Carpal Tunnel Syndrome (CTS)NCT07294157
Comparison of Rest Splints vs High-Intensity Laser Therapy in Carpal Tunnel Syndrome
A study testing Rest splint group and high-intensity laser therapy (HILT) in people with Carpal Tunnel Syndrome (CTS), run by Afyonkarahisar Health Sciences University at 2 sites in Turkey (Türkiye).
Trial summary
The aim of this study is to compare the effectiveness of rest splints and high-intensity laser therapy(HILT) added to physical therapy programs for patients with carpal tunnel syndrome in terms of pain, function, nerve conduction studies, and grip strength. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Carpal Tunnel Syndrome (CTS)
- What is being tested?
- Rest splint group and high-intensity laser therapy (HILT)
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 78 participants
- Where
- 2 sitesTurkey (Türkiye)
- Study dates
- 15 Dec 2025to 15 Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged 18-75 years who have been diagnosed with carpal tunnel syndrome based on their medical history, physical examination, clinical findings, and electromyography(EMG) results, who have applied to the outpatient clinic for physical therapy, and who have no contraindications for treatment will be included in the study after obtaining their consent.
Who cannot join
- Diabetes Mellitus
- Hypothyroidism
- Acromegaly
- Rheumatic Diseases
- Polyneuropathy
- Ipsilateral brachial plexopathy and traumatic nerve injury in the upper extremity
Show all 15Show fewer
- Previous injection into the carpal tunnel within the last 6 months and physical therapy
- Pregnancy
- History of malignant tumors
- Patients with cochlear implants
- Acquired Immunodeficiency Syndrome
- History of neck and/or shoulder surgery
- Corticosteroid consumption, analgesic medication use
- Epilepsy
- Skin lesion
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)2 sites, 2 recruiting
- Not yet recruiting
Afyonkarahisar Health Science University
Afyonkarahisar, 0300
Ramazan TUNCER, MD, 05060238608, ramazantuncer992@gmail.com
- Recruiting
Afyonkarahisar Health Sciences Unıversity
Afyonkarahisar, 0300
About this study
Official title: Comparison of the Effects of Rest Splints and High-Intensity Laser Therapy on Pain, Function, Nerve Conduction Studies, and Grip Strength in Patients With Carpal Tunnel Syndrome
The aim of this study is to compare the effectiveness of rest splints and high-intensity laser therapy(HILT) added to physical therapy programs for patients with carpal tunnel syndrome in terms of pain, function, nerve conduction studies, and grip strength.
Read the detailed description
Carpal tunnel syndrome (CTS) is the most common entrapment nerve compression, causing numbness and tingling in the hand, atrophy and muscle weakness in advanced stages. Any condition that increases the volume of the carpal tunnel and narrows the diameter of the tunnel can increase the compression of the median nerve under the transverse carpal ligament and cause symptoms. The use of a wrist splint or wrist brace is a common method of non-surgical treatment of carpal tunnel syndrome. The wrist splint is designed to allow rotation and supination, while eliminating the possibility of extension, flexion and radial-ulnar deviation.High-intensity laser therapy is used to provide symptomatic relief and reduce pain-related inflammation. The soothing effect of the laser is remarkable, especially in acute cases, but in the case of chronic disorders, the pain may be aggravated after the first treatments and is continued only if it decreases.
This study was designed as a prospective randomised controlled trial. Participants were randomised into 3 groups. The 1st group will receive wrist range of motion exercises, isometric strengthening, intrinsic muscle strengthening, wrist stretching, desensitization exercises, tendon sliding exercises, median nerve sliding exercises, wrist flexion and extension exercises, grip strengthening exercises and resting splint application for 6 weeks, 5 days a week, 30 sessions in total. The 2nd group (HILT group) will be given high intensity laser therapy 5 days a week for 6 weeks (30 sessions in total) in addition to the physical therapy program. The 3rd group will be the sham HILT group and physical therapy exercises will be applied like the other groups.
