 months; or c) work in bar or guesthouse

Who cannot join

Contraindication to country-recommended PrEP regimen per national guidelines
Participation in another HIV prevention study

Trial locations and contacts

1 site in 1 country.

Uganda1 site

Infectious Diseases Research Collaboration
Kampala

Other trials in Uganda

About this study

Read the detailed description

The overall goal of this study is to refine and pilot test a Peer-led Dynamic Choice HIV Prevention intervention tailored to women at elevated HIV risk in southwestern Uganda. We will conduct a single-arm pilot trial of the intervention enrolling approximately 60 women to assess the feasibility, acceptability, and preliminary effectiveness of the Peer-led Dynamic Choice Prevention intervention.

Conditions: HIV/AIDS
Being tested: Peer-led Dynamic Choice HIV Prevention (DCP) intervention
Keywords: Biomedical HIV Prevention, Peer Mentor Intervention, Uganda, Dynamic Choice HIV Prevention
Medical subject headings: Acquired Immunodeficiency Syndrome

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Peer-led Dynamic Choice HIV Prevention (DCP) interventionOther
The intervention consists of peer mentor training on patient-centered choice counseling and Peer-led DCP services, and will be delivered by the peer mentor with clinician support:
1. HIV prevention product choice with option to switch over time
2. Rapid access to PEP from peer mentor for unplanned exposures
3. Integration of STI testing and treatment
4. Travel kit
5. Phone/SMS contact for peer support

Study groups in NCT07298785
Study group	Role	What they receive
Peer-led Dynamic Choice HIV Prevention (DCP) intervention	Experimental	Not described Receives: Other: Peer-led Dynamic Choice HIV Prevention (DCP) intervention

What is being measured

The primary outcome is the main question the study is designed to answer.

Biomedical HIV prevention coverage
Percentage of follow-up months that a participant uses a biomedical HIV prevention product
Measured: 24 weeks

Secondary outcomes (2)

At-risk biomedical HIV prevention coverage
Percentage of at-risk follow-up months that a participant uses a biomedical HIV prevention product
Measured: 24 weeks
Feasibility of delivery of the Peer-Led DCP intervention by peers
Proportion of participants with Peer-led DCP intervention services delivered by peer mentor
Measured: 24 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

27 Jan 202614 Aug 2026

First posted23 Dec 2025
Study start27 Jan 2026
Primary completion14 Aug 2026
Study completion14 Aug 2026

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for HIV/AIDSStudies of the same condition, open and under way.
More trials run by University of California, San FranciscoThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Prevention
Allocation: Not applicable
Intervention model: Single group
Model description: Single-arm pilot trial to refine and pilot test the Peer-led DCP intervention.
Masking: None (open label)
Enrolment: 60 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07298785
Sponsor's protocol ID: 25-43821
Other IDs: R01MH137799
Status last verified: Oct 2026
First submitted: 19 Dec 2025
Last updated: 6 Oct 2026
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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All HIV/AIDS trials

Study at a glance

From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Peer-led Dynamic Choice HIV Prevention for Women: The Peer-led DCP Pilot Study
ClinicalTrials.gov ID: NCT07298785
Acronym / sponsor ID: 25-43821
Conditions: HIV/AIDS
Keywords: Biomedical HIV Prevention, Peer Mentor Intervention, Uganda, Dynamic Choice HIV Prevention
Study type: Interventional
Recruitment status: Completed
Enrolment: 60 participants (actual)
Lead sponsor: University of California, San FranciscoUniversity, hospital or other
Collaborators: National Institute of Mental Health (NIMH), Infectious Diseases Research Collaboration, Uganda, University of California, Berkeley
Study start: 27 Jan 2026 (actual)
Primary completion: 14 Aug 2026 (actual)
Study completion: 14 Aug 2026 (actual)
First posted: 23 Dec 2025 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

Study design

Primary purpose: Prevention
Allocation: Not applicable
Intervention model: Single group
Masking: None (open label)
Number of arms: 1
Model description: Single-arm pilot trial to refine and pilot test the Peer-led DCP intervention.

Arm	Type	Receives
Peer-led Dynamic Choice HIV Prevention (DCP) intervention	Experimental	Other: Peer-led Dynamic Choice HIV Prevention (DCP) intervention

Who may qualify

Ages: 15 years and older
Sex: Female only
Healthy volunteers: Accepted
Age groups: Child, Adult, Older adult

Key inclusion criteria (4 listed)

Age >=18 years or mature or mature minor >=15 years;
Female sex at birth;
HIV negative by country-standard testing algorithm
Elevated risk of HIV exposure, defined as at least 1 of the following: a) eligible for PrEP based on Uganda Ministry of Health Guidelines; b) exchange of sex for goods or money in last 6 months; or c) work in bar or guesthouse

Key exclusion criteria (2 listed)

Contraindication to country-recommended PrEP regimen per national guidelines
Participation in another HIV prevention study

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Peer-led Dynamic Choice HIV Prevention (DCP) interventionThe intervention consists of peer mentor training on patient-centered choice counseling and Peer-led DCP services, and will be delivered by the peer mentor with clinician support: 1. HIV prevention product choice with option to switch over time 2. Rapid access to PEP from peer mentor for unplanned exposures 3. Integration of STI testing and treatment 4. Travel kit 5. Phone/SMS contact for peer support	Other	Peer-led Dynamic Choice HIV Prevention (DCP) intervention

Primary outcome

Biomedical HIV prevention coverage
Time frame: 24 weeks
Percentage of follow-up months that a participant uses a biomedical HIV prevention product

2 secondary outcomes

At-risk biomedical HIV prevention coverage
Time frame: 24 weeks
Feasibility of delivery of the Peer-Led DCP intervention by peers
Time frame: 24 weeks

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
Individual participant dataSharing planned: No

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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Catherine Koss, MD principal investigator

University of California, San Francisco

Jane Kabami, MPH, PhD(c) principal investigator

Infectious Diseases Research Collaboration

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Peer-led Dynamic Choice HIV Prevention (DCP) intervention in people with HIV/AIDS, run by University of California, San Francisco at 1 site in Uganda.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Uganda. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Biomedical HIV prevention coverage (time frame: 24 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07298785.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.