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AzTrials

CancerNCT07261267

Music Therapy's Effect on Cancer Patients Undergoing Radiotherapy

A study testing Music Therapy in people with Cancer and Radiotherapy, run by Kocaeli University at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The goal of this randomized controlled clinical study is to learn about the effects of music therapy on anxiety, stress, pain, and patient satisfaction in cancer patients who are newly starting radiotherapy (radiation treatment). Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Cancer, Radiotherapy
What is being tested?
Music Therapy
Could I receive a placebo?
No, everyone receives an active treatment
How many people
72 participants
Where
1 siteTurkey (Türkiye)
Study dates
1 Jan 2026to 18 Jun 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Must be a cancer patient 18 years of age or older.
  • Must be newly starting curative external radiotherapy.
  • Must volunteer to participate in the study and sign the Informed Consent form.

Who cannot join

  • Having an advanced stage psychiatric disorder (e.g., schizophrenia).
  • Having hearing loss.
  • Having a prior history of an adverse reaction to music therapy.
  • Receiving radiotherapy for palliative (symptom relief) purposes.
  • Having received radiotherapy previously (for reasons such as brachytherapy, a different type of cancer, or recurrence).

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site
  • Kocaeli University Hospital

    Kocaeli

Other trials in Turkey (Türkiye)

About this study

Official title: The Effect of Music Therapy on the Radiotherapy Experience of Cancer Patients Undergoing Radiotherapy: A Randomised Controlled Trial

The goal of this randomized controlled clinical study is to learn about the effects of music therapy on anxiety, stress, pain, and patient satisfaction in cancer patients who are newly starting radiotherapy (radiation treatment).

The main questions it aims to answer are:

Read more

Can music therapy lower the levels of anxiety and stress in patients receiving radiotherapy? Can music therapy improve the pain felt during the radiotherapy experience and overall satisfaction? Researchers will compare patients receiving standard radiotherapy (control group) with patients receiving music therapy alongside their radiotherapy (experimental group).

Participants (72 total) will:

Be 18 years and older and newly starting curative radiotherapy. Answer short surveys (STAI-SF, SDT, VAS) to measure their anxiety, stress, and pain levels before and after treatment.

Participants in the experimental group will receive a 15-20 minute music therapy session consisting of meditative and instrumental music during their first radiotherapy session.

This study aims to provide reliable data to guide clinical practice by showing whether music therapy offers a multifaceted approach to managing the psychological and physical challenges associated with cancer treatment.

Read the detailed description

This study is a single-blind randomized controlled trial 20202020evaluating the effect of music therapy in managing the emotional and physical difficulties experienced by cancer patients who are newly starting curative radiotherapy (RT).Study Site: The study will take place at the Kocaeli University Hospital Radiation Oncology Unit.Objectives: The primary aim is to examine the effect of music therapy on anxiety, stress, pain, and patient satisfaction, and to determine how it can improve the RT experience.Intervention Application:Timing and Duration: Music therapy will be administered during the first RT session in sessions lasting 15-20 minutes. (Literature reports that $<20$ minutes reduces anxiety ).Provider: The intervention will be administered by a certified music therapist. Music Selection: Patients will be asked to choose music that has a meditative effect, is instrumental (without lyrics), and lacks peaks (sudden attacks), based on their preference and inclination. The music options provided will include Far Eastern music, music accompanied by a light-beat rhythm instrument (bendir), Ney-heavy Mesnevi music with meditative effects, and meditative Saba makam music.Listening Method: The patient's selected music will be played via headphones for 15 minutes before the session, and as ambient listening during the session. For patients with head and neck or brain cancer, only ambient listening will be used during the procedure for consistency.Data Collection and Timeline:Measurement Location: Measurements will be taken by researchers at the Kocaeli University Radiation Oncology Unit.Study Duration: The study starts on December 1, 2025, and ends on January31, 2026, with a total duration of 7 months.

Statistical Analysis:The collected data will be analyzed using the following methods: Between-group comparisons: Independent Sample T-test or Mann-Whitney U test37.Pre-post changes: Repeated Measures ANOVA.The significance level is set at $p<0.05.

