Cerebral PalsyNCT07244146
Effects of CHRIST Among Children With Spastic CP
A study testing CHRIST in people with Cerebral Palsy, run by Riphah International University at 1 site in Pakistan.
Trial summary
This Quasi experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength amonfg children with Spastic Cerebral Palsy. The study involves 14 children from 6-12 years of age, and will be given intervention for 10 weeks period. Read more about this study
- Who is it for?
- Ages 6 to 12 years
- Conditions the study is for
- Cerebral Palsy
- What is being tested?
- CHRIST
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 14 participants
- Where
- 1 sitePakistan
- Study dates
- 22 Oct 2025to 16 Jun 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 12 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Children Diagnosed with hemiplegic spastic cerebral palsy.
- Age 6-12 years.
- Capable of following commands regarding hand use and testing.
- Capable of communicating needs.
- Parents or caregivers willing to provide informed consent and participate in the study.
- No contraindications to moderate physical activity.
- Able to lift the more affected arm 15 cm above a table surface and grasp light objects
Who cannot join
- Children with musculoskeletal system injuries, including upper limb fractures or contractures, as well as those who had received medications affecting muscle strength or spasticity, were excluded from the study.
- Orthopedic surgery involving the more affected hand within the past 6 months.
- Children with Cardiovascular disease.
- Lack of cooperation with instructions or other behavioral challenges that prevent effective delivery of intensive therapy.
- Visual impairments that may hinder active participation.
- Seizure or family history of seizure disorders
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Imran Amjad
Lahore, Punjab Province, 5400
Muhmmad Asif Javed, MS, 033224209422, a.javed@ripah.edu.pk
Fairy Ali, MS*, 03314307661, fairyali@yahoo.com
About this study
Official title: Effects of Comprehensive Hand Intense Strength Training on In Hand Manipulation and Grip Strength Among Children With Spastic Cerebral Palsy
This Quasi experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength amonfg children with Spastic Cerebral Palsy. The study involves 14 children from 6-12 years of age, and will be given intervention for 10 weeks period.
Key performance outcomes- In Hand Manipulation and Grip Strength will be assessed both before and after the intervention. This study aims to address this gap by evaluating the effects of the CHRIST on IHM and grip strength in children diagnosed with spastic cerebral palsy. The hypothesis is that integrating strength training with high repetition, functionally relevant tasks yields greater and more practical gains than strength training or conventional therapy alone. Data will be analyzed through SPSS version 27.0
Read the detailed description
This Quasi Experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength in children with Spastic Cerebral Palsy. CHRIST was designed to enhance the motor ability of children. The efficacy of this program will be investigated through a Quasi Experimental study. Data will be collected from special schools and rehabilitation centers having children with spastic cerebral palsy. The intervention CHRIST will be given thrice a week for forty minutes. The study will be completed in 10 weeks after approval of the synopsis. The study will include 14 children, male and female. Inclusion criteria for the study will include patients diagnosed with spastic CP. Data will be collected from children aged 6 to 12 years old. IHM will be measured by Melbourne Assessment 2 scale (MA2). Grip Strength will be measured by dynamometer. IHM \& Grip Strength will be assessed both before and after the intervention.This study aims to address this gap by evaluating the effects of CHRIST on IHM and grip strength in children diagnosed with spastic cerebral palsy. The hypothesis is that integrating strength training with high repetition, functionally relevant tasks yields greater and more practical gains than strength training or conventional therapy alone. Data will be analyzed through SPSS version 27.0
- Conditions
- Cerebral Palsy
- Being tested
- CHRIST
- Keywords
- Hemiplegic spastic cerebral palsy, In-hand manipulation, , Grip strength
- Medical subject headings
- Cerebral Palsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CHRISTOther
CHRIST, is a treadmill-based training with body weight supported by the upper limbs. There will be a session of 40 minutes, which includes 3 sets (10 minutes exercise with 3 minutes rest period per set), three times a week, over a 10 week period. By maintaining the posture of the quadruped, the abdomen and weight of the lower limb will be supported by using a support board under the abdomen. The speed of the treadmill for the upper limbs will be 0.3-1.2 km/h.
| Study group | Role | What they receive |
|---|---|---|
| The intervention will be comprehensive hand repetitive intense strength training | Experimental | CHRIST, is a treadmill-based training with body weight supported by the upper limbs. There will be a session of 40 minutes, which includes 3 sets (10 minutes exercise with 3 minutes rest period per set), three times a week, over a 10 week period. By maintaining the posture of the quadruped, the abdomen and weight of the lower limb will be supported by using a support board under the abdomen. The speed of the treadmill for the upper limbs will be 0.3-1.2 km/h. Results will be evaluated by MA2 and dynamometer. Receives: Other: CHRIST |
What is being measured
The primary outcome is the main question the study is designed to answer.
