Physical FitnessBPIT_5LINE_369NCT07256717
BPIT 5-Week Multi-Site Study: Movement Efficiency, Mobility & Neuromuscular Adaptation
A study testing Balanced Progressive Intensity Training (BPIT) 5-Line Method in people with Physical Fitness, run by MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc. at 10 sites in 2 countries.
Trial summary
This prospective, multi-site, single-arm interventional study evaluates the 5-Line Principle of Balanced Progressive Intensity Training (BPIT) over 5 weeks in healthy adults aged 18-65 years. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Physical Fitness
- What is being tested?
- Balanced Progressive Intensity Training (BPIT) 5-Line Method
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 369 participants
- Where
- 10 sitesin 2 countries
- Study dates
- 10 Oct 2025to 25 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults aged 18-65 years Generally healthy with regular physical activity history (at least 1-2 sessions per week for the past 3 months) Able to commit to 3-5 supervised training sessions per week for 5 weeks Willing and able to provide written informed consent Cleared by pre-screening (no acute injury, no contraindications)
Who cannot join
- Acute musculoskeletal injury within the past 3 months Known cardiovascular, metabolic, or orthopaedic conditions that contraindicate exercise Pregnancy or planning pregnancy Use of medications or supplements that significantly affect muscle recovery or performance (e.g., corticosteroids, anabolic agents) Inability to follow the BPIT protocol or attend required sessions
Trial locations and contacts
10 sites in 2 countries. Contact the study team or a site near you to ask about taking part.
10 sites in 2 countries
India7 sites, 7 recruiting
- Recruiting
GFFI Fitness Academy
Agra, Uttar Pradesh, 282005
Jeet Sharma, CPT, +91-9990744422, nutrieon.reports@gmail.com
Gerik Mehta, CPT, CSCS, 8586836625, gerik.mehta9@gmail.com
- Recruiting
Indian Institute of Kinesiology & Biomechanics Science (IIKBS)
Burhānpur, Madhya Pradesh, 450331
Dr. Anya Petrova, M.D., Ph.D. (Sports Med), +919990744422, info@iikbs.org
Laura Green, R.N., +91-9990744422, info@iikbs.org
- Recruiting
Shri Mahaveer Ortho Clinic
Delhi, National Capital Territory of Delhi, 110032
Dr Karun Jain, MBBS, D'Ortho, MS Ortho, +91-8285257076, karunjain@live.com
Karun Jain, MBBS
- Recruiting
Regain Fitness Zone
Greater Noida, Uttar Pardesh, 201310
Chetan Sethi, MMSx Pro / CPT, +91-98998200922, contact@regainfitnesszone.com
Chetan Sethi, CPT, CSCS, +919899820922, contact@regainfitnesszone.com
- Recruiting
GFFI Fitness Academy
New Delhi, National Capital Territory of Delhi, 110026
Sumit Khoney, MMSx Pro / CPT, 08586836625, info@gffi-fitness.org
Pankaj Mehta, M.P.Ed., +918447431421, Pankaj@gffi-fitness.org
- Recruiting
Active India Health & Fitness Trust (AIHFT)
New Delhi, National Capital Territory of Delhi, 110063
Anupama Mahajan, Ph.D. (Maths), +91-9873194695, pankajprocoach@gmail.com
Anupama Mahajan, PhD, +919873194695, pankajprocoach@gmail.com
- Recruiting
Body Mechanics Gym P Ltd
New Delhi, National Capital Territory of Delhi, 110092
Sunny Ghambir, CPT, 9990960606, neeraj.gffi@gmail.com
Gaurav Sharma, CPT, CSCS, 9990960606, neeraj.gffi@gmail.com
United States3 sites, 3 recruiting
- Recruiting
BodyGNTX Fitness Institute
Columbus, Ohio, 43220
Neeraj Mehta, Ph.D. (Biomechanics), 6148228038, neeraj.gffi@gmail.com
Ashita Malhotra, GCP, 6148228038, neeraj.gffi@gmail.com
- Recruiting
MMSx Authority Biomechanics Department
Powell, Ohio, 43065
Tina Malhotra, MMSx Pro / CPT, 6144775031, mmsxauthority@gmail.com
Sunita Malhotra, GCP, 6144776065
- Recruiting
MMSx AUTHORITY INSTITUTE FOR MOVEMENT MECHANICS & BIOMECHANICS RESEARCH (COORDINATING CENTER)