- Conditions
- Carpal Tunnel Syndrome (CTS)
- Being tested
- Rest splint group, high-intensity laser therapy (HILT), sham high-intensity laser therapy (HILT)
- Keywords
- Carpal Tunnel Syndrome, Physical Therapy Modalities, Electromyography veya Nerve Conduction
- Medical subject headings
- Carpal Tunnel Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Rest splint groupDevice
We routinely provide the following physical therapy program to patients with carpal tunnel syndrome in our physical therapy unit: hand wrist ROM isometric strengthening, intrinsic muscle strengthening, hand wrist stretching, desensitization exercises, tendon gliding exercises, median nerve gliding exercises, wrist flexion and extension exercises, grip strengthening exercises) will be provided to patients with carpal tunnel syndrome in our physical therapy unit, and they will be instructed to use the resting splint as much as possible during the day and maximally at night for 6 weeks. Rest splint: The WingMed brand splint is specially designed to hold the wrist in a neutral position with volar support, allowing pronation and supination of the wrist but not allowing flexion, extension, radial, or ulnar deviation.
high-intensity laser therapy (HILT)Device
Group 2 (high-intensity laser therapy (HILT)) will undergo pulsed laser therapy using the HIRO 3 device (ASA Laser, Arcugnano, Italy) five times a week for 6 weeks (a total of 30 sessions, one session per day) in addition to the physical therapy program. During each session, a three-phase treatment program will be administered to patients once a day, accompanied by a physical therapist, consisting of nerve/tendon gliding exercises.
sham high-intensity laser therapy (HILT)Device
The sham-HILT group will receive sham laser therapy using the HIRO 3 device (ASA Laser, Arcugnano, Italy) five times a week for six weeks (a total of 30 sessions, one session per day) in addition to the physical therapy program. After patients see that the device is turned on during the sham application, the same treatment will be applied to the same treatment area for the same duration without allowing laser current output from the device.
| Study group | Role | What they receive |
|---|---|---|
| Experimental: 1. Group (rest splint group) | Experimental | The physical therapy program we routinely provide to patients with carpal tunnel syndrome in our physical therapy unit (wrist ROM isometric strengthening, intrinsic muscle strengthening, wrist stretching, desensitization exercises, tendon gliding exercises, median nerve gliding exercises, wrist flexion and extension exercises, grip strengthening exercises) will be provided to patients with carpal tunnel syndrome in our physical therapy unit. Patients will be instructed to use a splint for rest as much as possible during the day and for as long as possible at night for a period of 6 weeks. Receives: Device: Rest splint group |
| Experimental: Group 2 (high-intensity laser therapy (HILT)) | Experimental | This group will receive high-intensity laser therapy applied over the carpal tunnel region. HILT delivers deep tissue photothermal and photomechanical effects, promoting tissue repair and reducing inflammation. The treatment is expected to decrease pain and improve nerve conduction and grip strength. Receives: Device: high-intensity laser therapy (HILT) |
| Sham Comparator: Group 3 (sham high-intensity laser therapy (HILT) ) | Sham comparator | Participants in this group will undergo a placebo laser treatment using the same device without active laser emission. The procedure will mimic the real HILT application to ensure blinding. This group will help distinguish the true therapeutic effects of HILT from placebo responses. Receives: Device: sham high-intensity laser therapy (HILT) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual Analog Scale (VAS):
Patients' musculoskeletal pain intensity was assessed using the visual analog scale (VAS). The meanings of the numbers placed on a 10 cm line from 0 to 10 were explained to the patients. It was explained that no pain was 0, the most severe pain ever experienced was 10, and moderate pain was 5 points. Based on these explanations, patients were asked to rate their pain levels for the past week.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Secondary outcomes (12)
Boston Carpal Tunnel Questionnaire:
This questionnaire determines the severity of CTS-specific symptoms and functional outcome using a scale for each. The symptom severity subgroup is determined using 11 questions scored from 1 to 5, with a maximum score of 55. The higher the score, the greater the symptom severity. The functional subgroup assesses the difficulty of 8 functional activities scored from 1 to 5, with a maximum score of 40. The higher the score, the poorer the functional capacity.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
LANSS neuropathic pain assessment scale
