StrokeVIPERSNCT07254949
Vision and Proprioception Evaluation With Robotics After Stroke
An observational study of Stroke and Control Condition, run by Dr. Sean Dukelow at 2 sites in Canada.
Trial summary
Stroke is highly prevalent in Canada and can lead to profound upper limb impairments in motor and sensory function, as well and vision. Clinical assessments for these functions often lack sensitivity making detecting impairments and tracking their recovery after stroke difficult. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Stroke, Control Condition
- How many people
- 425 participants
- Where
- 2 sitesCanada
- Study dates
- Jan 2026to Jun 2031
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: 425 participants will be recruited for this study (225 stroke participants and 200 matched control participants who have not experienced a stroke). All participant will be aged 18 or older.
Who may be able to join
- 18 years of age or older
- First clinical diagnosis of stroke
- No recent muscle skeletal injuries to the arms, neck, or back
- No history of other neurological disease/injury (Ie. MS, Parkinson's, Brain Tumour, etc.)
- Corrected vision 20/50 or better
- Able to follow multi-step commands.
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- Living independently prior to stroke
- Can consent to participate in research
- 18 years of age or older
- No history stroke, or Trans Ischemic Attack (TIA)
- No recent muscle skeletal injures to the arms, neck, or back
- No history of other neurological disease/ injury (Ie. MS, Parkinson's, Brain Tumour, etc)
- No pre-stroke history of eye movement disorders
- Corrected vision 20/50 or better
- Able to follow multi-step commands
- Can consent to participate in research
Who cannot join
- Prior history of stroke/significant neurologic problem (e.g. Parkinson's)
- Symptomatic medical conditions that would interfere with participation (e.g. uncontrolled angina)
- Contraindications to Magnetic Resonance Imaging (MRI)
- Pre-stroke history of visual field/oculomotor abnormalities.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Canada2 sites
Carewest Dr. Vernon Fanning Centre
Calgary, Alberta
Rachel Stone, 403-944-4050, robotlab@ucalgary.ca
Foothills Medical Centre
Calgary, Alberta
Rachel Stone, 403-944-4050, robotlab@ucalgary.ca
About this study
Stroke is highly prevalent in Canada and can lead to profound upper limb impairments in motor and sensory function, as well and vision. Clinical assessments for these functions often lack sensitivity making detecting impairments and tracking their recovery after stroke difficult. It is known that sensory function and vision interact to inform motor behaviours, yet how each of these modalities might contribute to motor impairments and subsequent recovery after stroke is undetermined.
Using robotics to assess neurologic function after a stroke can be very beneficial, as they can measure on the scale of millimetres and milliseconds which can more easily detect subtle deficits in a persons function. Compared to current clinical tools, robotics offer greater objectivity and reliability, as they do not rely on the examiners clinical experience and/or impression. The use of robotics not only offers a more precise measurement, but robotics assessments can be completed in a relatively short amount of time, in comparison to some of the current clinical assessment tools, which can take along time to complete. In addition to robotics, collecting neuroimaging (MRI/CT) will allow us to relate our robotic and eye-tracking measures to neuroanatomical information about the person's stroke. With this data, we will assess how the brain changes post-stroke in relation to the recovery of motor, sensory and visual functions.
Read more
This research will: 1) examine the relationship between visual and proprioceptive impairment on motor and eye movement behaviour over time after stroke, and 2) identify neuroanatomical correlates of visual, proprioceptive and sensory integrative dysfunction that impact motor recovery after stroke and examine the ability of regional damage and network disruption to predict recovery.
Objectives:
- Determine the impact of visual field loss and visual neglect in stroke survivors with impaired movement over the first 6 months post-stroke.
- Identify the impact of Proprioceptive Impairment and Sensory Integration Impairment on recovery post-stroke using robotics and eye tracking.
- Understand the impact of damage to neuroanatomic structures involved in vision, proprioception and sensory integration on motor recovery using MRI after stroke.
The VIPERS study is recruiting both stroke and control participants. Stroke participants are recruited within the first 28 days post-stroke and are assessed longitudinally across the first 6-months post-stroke (four study timepoints). Control participants just complete a single session.
