Chronic Knee PainPain-DriveNCT07281651
Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive
An observational study of Chronic Knee Pain and Fibromyalgia, run by University of Nottingham at 1 site in United Kingdom.
Trial summary
Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia). Pain is often not directly related to the degree of muscle or joint damage. Read more about this study
- Who is it for?
- Ages 40 years and olderHealthy volunteers can take part
- Conditions the study is for
- Chronic Knee Pain, Fibromyalgia
- What is being tested?
- Central Pain Hypersensitivity
- How many people
- 135 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 24 Nov 2025to Sep 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Participants may be recruited via various routes. Recruitment will primarily be through the Investigating Musculoskeletal Health and Wellbeing (IMH\&W) cohort, which comprises over 7610 people with and without a range of musculoskeletal conditions. Participants with knee pain or fibromyalgia or healthy pain free individuals may be recruited via word of mouth, via University of Nottingham intranet and posters. Participant with fibromyalgia may be recruited to take part via local community support groups.
Who may be able to join
- Knee pain group
- History of knee pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months
- Fibromyalgia group
- Fibromyalgia diagnosis (participant self-reporting a previous diagnosis by a clinician)
- Pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months
- Control group
- Pain free individuals without known osteoarthritis
Who cannot join
- BMI>35
- Body weight of 250kg or higher
- Pregnancy (women)
- Inability to give consent
- Inability to meet the requirements of clinical assessment
- Performed strenuous physical exercise in the past 24 hours prior to testing
- Consumed alcohol on day of testing
- Consumed caffeine on day of testing
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site, 1 recruiting
- Recruiting
University of Nottingham Graduate Entry Medicine and Health, Royal Derby Hospital, Uttoxeter Road, Derby
Derby, Derbyshire, DE22 3DT
Ben Lightowler, MSc, +44 (0)1332 724688, benjamin.lightowler@nottingham.ac.uk
About this study
Official title: Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive, in People With Knee Pain, and in People With Fibromyalgia Syndrome (Pain-Neural Drive)
Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia). Pain is often not directly related to the degree of muscle or joint damage. Adaptations of the central nervous system (brain, spinal cord and nerves) often occur in chronic musculoskeletal conditions and can influence how we feel pain (central pain hypersensitivity). Pain can impact on muscle activity and movement. Muscle activity is also governed by nerve signals from the central nervous system (neural drive).
The goal of this cross-sectional observational study is to investigate whether chronic musculoskeletal pain is associated with altered nerve signalling (neural drive) to skeletal muscles in adults 40 years or over with chronic knee pain, fibromyalgia and healthy pain free volunteers.
Read more
The main questions it aims to answer are:-
- Is central pain hypersensitivity associated with altered nerve signalling to skeletal muscles in adults 40 years or over with chronic pain (knee pain and for fibromyalgia) as well as healthy volunteers?
- Is altered nerve signalling to skeletal muscles associated with physical function and disability?
Participants will be asked to:-
- Have sensory testing to determine how they feel pain
- Complete static leg and arm muscle contractions with electrodes on the skin to measure muscle electrical activity
- Complete questionnaires
- Perform a short set of mobility tasks including walking, rising from a chair and balancing.
Read the detailed description
Participants will be required to attend two visits to Derby Medical School.
Screening and eligibility assessment:- Prior to booking an appointment to attend the study, potential participants will be given the opportunity to ask questions and be pre-screened for eligibility for the study.
Participation involves two study visits:- Visit 1 involves screening for eligibility, and providing informed consent. A brief history of pain condition and clinical knee assessment will be carried out. Familiarisation with the muscle testing protocol (practicing a set of muscle contractions) a questionnaire booklet will be provided at this visit. Visit 1 will last between 30 and 45 minutes.
Visit 2 is the test session. Body weight and height will be taken. Pain sensitivity testing (quantitative sensory testing) will be followed by neuromuscular testing while sitting in a specially designed chair. Isometric muscle contractions will be measured using an isometric dynamometer. One muscle will be tested in the lower legs and one muscle in the upper arms (on both sides).
Electrodes will be placed on a muscle at the front of the leg (tibialis anterior) and at the front of the upper arm (biceps brachii). A battery of isometric (static) muscle contractions will be performed following a force trace visual feedback on a monitor. To test whether experimental remote pain has an influence on neuromuscular functioning, a temporary pain stimulus will be applied to the arm via blood pressure cuff to a subjective level of 4/10 where '0' no pain and '10' worse pain or discomfort imaginable. A series of muscle contractions will be carried out during the remote discomfort stimulus lasting approximately 2 minutes. If discomfort becomes too much at any time the cuff will be removed immediately.