Powell, Ohio, 43065
Neeraj Mehta, Ph.D. (Biomechanics), 6148228038, neeraj.gffi@gmail.com
Sunita Malhotra, GCP, 6144776065, sunita_5757@hotmail.com
About this study
Official title: Balanced Progressive Intensity Training (BPIT): A Five-Week Multi-Site Clinical Evaluation of Functional Movement, Mobility, and Neuromuscular Adaptation in Healthy Adults (18-65 Years)
This prospective, multi-site, single-arm interventional study evaluates the 5-Line Principle of Balanced Progressive Intensity Training (BPIT) over 5 weeks in healthy adults aged 18-65 years. All participants receive supervised BPIT sessions (3-5 per week) progressing through five intensity lines defined by anatomical landmarks and ground reaction force:
Ground-Based (Low) Knee-Level (Low-Moderate) Standing (Moderate) Head-Level (Moderate-High) Plyometric (High-Impact)
The study aims to quantify improvements in functional movement efficiency, joint mobility, postural control, strength adaptation, and heart-rate variability while monitoring safety and individual overload indicators.
Read the detailed description
Primary Outcome Measures
Change in Functional Movement Screen (FMS) total score from baseline to Week 5 Change in Y-Balance Test reach distance (composite score) Timeframe: Baseline and Week 5
Secondary Outcome Measures
Change in 1-RM or estimated strength (squat, deadlift, overhead press) Change in resting HRV (RMSSD) Change in joint range of motion (goniometry) and postural sway Incidence of training-related discomfort or minor injury Timeframe: Baseline, weekly, and Week 5
Arms/Intervention Experimental: BPIT 5-Line Training Group Intervention: Behavioral: Balanced Progressive Intensity Training (BPIT) 5-Line Method Description: 5-week supervised progressive training using the BPIT 5-Line framework (ground-based → plyometric) Eligibility
Ages Eligible: 18 Years to 65 Years Sexes Eligible: All Accepts Healthy Volunteers: Yes
Inclusion Criteria
Healthy adults with regular exercise history Able to attend 3-5 training sessions/week Signed informed consent
Exclusion Criteria
Recent injury (<3 months) Known cardiovascular, metabolic, or orthopaedic contraindications Pregnancy
Study Locations 13 Locations in India 2 Locations in USA, (Details of the location is uploaded on mmsxauthority.com webiste)
MMSx Authority , USA, GFFI Fitness Academy, New Delhi BodyGNTX USA BFS/AIHFT-approved facilities
Countries of Recruitment India U.S. FDA-regulated? No / No / No Human Subjects Protection Review Board Status Approved (or Submit for review if not yet) Board Name: Institutional Ethics Committee - MMSx Authority / GFFI Approval Number: BPIT-MULTI-2025-001 (or pending) Data Monitoring Committee No
- Conditions
- Physical Fitness
- Being tested
- Balanced Progressive Intensity Training (BPIT) 5-Line Method
- Keywords
- Balanced Progressive Intensity Training, BPIT, 5-Line Principle, Movement Efficiency, Heart Rate Variability, Postural Control, Strength Training, Exercise Intervention, Neuromuscular Adaptation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Balanced Progressive Intensity Training (BPIT) 5-Line MethodBehavioural
5-week supervised progressive training using the BPIT 5-Line framework developed by Dr. Neeraj Mehta.
| Study group | Role | What they receive |
|---|---|---|
| BPIT 5-Line Training Group | Experimental | All participants receive the 5-week Balanced Progressive Intensity Training (BPIT) program using the 5-Line Principle (ground-based → knee-level → standing → head-level → plyometric) under supervised sessions 3-5 times per week. Receives: Behavioral: Balanced Progressive Intensity Training (BPIT) 5-Line Method |
What is being measured
The primary outcome is the main question the study is designed to answer.
