Sore-throatNCT07246850
A Randomized, Triple-blind, Placebo-controlled Study to Evaluate the Effects of a Throat Spray on the Incidence and Duration of Sickness
A study testing Beekeeper's Propolis Throat Spray in people with Sore-throat and Common Cold, run by Beekeeper's Naturals Inc at 1 site in United States.
Trial summary
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of Beekeeper's Naturals Propolis Immune Support Throat Spray on the incidence and duration of sickness over a 16-week period. The study will enroll 100 healthy adults aged 18 to 65. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Sore-throat, Common Cold
- What is being tested?
- Beekeeper's Propolis Throat Spray
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- 30 Dec 2024to Nov 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Be male or female
- Be aged 18-65
- Meet at least one of the following criteria:
- Work in a hospital or other healthcare setting Work in a school
- Have a child/children under the age of 10
- Be willing to take the test or placebo product once daily and complete study questionnaires every four weeks for the 16-week study period
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- Be willing to refrain from taking any over-the-counter products, herbal remedies, or supplements that target immune function during the study period and for two weeks prior.
- Be willing to maintain their current diet, sleep schedule, and activity level for the duration of the study.
- Be in good general health and not live with any uncontrolled chronic conditions.
- Reside in the United States.
Who cannot join
- Has undergone any surgeries or invasive treatments in the past six months or plans to undergo any during the study period
- Anyone with seasonal allergies
- Anyone who follows a restrictive diet (e.g., keto, vegan, raw, carnivore, etc.).
- Anyone who got a vaccination in the last 2 weeks.
- Anyone taking one or more prescription medications:
- Corticosteroids: Prednisone (prednisone), Deltasone (prednisolone), Medrol (methylprednisolone), Decadron (dexamethasone), Cortef (hydrocortisone), Kenalog (triamcinolone), Flonase (fluticasone), Nasonex (mometasone) Biologics (Immunomodulating Agents): Humira (adalimumab), Enbrel (etanercept), Remicade (infliximab), Stelara (ustekinumab), Cosentyx (secukinumab), Taltz (ixekizumab), Orencia (abatacept), Simponi (golimumab), Xeljanz (tofacitinib), Rituxan (rituximab), Actemra (tocilizumab), Kineret (anakinra) DMARDs (Disease-Modifying Antirheumatic Drugs): Methotrexate (methotrexate), Plaquenil (hydroxychloroquine), Arava (leflunomide), Azulfidine (sulfasalazine), Imuran (azathioprine), CellCept (mycophenolate mofetil), Cytoxan (cyclophosphamide) JAK Inhibitors: Olumiant (baricitinib), Rinvoq (upadacitinib), Jakafi (ruxolitinib) Other Immunosuppressive Medications: Prograf (tacrolimus), Neoral, Sandimmune (cyclosporine), Rapamune (sirolimus), Zortress (everolimus)
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- Has had any major illness in the past three months.
- Drinks heavily (defined as 8 or more alcoholic drinks per week for women or 15 or more alcoholic drinks per week for men).
- Uses illicit drugs.
- Has known allergies or hypersensitivities to any of the study product ingredients.
- Is immunocompromised due to a medical condition or due to immunosuppressive medications or treatments.
- Has any known autoimmune conditions.
- Has any chronic health conditions that could impact participation in the study, including cancer, liver, or mental health disorders.
- Has known serious allergic reactions requiring the use of an Epi-Pen.
- Is currently pregnant, trying to conceive, or breastfeeding.
- Is currently participating in another research study or plans to do so during the 16-week study period.
- Has a history of substance abuse.
- Is currently a smoker or has been a smoker in the past three months.
Trial locations and contacts
1 site in 1 country.
About this study
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of Beekeeper's Naturals Propolis Immune Support Throat Spray on the incidence and duration of sickness over a 16-week period. The study will enroll 100 healthy adults aged 18 to 65.
- Conditions
- Sore-throat, Common Cold
- Being tested
- Beekeeper's Propolis Throat Spray, Placebo Throat Spray
- Medical subject headings
- Pharyngitis, Common Cold
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Beekeeper's Propolis Throat SprayDietary supplement
Participants will administer four sprays of Beekeeper's Propolis Throat Spray into the back of the mouth once daily in the morning for 16 weeks.