The Self-Rating of Neuropathic Symptoms and Signs (S-LANSS) scale will be administered to all patients to determine the presence of neuropathic pain. The SLANSS scale is a measure used to distinguish neuropathic pain from nociceptive pain. Unlike the LANSS scale, the physician does not examine the patient in this scale, making it easier to administer. The S-LANSS scale consists of a total of 7 questions. The patient fills out this scale themselves. The first 5 questions consist of questions that inquire about pain symptoms, while the last 2 questions include a clinical examination that the patient performs on themselves. The answers to the questions are yes/no. Each question has a different score. The total score on the scale is 24. A total score of 12 or higher suggests neuropathic pain. The Turkish version of the S-LANSS scale has been validated and is reliable.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Pittsburgh Sleep Quality Index (PSQI)
This scale, used to assess sleep quality, consists of 24 questions that inquire about sleep quality over the past 4 weeks. The scale has 7 components, each of which is scored on a scale of 0-3. The total PUKİ score ranges from 0 to 21, with a score higher than 5 indicating poor sleep quality. Turkish validity and reliability studies have been conducted.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Quick DASH Questionnaire
Created to assess functional status and symptoms by focusing on physical function in the upper extremities. This questionnaire contains a total of 11 items. Symptoms or difficulty are rated on a scale of 1 to 5. At least 10 questions must be answered to calculate the Quick DASH score. The calculation result is rated between 0 and 100.0. 0 indicates no difficulty or symptoms, while 100 indicates no activity or severe symptom
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Median nerve distal motor latency
The compound muscle action potential amplitude (CMAP) will be obtained via surface electrodes placed on the abductor pollicis brevis muscle. The active recording electrode will be placed on the muscle belly and the reference electrode on the tendon insertion. The median nerve will be stimulated 8 cm proximal to the active recording electrode. Distal motor latencies will be measured from the onset of the stimulus artifact to the onset of the CMAP.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Median nerve compound muscle action potential amplitude (CMAP)
CMAPs will be obtained via surface electrodes placed on the abductor pollicis brevis muscle. The active recording electrode will be placed on the muscle belly, and the reference electrode will be placed at the tendon insertion. The median nerve will be stimulated 8 cm proximal to the active recording electrode. The amplitude of the CMAP will be measured from the baseline to the negative peak.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Motor nerve conduction velocity
The compound muscle action potential amplitude (CMAP) will be obtained via surface electrodes placed on the abductor pollicis brevis muscle. The median nerves will be stimulated at the wrist and antecubital fossa levels. Distal motor latencies will be measured from the onset of the stimulus artifact to the onset of the CMAP. Motor nerve conduction velocity will be calculated by dividing the distance by the distal motor latency.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Second finger sensory nerve action potential amplitude
Sensory nerve action potential amplitudes (SNAP) will be obtained using the orthodromic method and recorded with the second ring electrodes. The median nerves will be stimulated at the proximal and distal interphalangeal joints of the index finger and palm. Distal sensory latencies will be measured from the onset of the stimulus artifact to the onset of the SNAP.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Median nerve distal sensory latency
Sensory nerve action potential amplitudes (SNAP) will be obtained using an orthodromic method and recorded using surface electrodes placed on the wrist. The median nerves will be stimulated at the proximal and distal interphalangeal joints of the index finger. Distal sensory latencies will be measured from the onset of the stimulus artifact to the onset of the SNAP. Sensory nerve conduction velocity will be calculated by dividing the distance by the distal sensory latency.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
)Sensory nerve conduction velocity
Sensory nerve action potential amplitudes (SNAP) will be obtained using an orthodromic method and recorded with ring electrodes. The median nerves will be stimulated at the proximal and distal interphalangeal joints of the index finger. Distal sensory latencies will be measured from the onset of the stimulus artifact to the onset of the SNAP. Sensory nerve conduction velocity will be calculated by dividing the distance by the distal sensory latency.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Grip strength
A hand dynamometer (JAMAR) will be used to assess grip strength. The patient will perform three consecutive tests while sitting with shoulders abducted and neutrally rotated, elbow flexed at 90°, and forearm and wrist in a neutral position. The best of these measurements will be recorded in kilograms.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Pinchmeter
A pinchmeter will be used to evaluate pulp-to-pulp grip strength. The patient will sit with shoulders abducted and neutrally rotated, elbow flexed at 90°, and forearm and wrist in a neutral position, and will perform three consecutive tests. The best of these measurements will be recorded in kilograms.