Movement Efficiency Score (MES, 0-10)
Change from baseline in the proprietary Movement Efficiency Score (MES), a validated composite metric of biomechanical function, movement quality, and postural alignment (derived from MMSx Flaw Checklist, visual/video analysis, and functional mapping).
Measured: Baseline (Week 0) and end of study (Week 5)
Secondary outcomes (4)
Range of Motion (ROM)
Change from baseline in joint range of motion (degrees) measured by goniometry at key sites (shoulder, hip, spine, ankle).
Measured: Baseline and Week 5
VAS Pain Score
Change from baseline in participant-reported pain/discomfort on a 0-10 Visual Analog Scale.
Measured: Baseline and Week 5
Strength Index
Change from baseline in Strength Index calculated as Reps × Load (or estimated 1RM where applicable) for key movements.
Measured: Baseline and Week 5
Mobility Limitation (%)
Change from baseline in self-reported percentage limitation in daily functional tasks due to mobility restrictions.
Measured: Baseline and Week 5
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Dec 2025
- Study start10 Oct 2025
- Primary completion15 Feb 2026 (estimated)
- Study completion25 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Physical FitnessStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 369 participants (estimated)
Sponsor and investigators
- Lead sponsor
- MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.
- Sponsor type
- University, hospital or other
- Collaborators
- BodyGNTX Fitness Institute, GFFI Fitness Academy, Indian Institute of Kinesiology and Biomechanics Science (IIKBS), Bureau of Fitness Standards (BFS), Active India Health & Fitness Trust (AIHFT), Body Mechanic Chain of Gyms, Shri Mahaveer Ortho Clinic, Regain Fitness Zone, MMSx Authority Biomechanics Department
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07256717
- Sponsor's protocol ID
- BPIT-MULTI-2025-001
- Other IDs
- MACREB-BPIT-2025-014
- Acronym
- BPIT_5LINE_369
- Status last verified
- Dec 2025
- First submitted
- 18 Nov 2025
- Last updated
- 16 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Balanced Progressive Intensity Training (BPIT): A Five-Week Multi-Site Clinical Evaluation of Functional Movement, Mobility, and Neuromuscular Adaptation in Healthy Adults (18-65 Years)
- ClinicalTrials.gov ID
- NCT07256717
- Acronym / sponsor ID
- BPIT_5LINE_369 / BPIT-MULTI-2025-001
- Conditions
- Physical Fitness
- Keywords
- Balanced Progressive Intensity Training, BPIT, 5-Line Principle, Movement Efficiency, Heart Rate Variability, Postural Control, Strength Training, Exercise Intervention
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 369 participants (estimated)
- Lead sponsor
- MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.University, hospital or other
- Collaborators
- BodyGNTX Fitness Institute, GFFI Fitness Academy, Indian Institute of Kinesiology and Biomechanics Science (IIKBS), Bureau of Fitness Standards (BFS), Active India Health & Fitness Trust (AIHFT), Body Mechanic Chain of Gyms, Shri Mahaveer Ortho Clinic, Regain Fitness Zone, MMSx Authority Biomechanics Department
- Study start
- 10 Oct 2025 (actual)
- Primary completion
- 15 Feb 2026 (estimated)
- Study completion
- 25 Feb 2026 (estimated)
- First posted
- 1 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective, multi-site, single-arm interventional study evaluates the 5-Line Principle of Balanced Progressive Intensity Training (BPIT) over 5 weeks in healthy adults aged 18-65 years. All participants receive supervised BPIT sessions (3-5 per week) progressing through five intensity lines defined by anatomical landmarks and ground reaction force:
Ground-Based (Low) Knee-Level (Low-Moderate) Standing (Moderate) Head-Level (Moderate-High) Plyometric (High-Impact)
The study aims to quantify improvements in functional movement efficiency, joint mobility, postural control, strength adaptation, and heart-rate variability while monitoring safety and individual overload indicators.
