Endurance TrainingNCT07263126
Effect of Bicycle Ergometer Training on Fat Tissue Amount and Metabolism
A study testing endurance training with bicycle ergometer in termoneutral ambient temperature and endurance training with bicycle ergometer in lightly cold ambient temperature in people with Endurance Training, run by Pamukkale University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to investigate the effect of endurance training performed with a bicycle ergometer at different ambient temperatures on the amount of fat tissue and fat tissue metabolism in overweight and obese women. Read more about this study
- Who is it for?
- Ages 20 to 40 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Endurance Training
- What is being tested?
- endurance training with bicycle ergometer in termoneutral ambient temperature and endurance training with bicycle ergometer in lightly cold ambient temperature
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 27 May 2025to 27 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Being female,
- Being between 20-40 years old,
- Having a BMI between 25 and 34.9,
- Having a waist circumference greater than 80 cm,
- Not having participated in any exercise program in the last 3 months ,
- Not having experienced a change of more than 10% in body weight in the last 6 months.
Who cannot join
- On a weight loss diet,
- Having cancer, unstable heart disease, cerebrovascular disease, metabolic disease, diabetes, hypertension, psychiatric disorders, or other conditions or neurological disorders,
- Having a musculoskeletal disorder or any disease/injury that may affect participation in exercise training,
- Participating in regular physical activity (at least 150 minutes of moderate-intensity physical activity or 75 minutes of vigorous-intensity physical activity or an equivalent combination of both during the week),
- Being pregnant or breastfeeding,
- Having undergone surgery for the treatment of obesity,
- Receiving pharmacological treatment for obesity. Participants who did not attend more than 20% of the endurance training program will be excluded from the study.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Bicycle Ergometer Training in Thermoneutral and Lightly Cold Ambient Temperatures on Fat Tissue Amount and Metabolism in Overweight and Obese Women
The aim of this study is to investigate the effect of endurance training performed with a bicycle ergometer at different ambient temperatures on the amount of fat tissue and fat tissue metabolism in overweight and obese women.
Read the detailed description
This study will examine the effects of 12 weeks of endurance training on a bicycle ergometer at thermoneutral and slightly cold ambient temperatures on body composition, subcutaneous and visceral fat tissue thickness, and levels of irisin, leptin, adiponectin, apelin, IL-6 and FGF-21 in the blood of overweight and obese women.
- Conditions
- Endurance Training
- Being tested
- endurance training with bicycle ergometer in termoneutral ambient temperature, endurance training with bicycle ergometer in lightly cold ambient temperature
- Keywords
- Bicycle Ergometer, Overweight, Obese
- Medical subject headings
- Overweight, Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
endurance training with bicycle ergometer in termoneutral ambient temperatureOther
trained with bicycle ergometer three times a week for three months.
endurance training with bicycle ergometer in lightly cold ambient temperatureOther
trained with bicycle ergometer three times a week for three months.
| Study group | Role | What they receive |
|---|---|---|
| Case group 1 | Experimental | participants trained in termoneutral ambient temperature Receives: Other: endurance training with bicycle ergometer in termoneutral ambient temperature |
| Case group 2 | Active comparator | participants trained in lightly cold ambient temperature Receives: Other: endurance training with bicycle ergometer in lightly cold ambient temperature |
| control group | No intervention | participants do not trained |
What is being measured
The primary outcome is the main question the study is designed to answer.
rate of BMI
assesed with height and body weight
Measured: baseline/ through study completion, an average 3 months
analysis of biyoelectric impedans Bioelectrical impedance analysis
assesed with with a Tanita BC 418 brand device.
Measured: baseline/ through study completion, an average 3 months
Waist circumference Waist hip ratio
Waist circumference will be measured with a tape measure.
Measured: baseline/ through study completion, an average 3 months
rate of subcutaneous and visceral adipose tissue thickness
assesed with Ultrasonography
Measured: baseline/ through study completion, an average 3 months
concentration of serum irisin
assesed with blood analysis
Measured: baseline/ through study completion, an average 3 months
concentration of serum adiponectin
assesed with blood analysis
Measured: baseline/ through study completion, an average 3 months
concentration of serum apelin
assesed with blood analysis
Measured: baseline/ through study completion, an average 3 months
concentration of serum IL-6
assesed with blood analysis
Measured: baseline/ through study completion, an average 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Dec 2025
- Study start27 May 2025
- Primary completion27 Sep 2025
- Study completion27 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Endurance TrainingStudies of the same condition, open and under way.
- More trials run by Pamukkale UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Endurance training in termoneutral ambient, Endurance training in lightly cold ambient, control group (the waiting list group)
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- Pamukkale University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Şule ŞİMŞEK, Pamukkale University
- Investigators
- Ummuhan Baş Aslan, Prof. Dr., Study director, Prof. Dr.