Physical performance and self-reported physical functioning and disability will be measured with a simple performance measure and questionnaires respectively. A pre-test questionnaire will be used to collect relevant data, including: pain severity, duration of pain condition, duration of pain, other medical conditions, gender, ethnicity, smoking status, employment status, use of pain medications. The questionnaire also includes validated questionnaires on quality of life, central aspects of pain, disability, physical functioning, fatigue and physical activity.
- Conditions
- Chronic Knee Pain, Fibromyalgia
- Being tested
- Central Pain Hypersensitivity
- Keywords
- Chronic Pain, Musculoskeletal Conditions, Fibromyalgia, Muscle Function, Physical Functioning, Disability, Central Aspects of Pain
- Medical subject headings
- Fibromyalgia, Chronic Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Central Pain HypersensitivityOther
No intervention carried out
| Study group | Role | What they receive |
|---|---|---|
| Chronic Knee Pain | Adults with knee pain lasting over 3 months Receives: Other: Central Pain Hypersensitivity | |
| Fibromyalgia | Adults with Fibromyalgia Receives: Other: Central Pain Hypersensitivity | |
| Control Group | Adults without chronic pain conditions Receives: Other: Central Pain Hypersensitivity |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pressure Pain Threshold
Pressure Pain Threshold as an index of central pain hypersensitivity.
Pressure Pain Threshold (PPT) performed with digital algometer, applied at proximal forearm. A gradually increasing pressure is applied, and participants indicate when the sensation of pressure turns to pain. PPDT measured in Kilopascals (kPa). Three tests applied, which are then mean averaged. Lower PPT indicates greater pain sensitivity.
Measured: Once at baseline
Temporal Summation
Temporal Summation as an index of central pain hypersensitivity.
Temporal Summation (TS) assessed using a puncate stimulator (designed not to puncture the skin). Participants rate their experience of sharpness during the stimulus on a 10 cm visual analogue scale, first following one application, and second following 10 repeated applications. TS is calculated by subtracting first score from second (in cm). Higher positive scores indicate higher sensitivity.
Measured: Once at baseline
Conditioned Pain Modulation
Conditioned Pain Modulation as an index of central pain hypersensitivity.
Conditioned pain modulation (CPM) involves temporary ischaemic pain at one arm by way of blood pressure cuff. PPT simultaneously applied to opposite forearm. CPM calculated as conditioned PPT minus non-conditioned PPT in kilopascals (kPa). Lower positive or negative CPM indicates higher sensitivity.
Measured: Once at baseline
Short Physical Performance Battery Test
A measure of physical performance of basic physical tasks, which is made up of for tasks:-
Standing balance: participants are timed as to how long they can maintain standing balance unassisted without walking aids. First with feet side by side, second in semi-tandem stance, third in full tandem-stance. Points are awarded if balance is maintained for 10 seconds.
Walking speed: participants are timed to walk a short distance (3 or 4 meters) at their usual walking pace. Allowed to use their usual walking aids. Points are awarded based on pre-set time scales for completing the walk.
Repeated sit to stand: participants timed as to how many times they can sit to stand 5 times from an average height chair. Points awarded based on pre-set durations.
Points are combined to give an overall score ranging from 0 - 12. A higher overall score = higher physical performance.
Measured: Once at baseline
Motor Unit Firing Characteristics of skeletal muscles via High Density Surface Electromyography (HDsEMG)
Motor unit firing characteristics will be captured using HDsEMG during a range of sub-maximal skeletal muscle contractions. HDsEMG sensor will be placed on the skin over the muscles tibialis anterior and biceps brachii bilaterally to record muscle activation. Established methods will allow analysis of motor unit firing characteristics in terms of size, number, complexity, reliability and firing rate.
Measured: Once at baseline
Secondary outcomes (8)
Central Aspects of Pain Questionnaire
A self completed questionnaire giving a central aspects of pain factor, an index of central nervous system aspects of pain. The questionnaire includes 8 items covering neuropathic-like pain, fatigue, cognitive difficulty, catastrophizing, anxiety, sleep disturbance, depression and widespread pain. For the former 7 items, respondents rate the frequency of experiencing symptoms over the past week with four options "never", "sometimes", "often", "always". The widespread pain item involves shading areas of a manakin relating to painful areas of the body experienced on most days in the last four weeks. All items are combined to give an overall score. Scores can range from 0 to 16. The higher the score, the greater the central aspects of pain factor.