Detailed description
Primary Outcome Measures
Change in Functional Movement Screen (FMS) total score from baseline to Week 5 Change in Y-Balance Test reach distance (composite score) Timeframe: Baseline and Week 5
Secondary Outcome Measures
Change in 1-RM or estimated strength (squat, deadlift, overhead press) Change in resting HRV (RMSSD) Change in joint range of motion (goniometry) and postural sway Incidence of training-related discomfort or minor injury Timeframe: Baseline, weekly, and Week 5
Arms/Intervention Experimental: BPIT 5-Line Training Group Intervention: Behavioral: Balanced Progressive Intensity Training (BPIT) 5-Line Method Description: 5-week supervised progressive training using the BPIT 5-Line framework (ground-based → plyometric) Eligibility
Ages Eligible: 18 Years to 65 Years Sexes Eligible: All Accepts Healthy Volunteers: Yes
Inclusion Criteria
Healthy adults with regular exercise history Able to attend 3-5 training sessions/week Signed informed consent
Exclusion Criteria
Recent injury (<3 months) Known cardiovascular, metabolic, or orthopaedic contraindications Pregnancy
Study Locations 13 Locations in India 2 Locations in USA, (Details of the location is uploaded on mmsxauthority.com webiste)
MMSx Authority , USA, GFFI Fitness Academy, New Delhi BodyGNTX USA BFS/AIHFT-approved facilities
Countries of Recruitment India U.S. FDA-regulated? No / No / No Human Subjects Protection Review Board Status Approved (or Submit for review if not yet) Board Name: Institutional Ethics Committee - MMSx Authority / GFFI Approval Number: BPIT-MULTI-2025-001 (or pending) Data Monitoring Committee No
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| BPIT 5-Line Training Group | Experimental | Behavioral: Balanced Progressive Intensity Training (BPIT) 5-Line MethodAll participants receive the 5-week Balanced Progressive Intensity Training (BPIT) program using the 5-Line Principle (ground-based → knee-level → standing → head-level → plyometric) under supervised sessions 3-5 times per week. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Adults aged 18-65 years Generally healthy with regular physical activity history (at least 1-2 sessions per week for the past 3 months) Able to commit to 3-5 supervised training sessions per week for 5 weeks Willing and able to provide written informed consent Cleared by pre-screening (no acute injury, no contraindications)
Key exclusion criteria (1 listed)
- Acute musculoskeletal injury within the past 3 months Known cardiovascular, metabolic, or orthopaedic conditions that contraindicate exercise Pregnancy or planning pregnancy Use of medications or supplements that significantly affect muscle recovery or performance (e.g., corticosteroids, anabolic agents) Inability to follow the BPIT protocol or attend required sessions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Balanced Progressive Intensity Training (BPIT) 5-Line Method5-week supervised progressive training using the BPIT 5-Line framework developed by Dr. Neeraj Mehta. | Behavioural | BPIT 5-Line Training Group |
Primary outcome
Movement Efficiency Score (MES, 0-10)
Time frame: Baseline (Week 0) and end of study (Week 5)
Change from baseline in the proprietary Movement Efficiency Score (MES), a validated composite metric of biomechanical function, movement quality, and postural alignment (derived from MMSx Flaw Checklist, visual/video analysis, and functional mapping).
4 secondary outcomes
Range of Motion (ROM)
Time frame: Baseline and Week 5
VAS Pain Score
Time frame: Baseline and Week 5
Strength Index
Time frame: Baseline and Week 5
Mobility Limitation (%)
Time frame: Baseline and Week 5
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Dec 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
MMSx AUTHORITY INSTITUTE FOR MOVEMENT MECHANICS & BIOMECHANICS RESEARCH (COORDINATING CENTER)
Powell, United States
10 sites in 2 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Balanced Progressive Intensity Training (BPIT) 5-Line Method in people with Physical Fitness, run by MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc. at 10 sites in 2 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 10 sites in India, United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Movement Efficiency Score (MES, 0-10) (time frame: Baseline (Week 0) and end of study (Week 5)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Dec 2025.