Lung Cancer (Suspected or Confirmed)NCT07235098
Effect of a Music Intervention in Reducing Distress and Pain in Patients With Lung Cancer Undergoing Mini-invasive Surgery
A study testing Music therapy intervention in people with Lung Cancer (Suspected or Confirmed), run by Oncology Institute of Southern Switzerland at 1 site in Switzerland.
Trial summary
This study aims at evaluating whether music therapy intervention is effective in decreasing psychological (distress) and physical symptoms (pain) in patients with suspected or diagnosed lung cancer undergoing minimally invasive lung surgery. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Lung Cancer (Suspected or Confirmed)
- What is being tested?
- Music therapy intervention
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 74 participants
- Where
- 1 siteSwitzerland
- Study dates
- 19 Jun 2026to 31 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Suspected or confirmed diagnosis of lung cancer
- Age ≥ 18 years
- Indication for lung resection through a minimally invasive surgery
- Signed written informed consent
Who cannot join
- Endocrinological disorders involving cortisol axis
- Chronic steroid intake > 10 mg/day
- Concomitant treatment with drugs against symptomatic anxiety and/or depression
- Partial or complete hearing loss
- Inability to follow the schedule of investigation
- Patient unwilling to refrain from actively listening to other music (e.g., via other personal devices/headphones) outside of the prescribed musical intervention defined by the study protocol during the hospitalization.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Switzerland1 site, 1 recruiting
- Recruiting
Oncology Institute of Southern Switzerland (IOSI)
Bellinzona, Canton Ticino, 6500
Patrizia Froesch, MD, +41 91 811 48 40, patrizia.froesch@eoc.ch
Luigi Tortola, PhD, +41 91 811 96 68, luigi.tortola@eoc.ch
About this study
Official title: Effect of a Music Intervention in Reducing Distress and Pain in Patients With Suspected or Diagnosed Lung Cancer Undergoing Mini-Invasive Surgery
This study aims at evaluating whether music therapy intervention is effective in decreasing psychological (distress) and physical symptoms (pain) in patients with suspected or diagnosed lung cancer undergoing minimally invasive lung surgery.
Read the detailed description
A diagnosis of cancer may result in extensive emotional, physical and social suffering. Moreover, surgical treatment of lung cancer represents itself a stressful event. It is important that cancer care incorporates services that help meet patients' psychological, social and spiritual needs. Music therapy interventions have been used to alleviate symptoms and treatment side effects in cancer patients and their efficacy has been demonstrated in various settings. Within the distinction between music therapy (a personalized approach based on the interaction with a trained music therapist) and music medicine (with pre-recorded music), the best efficacy results have been reported with music therapy.
The use of music listening is growing in the field of music therapy intervention because of the impact musical contents can have on physiological, psychological and behavioural levels.
The primary objective of this study is to evaluate whether music therapy intervention is effective in decreasing psychological (distress) and physical symptoms (pain) in patients with suspected or diagnosed lung cancer undergoing minimally invasive lung surgery. Secondary objectives are the evaluation of the decrease of the serum cortisol as biomarker of stress and the request of additional doses of analgesics for pain control.
- Conditions
- Lung Cancer (Suspected or Confirmed)
- Being tested
- Music therapy intervention
- Keywords
- lung cancer, pain, anxiety, music
- Medical subject headings
- Lung Neoplasms, Pain, Anxiety Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Music therapy interventionOther
Patient randomized to experimental Arm A will receive a classical music therapy intervention throughout the duration of their hospital stay for a minimally invasive lung resection.
| Study group | Role | What they receive |
|---|---|---|
| Arm A treated with classical music therapy and standard of care | Experimental | Patients with suspected or diagnosed lung cancer undergoing minimally invasive lung resection will be treated with classical music therapy and standard of care. Receives: Other: Music therapy intervention |
| Arm B treated with standard of care only | No intervention | Patients with suspected or diagnosed lung cancer undergoing minimally invasive lung resection will be treated with standard of care only. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Level of distress
Change of the level of distress on the Distress thermometer
Measured: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)
Pain intensity
Change of pain intensity on the numerical scale
Measured: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)
Secondary outcomes (2)
Serum cortisol levels
Change in the levels of serum cortisol measured in the morning
Measured: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)
Additional doses of analgesics for pain control
Number of additional doses of analgesics administered for pain control per day
Measured: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Nov 2025
- Study start19 Jun 2026
- Primary completion31 Dec 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Lung Cancer (Suspected or Confirmed)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This is a monocentric open-label randomized controlled clinical trial with two arms: * Arm A: classical music therapy + standard of care (SOC) * Arm B: SOC only Patients scheduled for minimally invasive lung resection, with a suspected or confirmed diagnosis of lung cancer, will be enrolled and randomized to one of the two arms of the study.
