Rotator Cuff SyndromeNCT07294729
Mulligan and Proprioceptive Neuromuscular Facilitation Techniques in Individuals With Rotator Cuff Lesions
A study testing Mulligan Mobilization and Proprioceptive Neuromuscular Facilitation in people with Rotator Cuff Syndrome and Rotator Cuff Injuries, run by Medipol University at 1 site in Turkey (Türkiye).
Trial summary
This study aims to compare the effects of Mulligan mobilization with movement (MWM) and Proprioceptive Neuromuscular Facilitation (PNF) techniques on pain, functionality, proprioception, and quality of life in individuals diagnosed with rotator cuff lesions. Read more about this study
- Who is it for?
- Ages 30 to 70 years
- Conditions the study is for
- Rotator Cuff Syndrome, Rotator Cuff Injuries
- What is being tested?
- Mulligan Mobilization and Proprioceptive Neuromuscular Facilitation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 25 Dec 2025to 9 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Male and female participants between 30 and 70 years of age.
- A diagnosis of partial supraspinatus tear made by a physical medicine and rehabilitation s-specialist.
- Confirmation of the diagnosis through radiological imaging methods.
- No history of any shoulder surgery.
- Shoulder symptoms persisting for more than 4 weeks.
Who cannot join
- Individuals who are unable to cooperate or who have mental health problems.
- Individuals who have participated in any shoulder-related physiotherapy program within the last 3 months.
- Individuals with other musculoskeletal conditions that may affect the shoulder region.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effects of Mulligan and Proprioceptive Neuromuscular Facilitation Techniques on Pain, Functionality, Proprioception, and Quality of Life in Individuals With Rotator Cuff Lesions
This study aims to compare the effects of Mulligan mobilization with movement (MWM) and Proprioceptive Neuromuscular Facilitation (PNF) techniques on pain, functionality, proprioception, and quality of life in individuals diagnosed with rotator cuff lesions. A total of 45 participants aged 30-70 years with partial supraspinatus tears confirmed by clinical and radiological assessment will be randomly assigned to three groups: conventional physiotherapy, Mulligan + conventional physiotherapy, and PNF + conventional physiotherapy. All groups will receive a standardized three-week physiotherapy program, while the Mulligan and PNF groups will additionally undergo their respective manual therapy interventions. Outcome measures will include pain intensity (VAS), shoulder range of motion, functional disability (DASH), joint position sense, and rotator cuff-specific quality of life (RC-QoL). The study seeks to determine which manual therapy approach (Mulligan or PNF) provides superior improvements in clinical outcomes compared with conventional treatment alone.
Read the detailed description
Rotator cuff lesions are among the most common causes of shoulder pain and functional limitation, often resulting from overuse, degenerative changes, impaired neuromuscular control, or acute trauma. These conditions may lead to significant restrictions in daily living activities and decreased quality of life. Conservative physiotherapy remains the primary treatment approach for individuals with partial-thickness rotator cuff tears, emphasizing pain relief, range of motion restoration, neuromuscular control, and functional improvement. Recent literature suggests that manual therapy techniques, when combined with exercise programs, may enhance clinical outcomes by providing additional benefits in pain modulation, joint mobility, and sensorimotor function.
This study is designed to investigate and compare the clinical efficacy of two commonly used manual therapy techniques-Mulligan Mobilization With Movement (MWM) and Proprioceptive Neuromuscular Facilitation (PNF)-in individuals with rotator cuff lesions. Although both approaches are widely used in clinical practice, there is currently no comparative research evaluating their relative effectiveness on pain, functionality, proprioception, and quality of life. By integrating these techniques into a structured physiotherapy program, the study aims to determine whether either method provides superior therapeutic benefits.
A total of 45 participants aged 30-70 years with a confirmed diagnosis of partial supraspinatus tear will be included. Diagnosis will be established by a physical medicine and rehabilitation specialist and verified through appropriate imaging techniques. Participants will be randomly allocated into three groups: (1) Conventional Physiotherapy (Control), (2) Mulligan + Conventional Physiotherapy, and (3) PNF + Conventional Physiotherapy. All groups will receive a standardized physiotherapy program consisting of wand exercises, Codman pendulum exercises, stretching, finger-ladder exercises, strengthening with elastic bands tailored to individual capability, and TENS applied at 100 Hz for 20 minutes per session. This program will be administered four times per week for three weeks under physiotherapist supervision.
