Acquired Aplastic AnaemiaNCT07259863
Clinico-Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate .
An observational study of Acquired Aplastic Anaemia, run by Assiut University.
Trial summary
1. Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia. 2. Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia. Read more about this study
- Who is it for?
- Ages 1 year to 18 years
- Conditions the study is for
- Acquired Aplastic Anaemia
- How many people
- 35 participants
- Where
- No sites listed yet
- Study dates
- 1 Dec 2025to 30 Nov 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 year to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Children at 1 to 18 years old diagnosed with acquired aplastic anemia at assuit governorate from october 2020 to october 2026
Who may be able to join
- 1- Children aged 1-18 years old diagnosed with acquired aplastic anemia 2-Fulfillment of the diagnostic criteria for acquired AA 3-patient with complete medical records,including diagnostic ,labaratory and treatement data 4-Diagnosed or treated at assuit university children hospital and the central health insurance clinic at assuit Governorate (october 2020 to october 2026)
Who cannot join
- 1-children with congental bone marrow failure syndrome 2-patient with a history of chemotherapy or radiotherapy prior to diagnosis 2-cases with incomplete medical or insufficient medical records that prevented confirmination of diagnosis or extraction of essential study data
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Clinico_Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate.
- Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia.
- Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.
Read the detailed description
Aplastic anaemia is a term describing the common findings of pancytopenia and marrow hypoplasia from arising variety of disease states, including acquired aplastic anaemia and a variety of congenital marrow failure states(1). The global incidence of paediatric AA varies geographically, with rates of 2 to 3 cases per million per year in Europe, but higher in East Asia and certain developing regions(2) .Among Egyptian Children, inherited bone marrow failure syndromes (BMFS), including AA, constitute about 10-15%of all BMFS and up to 30% of paediatric BMFS ,with an average of 65 cases per million live births each year .Acquired AA remains the predominant from in older children and adolescent , while inherited forms are more common in younger children(3).The clinical presentation of aplastic anaemia regularly consists of symptoms associated with pancytopenia, including fatigue, pallor, bruising, bleeding, and extended susceptibility to infections(4). Identified etiologic risk factors include infections of viral origin, such as hepatitis-associated, Epstein-Barr, parvovirus, human immunodeficiency virus, varicella zoster, measles and other viruses, as well as exposure to toxic chemicals (e.g. benzene, pesticides and insecticides) and ionizing radiation (5). Over the last three decades, bone marrow transplantation (BMT) from a matched related donor (MRD) has been the treatment of choice for children with acquired AA (6) The Rationale of our study: aplastic anaemia in children is a serious ,life threatening bone marrow failure syndrome ,often resulting from immune-mediated destruction of hematopoietic stem cell triggered by factors such as viral infections, environmental toxin, or genetic predispositions and requires precise diagnosis to distinguish from inherited bone marrow failure syndromes or hypoplastic myelodysplastic syndrome to guide appropriate treatment strategies .
The Research question: What is the clinico-epidemiological profile of acquired aplastic anaemia among children at Assiut governorate.
- Conditions
- Acquired Aplastic Anaemia
- Being tested
- observational case series study no intervention
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
observational case series study no interventionOther
Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia. 2.Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.
What is being measured
The primary outcome is the main question the study is designed to answer.
Acquired Aplastic Anemia among children
Determine the clinic-epidemiological profile of acquired aplastic anemia among children at assiut governorate
Measured: from October 2020 to October 2026
determine the clinico-Epidemiological profile of acquired aplastic anemia among children at assuit governorate
To descripe and record clinical characteristic ,management,and outcomes of the included cases
Measured: from october 2020 to october 2026
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Dec 2025
- Study start1 Dec 2025 (estimated)
- Primary completion30 Oct 2026 (estimated)
- Study completion30 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acquired Aplastic AnaemiaStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Other
- Enrolment
- 35 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sara Ramadan Hassanein Hassan, Assiut University
- Investigators
- Mostafa Mohamed Embaby, professor of pediatic, Principal investigator, Departement of Familly medicine Assuit University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07259863
- Sponsor's protocol ID
- Aplastic anemia in children .
