Socket PreservationNCT07239193
Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites
A study testing Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF) and Mineralized Plasmatic Matrix (MPM) in people with Socket Preservation and Alveolar Ridge Preservation, run by Cairo University at 1 site in Egypt.
Trial summary
When a tooth is removed, the bone around it (called the alveolar ridge) naturally shrinks. This study compares two bone grafting materials to find out which one better preserves bone after molar extraction: Demineralized Dentin Matrix (DDM): A material made from the patient's own extracted tooth, treated to remove… Read more about this study
- Who is it for?
- Ages 18 to 55 years
- Conditions the study is for
- Socket Preservation, Alveolar Ridge Preservation
- What is being tested?
- Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF) and Mineralized Plasmatic Matrix (MPM)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2025to 1 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Non-restorable tooth indicated for extraction Multi-rooted teeth Age group of 18 to 55 years Patients free from any systemic disease that may affect bone healing.
Who cannot join
- Pregnant females Active infection at extraction site Smokers Systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...) Poor oral hygiene. Patient with systemic disease that may affect bone healing. o Uncooperative patient.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Faculty of Dentistry, Cairo University - Department of Oral and Maxillofacial Surgery
Cairo, 12613
Faculty of Dentistry, Cairo University., 23634965, dentmail@dentistry.cu.edu.eg
About this study
Official title: Effect of Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites; A Randomized Clinical Trial.
When a tooth is removed, the bone around it (called the alveolar ridge) naturally shrinks. This study compares two bone grafting materials to find out which one better preserves bone after molar extraction:
Demineralized Dentin Matrix (DDM): A material made from the patient's own extracted tooth, treated to remove minerals while keeping bone-forming proteins.
Mineralized Plasmatic Matrix (MPM): A mixture of a standard bone substitute and platelet-rich plasma from the patient's blood.
Read the detailed description
Alveolar ridge resorption is a predictable biological process following tooth extraction, particularly in molar sites where the bone structure is more complex. Maintaining ridge volume is essential for optimal future implant placement and prosthetic rehabilitation. Various grafting materials and biologic enhancers have been used to minimize post-extraction bone loss; however, cost, availability, and biocompatibility remain significant challenges, especially with xenograft and allograft materials.
This randomized clinical trial investigates and compares two autogenous and biologically enhanced approaches for alveolar ridge preservation following molar extraction. The first method utilizes Demineralized Dentin Matrix (DDM) prepared from the patient's own extracted tooth. DDM provides a naturally derived scaffold rich in collagen and bone morphogenetic proteins (BMPs), offering both osteoconductive and osteoinductive potential. The second method uses a Mineralized Plasmatic Matrix (MPM), a combination of a xenograft bone substitute mixed with Platelet-Rich Plasma (PRP), which represents a widely used regenerative option in oral surgery.
The study is designed as a parallel-group, single-blind, randomized clinical trial conducted at the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University. Eligible adult patients requiring extraction of non-restorable multi-rooted molars will be enrolled and allocated equally into two groups. Both groups will undergo atraumatic extraction followed by immediate socket grafting with either DDM+PRF or MPM+PRP.
Standardized postoperative care will be provided to all participants, and healing will be monitored both clinically and radiographically. Cone-beam computed tomography (CBCT) will be used to evaluate alveolar bone width, height, and density immediately after extraction and at 4 months postoperatively. Pain and soft-tissue healing will also be assessed using validated clinical indices.
The study's primary objective is to determine whether Demineralized Dentin Matrix (DDM) provides superior preservation of alveolar ridge dimensions and bone quality compared to Mineralized Plasmatic Matrix (MPM) in molar extraction sites. The hypothesis tested is that there will be no significant difference between both materials regarding bone preservation and regeneration outcomes.
This trial is expected to provide evidence supporting the clinical viability of using recycled autogenous tooth material as a cost-effective and biocompatible alternative to commercially available xenografts, potentially expanding regenerative options for clinicians and improving access to affordable biologic grafting solutions.
- Conditions
- Socket Preservation, Alveolar Ridge Preservation
- Being tested
- Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF), Mineralized Plasmatic Matrix (MPM)
- Keywords
- socket preservation, alveolar ridge preservation, DDM, demineralized dentin matrix, MPM, mineralized plasmatic matrix
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF)Biological
Autogenous dentin-derived grafting material is used as a bone substitute for alveolar ridge preservation following molar extraction. PRF, obtained from the patient's centrifuged blood, is mixed with DDM to enhance graft stability and promote healing.
