Rebound Pain Impact After Hip Surgery With Nerve BlockNCT07295184
Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block
An observational study of Rebound Pain Impact After Hip Surgery With Nerve Block, run by Konya City Hospital at 1 site in Turkey (Türkiye).
Trial summary
Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising… Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Rebound Pain Impact After Hip Surgery With Nerve Block
- What is being tested?
- Peripheral nerve block applied and Only multimodal analgesia applied
- Type of treatment
- Pill or oral medicine, Injection or infusion
- How many people
- 90 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 12 May 2026to 29 Sep 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: We conducted a pilot study on 20 patients using the 'goodness-of-fit tests: contingency tables' test with G Power software. In our study, the incidence of rebound pain was 40%, and postoperative delirium developed in 50% of patients with rebound pain, compared to 8.3% in patients without rebound pain. Based on these data, an effect size of 0.356 was found, and an analysis was conducted using α=0.05, 90% power. The sample size was calculated as 83 patients. Considering the dropout rate, a total of 90 patients (36 patients with rebound pain and 54 patients without rebound pain) were calculated to be included in the study.
Who may be able to join
- Patients aged 18-80
- ASA I-III risk groups
- Undergoing elective hip surgery
Who cannot join
- Preoperative history of delirium, dementia, or major neurological disease
- Present cognitive impairment or severe hearing or visual impairment that could affect pain assessment
- Development of mechanical ventilation requirement in the intensive care unit; Need for bilateral hip surgery
- Failure to provide meaningful analgesia after block application due to surgical pain outside the scope of the block
- Patient's inability to complete the pain diary during postoperative follow-up;
- Urgent hip surgery
- Voluntary failure to give consent or request to withdraw from the study.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block: A Prospective Observational Study
Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising healthcare costs.
The incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden.
Effective postoperative pain control is critical not only for maintaining quality of life but also for preserving cognitive well-being. In this context, peripheral nerve blocks are frequently used for pain management following hip surgery.
Read the detailed description
Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising healthcare costs.
The incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden.
Effective postoperative pain control is critical not only for maintaining quality of life but also for preserving cognitive well-being. In this context, peripheral nerve blocks are frequently used for pain management following hip surgery.
In recent years, the Pericapsular Nerve Group block and the supra-inguinal fascia iliaca block have gained attention as regional anesthesia techniques that provide effective analgesia by targeting the nerve branches innervating the anterior capsule of the hip joint.
- Being tested
- Peripheral nerve block applied, Only multimodal analgesia applied
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Peripheral nerve block appliedOther
Pericapsular Nerve Group block and the supra-inguinal fascia iliaca block applied
Only multimodal analgesia appliedOther
Postoperative analgesia (paracetamol 1000 mg intravenously every 8 hours and celecoxib 200 mg orally every 12 hours)
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of delirium
The incidence of delirium will be evaluated in the first 72 hours postoperatively in the intensive care unit.
Measured: 72 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Dec 2025
- Study start12 May 2026
- Primary completion29 Sep 2026
- Study completion29 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Rebound Pain Impact After Hip Surgery With Nerve BlockStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 90 participants (actual)
Sponsor and investigators
- Lead sponsor
- Konya City Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, HASAN ŞENAY, Konya City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07295184
- Sponsor's protocol ID
- Rebound pain
- Status last verified
- Sep 2026
- First submitted
- 8 Dec 2025
- Last updated
- 30 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Rebound Pain on Postoperative Intensive Care Delirium in Patients Undergoing Hip Surgery With Peripheral Nerve Block: A Prospective Observational Study
- ClinicalTrials.gov ID
- NCT07295184
- Acronym / sponsor ID
- Rebound pain
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 90 participants (actual)
- Lead sponsor
- Konya City HospitalUniversity, hospital or other
- Study start
- 12 May 2026 (actual)
- Primary completion
- 29 Sep 2026 (actual)
- Study completion
- 29 Sep 2026 (actual)
- First posted
- 19 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising healthcare costs.
The incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden.
Effective postoperative pain control is critical not only for maintaining quality of life but also for preserving cognitive well-being. In this context, peripheral nerve blocks are frequently used for pain management following hip surgery.
Detailed description
Postoperative delirium is a significant and commonly encountered complication in patients undergoing hip surgery, particularly among the elderly. Postoperative delirium is associated with serious consequences, including prolonged intensive care unit stay, increased complication rates, higher mortality risk, and rising healthcare costs.
The incidence of Postoperative delirium after hip fracture surgery has been reported to range between 13% and 55.9%, indicating a substantial clinical burden.
Effective postoperative pain control is critical not only for maintaining quality of life but also for preserving cognitive well-being. In this context, peripheral nerve blocks are frequently used for pain management following hip surgery.
In recent years, the Pericapsular Nerve Group block and the supra-inguinal fascia iliaca block have gained attention as regional anesthesia techniques that provide effective analgesia by targeting the nerve branches innervating the anterior capsule of the hip joint.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- We conducted a pilot study on 20 patients using the 'goodness-of-fit tests: contingency tables' test with G Power software. In our study, the incidence of rebound pain was 40%, and postoperative delirium developed in 50% of patients with rebound pain, compared to 8.3% in patients without rebound pain. Based on these data, an effect size of 0.356 was found, and an analysis was conducted using α=0.05, 90% power. The sample size was calculated as 83 patients. Considering the dropout rate, a total of 90 patients (36 patients with rebound pain and 54 patients without rebound pain) were calculated to be included in the study.
Key inclusion criteria (3 listed)
- Patients aged 18-80
- ASA I-III risk groups
- Undergoing elective hip surgery
Key exclusion criteria (7 listed)
- Preoperative history of delirium, dementia, or major neurological disease
- Present cognitive impairment or severe hearing or visual impairment that could affect pain assessment
- Development of mechanical ventilation requirement in the intensive care unit; Need for bilateral hip surgery
- Failure to provide meaningful analgesia after block application due to surgical pain outside the scope of the block
- Patient's inability to complete the pain diary during postoperative follow-up;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Peripheral nerve block appliedPericapsular Nerve Group block and the supra-inguinal fascia iliaca block applied | Other | – |
| Only multimodal analgesia appliedPostoperative analgesia (paracetamol 1000 mg intravenously every 8 hours and celecoxib 200 mg orally every 12 hours) | Other | – |
Primary outcome
Incidence of delirium
Time frame: 72 hours
The incidence of delirium will be evaluated in the first 72 hours postoperatively in the intensive care unit.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Sep 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Rebound Pain Impact After Hip Surgery With Nerve Block, run by Konya City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of delirium (time frame: 72 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2026.