Conditions
Cancer, Radiotherapy
Being tested
Music Therapy, Standard Care (in control arm)
Keywords
Music Therapy, Radiotherapy, Anxiety, Pain, Stress
Medical subject headings
Neoplasms, Anxiety Disorders, Pain

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Music TherapyOther

    Intervention: A personalized 15-20 minute music listening session is administered by a certified music therapist during the first session of radiotherapy.

    Patients select from a list of meditative, instrumental (wordless), and music that lacks peaks (sudden attacks).

    Music is presented via headphones before the session and as ambient listening during the session.

  • Standard Care (in control arm)Other

    Intervention: These patients do not receive the music therapy intervention during their radiotherapy treatment.

Study groups in NCT07261267
Study groupRoleWhat they receive
Music Therapy Group (Experimental Arm)ExperimentalDescription: Consists of patients receiving curative radiotherapy (RT) who receive the music therapy intervention in addition to standard care to improve their radiotherapy experience.
Receives: Other: Music Therapy
Control Group (Standard Care Arm)Active comparatorDescription: Consists of patients receiving curative radiotherapy (RT) who receive only the standard radiation oncology care as per hospital protocol during their treatment.
Receives: Other: Standard Care (in control arm)

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Change in Anxiety Level (STAI-SF)

    ssessment of the effect of the music therapy intervention on the anxiety levels of cancer patients receiving curative radiotherapy, using the State-Trait Anxiety Inventory-Short Form (STAI-SF). The measured difference will be compared between the intervention group and the control group.

    Measured: mmediately before the start of the radiotherapy session (Pre-test) and immediately after the end of the radiotherapy session (Post-test).

  2. Change in Stress Level (SDT)

    Assessment of the effect of the music therapy intervention on the general distress/stress levels experienced by cancer patients receiving curative radiotherapy, using the Symptom Distress Thermometer (SDT). The measured difference will be compared between the intervention group and the control group.

    Measured: Immediately before the start of the radiotherapy session (Pre-test) and immediately after the end of the radiotherapy session (Post-test).

Secondary outcomes (2)
  1. Change in Procedural Pain Level (VAS)

    Assessment of the effect of the music therapy intervention on the severity of pain felt during or related to the radiotherapy procedure, using the Visual Analog Scale (VAS). The measured difference will be compared between the groups.

    Measured: Immediately before the start of the radiotherapy session (Pre-test) and immediately after the end of the radiotherapy session

  2. Patient Satisfaction Level (VAS)

    Assessment of the effect of the music therapy intervention on patients' overall satisfaction levels with their radiotherapy experience, using the Visual Analog Scale (VAS). Satisfaction scores will be compared between the groups.

    Measured: Immediately after the end of the radiotherapy session (Post-test).

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted3 Dec 2025
  2. Study start1 Jan 2026
  3. Primary completion18 Jun 2026
  4. Study completion18 Jun 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Supportive care
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
72 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07261267
Sponsor's protocol ID
17.07.2025 - 2025/1
Status last verified
Aug 2026
First submitted
21 Nov 2025
Last updated
5 Aug 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: The specific IPD to be shared includes all individual, anonymized patient data collected in the study. This data comprises: Demographic Data (such as age and gender). Disease and Treatment Information (such as cancer type, RT start date). Data from All Scales Used (STAI-SF, SDT, VAS Pain, VAS Satisfaction, and EORTC QLQ-INFO25 scores). The data will be coded to exclude any direct identifiers that could reveal the participants' identity.

Publications

  • Yang HF, Chang WW, Chou YH, Huang JY, Liao YS, Liao TE, Tseng HC, Chang ST, Chen HL, Ke YF, Tsai PF, Chan HM, Chang BJ, Hwang YT, Tsai HY, Lee YC. Impact of background music listening on anxiety in cancer patients undergoing initial radiation therapy: a randomized clinical trial. Radiat Oncol. 2024 Jun 11;19(1):73. doi: 10.1186/s13014-024-02460-3.