In the Mulligan group, the MWM technique will be applied prior to the exercise program. The intervention will target shoulder flexion, abduction, internal rotation, and external rotation. Using a mobilization belt to optimize joint gliding, the therapist will guide the participant through active, pain-free movements while applying a sustained accessory glide. The technique will initially be performed for 10 repetitions in the first two sessions and progressed to 3 sets of 10 repetitions in later sessions.
In the PNF group, a "hold-relax active movement" approach will be used to enhance proprioceptive input, neuromuscular activation, and functional movement patterns. Participants will perform isometric contractions in the shortened range of the agonist muscle, followed by relaxation and quick passive movement into the elongated range of the antagonist pattern. They will then perform isotonic contractions of the agonist. This cycle will be repeated several times until adequate muscle activation or fatigue is achieved. PNF will also be performed prior to the conventional exercise program.
Outcome measurements will be performed at baseline and at the end of the three-week intervention period. Pain intensity will be assessed using the Visual Analog Scale (VAS), and shoulder joint range of motion will be measured using the Goniometer Pro smartphone application, which has demonstrated good validity and reliability. Functional disability will be evaluated using the Turkish version of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, while proprioception will be measured through joint position sense testing at 60 degrees of flexion and abduction using Goniometer Pro. Quality of life will be assessed through the Rotator Cuff Quality of Life (RC-QoL) questionnaire, which has been validated for Turkish-speaking patients with rotator cuff pathology.
Statistical analyses will be conducted using SPSS 25.0. Normality will be tested through skewness-kurtosis values. Depending on distribution, within-group comparisons will utilize paired t-tests or Wilcoxon signed-rank tests; between-group comparisons will use one-way ANOVA or Kruskal-Wallis tests. When significant group differences are identified, appropriate post-hoc analyses will be performed. A significance level of p < 0.05 will be adopted.
This study is expected to contribute important evidence regarding the comparative effectiveness of Mulligan MWM and PNF techniques for rotator cuff lesions. The findings may support clinicians in selecting the most beneficial manual therapy approach to optimize patient outcomes in terms of pain reduction, functional capacity, proprioceptive accuracy, and overall quality of life. The results may also guide future research focusing on combined manual therapy and exercise interventions for shoulder pathologies.
- Conditions
- Rotator Cuff Syndrome, Rotator Cuff Injuries
- Being tested
- Control Group (Conventional Physiotherapy), Mulligan Mobilization, Proprioceptive Neuromuscular Facilitation
- Keywords
- Rotator Cuff Syndrome, Mulligan Mobilization, Manual Therapy, Proprioceptive Neuromuscular Facilitation, Physiotherapy, Shoulder Rehabilitation
- Medical subject headings
- Rotator Cuff Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Control Group (Conventional Physiotherapy)Other
Participants in the control group will receive a supervised conventional physiotherapy program consisting of wand, pendulum, stretching, and finger-ladder exercises, strengthening with elastic bands, and TENS applied to the painful area at 100 Hz for 20 minutes per session.
Mulligan MobilizationOther
Participants in the Mulligan group will receive the conventional physiotherapy program plus Mulligan Movement With Mobilization (MWM) techniques applied twice weekly before exercises. The physiotherapist will use a mobilization belt to provide joint glide while participants perform pain-free active movements in flexion, abduction, and rotation.
Proprioceptive Neuromuscular FacilitationOther
Participants in the PNF group will receive the conventional physiotherapy program plus PNF "hold-relax active movement" techniques applied before exercises. The physiotherapist will guide participants through repeated isometric, passive, and isotonic contractions to enhance proprioceptive input, muscle activation, and joint mobility.