- Masking
- None (open label)
- Enrolment
- 74 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Oncology Institute of Southern Switzerland
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07235098
- Sponsor's protocol ID
- IOSI-MUSICAL-001
- Status last verified
- Jul 2026
- First submitted
- 14 Nov 2025
- Last updated
- 8 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 8 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of a Music Intervention in Reducing Distress and Pain in Patients With Suspected or Diagnosed Lung Cancer Undergoing Mini-Invasive Surgery
- ClinicalTrials.gov ID
- NCT07235098
- Acronym / sponsor ID
- IOSI-MUSICAL-001
- Conditions
- Lung Cancer (Suspected or Confirmed)
- Keywords
- lung cancer, pain, anxiety, music
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 74 participants (estimated)
- Lead sponsor
- Oncology Institute of Southern SwitzerlandUniversity, hospital or other
- Study start
- 19 Jun 2026 (actual)
- Primary completion
- 31 Dec 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 19 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims at evaluating whether music therapy intervention is effective in decreasing psychological (distress) and physical symptoms (pain) in patients with suspected or diagnosed lung cancer undergoing minimally invasive lung surgery.
Detailed description
A diagnosis of cancer may result in extensive emotional, physical and social suffering. Moreover, surgical treatment of lung cancer represents itself a stressful event. It is important that cancer care incorporates services that help meet patients' psychological, social and spiritual needs. Music therapy interventions have been used to alleviate symptoms and treatment side effects in cancer patients and their efficacy has been demonstrated in various settings. Within the distinction between music therapy (a personalized approach based on the interaction with a trained music therapist) and music medicine (with pre-recorded music), the best efficacy results have been reported with music therapy.
The use of music listening is growing in the field of music therapy intervention because of the impact musical contents can have on physiological, psychological and behavioural levels.
The primary objective of this study is to evaluate whether music therapy intervention is effective in decreasing psychological (distress) and physical symptoms (pain) in patients with suspected or diagnosed lung cancer undergoing minimally invasive lung surgery. Secondary objectives are the evaluation of the decrease of the serum cortisol as biomarker of stress and the request of additional doses of analgesics for pain control.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This is a monocentric open-label randomized controlled clinical trial with two arms: * Arm A: classical music therapy + standard of care (SOC) * Arm B: SOC only Patients scheduled for minimally invasive lung resection, with a suspected or confirmed diagnosis of lung cancer, will be enrolled and randomized to one of the two arms of the study.
| Arm | Type | Receives |
|---|---|---|
| Arm A treated with classical music therapy and standard of care | Experimental | Other: Music therapy interventionPatients with suspected or diagnosed lung cancer undergoing minimally invasive lung resection will be treated with classical music therapy and standard of care. |
| Arm B treated with standard of care only | No intervention | –Patients with suspected or diagnosed lung cancer undergoing minimally invasive lung resection will be treated with standard of care only. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Suspected or confirmed diagnosis of lung cancer
- Age ≥ 18 years
- Indication for lung resection through a minimally invasive surgery
- Signed written informed consent
Key exclusion criteria (6 listed)
- Endocrinological disorders involving cortisol axis
- Chronic steroid intake > 10 mg/day
- Concomitant treatment with drugs against symptomatic anxiety and/or depression
- Partial or complete hearing loss
- Inability to follow the schedule of investigation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Music therapy interventionPatient randomized to experimental Arm A will receive a classical music therapy intervention throughout the duration of their hospital stay for a minimally invasive lung resection. | Other | Arm A treated with classical music therapy and standard of care |
Primary outcome
Level of distress
Time frame: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)
Change of the level of distress on the Distress thermometer
Pain intensity
Time frame: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)
Change of pain intensity on the numerical scale
2 secondary outcomes
Serum cortisol levels
Time frame: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)
Additional doses of analgesics for pain control
Time frame: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jul 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Music therapy intervention in people with Lung Cancer (Suspected or Confirmed), run by Oncology Institute of Southern Switzerland at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 8 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Patrizia Froesch, MD (+41 91 811 48 40, patrizia.froesch@eoc.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Level of distress (time frame: From the day of surgery until the day of discharge from the hospital (in average 6 days after surgery)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jul 2026.