Measured: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Dec 2025
- Study start15 Dec 2025
- Primary completion15 Jul 2026 (estimated)
- Study completion15 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Carpal Tunnel Syndrome (CTS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 78 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Afyonkarahisar Health Sciences University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ramazan Tuncer, Afyonkarahisar Health Sciences University
- Investigators
- Ümit DÜNDAR, Profesor, Principal investigator, AFYONKARAHİSAR HEALTH SCİENCES UNİVERSITY
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07294157
- Sponsor's protocol ID
- 2024-KAEK-09
- Status last verified
- Jan 2026
- First submitted
- 7 Dec 2025
- Last updated
- 13 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Ashour AA, Yehia RM, ElMeligie MM, Hanafy AF. Effectiveness of high intensity laser therapy on pain, grip strength and median nerve conductivity in pregnant women with carpal tunnel syndrome: A randomized controlled trial. J Hand Ther. 2023 Jul-Sep;36(3):536-545. doi: 10.1016/j.jht.2022.03.005. Epub 2022 Jul 8.
PubMed 35817691Yigit F, Ordahan B. Effects of high-intensity laser therapy on pain, functional status, hand grip strength, and median nerve cross-sectional area by ultrasonography in patients with carpal tunnel syndrome. Lasers Med Sci. 2023 Oct 31;38(1):248. doi: 10.1007/s10103-023-03913-z.
PubMed 37906312Ezzati K, Laakso EL, Saberi A, Yousefzadeh Chabok S, Nasiri E, Bakhshayesh Eghbali B. A comparative study of the dose-dependent effects of low level and high intensity photobiomodulation (laser) therapy on pain and electrophysiological parameters in patients with carpal tunnel syndrome. Eur J Phys Rehabil Med. 2020 Dec;56(6):733-740. doi: 10.23736/S1973-9087.19.05835-0. Epub 2019 Nov 18.
PubMed 31742366
Study at a glance
From the registry record, last updated by the sponsor on 13 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Effects of Rest Splints and High-Intensity Laser Therapy on Pain, Function, Nerve Conduction Studies, and Grip Strength in Patients With Carpal Tunnel Syndrome
- ClinicalTrials.gov ID
- NCT07294157
- Acronym / sponsor ID
- 2024-KAEK-09
- Conditions
- Carpal Tunnel Syndrome (CTS)
- Keywords
- Carpal Tunnel Syndrome, Physical Therapy Modalities, Electromyography veya Nerve Conduction
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 78 participants (estimated)
- Lead sponsor
- Afyonkarahisar Health Sciences UniversityUniversity, hospital or other
- Study start
- 15 Dec 2025 (actual)
- Primary completion
- 15 Jul 2026 (estimated)
- Study completion
- 15 Sep 2026 (estimated)
- First posted
- 19 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to compare the effectiveness of rest splints and high-intensity laser therapy(HILT) added to physical therapy programs for patients with carpal tunnel syndrome in terms of pain, function, nerve conduction studies, and grip strength.