- Conditions
- Stroke, Control Condition
- Keywords
- Stroke, Sensation, Movement, Vision, Robotics, Eye-Tracking, Imaging
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Stroke | Stroke Participants - Individuals with first time stroke | |
| Control | Control Participants - Individuals not suffering stroke or other neurological disorders |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visually Guided Reaching Score
Measured: Enrolment to six-months post stroke
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Nov 2025
- Study startJan 2026 (estimated)
- Primary completionJan 2031 (estimated)
- Study completionJun 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 425 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dr. Sean Dukelow
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Dr. Sean Dukelow, University of Calgary
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07254949
- Sponsor's protocol ID
- REB25-1170
- Other IDs
- 197953
- Acronym
- VIPERS
- Status last verified
- Nov 2025
- First submitted
- 19 Nov 2025
- Last updated
- 28 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Formal data transfer agreements/legal contracts are required to share IPD with other researchers outside of the main study site.
Study at a glance
From the registry record, last updated by the sponsor on 28 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Vision and Proprioception Evaluation With Robotics After Stroke
- ClinicalTrials.gov ID
- NCT07254949
- Acronym / sponsor ID
- VIPERS / REB25-1170
- Conditions
- Stroke, Control Condition
- Keywords
- Stroke, Sensation, Movement, Vision, Robotics, Eye-Tracking, Imaging
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 425 participants (estimated)
- Lead sponsor
- Dr. Sean DukelowUniversity, hospital or other
- Study start
- Jan 2026 (estimated)
- Primary completion
- Jan 2031 (estimated)
- Study completion
- Jun 2031 (estimated)
- First posted
- 28 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Stroke is highly prevalent in Canada and can lead to profound upper limb impairments in motor and sensory function, as well and vision. Clinical assessments for these functions often lack sensitivity making detecting impairments and tracking their recovery after stroke difficult. It is known that sensory function and vision interact to inform motor behaviours, yet how each of these modalities might contribute to motor impairments and subsequent recovery after stroke is undetermined.
Using robotics to assess neurologic function after a stroke can be very beneficial, as they can measure on the scale of millimetres and milliseconds which can more easily detect subtle deficits in a persons function. Compared to current clinical tools, robotics offer greater objectivity and reliability, as they do not rely on the examiners clinical experience and/or impression. The use of robotics not only offers a more precise measurement, but robotics assessments can be completed in a relatively short amount of time, in comparison to some of the current clinical assessment tools, which can take along time to complete. In addition to robotics, collecting neuroimaging (MRI/CT) will allow us to relate our robotic and eye-tracking measures to neuroanatomical information about the person's stroke. With this data, we will assess how the brain changes post-stroke in relation to the recovery of motor, sensory and visual functions.
This research will: 1) examine the relationship between visual and proprioceptive impairment on motor and eye movement behaviour over time after stroke, and 2) identify neuroanatomical correlates of visual, proprioceptive and sensory integrative dysfunction that impact motor recovery after stroke and examine the ability of regional damage and network disruption to predict recovery.
Objectives:
- Determine the impact of visual field loss and visual neglect in stroke survivors with impaired movement over the first 6 months post-stroke.
- Identify the impact of Proprioceptive Impairment and Sensory Integration Impairment on recovery post-stroke using robotics and eye tracking.
- Understand the impact of damage to neuroanatomic structures involved in vision, proprioception and sensory integration on motor recovery using MRI after stroke.
The VIPERS study is recruiting both stroke and control participants. Stroke participants are recruited within the first 28 days post-stroke and are assessed longitudinally across the first 6-months post-stroke (four study timepoints). Control participants just complete a single session.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Stroke | – | –Stroke Participants - Individuals with first time stroke |
| Control | – | –Control Participants - Individuals not suffering stroke or other neurological disorders |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- 425 participants will be recruited for this study (225 stroke participants and 200 matched control participants who have not experienced a stroke). All participant will be aged 18 or older.
Key inclusion criteria (16 listed)
- 18 years of age or older
- First clinical diagnosis of stroke
- No recent muscle skeletal injuries to the arms, neck, or back
- No history of other neurological disease/injury (Ie. MS, Parkinson's, Brain Tumour, etc.)
- Corrected vision 20/50 or better
Key exclusion criteria (4 listed)
- Prior history of stroke/significant neurologic problem (e.g. Parkinson's)
- Symptomatic medical conditions that would interfere with participation (e.g. uncontrolled angina)
- Contraindications to Magnetic Resonance Imaging (MRI)
- Pre-stroke history of visual field/oculomotor abnormalities.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Visually Guided Reaching Score
Time frame: Enrolment to six-months post stroke
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Nov 2025.
- Individual participant dataSharing planned: No. Formal data transfer agreements/legal contracts are required to share IPD with other researchers outside of the main study site.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stroke and Control Condition, run by Dr. Sean Dukelow at 2 sites in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 16 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 28 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visually Guided Reaching Score (time frame: Enrolment to six-months post stroke). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Nov 2025.