Measured: Once at baseline
Neuromuscular control
A range of isometric muscle contraction patterns will be performed (tibialis anterior and biceps brachii) in terms of contraction strength, duration and rate of force generation. Neuromuscular control metrics will include force steadiness, and force accuracy.
Measured: Once at baseline
Neuromuscular functioning alongside remote pain stimulus
To test whether experimental remote pain has an influence on neuromuscular functioning, a temporary pain stimulus will be applied to the arm via blood pressure cuff to a subjective level of 4/10 where '0' no pain and '10' worse pain or discomfort imaginable. A series of isometric (static) muscle contractions will be carried out during the remote discomfort stimulus lasting approximately 2 minutes. If discomfort becomes too much at any time the cuff will be removed immediately.
The effect of remote pain stimulus on neuromuscular functioning will be analysed in terms of neuromuscular control (including force steadiness, and force accuracy) and motor unit firing characteristics (using HDsEMG).
Measured: Once at baseline
Pain Intensity
Pain intensity measured by self-report using an 11 point numerical rating scale from 0-10, where 0 is no pain and 10 is the worst pain imaginable.
Three items will be administered, using the 11 point scale detailed above:-
- Over the past 4 weeks, how strong was your strongest pain?
- Over the past 4 weeks, how strong was your pain on average?
- How would you assess your pain now, at this moment?
Measured: Once via questionnaire prior to objective testing, however current pain level also completed on day of objective testing. Both are at baseline.
RAND 36 Item Survey 1.0 - Physical Performance sub-scale (SF-36 PF)
The RAND SF-36 PF is a sub-scale of the overall RAND SF-36 quality of life self-completed questionnaire. The SF-36 PF is a measure of Physical Functioning.
There are 10 question covering a range of every day physical functioning activities. Three responses are possible regarding the level of limitation experienced for each item i.e. "not limited at all" (three points), "limited a little" (2 points) or "limited a lot" (1 point). The overall SF-36 PF score is from 0-100, where 100 indicates the most favourable health state.
Measured: Once at baseline.
Health Assessment Questionnaire - Disability Index (HAQ-DI)
The HAQ-DI is a self-completed questionnaire designed to measure a person's functional ability over the past week. It covers eight categories of daily activities, including:- Dressing and Grooming; Arising; Eating; Walking; Hygiene; Reach; Grip and Activities. It also asks questions on the use of aids or devices and the need for help from other people. Each item is scored from 0-3. The overall HAQ-DI score is calculated by summing all the domains, and dividing by eight, providing an ordinal score from 0 (no-disability) to 3 (severe disability).
Measured: Once at baseline
Modified Fatigue Impact Scale (MFIS)
The MFIS is a self-completed questionnaire which provides a measure of how fatigue impacts on daily life. It has 21 items and provides an overall score out of 84 with higher scores indicating a greater impact of fatigue. Four sub-scales can be calculated: physical, cognitive and psychosocial, indicating how much fatigue impacts on these aspects of health and wellbeing.
Measured: Once at baseline
Physical Activity Scale for the Elderly (PASE)
The PASE is a self-completed questionnaire which measures physical activity levels over the past 7 days. It includes activities relating to leisure, household and occupation. It provides an overall score from 0-400 or more and a higher score indicates higher levels of physical activity.
Measured: Once at baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Dec 2025
- Study start24 Nov 2025
- Primary completionSep 2026 (estimated)
- Study completionSep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Knee PainStudies of the same condition, open and under way.
- More trials run by University of NottinghamThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 135 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Nottingham
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Stephanie Smith, University of Nottingham
- Investigators
- Stephanie Smith, PhD, Principal investigator, University of NottinghamMathew Piasecki, PhD, Principal investigator, University of Nottingham
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07281651
- Sponsor's protocol ID
- FMHS 36-1124 / FMHS 128-0425
- Acronym
- Pain-Drive
- Status last verified
- Dec 2025
- First submitted
- 17 Nov 2025
- Last updated
- 15 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive, in People With Knee Pain, and in People With Fibromyalgia Syndrome (Pain-Neural Drive)
- ClinicalTrials.gov ID
- NCT07281651
- Acronym / sponsor ID
- Pain-Drive / FMHS 36-1124 / FMHS 128-0425
- Conditions
- Chronic Knee Pain, Fibromyalgia
- Keywords
- Chronic Pain, Musculoskeletal Conditions, Fibromyalgia, Muscle Function, Physical Functioning, Disability, Central Aspects of Pain
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 135 participants (estimated)
- Lead sponsor
- University of NottinghamUniversity, hospital or other
- Study start
- 24 Nov 2025 (actual)
- Primary completion
- Sep 2026 (estimated)
- Study completion
- Sep 2026 (estimated)
- First posted
- 15 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia). Pain is often not directly related to the degree of muscle or joint damage. Adaptations of the central nervous system (brain, spinal cord and nerves) often occur in chronic musculoskeletal conditions and can influence how we feel pain (central pain hypersensitivity). Pain can impact on muscle activity and movement. Muscle activity is also governed by nerve signals from the central nervous system (neural drive).