Detailed description
Carpal tunnel syndrome (CTS) is the most common entrapment nerve compression, causing numbness and tingling in the hand, atrophy and muscle weakness in advanced stages. Any condition that increases the volume of the carpal tunnel and narrows the diameter of the tunnel can increase the compression of the median nerve under the transverse carpal ligament and cause symptoms. The use of a wrist splint or wrist brace is a common method of non-surgical treatment of carpal tunnel syndrome. The wrist splint is designed to allow rotation and supination, while eliminating the possibility of extension, flexion and radial-ulnar deviation.High-intensity laser therapy is used to provide symptomatic relief and reduce pain-related inflammation. The soothing effect of the laser is remarkable, especially in acute cases, but in the case of chronic disorders, the pain may be aggravated after the first treatments and is continued only if it decreases.
This study was designed as a prospective randomised controlled trial. Participants were randomised into 3 groups. The 1st group will receive wrist range of motion exercises, isometric strengthening, intrinsic muscle strengthening, wrist stretching, desensitization exercises, tendon sliding exercises, median nerve sliding exercises, wrist flexion and extension exercises, grip strengthening exercises and resting splint application for 6 weeks, 5 days a week, 30 sessions in total. The 2nd group (HILT group) will be given high intensity laser therapy 5 days a week for 6 weeks (30 sessions in total) in addition to the physical therapy program. The 3rd group will be the sham HILT group and physical therapy exercises will be applied like the other groups.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Experimental: 1. Group (rest splint group) | Experimental | Device: Rest splint groupThe physical therapy program we routinely provide to patients with carpal tunnel syndrome in our physical therapy unit (wrist ROM isometric strengthening, intrinsic muscle strengthening, wrist stretching, desensitization exercises, tendon gliding exercises, median nerve gliding exercises, wrist flexion and extension exercises, grip strengthening exercises) will be provided to patients with carpal tunnel syndrome in our physical therapy unit. Patients will be instructed to use a splint for rest as much as possible during the day and for as long as possible at night for a period of 6 weeks. |
| Experimental: Group 2 (high-intensity laser therapy (HILT)) | Experimental | Device: high-intensity laser therapy (HILT)This group will receive high-intensity laser therapy applied over the carpal tunnel region. HILT delivers deep tissue photothermal and photomechanical effects, promoting tissue repair and reducing inflammation. The treatment is expected to decrease pain and improve nerve conduction and grip strength. |
| Sham Comparator: Group 3 (sham high-intensity laser therapy (HILT) ) | Sham comparator | Device: sham high-intensity laser therapy (HILT)Participants in this group will undergo a placebo laser treatment using the same device without active laser emission. The procedure will mimic the real HILT application to ensure blinding. This group will help distinguish the true therapeutic effects of HILT from placebo responses. |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Patients aged 18-75 years who have been diagnosed with carpal tunnel syndrome based on their medical history, physical examination, clinical findings, and electromyography(EMG) results, who have applied to the outpatient clinic for physical therapy, and who have no contraindications for treatment will be included in the study after obtaining their consent.
Key exclusion criteria (15 listed)
- Diabetes Mellitus
- Hypothyroidism
- Acromegaly
- Rheumatic Diseases
- Polyneuropathy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Rest splint groupWe routinely provide the following physical therapy program to patients with carpal tunnel syndrome in our physical therapy unit: hand wrist ROM isometric strengthening, intrinsic muscle strengthening, hand wrist stretching, desensitization exercises, tendon gliding exercises, median nerve gliding exercises, wrist flexion and extension exercises, grip strengthening exercises) will be provided to patients with carpal tunnel syndrome in our physical therapy unit, and they will be instructed to use the resting splint as much as possible during the day and maximally at night for 6 weeks. Rest splint: The WingMed brand splint is specially designed to hold the wrist in a neutral position with volar support, allowing pronation and supination of the wrist but not allowing flexion, extension, radial, or ulnar deviation. | Device | Experimental: 1. Group (rest splint group) |
| high-intensity laser therapy (HILT)Group 2 (high-intensity laser therapy (HILT)) will undergo pulsed laser therapy using the HIRO 3 device (ASA Laser, Arcugnano, Italy) five times a week for 6 weeks (a total of 30 sessions, one session per day) in addition to the physical therapy program. During each session, a three-phase treatment program will be administered to patients once a day, accompanied by a physical therapist, consisting of nerve/tendon gliding exercises. | Device | Experimental: Group 2 (high-intensity laser therapy (HILT)) |
| sham high-intensity laser therapy (HILT)The sham-HILT group will receive sham laser therapy using the HIRO 3 device (ASA Laser, Arcugnano, Italy) five times a week for six weeks (a total of 30 sessions, one session per day) in addition to the physical therapy program. After patients see that the device is turned on during the sham application, the same treatment will be applied to the same treatment area for the same duration without allowing laser current output from the device. | Device | Sham Comparator: Group 3 (sham high-intensity laser therapy (HILT) ) |
Primary outcome
Visual Analog Scale (VAS):
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Patients' musculoskeletal pain intensity was assessed using the visual analog scale (VAS). The meanings of the numbers placed on a 10 cm line from 0 to 10 were explained to the patients. It was explained that no pain was 0, the most severe pain ever experienced was 10, and moderate pain was 5 points. Based on these explanations, patients were asked to rate their pain levels for the past week.
