AcneAVNCT07240051
Efficacy of Different Types of Chemical Peels in the Treatment of Acne Vulgaris
A study testing Glycolic acid peel alone, salicylic acid and modified jessener in people with Acne and Peeling, run by Nahla Maher Mahmoud Mahran at 1 site in Egypt.
Trial summary
Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial. Read more about this study
- Who is it for?
- Ages Up to 65 yearsHealthy volunteers can take part
- What is being tested?
- Glycolic acid peel alone, salicylic acid and modified jessener
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteEgypt
- Study dates
- 9 Mar 2024to 12 Jul 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 65 years
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Facial active acne (mild and moderate cases)
- post-acne hyperpigmentation
- a minimum age of 18 years
- skin phototype III or IV
Who cannot join
- Pregnant or nursing women
- active infection in the treatment area (e.g., verrucae and herpes simplex)
- systemic disease (hypertension, diabetes, or bleeding tendency)
- systemic retinoid or laser treatment within the last 6 months
- history of keloidal tendency or Aspirin sensitivity.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial
Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial.
- Being tested
- Glycolic acid peel alone, salicylic acid, modified jessener
- Keywords
- acne vulgaris, chemical peeling
- Medical subject headings
- Acne Vulgaris
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Glycolic acid peel aloneProcedure or surgery
Using a cotton tip applicator, a single coat of commercially prepared 50% GA peeling agent was evenly applied to the patient's face. Neutralization of the peel was done on reaching uniform erythema (endpoint) within 3-5 minutes. If frosting was observed in any area before the set time or endpoint, the area was neutralized with sodium bicarbonate
salicylic acidProcedure or surgery
Using a cotton tip applicator, a single coat of commercially prepared 30% SA peeling agent was evenly applied to the patient's face, moving from the forehead and advancing to the cheeks, chin, glabella, nose, and perioral area. Once white crystallization appeared, patients were asked to wash their faces with water.
modified jessenerProcedure or surgery
Commercially prepared MJ peel was applied using a gauze piece and light hand pressure. A single coat of peel was uniformly applied over the entire face. The coat was allowed to dry completely until erythema or frosting occurred, at which point patients were asked to wash their faces with cold water.
| Study group | Role | What they receive |
|---|---|---|
| glycolic acid group | Active comparator | 30 patients received 50% glycolic acid peels Receives: Procedure: Glycolic acid peel alone |
| Salicylic acid group | Active comparator | 30 patients received Salicylic acid 30% Receives: Procedure: salicylic acid |
| Modified Jessener group | Active comparator | 30 patients received MJ peel Receives: Procedure: modified jessener |
What is being measured
The primary outcome is the main question the study is designed to answer.
improvement in acne vulgaris by assessing Global acne scoring system and post-acne hyperpigmentation index
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Nov 2025
- Study start9 Mar 2024
- Primary completion10 Jun 2024
- Study completion12 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AcneStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 90 participants (actual)
Sponsor and investigators
- Lead sponsor
- Nahla Maher Mahmoud Mahran
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Nahla Maher Mahmoud Mahran, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07240051
- Sponsor's protocol ID
- MS-327-2023
- Acronym
- AV
- Status last verified
- Nov 2025
- First submitted
- 16 Nov 2025
- Last updated
- 20 Nov 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07240051
- Acronym / sponsor ID
- AV / MS-327-2023
- Keywords
- acne vulgaris, chemical peeling
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 90 participants (actual)
- Lead sponsor
- Nahla Maher Mahmoud MahranUniversity, hospital or other
- Study start
- 9 Mar 2024 (actual)
- Primary completion
- 10 Jun 2024 (actual)
- Study completion
- 12 Jul 2024 (actual)
- First posted
- 20 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Assessment of the Efficacy and Safety of 50% Glycolic Acid, 30% Salicylic Acid, and Modified Jessner's Chemical Peels in the Treatment of Active Acne and Post-acne Hyperpigmentation: Randomized Controlled Trial.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| glycolic acid group | Active comparator | Procedure: Glycolic acid peel alone30 patients received 50% glycolic acid peels |
| Salicylic acid group | Active comparator | Procedure: salicylic acid30 patients received Salicylic acid 30% |
| Modified Jessener group | Active comparator | Procedure: modified jessener30 patients received MJ peel |
Who may qualify
- Ages
- Up to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (4 listed)
- Facial active acne (mild and moderate cases)
- post-acne hyperpigmentation
- a minimum age of 18 years
- skin phototype III or IV
Key exclusion criteria (5 listed)
- Pregnant or nursing women
- active infection in the treatment area (e.g., verrucae and herpes simplex)
- systemic disease (hypertension, diabetes, or bleeding tendency)
- systemic retinoid or laser treatment within the last 6 months
- history of keloidal tendency or Aspirin sensitivity.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Glycolic acid peel aloneUsing a cotton tip applicator, a single coat of commercially prepared 50% GA peeling agent was evenly applied to the patient's face. Neutralization of the peel was done on reaching uniform erythema (endpoint) within 3-5 minutes. If frosting was observed in any area before the set time or endpoint, the area was neutralized with sodium bicarbonate | Procedure or surgery | glycolic acid group |
| salicylic acidUsing a cotton tip applicator, a single coat of commercially prepared 30% SA peeling agent was evenly applied to the patient's face, moving from the forehead and advancing to the cheeks, chin, glabella, nose, and perioral area. Once white crystallization appeared, patients were asked to wash their faces with water. | Procedure or surgery | Salicylic acid group |
| modified jessenerCommercially prepared MJ peel was applied using a gauze piece and light hand pressure. A single coat of peel was uniformly applied over the entire face. The coat was allowed to dry completely until erythema or frosting occurred, at which point patients were asked to wash their faces with cold water. | Procedure or surgery | Modified Jessener group |
Primary outcome
improvement in acne vulgaris by assessing Global acne scoring system and post-acne hyperpigmentation index
Time frame: 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Nov 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Glycolic acid peel alone, salicylic acid and modified jessener in people with Acne and Peeling, run by Nahla Maher Mahmoud Mahran at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
improvement in acne vulgaris by assessing Global acne scoring system and post-acne hyperpigmentation index (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Nov 2025.