Jamma Dynamometer
Grip strength will be measured by Jammar Dynamometer. The hand-held dynamometer are reliable measurement instruments to measure muscle strength of the arm and hand in children with unilateral spastic cerebral palsy, aged 7 12 years
Measured: Baseline, 1st week and 10th week
Secondary outcomes (1)
Melbourne assessment 2 (MA2)
Melbourne Assessment 2 (MA2) will be used to assess in-hand manipulation before and after the intervention (CHRIST) to evaluate the impact. MA2 is a reliable and valid tool for assessment of upper limb in children with CP.
Measured: Baseline, 1st week and 10th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Nov 2025
- Study start22 Oct 2025
- Primary completion2 Jun 2026 (estimated)
- Study completion16 Jun 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cerebral PalsyStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- This Quasi experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength amonfg children with Spastic Cerebral Palsy. The study involves 14 children from 6-12 years of age, and will be given intervention for 10 weeks period. Key performance outcomes- In Hand Manipulation and Grip Strength will be assessed both before and after the intervention. This study aims to address this gap by evaluating the effects of the CHRIST on IHM and grip strength in children diagnosed with spastic cerebral palsy. The hypothesis is that integrating strength training with high repetition, functionally relevant tasks yields greater and more practical gains than strength training or conventional therapy alone. Data will be analyzed through SPSS version 27.0
- Masking
- None (open label)
- Enrolment
- 14 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- FAIRY ALI, MSPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07244146
- Sponsor's protocol ID
- REC/RCR&AHS/FAIRY ALI
- Status last verified
- Nov 2025
- First submitted
- 17 Nov 2025
- Last updated
- 24 Nov 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Lee DR, You JH, Lee NG, Oh JH, Cha YJ. Comprehensive Hand Repetitive Intensive Strengthening Training (CHRIST)-induced morphological changes in muscle size and associated motor improvement in a child with cerebral palsy: an experimenter-blind study. NeuroRehabilitation. 2009;24(2):109-17. doi: 10.3233/NRE-2009-0460.
PubMed 19339750
Study at a glance
From the registry record, last updated by the sponsor on 24 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Comprehensive Hand Intense Strength Training on In Hand Manipulation and Grip Strength Among Children With Spastic Cerebral Palsy
- ClinicalTrials.gov ID
- NCT07244146
- Acronym / sponsor ID
- REC/RCR&AHS/FAIRY ALI
- Conditions
- Cerebral Palsy
- Keywords
- Hemiplegic spastic cerebral palsy, In-hand manipulation, , Grip strength
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 14 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 22 Oct 2025 (actual)
- Primary completion
- 2 Jun 2026 (estimated)
- Study completion
- 16 Jun 2026 (estimated)
- First posted
- 24 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This Quasi experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength amonfg children with Spastic Cerebral Palsy. The study involves 14 children from 6-12 years of age, and will be given intervention for 10 weeks period.