| Study group | Role | What they receive |
|---|---|---|
| Control Group (Conventional Physiotherapy) | Active comparator | All participants will receive a conventional physiotherapy program for 3 weeks, 4 days per week. The program includes wand exercises in all directions (10 repetitions with a 2-second end-range hold), Codman pendulum exercises in flexion, abduction, and circular motions (10 repetitions), stretching exercises held for 20 seconds for 5 repetitions in all directions, and finger-ladder exercises for flexion and abduction (10 repetitions). Strengthening exercises will be performed using elastic bands selected according to each participant's physical capacity (3 sets of 10 repetitions). All sessions will be supervised by a physiotherapist. Additionally, TENS will be applied to the painful area at 100 Hz for 20 minutes in each session. Receives: Other: Control Group (Conventional Physiotherapy) |
| Mulligan Group | Experimental | In the Mulligan group, the MWM (Movement With Mobilization) technique will be applied in addition to the conventional exercise program. MWM will be performed twice a week for 3 weeks in flexion, abduction, internal rotation, and external rotation. The technique will be applied before exercises. A mobilization belt will be used to provide an effective glide, and participants will first demonstrate the painful or restricted movement. The belt will be placed around the shoulder, and the joint positioned pain-free. A glide force will be applied while the participant performs the movement actively, followed by a 3-second hold at the end range. The first two sessions will include 10 repetitions; subsequent sessions will include 3 sets of 10 repetitions. Participants will be positioned supine for rotation techniques and seated for flexion and abduction. Receives: Other: Control Group (Conventional Physiotherapy); Other: Mulligan Mobilization |
| Proprioceptive Neuromuscular Facilitation Group | Experimental | Before the standard physiotherapy and exercise program, the "hold-relax active movement" technique will be applied to increase circulation around the joint and enhance muscle activation. This technique is based on repeated isotonic contractions that do not require continuous effort.
The physiotherapist will first ask the participant to perform an isometric contraction in the shortened position of the agonist pattern. Then the participant will be instructed to relax, and the segment will be moved quickly and passively into the lengthened position of the antagonist pattern. The participant will then be asked to perform an isotonic contraction of the agonist pattern again.
This sequence will be repeated several times until contraction is adequately felt in the weak muscles or until fatigue occurs. Care will be taken to ensure that the passive movement into the antagonist direction is performed smoothly and quickly. Receives: Other: Control Group (Conventional Physiotherapy); Other: Proprioceptive Neuromuscular Facilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Joint Position Sense
Joint position sense will be assessed using the Becure Extremity ROM system. Joint position sense will be assessed at 60 degrees of shoulder flexion and shoulder abduction. While standing, the participant will first be asked to lift the arm with eyes open and memorize the position at 60 degrees. Then, with eyes closed, the participant will be instructed to raise the arm to the same position reached when the eyes were open. The shoulder angle obtained with eyes closed will be recorded. The difference between the angles measured with eyes open and eyes closed will be considered the joint position sense error. This method will be performed at 60 degrees of both flexion and abduction.
Measured: 3 weeks
Secondary outcomes (4)
Pain (VAS Score)
The Visual Analog Scale (VAS) is a commonly used method for assessing pain intensity. Participants will be asked to mark the level of pain they feel on a 100-mm line. The lower end of the line represents low pain intensity, while the upper end indicates high pain intensity.
Measured: 3 weeks
Range of Motion (Shoulder Flexion, Abduction, Internal and External Rotation Measured in Degrees)
The shoulder range of motion of the participants will be measured using the Goniometer Pro smartphone application. Flexion and abduction will be assessed within a range of 0-180 degrees, and internal and external rotation within a range of 0-90 degrees.
Measured: 3 weeks
Disability (DASH Questionnaire Score)
The Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire is used to assess physical disability and functional status in upper extremity injuries. The questionnaire consists of three subcategories. The first section contains 30 items evaluating the patient's functional status and symptoms. Of these 30 items, 21 assess daily living activities, 5 assess symptoms (pain, pain with activity, tingling, weakness, and movement limitations), and the remaining 4 assess social function, work, sleep, and self-confidence. The work module consists of 4 additional items evaluating the individual's work-related function. Each question is scored using a 5-point Likert scale (1: no difficulty, 2: mild difficulty, 3: moderate difficulty, 4: severe difficulty, 5: unable to do). Higher scores indicate greater disability.
Measured: 3 weeks
Quality of Life (RC-QoL Score)
The Rotator Cuff Quality of Life (RC-QoL) questionnaire is a condition-specific assessment tool designed to measure quality of life in individuals with rotator cuff pathology. The scale consists of 34 items organized into five domains: physical symptoms, work-related activities, activities of daily living, social functioning, and emotional well-being. Each question is scored on a scale from 0 to 100, where "0" indicates severe pain and "100" indicates no pain. Higher scores reflect better quality of life. The total score is calculated by summing the item scores, dividing by the number of answered items, and expressing the result as a percentage.