The goal of this cross-sectional observational study is to investigate whether chronic musculoskeletal pain is associated with altered nerve signalling (neural drive) to skeletal muscles in adults 40 years or over with chronic knee pain, fibromyalgia and healthy pain free volunteers.
The main questions it aims to answer are:-
- Is central pain hypersensitivity associated with altered nerve signalling to skeletal muscles in adults 40 years or over with chronic pain (knee pain and for fibromyalgia) as well as healthy volunteers?
- Is altered nerve signalling to skeletal muscles associated with physical function and disability?
Participants will be asked to:-
- Have sensory testing to determine how they feel pain
- Complete static leg and arm muscle contractions with electrodes on the skin to measure muscle electrical activity
- Complete questionnaires
- Perform a short set of mobility tasks including walking, rising from a chair and balancing.
Detailed description
Participants will be required to attend two visits to Derby Medical School.
Screening and eligibility assessment:- Prior to booking an appointment to attend the study, potential participants will be given the opportunity to ask questions and be pre-screened for eligibility for the study.
Participation involves two study visits:- Visit 1 involves screening for eligibility, and providing informed consent. A brief history of pain condition and clinical knee assessment will be carried out. Familiarisation with the muscle testing protocol (practicing a set of muscle contractions) a questionnaire booklet will be provided at this visit. Visit 1 will last between 30 and 45 minutes.
Visit 2 is the test session. Body weight and height will be taken. Pain sensitivity testing (quantitative sensory testing) will be followed by neuromuscular testing while sitting in a specially designed chair. Isometric muscle contractions will be measured using an isometric dynamometer. One muscle will be tested in the lower legs and one muscle in the upper arms (on both sides).
Electrodes will be placed on a muscle at the front of the leg (tibialis anterior) and at the front of the upper arm (biceps brachii). A battery of isometric (static) muscle contractions will be performed following a force trace visual feedback on a monitor. To test whether experimental remote pain has an influence on neuromuscular functioning, a temporary pain stimulus will be applied to the arm via blood pressure cuff to a subjective level of 4/10 where '0' no pain and '10' worse pain or discomfort imaginable. A series of muscle contractions will be carried out during the remote discomfort stimulus lasting approximately 2 minutes. If discomfort becomes too much at any time the cuff will be removed immediately.
Physical performance and self-reported physical functioning and disability will be measured with a simple performance measure and questionnaires respectively. A pre-test questionnaire will be used to collect relevant data, including: pain severity, duration of pain condition, duration of pain, other medical conditions, gender, ethnicity, smoking status, employment status, use of pain medications. The questionnaire also includes validated questionnaires on quality of life, central aspects of pain, disability, physical functioning, fatigue and physical activity.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Chronic Knee Pain | – | Other: Central Pain HypersensitivityAdults with knee pain lasting over 3 months |
| Fibromyalgia | – | Other: Central Pain HypersensitivityAdults with Fibromyalgia |
| Control Group | – | Other: Central Pain HypersensitivityAdults without chronic pain conditions |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Participants may be recruited via various routes. Recruitment will primarily be through the Investigating Musculoskeletal Health and Wellbeing (IMH\&W) cohort, which comprises over 7610 people with and without a range of musculoskeletal conditions. Participants with knee pain or fibromyalgia or healthy pain free individuals may be recruited via word of mouth, via University of Nottingham intranet and posters. Participant with fibromyalgia may be recruited to take part via local community support groups.
