AnalgesiaQLB&LPBNCT07280182
Effect of the Quadratus Lumborum Block Versus the Lumbar Plexus for Spiral Thighplasty Surgery
A study testing Ultrasound-Guided Trans-muscular QLB and Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) Block in people with Analgesia, run by Menoufia University at 1 site in Egypt.
Trial summary
Whether trans muscular QLB provides postoperative analgesia compared with LPB after thigh lift surgery Read more about this study
- Who is it for?
- Ages 18 to 55 years
- Conditions the study is for
- Analgesia
- What is being tested?
- Ultrasound-Guided Trans-muscular QLB and Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) Block
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 42 participants
- Where
- 1 siteEgypt
- Study dates
- 13 Dec 2025to 14 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- ASA ( American Society of Anaesthesia) I-II
- elective bilateral spiral thigh lift under general anesthesia
- consent to regional block and trial participation
Who cannot join
- Coagulopathy or therapeutic anticoagulation not meeting ASRA safety windows
- infection at injection sites
- allergy to local anesthetics
- preexisting significant neuropathy
- BMI > 35 kg/m² if impeding ultrasound visualization; renal/hepatic failure; pregnancy; inability to use NRS; chronic opioid use >60 mg oral morphine equivalents/day; contraindication to study analgesics.
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of medicine,Menofia university hospitals
Cairo, Shibin El Kom, 32511
About this study
Official title: Comparing the Early Postoperative Analgesic Effect of the Transmuscular Quadratus Lumborum Block Versus the Lumbar Plexus Block for Patients Undergoing Spiral Thighplasty Surgery
Whether trans muscular QLB provides postoperative analgesia compared with LPB after thigh lift surgery
Read the detailed description
Adequate analgesia after spiral thigh reduction (thigh lift) is essential for early mobilization and patient satisfaction. Quadratus lumborum block (QLB) has shown analgesic efficacy comparable to lumbar plexus block (LPB) for hip area surgery with potential advantages in motor-sparing and safety
- Conditions
- Analgesia
- Being tested
- Ultrasound-Guided Trans-muscular QLB, Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) Block
- Keywords
- spiral thighplasty , pain , nerve block
- Medical subject headings
- Agnosia, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound-Guided Trans-muscular QLBOther
With the patient lateral decubitus position, a low-frequency curvilinear probe in the 'Shamrock' view at L2-L4. In-plane posterior-to-anterior needle advancement through the Quadratus lumborum to the interfascial plane anterior to QL and posterior to Psoas major. Inject 30 mL Bupivacaine 0.25% after negative aspiration and hydrodissection to confirm proper spread . Then the patient will be turned to the other side, and the block will be done with the same technique
Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) BlockOther
Lateral decubitus, Shamrock view to identify the Psoas compartment; in-plane needle advancement to the Psoas compartment adjacent to the transverse process. Inject 30 mL of Bupivacaine 0.25% in 5 mL increments, aspirating frequently. This will be done in the same position for both sides
| Study group | Role | What they receive |
|---|---|---|
| Group QLB | Other | Ultrasound-Guided Trans-muscular QLB Receives: Other: Ultrasound-Guided Trans-muscular QLB |
| Group LPB | Other | Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) Block Receives: Other: Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual analogue scale score
Visual analogue scale score at 1st,6th,12th and 24 h (where 0 is interpreted as no pain, 1-4 mild pain, 5-6 moderate pain, 7-10 severe pain)
Measured: 24 hours
Secondary outcomes (6)
Time for first analgesic request
first analgesic request
Measured: 24 hours
Opioid consumption
cumulative opioid consumption
Measured: 24 hours
Time to walk >30 (meter)
walk >30 (meter)
Measured: 24 hours
Performance Time
block performance time
Measured: minutes
The number of patients who develop block-related complications
nausea and vomiting , hypotension
Measured: 24 hours
the patients Satisfaction questionnaire
pateints are either : Dissatisfied Neither satisfied nor dissatisfied Satisfied Very satisfied
Measured: 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Dec 2025
- Study start13 Dec 2025
- Primary completion28 Feb 2026
- Study completion14 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AnalgesiaStudies of the same condition, open and under way.