Measured: 3 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Dec 2025
- Study start25 Dec 2025
- Primary completion20 Apr 2026
- Study completion9 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Rotator Cuff SyndromeStudies of the same condition, open and under way.
- More trials run by Medipol UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study uses a parallel-group randomized controlled trial design in which participants with rotator cuff lesions are assigned to one of three groups: (1) Conventional Physiotherapy, (2) Mulligan Mobilization With Movement plus Conventional Physiotherapy, or (3) Proprioceptive Neuromuscular Facilitation plus Conventional Physiotherapy.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Medipol University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Emre DANSUK, Medipol University
- Investigators
- Emre Dansuk, PhD, Principal investigator, Medipol University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07294729
- Sponsor's protocol ID
- E-10840098-202.3.02-7892
- Status last verified
- Aug 2026
- First submitted
- 8 Dec 2025
- Last updated
- 5 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data underlying the results reported in the published article will be made available upon reasonable request to the corresponding author for scientifically sound research purposes. Data access will be subject to approval of the proposed use and completion of an appropriate data-sharing agreement, in accordance with institutional policies and applicable ethical requirements.
Study at a glance
From the registry record, last updated by the sponsor on 5 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Mulligan and Proprioceptive Neuromuscular Facilitation Techniques on Pain, Functionality, Proprioception, and Quality of Life in Individuals With Rotator Cuff Lesions
- ClinicalTrials.gov ID
- NCT07294729
- Acronym / sponsor ID
- E-10840098-202.3.02-7892
- Conditions
- Rotator Cuff Syndrome, Rotator Cuff Injuries
- Keywords
- Rotator Cuff Syndrome, Mulligan Mobilization, Manual Therapy, Proprioceptive Neuromuscular Facilitation, Physiotherapy, Shoulder Rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Medipol UniversityUniversity, hospital or other
- Study start
- 25 Dec 2025 (actual)
- Primary completion
- 20 Apr 2026 (actual)
- Study completion
- 9 Jul 2026 (actual)
- First posted
- 19 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare the effects of Mulligan mobilization with movement (MWM) and Proprioceptive Neuromuscular Facilitation (PNF) techniques on pain, functionality, proprioception, and quality of life in individuals diagnosed with rotator cuff lesions. A total of 45 participants aged 30-70 years with partial supraspinatus tears confirmed by clinical and radiological assessment will be randomly assigned to three groups: conventional physiotherapy, Mulligan + conventional physiotherapy, and PNF + conventional physiotherapy. All groups will receive a standardized three-week physiotherapy program, while the Mulligan and PNF groups will additionally undergo their respective manual therapy interventions. Outcome measures will include pain intensity (VAS), shoulder range of motion, functional disability (DASH), joint position sense, and rotator cuff-specific quality of life (RC-QoL). The study seeks to determine which manual therapy approach (Mulligan or PNF) provides superior improvements in clinical outcomes compared with conventional treatment alone.
Detailed description
Rotator cuff lesions are among the most common causes of shoulder pain and functional limitation, often resulting from overuse, degenerative changes, impaired neuromuscular control, or acute trauma. These conditions may lead to significant restrictions in daily living activities and decreased quality of life. Conservative physiotherapy remains the primary treatment approach for individuals with partial-thickness rotator cuff tears, emphasizing pain relief, range of motion restoration, neuromuscular control, and functional improvement. Recent literature suggests that manual therapy techniques, when combined with exercise programs, may enhance clinical outcomes by providing additional benefits in pain modulation, joint mobility, and sensorimotor function.
This study is designed to investigate and compare the clinical efficacy of two commonly used manual therapy techniques-Mulligan Mobilization With Movement (MWM) and Proprioceptive Neuromuscular Facilitation (PNF)-in individuals with rotator cuff lesions. Although both approaches are widely used in clinical practice, there is currently no comparative research evaluating their relative effectiveness on pain, functionality, proprioception, and quality of life. By integrating these techniques into a structured physiotherapy program, the study aims to determine whether either method provides superior therapeutic benefits.