Key performance outcomes- In Hand Manipulation and Grip Strength will be assessed both before and after the intervention. This study aims to address this gap by evaluating the effects of the CHRIST on IHM and grip strength in children diagnosed with spastic cerebral palsy. The hypothesis is that integrating strength training with high repetition, functionally relevant tasks yields greater and more practical gains than strength training or conventional therapy alone. Data will be analyzed through SPSS version 27.0
Detailed description
This Quasi Experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength in children with Spastic Cerebral Palsy. CHRIST was designed to enhance the motor ability of children. The efficacy of this program will be investigated through a Quasi Experimental study. Data will be collected from special schools and rehabilitation centers having children with spastic cerebral palsy. The intervention CHRIST will be given thrice a week for forty minutes. The study will be completed in 10 weeks after approval of the synopsis. The study will include 14 children, male and female. Inclusion criteria for the study will include patients diagnosed with spastic CP. Data will be collected from children aged 6 to 12 years old. IHM will be measured by Melbourne Assessment 2 scale (MA2). Grip Strength will be measured by dynamometer. IHM \& Grip Strength will be assessed both before and after the intervention.This study aims to address this gap by evaluating the effects of CHRIST on IHM and grip strength in children diagnosed with spastic cerebral palsy. The hypothesis is that integrating strength training with high repetition, functionally relevant tasks yields greater and more practical gains than strength training or conventional therapy alone. Data will be analyzed through SPSS version 27.0
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- This Quasi experimental study investigates the effects of CHRIST on In Hand Manipulation and Grip Strength amonfg children with Spastic Cerebral Palsy. The study involves 14 children from 6-12 years of age, and will be given intervention for 10 weeks period. Key performance outcomes- In Hand Manipulation and Grip Strength will be assessed both before and after the intervention. This study aims to address this gap by evaluating the effects of the CHRIST on IHM and grip strength in children diagnosed with spastic cerebral palsy. The hypothesis is that integrating strength training with high repetition, functionally relevant tasks yields greater and more practical gains than strength training or conventional therapy alone. Data will be analyzed through SPSS version 27.0
| Arm | Type | Receives |
|---|---|---|
| The intervention will be comprehensive hand repetitive intense strength training | Experimental | Other: CHRISTCHRIST, is a treadmill-based training with body weight supported by the upper limbs. There will be a session of 40 minutes, which includes 3 sets (10 minutes exercise with 3 minutes rest period per set), three times a week, over a 10 week period. By maintaining the posture of the quadruped, the abdomen and weight of the lower limb will be supported by using a support board under the abdomen. The speed of the treadmill for the upper limbs will be 0.3-1.2 km/h. Results will be evaluated by MA2 and dynamometer. |
Who may qualify
- Ages
- 6 to 12 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (7 listed)
- Children Diagnosed with hemiplegic spastic cerebral palsy.
- Age 6-12 years.
- Capable of following commands regarding hand use and testing.
- Capable of communicating needs.
- Parents or caregivers willing to provide informed consent and participate in the study.
Key exclusion criteria (6 listed)
- Children with musculoskeletal system injuries, including upper limb fractures or contractures, as well as those who had received medications affecting muscle strength or spasticity, were excluded from the study.
- Orthopedic surgery involving the more affected hand within the past 6 months.
- Children with Cardiovascular disease.
- Lack of cooperation with instructions or other behavioral challenges that prevent effective delivery of intensive therapy.
- Visual impairments that may hinder active participation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CHRISTCHRIST, is a treadmill-based training with body weight supported by the upper limbs. There will be a session of 40 minutes, which includes 3 sets (10 minutes exercise with 3 minutes rest period per set), three times a week, over a 10 week period. By maintaining the posture of the quadruped, the abdomen and weight of the lower limb will be supported by using a support board under the abdomen. The speed of the treadmill for the upper limbs will be 0.3-1.2 km/h. | Other | The intervention will be comprehensive hand repetitive intense strength training |
Primary outcome
Jamma Dynamometer
Time frame: Baseline, 1st week and 10th week
Grip strength will be measured by Jammar Dynamometer. The hand-held dynamometer are reliable measurement instruments to measure muscle strength of the arm and hand in children with unilateral spastic cerebral palsy, aged 7 12 years
1 secondary outcome
Melbourne assessment 2 (MA2)
Time frame: Baseline, 1st week and 10th week
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Nov 2025.
- Background: PubMed 19339750Lee DR, You JH, Lee NG, Oh JH, Cha YJ. Comprehensive Hand Repetitive Intensive Strengthening Training (CHRIST)-induced morphological changes in muscle size and associated motor improvement in a child with cerebral palsy: an experimenter-blind study. NeuroRehabilitation. 2009;24(2):109-17. doi: 10.3233/NRE-2009-0460.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
FAIRY ALI, MSPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing CHRIST in people with Cerebral Palsy, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact IMRAN AMJAD, PHD (9233224390125, imran.amjad@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Jamma Dynamometer (time frame: Baseline, 1st week and 10th week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07244146, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Nov 2025.