    PubMed 38862982
  • Wilson JM, Franqueiro AR, Edwards RR, Chai PR, Schreiber KL. Individuals with fibromyalgia report greater pain sensitivity than healthy adults while listening to their favorite music: the contribution of negative affect. Pain Med. 2024 May 2;25(5):352-361. doi: 10.1093/pm/pnae005.

    PubMed 38291916
  • Terzi, E. (2022). The effect of listening to music with or without patient selection on pain during cesarean section and its contribution to anesthesia technicians. Journal of Experimental and Clinical Medicine, 39(3), 786-792.

  • Tao WW, Jiang H, Tao XM, Jiang P, Sha LY, Sun XC. Effects of Acupuncture, Tuina, Tai Chi, Qigong, and Traditional Chinese Medicine Five-Element Music Therapy on Symptom Management and Quality of Life for Cancer Patients: A Meta-Analysis. J Pain Symptom Manage. 2016 Apr;51(4):728-747. doi: 10.1016/j.jpainsymman.2015.11.027. Epub 2016 Feb 12.

    PubMed 26880252
  • Gulbahar Ates S, Demirel BB, Kekilli E, Ozturk E, Ucmak G. Primary tumor heterogeneity on pre-treatment [68Ga]Ga-PSMA PET/CT for the prediction of biochemical recurrence in prostate cancer. Rev Esp Med Nucl Imagen Mol (Engl Ed). 2024 Nov-Dec;43(6):500032. doi: 10.1016/j.remnie.2024.500032. Epub 2024 Aug 2.

    PubMed 39097169
  • Hewis J. Music and Music Therapy in the Medical Radiation Sciences. J Med Imaging Radiat Sci. 2018 Dec;49(4):360-364. doi: 10.1016/j.jmir.2018.09.009. Epub 2018 Oct 23. No abstract available.

    PubMed 30514551
  • Jiang X, Gao J, Zheng Y. Effectiveness of traditional Chinese medicine music therapy on anxiety and depression emotions of lung cancer patients: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2021 Mar 26;100(12):e25040. doi: 10.1097/MD.0000000000025040.

    PubMed 33761662
  • Imani M, Jalali A, Salari N, Abbasi P. Effect of instrumental music on anxiety and depression among hemodialysis patients: A randomized controlled trial. J Educ Health Promot. 2021 Aug 31;10:305. doi: 10.4103/jehp.jehp_1472_20. eCollection 2021.

    PubMed 34667805
  • Forbes E, Baker AL, Britton B, Clover K, Skelton E, Moore L, Handley T, Oultram S, Oldmeadow C, Gibberd A, McCarter K. A systematic review of nonpharmacological interventions to reduce procedural anxiety among patients undergoing radiation therapy for cancer. Cancer Med. 2023 Oct;12(20):20396-20422. doi: 10.1002/cam4.6573. Epub 2023 Oct 6.

    PubMed 37803922
  • Fernando GVMC, Wanigabadu LU, Vidanagama B, Samaranayaka TSP, Jeewandara JMKC. "Adjunctive Effects of a Short Session of Music on Pain, Low-mood and Anxiety Modulation among Cancer Patients" - A Randomized Crossover Clinical Trial. Indian J Palliat Care. 2019 Jul-Sep;25(3):367-373. doi: 10.4103/IJPC.IJPC_22_19.

    PubMed 31413450
  • Chen HH, Lai CH, Hou YJ, Kuo LT. The Efficacy of Music Intervention in Patients with Cancer Receiving Radiation Therapy: A Systematic Review and Meta-Analysis. Cancers (Basel). 2025 Feb 18;17(4):691. doi: 10.3390/cancers17040691.

    PubMed 40002284

Questions about this trial

What is this clinical trial studying?

A study testing Music Therapy in people with Cancer and Radiotherapy, run by Kocaeli University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 5 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change in Anxiety Level (STAI-SF) (time frame: mmediately before the start of the radiotherapy session (Pre-test) and immediately after the end of the radiotherapy session (Post-test).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07261267, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Aug 2026.

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