A total of 45 participants aged 30-70 years with a confirmed diagnosis of partial supraspinatus tear will be included. Diagnosis will be established by a physical medicine and rehabilitation specialist and verified through appropriate imaging techniques. Participants will be randomly allocated into three groups: (1) Conventional Physiotherapy (Control), (2) Mulligan + Conventional Physiotherapy, and (3) PNF + Conventional Physiotherapy. All groups will receive a standardized physiotherapy program consisting of wand exercises, Codman pendulum exercises, stretching, finger-ladder exercises, strengthening with elastic bands tailored to individual capability, and TENS applied at 100 Hz for 20 minutes per session. This program will be administered four times per week for three weeks under physiotherapist supervision.
In the Mulligan group, the MWM technique will be applied prior to the exercise program. The intervention will target shoulder flexion, abduction, internal rotation, and external rotation. Using a mobilization belt to optimize joint gliding, the therapist will guide the participant through active, pain-free movements while applying a sustained accessory glide. The technique will initially be performed for 10 repetitions in the first two sessions and progressed to 3 sets of 10 repetitions in later sessions.
In the PNF group, a "hold-relax active movement" approach will be used to enhance proprioceptive input, neuromuscular activation, and functional movement patterns. Participants will perform isometric contractions in the shortened range of the agonist muscle, followed by relaxation and quick passive movement into the elongated range of the antagonist pattern. They will then perform isotonic contractions of the agonist. This cycle will be repeated several times until adequate muscle activation or fatigue is achieved. PNF will also be performed prior to the conventional exercise program.
Outcome measurements will be performed at baseline and at the end of the three-week intervention period. Pain intensity will be assessed using the Visual Analog Scale (VAS), and shoulder joint range of motion will be measured using the Goniometer Pro smartphone application, which has demonstrated good validity and reliability. Functional disability will be evaluated using the Turkish version of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, while proprioception will be measured through joint position sense testing at 60 degrees of flexion and abduction using Goniometer Pro. Quality of life will be assessed through the Rotator Cuff Quality of Life (RC-QoL) questionnaire, which has been validated for Turkish-speaking patients with rotator cuff pathology.
Statistical analyses will be conducted using SPSS 25.0. Normality will be tested through skewness-kurtosis values. Depending on distribution, within-group comparisons will utilize paired t-tests or Wilcoxon signed-rank tests; between-group comparisons will use one-way ANOVA or Kruskal-Wallis tests. When significant group differences are identified, appropriate post-hoc analyses will be performed. A significance level of p < 0.05 will be adopted.
This study is expected to contribute important evidence regarding the comparative effectiveness of Mulligan MWM and PNF techniques for rotator cuff lesions. The findings may support clinicians in selecting the most beneficial manual therapy approach to optimize patient outcomes in terms of pain reduction, functional capacity, proprioceptive accuracy, and overall quality of life. The results may also guide future research focusing on combined manual therapy and exercise interventions for shoulder pathologies.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
- Model description
- This study uses a parallel-group randomized controlled trial design in which participants with rotator cuff lesions are assigned to one of three groups: (1) Conventional Physiotherapy, (2) Mulligan Mobilization With Movement plus Conventional Physiotherapy, or (3) Proprioceptive Neuromuscular Facilitation plus Conventional Physiotherapy.
| Arm | Type | Receives |
|---|---|---|
| Control Group (Conventional Physiotherapy) | Active comparator | Other: Control Group (Conventional Physiotherapy)All participants will receive a conventional physiotherapy program for 3 weeks, 4 days per week. The program includes wand exercises in all directions (10 repetitions with a 2-second end-range hold), Codman pendulum exercises in flexion, abduction, and circular motions (10 repetitions), stretching exercises held for 20 seconds for 5 repetitions in all directions, and finger-ladder exercises for flexion and abduction (10 repetitions). Strengthening exercises will be performed using elastic bands selected according to each participant's physical capacity (3 sets of 10 repetitions). All sessions will be supervised by a physiotherapist. Additionally, TENS will be applied to the painful area at 100 Hz for 20 minutes in each session. |
| Mulligan Group | Experimental | Other: Control Group (Conventional Physiotherapy), Other: Mulligan MobilizationIn the Mulligan group, the MWM (Movement With Mobilization) technique will be applied in addition to the conventional exercise program. MWM will be performed twice a week for 3 weeks in flexion, abduction, internal rotation, and external rotation. The technique will be applied before exercises. A mobilization belt will be used to provide an effective glide, and participants will first demonstrate the painful or restricted movement. The belt will be placed around the shoulder, and the joint positioned pain-free. A glide force will be applied while the participant performs the movement actively, followed by a 3-second hold at the end range. The first two sessions will include 10 repetitions; subsequent sessions will include 3 sets of 10 repetitions. Participants will be positioned supine for rotation techniques and seated for flexion and abduction. |
| Proprioceptive Neuromuscular Facilitation Group | Experimental | Other: Control Group (Conventional Physiotherapy), Other: Proprioceptive Neuromuscular FacilitationBefore the standard physiotherapy and exercise program, the "hold-relax active movement" technique will be applied to increase circulation around the joint and enhance muscle activation. This technique is based on repeated isotonic contractions that do not require continuous effort. The physiotherapist will first ask the participant to perform an isometric contraction in the shortened position of the agonist pattern. Then the participant will be instructed to relax, and the segment will be moved quickly and passively into the lengthened position of the antagonist pattern. The participant will then be asked to perform an isotonic contraction of the agonist pattern again. This sequence will be repeated several times until contraction is adequately felt in the weak muscles or until fatigue occurs. Care will be taken to ensure that the passive movement into the antagonist direction is performed smoothly and quickly. |
Who may qualify
- Ages
- 30 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Male and female participants between 30 and 70 years of age.