Key inclusion criteria (7 listed)
- Knee pain group
- History of knee pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months
- Fibromyalgia group
- Fibromyalgia diagnosis (participant self-reporting a previous diagnosis by a clinician)
- Pain with an intensity level of 4 out of 10 or greater (where 0 is no pain and 10 is the worst pain imaginable) for most days in the past 3 months
Key exclusion criteria (8 listed)
- BMI>35
- Body weight of 250kg or higher
- Pregnancy (women)
- Inability to give consent
- Inability to meet the requirements of clinical assessment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Central Pain HypersensitivityNo intervention carried out | Other | Chronic Knee Pain, Control Group, Fibromyalgia |
Primary outcome
Pressure Pain Threshold
Time frame: Once at baseline
Pressure Pain Threshold as an index of central pain hypersensitivity. Pressure Pain Threshold (PPT) performed with digital algometer, applied at proximal forearm. A gradually increasing pressure is applied, and participants indicate when the sensation of pressure turns to pain. PPDT measured in Kilopascals (kPa). Three tests applied, which are then mean averaged. Lower PPT indicates greater pain sensitivity.
Temporal Summation
Time frame: Once at baseline
Temporal Summation as an index of central pain hypersensitivity. Temporal Summation (TS) assessed using a puncate stimulator (designed not to puncture the skin). Participants rate their experience of sharpness during the stimulus on a 10 cm visual analogue scale, first following one application, and second following 10 repeated applications. TS is calculated by subtracting first score from second (in cm). Higher positive scores indicate higher sensitivity.
Conditioned Pain Modulation
Time frame: Once at baseline
Conditioned Pain Modulation as an index of central pain hypersensitivity. Conditioned pain modulation (CPM) involves temporary ischaemic pain at one arm by way of blood pressure cuff. PPT simultaneously applied to opposite forearm. CPM calculated as conditioned PPT minus non-conditioned PPT in kilopascals (kPa). Lower positive or negative CPM indicates higher sensitivity.
Short Physical Performance Battery Test
Time frame: Once at baseline
A measure of physical performance of basic physical tasks, which is made up of for tasks:- Standing balance: participants are timed as to how long they can maintain standing balance unassisted without walking aids. First with feet side by side, second in semi-tandem stance, third in full tandem-stance. Points are awarded if balance is maintained for 10 seconds. Walking speed: participants are timed to walk a short distance (3 or 4 meters) at their usual walking pace. Allowed to use their usual walking aids. Points are awarded based on pre-set time scales for completing the walk. Repeated sit to stand: participants timed as to how many times they can sit to stand 5 times from an average height chair. Points awarded based on pre-set durations. Points are combined to give an overall score ranging from 0 - 12. A higher overall score = higher physical performance.
Motor Unit Firing Characteristics of skeletal muscles via High Density Surface Electromyography (HDsEMG)
Time frame: Once at baseline
Motor unit firing characteristics will be captured using HDsEMG during a range of sub-maximal skeletal muscle contractions. HDsEMG sensor will be placed on the skin over the muscles tibialis anterior and biceps brachii bilaterally to record muscle activation. Established methods will allow analysis of motor unit firing characteristics in terms of size, number, complexity, reliability and firing rate.
8 secondary outcomes
Central Aspects of Pain Questionnaire
Time frame: Once at baseline
Neuromuscular control
Time frame: Once at baseline
Neuromuscular functioning alongside remote pain stimulus
Time frame: Once at baseline
Pain Intensity
Time frame: Once via questionnaire prior to objective testing, however current pain level also completed on day of objective testing. Both are at baseline.
RAND 36 Item Survey 1.0 - Physical Performance sub-scale (SF-36 PF)
Time frame: Once at baseline.
Health Assessment Questionnaire - Disability Index (HAQ-DI)
Time frame: Once at baseline
Modified Fatigue Impact Scale (MFIS)
Time frame: Once at baseline
Physical Activity Scale for the Elderly (PASE)
Time frame: Once at baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Dec 2025.
- Individual participant dataSharing planned: No
Related trials for Chronic Knee Pain
Recruiting
BioPoly® Partial Resurfacing Knee Implant IDE
Knee Pain Chronic, Knee Osteoarthritis
RecruitingPhase 2
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
Osteoarthritis, Knee, Diabetic Neuropathic Pain
RecruitingPhase 2
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
Osteoarthritis, Knee, Chronic Pain
Not yet recruitingEarly Phase 1
Medication vs. Meditation for Chronic Knee Osteoarthritis
Knee Osteoarthristis
Recruiting
Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain.
Chronic Post-surgical Pain, Chronic Post Operative Pain
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Stephanie Smith, PhD principal investigator
University of Nottingham
Mathew Piasecki, PhD principal investigator
University of Nottingham
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Knee Pain and Fibromyalgia, run by University of Nottingham at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ben Lightowler, MSc (+44 (0)115 7484098, benjamin.lightowler@nottingham.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pressure Pain Threshold (time frame: Once at baseline). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Dec 2025.