12 secondary outcomes
Boston Carpal Tunnel Questionnaire:
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
LANSS neuropathic pain assessment scale
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Pittsburgh Sleep Quality Index (PSQI)
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Quick DASH Questionnaire
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Median nerve distal motor latency
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Median nerve compound muscle action potential amplitude (CMAP)
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Motor nerve conduction velocity
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Second finger sensory nerve action potential amplitude
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Median nerve distal sensory latency
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
)Sensory nerve conduction velocity
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Grip strength
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Pinchmeter
Time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Jan 2026.
- Background: PubMed 35817691Ashour AA, Yehia RM, ElMeligie MM, Hanafy AF. Effectiveness of high intensity laser therapy on pain, grip strength and median nerve conductivity in pregnant women with carpal tunnel syndrome: A randomized controlled trial. J Hand Ther. 2023 Jul-Sep;36(3):536-545. doi: 10.1016/j.jht.2022.03.005. Epub 2022 Jul 8.
- Background: PubMed 37906312Yigit F, Ordahan B. Effects of high-intensity laser therapy on pain, functional status, hand grip strength, and median nerve cross-sectional area by ultrasonography in patients with carpal tunnel syndrome. Lasers Med Sci. 2023 Oct 31;38(1):248. doi: 10.1007/s10103-023-03913-z.
- Background: PubMed 31742366Ezzati K, Laakso EL, Saberi A, Yousefzadeh Chabok S, Nasiri E, Bakhshayesh Eghbali B. A comparative study of the dose-dependent effects of low level and high intensity photobiomodulation (laser) therapy on pain and electrophysiological parameters in patients with carpal tunnel syndrome. Eur J Phys Rehabil Med. 2020 Dec;56(6):733-740. doi: 10.23736/S1973-9087.19.05835-0. Epub 2019 Nov 18.
- Effectiveness of high intensity laser therapy on pain, grip strength and median nerve conductivity in pregnant women with carpal tunnel syndrome: A randomized controlled trialLink provided by the sponsor.
- Effects of high-intensity laser therapy on pain, functional status, hand grip strength, and median nerve cross-sectional area by ultrasonography in patients with carpal tunnel syndromeLink provided by the sponsor.
- A comparative study of the dose-dependent effects of low level and high intensity photobiomodulation (laser) therapy on pain and electrophysiological parameters in patients with carpal tunnel syndromeLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ümit DÜNDAR, Profesor principal investigator
AFYONKARAHİSAR HEALTH SCİENCES UNİVERSITY
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Rest splint group and high-intensity laser therapy (HILT) in people with Carpal Tunnel Syndrome (CTS), run by Afyonkarahisar Health Sciences University at 2 sites in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ümit DÜNDAR, Profesor (05337494526, umitftr@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual Analog Scale (VAS): (time frame: Baseline(pre-treatment,after 6 weeks(post treatment)-after 12 weeks(post treatment)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07294157, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Jan 2026; AzTrials last refreshed its copy on 6 Nov 2026.