Mineralized Plasmatic Matrix (MPM)Biological
A xenogenic bone substitute is mixed with autologous platelet-rich plasma to form a mineralized plasmatic matrix, which serves as a control graft for ridge preservation after molar extraction.
| Study group | Role | What they receive |
|---|---|---|
| Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF) | Experimental | Participants in this group will receive socket grafting using Demineralized Dentin Matrix (DDM) prepared from their own extracted tooth. The dentin is cleaned, ground into particles, demineralized using 0.6 N hydrochloric acid, rinsed with saline, and mixed with autologous Platelet-Rich Fibrin (PRF) before being placed into the extraction socket. The socket is then closed with resorbable sutures for healing. Receives: Biological: Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF) |
| Mineralized Plasmatic Matrix (MPM) | Active comparator | Participants in this group will receive socket grafting using a Mineralized Plasmatic Matrix (MPM) composed of a commercially available xenograft mixed with Platelet-Rich Plasma (PRP). The mixture forms a cohesive mineralized matrix that is placed into the extraction socket and stabilized with sutures. Receives: Biological: Mineralized Plasmatic Matrix (MPM) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Alveolar Ridge Width
Measurement of horizontal bone width at the extraction site using cone-beam computed tomography (CBCT).
Measured: Baseline (immediately postoperative) and 4 months postoperatively.
Secondary outcomes (3)
Change in Alveolar Ridge Height
Measurement of vertical bone height at the extraction site using CBCT.
Measured: Baseline (immediately postoperative) and 4 months postoperatively.
Change in Bone Density
Evaluation of bone density in the grafted socket area using CBCT grayscale values.
Measured: Baseline (immediately postoperative) and 4 months postoperatively.
Postoperative Pain
Subjective evaluation of pain intensity at the surgical site using the Visual Analogue Scale (VAS).
Measured: 2 days, 1 week, and 1 month postoperatively.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Nov 2025
- Study start1 Dec 2025 (estimated)
- Primary completion1 Jul 2026 (estimated)
- Study completion1 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Socket PreservationStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to one of two parallel groups in a 1:1 ratio. Group A will receive socket grafting with autogenous Demineralized Dentin Matrix (DDM) mixed with Platelet-Rich Fibrin (PRF), while Group B will receive Mineralized Plasmatic Matrix (MPM) composed of xenograft mixed with Platelet-Rich Plasma (PRP). Each participant will receive only one type of intervention.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Suliman Ahmed Badr, Cairo University
- Investigators
- Tarek Ibrahim ElGhareeb, Phd, Study chair, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo UniversitySalah Eldin ElAbbasy, Phd, Study director, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo UniversityAhmed Suliman Ahmed, Bds, Principal investigator, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07239193
- Sponsor's protocol ID
- DDM in socket preservation
- Status last verified
- Nov 2025
- First submitted
- 16 Nov 2025
- Last updated
- 20 Nov 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Demineralized Dentin Matrix Versus Mineralized Plasmatic Matrix on Alveolar Ridge Preservation in Molar Extraction Sites; A Randomized Clinical Trial.
- ClinicalTrials.gov ID
- NCT07239193
- Acronym / sponsor ID
- DDM in socket preservation
- Conditions
- Socket Preservation, Alveolar Ridge Preservation
- Keywords
- socket preservation, alveolar ridge preservation, DDM, demineralized dentin matrix, MPM, mineralized plasmatic matrix
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Dec 2025 (estimated)
- Primary completion
- 1 Jul 2026 (estimated)
- Study completion
- 1 Nov 2026 (estimated)
- First posted
- 20 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
When a tooth is removed, the bone around it (called the alveolar ridge) naturally shrinks. This study compares two bone grafting materials to find out which one better preserves bone after molar extraction:
Demineralized Dentin Matrix (DDM): A material made from the patient's own extracted tooth, treated to remove minerals while keeping bone-forming proteins.
Mineralized Plasmatic Matrix (MPM): A mixture of a standard bone substitute and platelet-rich plasma from the patient's blood.
Detailed description
Alveolar ridge resorption is a predictable biological process following tooth extraction, particularly in molar sites where the bone structure is more complex. Maintaining ridge volume is essential for optimal future implant placement and prosthetic rehabilitation. Various grafting materials and biologic enhancers have been used to minimize post-extraction bone loss; however, cost, availability, and biocompatibility remain significant challenges, especially with xenograft and allograft materials.
This randomized clinical trial investigates and compares two autogenous and biologically enhanced approaches for alveolar ridge preservation following molar extraction. The first method utilizes Demineralized Dentin Matrix (DDM) prepared from the patient's own extracted tooth. DDM provides a naturally derived scaffold rich in collagen and bone morphogenetic proteins (BMPs), offering both osteoconductive and osteoinductive potential. The second method uses a Mineralized Plasmatic Matrix (MPM), a combination of a xenograft bone substitute mixed with Platelet-Rich Plasma (PRP), which represents a widely used regenerative option in oral surgery.
The study is designed as a parallel-group, single-blind, randomized clinical trial conducted at the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University. Eligible adult patients requiring extraction of non-restorable multi-rooted molars will be enrolled and allocated equally into two groups. Both groups will undergo atraumatic extraction followed by immediate socket grafting with either DDM+PRF or MPM+PRP.