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07263126
- Sponsor's protocol ID
- 23.07.2024/13
- Status last verified
- Aug 2026
- First submitted
- 27 May 2025
- Last updated
- 10 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Otero-Diaz B, Rodriguez-Flores M, Sanchez-Munoz V, Monraz-Preciado F, Ordonez-Ortega S, Becerril-Elias V, Baay-Guzman G, Obando-Monge R, Garcia-Garcia E, Palacios-Gonzalez B, Villarreal-Molina MT, Sierra-Salazar M, Antuna-Puente B. Exercise Induces White Adipose Tissue Browning Across the Weight Spectrum in Humans. Front Physiol. 2018 Dec 11;9:1781. doi: 10.3389/fphys.2018.01781. eCollection 2018.
PubMed 30618796
Study at a glance
From the registry record, last updated by the sponsor on 10 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Bicycle Ergometer Training in Thermoneutral and Lightly Cold Ambient Temperatures on Fat Tissue Amount and Metabolism in Overweight and Obese Women
- ClinicalTrials.gov ID
- NCT07263126
- Acronym / sponsor ID
- 23.07.2024/13
- Conditions
- Endurance Training
- Keywords
- Bicycle Ergometer, Overweight, Obese
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Pamukkale UniversityUniversity, hospital or other
- Study start
- 27 May 2025 (actual)
- Primary completion
- 27 Sep 2025 (actual)
- Study completion
- 27 Apr 2026 (actual)
- First posted
- 4 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate the effect of endurance training performed with a bicycle ergometer at different ambient temperatures on the amount of fat tissue and fat tissue metabolism in overweight and obese women.
Detailed description
This study will examine the effects of 12 weeks of endurance training on a bicycle ergometer at thermoneutral and slightly cold ambient temperatures on body composition, subcutaneous and visceral fat tissue thickness, and levels of irisin, leptin, adiponectin, apelin, IL-6 and FGF-21 in the blood of overweight and obese women.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
- Model description
- Endurance training in termoneutral ambient, Endurance training in lightly cold ambient, control group (the waiting list group)
| Arm | Type | Receives |
|---|---|---|
| Case group 1 | Experimental | Other: endurance training with bicycle ergometer in termoneutral ambient temperatureparticipants trained in termoneutral ambient temperature |
| Case group 2 | Active comparator | Other: endurance training with bicycle ergometer in lightly cold ambient temperatureparticipants trained in lightly cold ambient temperature |
| control group | No intervention | –participants do not trained |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Being female,
- Being between 20-40 years old,
- Having a BMI between 25 and 34.9,
- Having a waist circumference greater than 80 cm,
- Not having participated in any exercise program in the last 3 months ,
Key exclusion criteria (7 listed)
- On a weight loss diet,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| endurance training with bicycle ergometer in termoneutral ambient temperaturetrained with bicycle ergometer three times a week for three months. | Other | Case group 1 |
| endurance training with bicycle ergometer in lightly cold ambient temperaturetrained with bicycle ergometer three times a week for three months. | Other | Case group 2 |
Primary outcome
rate of BMI
Time frame: baseline/ through study completion, an average 3 months
assesed with height and body weight
analysis of biyoelectric impedans Bioelectrical impedance analysis
Time frame: baseline/ through study completion, an average 3 months
assesed with with a Tanita BC 418 brand device.
Waist circumference Waist hip ratio
Time frame: baseline/ through study completion, an average 3 months
Waist circumference will be measured with a tape measure.
rate of subcutaneous and visceral adipose tissue thickness
Time frame: baseline/ through study completion, an average 3 months
assesed with Ultrasonography
concentration of serum irisin
Time frame: baseline/ through study completion, an average 3 months
assesed with blood analysis
concentration of serum adiponectin
Time frame: baseline/ through study completion, an average 3 months
assesed with blood analysis
concentration of serum apelin
Time frame: baseline/ through study completion, an average 3 months
assesed with blood analysis
concentration of serum IL-6
Time frame: baseline/ through study completion, an average 3 months
assesed with blood analysis
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Aug 2026.
- Results publication: PubMed 30618796Otero-Diaz B, Rodriguez-Flores M, Sanchez-Munoz V, Monraz-Preciado F, Ordonez-Ortega S, Becerril-Elias V, Baay-Guzman G, Obando-Monge R, Garcia-Garcia E, Palacios-Gonzalez B, Villarreal-Molina MT, Sierra-Salazar M, Antuna-Puente B. Exercise Induces White Adipose Tissue Browning Across the Weight Spectrum in Humans. Front Physiol. 2018 Dec 11;9:1781. doi: 10.3389/fphys.2018.01781. eCollection 2018.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ummuhan Baş Aslan, Prof. Dr. study director
Prof. Dr.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing endurance training with bicycle ergometer in termoneutral ambient temperature and endurance training with bicycle ergometer in lightly cold ambient temperature in people with Endurance Training, run by Pamukkale University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
rate of BMI (time frame: baseline/ through study completion, an average 3 months). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07263126, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Aug 2026.