Placebo Throat SprayDietary supplement
Participants will administer four sprays of a placebo throat spray into the back of the mouth once daily in the morning for 16 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Beekeeper's Propolis Throat Spray | Experimental | Not described Receives: Dietary Supplement: Beekeeper's Propolis Throat Spray |
| Placebo Throat Spray | Placebo comparator | Not described Receives: Dietary Supplement: Placebo Throat Spray |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in incidence and duration of sickness
Self-reported via questionnaires comparing frequency and duration of illness episodes between groups
Measured: Baseline, Weeks 4, 8, 12, and 16
Secondary outcomes (3)
Perceived improvement in overall health
Participants will report perceived changes in their overall health using self-administered questionnaires.
Measured: Baseline, Week 4, Week 8, Week 12, and Week 16
Perceived improvement in overall well-being
Participants will report their sense of overall well-being using self-administered questionnaires throughout the study.
Measured: Baseline, Week 4, Week 8, Week 12, and Week 16
Perceived immune system support
Participants will rate their perception of immune system support using self-administered questionnaires during the study.
Measured: Baseline, Week 4, Week 8, Week 12, and Week 16
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Nov 2025
- Study start30 Dec 2024
- Primary completionNov 2025 (estimated)
- Study completionNov 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Sore-throatStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Beekeeper's Naturals Inc
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07246850
- Sponsor's protocol ID
- 20694
- Status last verified
- Nov 2025
- First submitted
- 19 Nov 2025
- Last updated
- 24 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized, Triple-blind, Placebo-controlled Study to Evaluate the Effects of a Throat Spray on the Incidence and Duration of Sickness
- ClinicalTrials.gov ID
- NCT07246850
- Acronym / sponsor ID
- 20694
- Conditions
- Sore-throat, Common Cold
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Beekeeper's Naturals IncIndustry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Study start
- 30 Dec 2024 (actual)
- Primary completion
- Nov 2025 (estimated)
- Study completion
- Nov 2025 (estimated)
- First posted
- 24 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of Beekeeper's Naturals Propolis Immune Support Throat Spray on the incidence and duration of sickness over a 16-week period. The study will enroll 100 healthy adults aged 18 to 65.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Beekeeper's Propolis Throat Spray | Experimental | Dietary Supplement: Beekeeper's Propolis Throat Spray |
| Placebo Throat Spray | Placebo comparator | Dietary Supplement: Placebo Throat Spray |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (10 listed)
- Be male or female
- Be aged 18-65
- Meet at least one of the following criteria:
- Work in a hospital or other healthcare setting Work in a school
- Have a child/children under the age of 10
Key exclusion criteria (18 listed)
- Has undergone any surgeries or invasive treatments in the past six months or plans to undergo any during the study period
- Anyone with seasonal allergies
- Anyone who follows a restrictive diet (e.g., keto, vegan, raw, carnivore, etc.).
- Anyone who got a vaccination in the last 2 weeks.
- Anyone taking one or more prescription medications:
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Beekeeper's Propolis Throat SprayParticipants will administer four sprays of Beekeeper's Propolis Throat Spray into the back of the mouth once daily in the morning for 16 weeks. | Dietary supplement | Beekeeper's Propolis Throat Spray |
| Placebo Throat SprayParticipants will administer four sprays of a placebo throat spray into the back of the mouth once daily in the morning for 16 weeks. | Dietary supplement | Placebo Throat Spray |
Primary outcome
Changes in incidence and duration of sickness
Time frame: Baseline, Weeks 4, 8, 12, and 16
Self-reported via questionnaires comparing frequency and duration of illness episodes between groups
3 secondary outcomes
Perceived improvement in overall health
Time frame: Baseline, Week 4, Week 8, Week 12, and Week 16
Perceived improvement in overall well-being
Time frame: Baseline, Week 4, Week 8, Week 12, and Week 16
Perceived immune system support
Time frame: Baseline, Week 4, Week 8, Week 12, and Week 16
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Nov 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Beekeeper's Propolis Throat Spray in people with Sore-throat and Common Cold, run by Beekeeper's Naturals Inc at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 18 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 24 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in incidence and duration of sickness (time frame: Baseline, Weeks 4, 8, 12, and 16). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Nov 2025.