- A diagnosis of partial supraspinatus tear made by a physical medicine and rehabilitation s-specialist.
- Confirmation of the diagnosis through radiological imaging methods.
- No history of any shoulder surgery.
- Shoulder symptoms persisting for more than 4 weeks.
Key exclusion criteria (3 listed)
- Individuals who are unable to cooperate or who have mental health problems.
- Individuals who have participated in any shoulder-related physiotherapy program within the last 3 months.
- Individuals with other musculoskeletal conditions that may affect the shoulder region.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Control Group (Conventional Physiotherapy)Participants in the control group will receive a supervised conventional physiotherapy program consisting of wand, pendulum, stretching, and finger-ladder exercises, strengthening with elastic bands, and TENS applied to the painful area at 100 Hz for 20 minutes per session. | Other | Control Group (Conventional Physiotherapy), Mulligan Group, Proprioceptive Neuromuscular Facilitation Group |
| Mulligan MobilizationParticipants in the Mulligan group will receive the conventional physiotherapy program plus Mulligan Movement With Mobilization (MWM) techniques applied twice weekly before exercises. The physiotherapist will use a mobilization belt to provide joint glide while participants perform pain-free active movements in flexion, abduction, and rotation. | Other | Mulligan Group |
| Proprioceptive Neuromuscular FacilitationParticipants in the PNF group will receive the conventional physiotherapy program plus PNF "hold-relax active movement" techniques applied before exercises. The physiotherapist will guide participants through repeated isometric, passive, and isotonic contractions to enhance proprioceptive input, muscle activation, and joint mobility. | Other | Proprioceptive Neuromuscular Facilitation Group |
Primary outcome
Joint Position Sense
Time frame: 3 weeks
Joint position sense will be assessed using the Becure Extremity ROM system. Joint position sense will be assessed at 60 degrees of shoulder flexion and shoulder abduction. While standing, the participant will first be asked to lift the arm with eyes open and memorize the position at 60 degrees. Then, with eyes closed, the participant will be instructed to raise the arm to the same position reached when the eyes were open. The shoulder angle obtained with eyes closed will be recorded. The difference between the angles measured with eyes open and eyes closed will be considered the joint position sense error. This method will be performed at 60 degrees of both flexion and abduction.
4 secondary outcomes
Pain (VAS Score)
Time frame: 3 weeks
Range of Motion (Shoulder Flexion, Abduction, Internal and External Rotation Measured in Degrees)
Time frame: 3 weeks
Disability (DASH Questionnaire Score)
Time frame: 3 weeks
Quality of Life (RC-QoL Score)
Time frame: 3 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Aug 2026.
- Individual participant dataSharing planned: Yes. De-identified individual participant data underlying the results reported in the published article will be made available upon reasonable request to the corresponding author for scientifically sound research purposes. Data access will be subject to approval of the proposed use and completion of an appropriate data-sharing agreement, in accordance with institutional policies and applicable ethical requirements.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Emre Dansuk, PhD principal investigator
Medipol University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mulligan Mobilization and Proprioceptive Neuromuscular Facilitation in people with Rotator Cuff Syndrome and Rotator Cuff Injuries, run by Medipol University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Joint Position Sense (time frame: 3 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Aug 2026.