Standardized postoperative care will be provided to all participants, and healing will be monitored both clinically and radiographically. Cone-beam computed tomography (CBCT) will be used to evaluate alveolar bone width, height, and density immediately after extraction and at 4 months postoperatively. Pain and soft-tissue healing will also be assessed using validated clinical indices.
The study's primary objective is to determine whether Demineralized Dentin Matrix (DDM) provides superior preservation of alveolar ridge dimensions and bone quality compared to Mineralized Plasmatic Matrix (MPM) in molar extraction sites. The hypothesis tested is that there will be no significant difference between both materials regarding bone preservation and regeneration outcomes.
This trial is expected to provide evidence supporting the clinical viability of using recycled autogenous tooth material as a cost-effective and biocompatible alternative to commercially available xenografts, potentially expanding regenerative options for clinicians and improving access to affordable biologic grafting solutions.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned to one of two parallel groups in a 1:1 ratio. Group A will receive socket grafting with autogenous Demineralized Dentin Matrix (DDM) mixed with Platelet-Rich Fibrin (PRF), while Group B will receive Mineralized Plasmatic Matrix (MPM) composed of xenograft mixed with Platelet-Rich Plasma (PRP). Each participant will receive only one type of intervention.
| Arm | Type | Receives |
|---|---|---|
| Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF) | Experimental | Biological: Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF)Participants in this group will receive socket grafting using Demineralized Dentin Matrix (DDM) prepared from their own extracted tooth. The dentin is cleaned, ground into particles, demineralized using 0.6 N hydrochloric acid, rinsed with saline, and mixed with autologous Platelet-Rich Fibrin (PRF) before being placed into the extraction socket. The socket is then closed with resorbable sutures for healing. |
| Mineralized Plasmatic Matrix (MPM) | Active comparator | Biological: Mineralized Plasmatic Matrix (MPM)Participants in this group will receive socket grafting using a Mineralized Plasmatic Matrix (MPM) composed of a commercially available xenograft mixed with Platelet-Rich Plasma (PRP). The mixture forms a cohesive mineralized matrix that is placed into the extraction socket and stabilized with sutures. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Non-restorable tooth indicated for extraction Multi-rooted teeth Age group of 18 to 55 years Patients free from any systemic disease that may affect bone healing.
Key exclusion criteria (1 listed)
- Pregnant females Active infection at extraction site Smokers Systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...) Poor oral hygiene. Patient with systemic disease that may affect bone healing. o Uncooperative patient.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF)Autogenous dentin-derived grafting material is used as a bone substitute for alveolar ridge preservation following molar extraction. PRF, obtained from the patient's centrifuged blood, is mixed with DDM to enhance graft stability and promote healing. | Biological | Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF) |
| Mineralized Plasmatic Matrix (MPM)A xenogenic bone substitute is mixed with autologous platelet-rich plasma to form a mineralized plasmatic matrix, which serves as a control graft for ridge preservation after molar extraction. | Biological | Mineralized Plasmatic Matrix (MPM) |
Primary outcome
Change in Alveolar Ridge Width
Time frame: Baseline (immediately postoperative) and 4 months postoperatively.
Measurement of horizontal bone width at the extraction site using cone-beam computed tomography (CBCT).
3 secondary outcomes
Change in Alveolar Ridge Height
Time frame: Baseline (immediately postoperative) and 4 months postoperatively.
Change in Bone Density
Time frame: Baseline (immediately postoperative) and 4 months postoperatively.
Postoperative Pain
Time frame: 2 days, 1 week, and 1 month postoperatively.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Nov 2025.
Related trials for Socket Preservation
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Bone and Soft Tissue Healing After Socket Preservation With NOVAMag or Permamem Membranes
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Application of Alloplastic Bone Graft With Polycaprolactone (PCL) Membrane and ECM-Collagen Membrane on Secondary Socket Healing in Third Molar Surgery.
Wisdom Tooth, Socket Preservation
Recruiting
Effect of Thymoquinone 0.2% Gel on Bone Density, Bone Width, and Socket Preservation After Tooth Extraction
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Injectable Alloplastic Bone Graft for Socket Preservation: Clinical, Radiographic, and Histological Evaluation
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Faculty of Dentistry, Cairo University - Department of Oral and Maxillofacial Surgery
Cairo, Egypt
Tarek Ibrahim ElGhareeb, Phd study chair
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University
Salah Eldin ElAbbasy, Phd study director
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University
Ahmed Suliman Ahmed, Bds principal investigator
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Demineralized Dentin Matrix (DDM) + Platelet-Rich Fibrin (PRF) and Mineralized Plasmatic Matrix (MPM) in people with Socket Preservation and Alveolar Ridge Preservation, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Alveolar Ridge Width (time frame: Baseline (immediately postoperative) and 4 months postoperatively.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Nov 2025; AzTrials last refreshed its copy on 7 Nov 2026.