- Status last verified
- Nov 2025
- First submitted
- 21 Nov 2025
- Last updated
- 2 Dec 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinico_Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate.
- ClinicalTrials.gov ID
- NCT07259863
- Acronym / sponsor ID
- Aplastic anemia in children .
- Conditions
- Acquired Aplastic Anaemia
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 35 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Dec 2025 (estimated)
- Primary completion
- 30 Oct 2026 (estimated)
- Study completion
- 30 Nov 2026 (estimated)
- First posted
- 2 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia.
- Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.
Detailed description
Aplastic anaemia is a term describing the common findings of pancytopenia and marrow hypoplasia from arising variety of disease states, including acquired aplastic anaemia and a variety of congenital marrow failure states(1). The global incidence of paediatric AA varies geographically, with rates of 2 to 3 cases per million per year in Europe, but higher in East Asia and certain developing regions(2) .Among Egyptian Children, inherited bone marrow failure syndromes (BMFS), including AA, constitute about 10-15%of all BMFS and up to 30% of paediatric BMFS ,with an average of 65 cases per million live births each year .Acquired AA remains the predominant from in older children and adolescent , while inherited forms are more common in younger children(3).The clinical presentation of aplastic anaemia regularly consists of symptoms associated with pancytopenia, including fatigue, pallor, bruising, bleeding, and extended susceptibility to infections(4). Identified etiologic risk factors include infections of viral origin, such as hepatitis-associated, Epstein-Barr, parvovirus, human immunodeficiency virus, varicella zoster, measles and other viruses, as well as exposure to toxic chemicals (e.g. benzene, pesticides and insecticides) and ionizing radiation (5). Over the last three decades, bone marrow transplantation (BMT) from a matched related donor (MRD) has been the treatment of choice for children with acquired AA (6) The Rationale of our study: aplastic anaemia in children is a serious ,life threatening bone marrow failure syndrome ,often resulting from immune-mediated destruction of hematopoietic stem cell triggered by factors such as viral infections, environmental toxin, or genetic predispositions and requires precise diagnosis to distinguish from inherited bone marrow failure syndromes or hypoplastic myelodysplastic syndrome to guide appropriate treatment strategies .
The Research question: What is the clinico-epidemiological profile of acquired aplastic anaemia among children at Assiut governorate.
Study design
- Observational model
- Case only
- Time perspective
- Other
Who may qualify
- Ages
- 1 year to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- Children at 1 to 18 years old diagnosed with acquired aplastic anemia at assuit governorate from october 2020 to october 2026
Key inclusion criteria (1 listed)
- 1- Children aged 1-18 years old diagnosed with acquired aplastic anemia 2-Fulfillment of the diagnostic criteria for acquired AA 3-patient with complete medical records,including diagnostic ,labaratory and treatement data 4-Diagnosed or treated at assuit university children hospital and the central health insurance clinic at assuit Governorate (october 2020 to october 2026)
Key exclusion criteria (1 listed)
- 1-children with congental bone marrow failure syndrome 2-patient with a history of chemotherapy or radiotherapy prior to diagnosis 2-cases with incomplete medical or insufficient medical records that prevented confirmination of diagnosis or extraction of essential study data
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| observational case series study no interventionAssessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia. 2.Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia. | Other | – |
Primary outcome
Acquired Aplastic Anemia among children
Time frame: from October 2020 to October 2026
Determine the clinic-epidemiological profile of acquired aplastic anemia among children at assiut governorate
determine the clinico-Epidemiological profile of acquired aplastic anemia among children at assuit governorate
Time frame: from october 2020 to october 2026
To descripe and record clinical characteristic ,management,and outcomes of the included cases
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Dec 2025.
- Individual participant dataSharing planned: No
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MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mostafa Mohamed Embaby, professor of pediatic principal investigator
Departement of Familly medicine Assuit University
Questions about this trial
What is this clinical trial studying?
An observational study of Acquired Aplastic Anaemia, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sara Ramadan Hassanein, Resident doctor (+2001018426240, sararamadan25399@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Acquired Aplastic Anemia among children (time frame: from October 2020 to October 2026). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Dec 2025.