- More trials run by Menoufia UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Prospective, randomized, parallel-group, double-blind, clinical trial. Primary endpoint: time for first analgesic request postoperatively. Key secondary endpoints: 24-hour opioid consumption (oral morphine equivalents), pain on movement at 6/12/24 hours, time to first ambulation, postoperative nausea/vomiting (PONV), block performance time, and block-related complications. Hypothesis: QLB is non-inferior to LPB for 24-hour pain scores and will yield less motor weakness
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 42 participants (actual)
Sponsor and investigators
- Lead sponsor
- Menoufia University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Amal Gouda Elsayed Safan, Menoufia University
- Investigators
- AMAL G SAFAN, MD, Study director, Menoufia University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07280182
- Sponsor's protocol ID
- 11/2025ANET2
- Other IDs
- Menoufia University
- Acronym
- QLB&LPB
- Status last verified
- Mar 2026
- First submitted
- 28 Nov 2025
- Last updated
- 17 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparing the Early Postoperative Analgesic Effect of the Transmuscular Quadratus Lumborum Block Versus the Lumbar Plexus Block for Patients Undergoing Spiral Thighplasty Surgery
- ClinicalTrials.gov ID
- NCT07280182
- Acronym / sponsor ID
- QLB&LPB / 11/2025ANET2
- Conditions
- Analgesia
- Keywords
- spiral thighplasty , pain , nerve block
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 42 participants (actual)
- Lead sponsor
- Menoufia UniversityUniversity, hospital or other
- Study start
- 13 Dec 2025 (actual)
- Primary completion
- 28 Feb 2026 (actual)
- Study completion
- 14 Mar 2026 (actual)
- First posted
- 12 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Whether trans muscular QLB provides postoperative analgesia compared with LPB after thigh lift surgery
Detailed description
Adequate analgesia after spiral thigh reduction (thigh lift) is essential for early mobilization and patient satisfaction. Quadratus lumborum block (QLB) has shown analgesic efficacy comparable to lumbar plexus block (LPB) for hip area surgery with potential advantages in motor-sparing and safety
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Prospective, randomized, parallel-group, double-blind, clinical trial. Primary endpoint: time for first analgesic request postoperatively. Key secondary endpoints: 24-hour opioid consumption (oral morphine equivalents), pain on movement at 6/12/24 hours, time to first ambulation, postoperative nausea/vomiting (PONV), block performance time, and block-related complications. Hypothesis: QLB is non-inferior to LPB for 24-hour pain scores and will yield less motor weakness
| Arm | Type | Receives |
|---|---|---|
| Group QLB | Other | Other: Ultrasound-Guided Trans-muscular QLBUltrasound-Guided Trans-muscular QLB |
| Group LPB | Other | Other: Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) BlockUltrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) Block |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- ASA ( American Society of Anaesthesia) I-II
- elective bilateral spiral thigh lift under general anesthesia
- consent to regional block and trial participation
Key exclusion criteria (5 listed)
- Coagulopathy or therapeutic anticoagulation not meeting ASRA safety windows
- infection at injection sites
- allergy to local anesthetics
- preexisting significant neuropathy
- BMI > 35 kg/m² if impeding ultrasound visualization; renal/hepatic failure; pregnancy; inability to use NRS; chronic opioid use >60 mg oral morphine equivalents/day; contraindication to study analgesics.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound-Guided Trans-muscular QLBWith the patient lateral decubitus position, a low-frequency curvilinear probe in the 'Shamrock' view at L2-L4. In-plane posterior-to-anterior needle advancement through the Quadratus lumborum to the interfascial plane anterior to QL and posterior to Psoas major. Inject 30 mL Bupivacaine 0.25% after negative aspiration and hydrodissection to confirm proper spread . Then the patient will be turned to the other side, and the block will be done with the same technique | Other | Group QLB |
| Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) BlockLateral decubitus, Shamrock view to identify the Psoas compartment; in-plane needle advancement to the Psoas compartment adjacent to the transverse process. Inject 30 mL of Bupivacaine 0.25% in 5 mL increments, aspirating frequently. This will be done in the same position for both sides | Other | Group LPB |
Primary outcome
Visual analogue scale score
Time frame: 24 hours
Visual analogue scale score at 1st,6th,12th and 24 h (where 0 is interpreted as no pain, 1-4 mild pain, 5-6 moderate pain, 7-10 severe pain)
6 secondary outcomes
Time for first analgesic request
Time frame: 24 hours
Opioid consumption
Time frame: 24 hours
Time to walk >30 (meter)
Time frame: 24 hours
Performance Time
Time frame: minutes
The number of patients who develop block-related complications
Time frame: 24 hours
the patients Satisfaction questionnaire
Time frame: 24 hours
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Mar 2026.
- Individual participant dataSharing planned: No
Related trials for Analgesia
RecruitingPhase 4
ESP Blocks for Posterior Spinal Fusion
Postoperative Pain
Not yet recruiting
Comparing Non-Medicine Strategies for Improving Low Back Pain
Chronic Low-back Pain (cLBP), High-Impact Chronic Pain (HICP)
Active, not recruiting
Efficacy of Laparoscopic-Assisted TAP Block in Laparoscopic Appendectomy
Appendectomy, Laparoscopic, Blockades Neuromuscular
Recruiting
SIRI Levels Following PENG Block in Pediatric Hip Surgery
Hip Dysplasia
Not yet recruitingPhase 2
A Clinical Trial of MK-6916 in Participants With Pain After Bunion Removal Surgery (MK-6916-007)
Pain Management
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
AMAL G SAFAN, MD study director
Menoufia University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ultrasound-Guided Trans-muscular QLB and Ultrasound-Guided Posterior Lumbar Plexus (Psoas Compartment) Block in people with Analgesia, run by Menoufia University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual analogue scale score (time frame: 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Mar 2026.