Periodontal Diseasesmicropl_perioNCT07231198
Detection of Microplastics in Patients With Periodontitis
An observational study of Periodontal Diseases and Periodontitis, run by Sigmund Freud PrivatUniversitat.
Trial summary
Plastic particles known as microplastics are now a ubiquitous part of the environment. Human exposure to microplastics occurs through the consumption of contaminated food and polluted air, which affect the intestinal system. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Periodontal Diseases, Periodontitis
- How many people
- 25 participants
- Where
- No sites listed yet
- Study dates
- 1 Feb 2026to 1 Feb 2028
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients with periodontitis, stage 3 or 4, with a full mouth probing score at the Department of Periodontology, Dental Clinics, Sigmund Freud University, Vienna, Austria
Who may be able to join
- Adults aged 18 and over
- Gender: Female / male / diverse
- Patients
- who have been diagnosed with stage III and IV periodontitis.
- who have not yet started periodontal treatment.
- who still have at least 20 teeth. Providing written consent to participate in the study.
Who cannot join
- Patients
- who have already been treated for periodontitis
- who have already undergone/begun periodontitis treatment
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Detection of Microplastics in Patients With Periodontitis - a Cross-sectional Study
Plastic particles known as microplastics are now a ubiquitous part of the environment. Human exposure to microplastics occurs through the consumption of contaminated food and polluted air, which affect the intestinal system. Several studies have detected the presence of microplastics in various parts of the human digestive system, e.g., in feces. Unfortunately, little is known about the presence of microplastics in the mouth as the primary part of the digestive system. Periodontal pockets can be considered an ideal deposition site for microplastics. Since microplastics are suspected of being an immunomodulatory factor, there is great interest in their presence in subgingival plaque and their possible exacerbation of chronic inflammatory diseases such as periodontitis. The following study aims to clarify the presence, classification, and concentration of microplastics in subgingival plaque. No comparable study has been identified to date.
- Conditions
- Periodontal Diseases, Periodontitis
- Keywords
- periodontitis, microplastics
- Medical subject headings
- Periodontal Diseases, Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| patients with periodontitis, stage 3 or 4 | Status assessment with supragingival cleaning Sample collection with sterile universal curette (steel) from the bottom of the pockets of the 4 deepest gum pockets (ST >= 5mm) pooled in ultrapure water |
What is being measured
The primary outcome is the main question the study is designed to answer.
Microplastics
number of patients with periodontitis with microplastics in periodontal pockets, quantification of microplastic particles in periodontal pockets, qualitative analysis of microplastic
Measured: one year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Nov 2025
- Study start1 Feb 2026 (estimated)
- Primary completion1 Feb 2027 (estimated)
- Study completion1 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Periodontal DiseasesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 25 participants (estimated)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Sigmund Freud PrivatUniversitat
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hady Haririan, Sigmund Freud PrivatUniversitat
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07231198
- Sponsor's protocol ID
- 17538733
- Other IDs
- SFU
- Acronym
- micropl_perio
- Status last verified
- Nov 2025
- First submitted
- 13 Nov 2025
- Last updated
- 19 Nov 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: microplastic findings
Publications
Francis DL, Pape Reddy SS. Microplastics in the Pathogenesis of Periodontal Diseases: A Narrative Review. Ann Glob Health. 2025 Oct 3;91(1):69. doi: 10.5334/aogh.4861. eCollection 2025.
PubMed 41079032
Study at a glance
From the registry record, last updated by the sponsor on 19 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Detection of Microplastics in Patients With Periodontitis - a Cross-sectional Study
- ClinicalTrials.gov ID
- NCT07231198
- Acronym / sponsor ID
- micropl_perio / 17538733
- Conditions
- Periodontal Diseases, Periodontitis
- Keywords
- periodontitis, microplastics
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- Sigmund Freud PrivatUniversitatUniversity, hospital or other
- Study start
- 1 Feb 2026 (estimated)
- Primary completion
- 1 Feb 2027 (estimated)
- Study completion
- 1 Feb 2028 (estimated)
- First posted
- 17 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Plastic particles known as microplastics are now a ubiquitous part of the environment. Human exposure to microplastics occurs through the consumption of contaminated food and polluted air, which affect the intestinal system. Several studies have detected the presence of microplastics in various parts of the human digestive system, e.g., in feces. Unfortunately, little is known about the presence of microplastics in the mouth as the primary part of the digestive system. Periodontal pockets can be considered an ideal deposition site for microplastics. Since microplastics are suspected of being an immunomodulatory factor, there is great interest in their presence in subgingival plaque and their possible exacerbation of chronic inflammatory diseases such as periodontitis. The following study aims to clarify the presence, classification, and concentration of microplastics in subgingival plaque. No comparable study has been identified to date.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| patients with periodontitis, stage 3 or 4 | – | –Status assessment with supragingival cleaning Sample collection with sterile universal curette (steel) from the bottom of the pockets of the 4 deepest gum pockets (ST >= 5mm) pooled in ultrapure water |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with periodontitis, stage 3 or 4, with a full mouth probing score at the Department of Periodontology, Dental Clinics, Sigmund Freud University, Vienna, Austria
Key inclusion criteria (6 listed)
- Adults aged 18 and over
- Gender: Female / male / diverse
- Patients
Key exclusion criteria (3 listed)
- Patients
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Microplastics
Time frame: one year
number of patients with periodontitis with microplastics in periodontal pockets, quantification of microplastic particles in periodontal pockets, qualitative analysis of microplastic
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Nov 2025.
- Background: PubMed 41079032Francis DL, Pape Reddy SS. Microplastics in the Pathogenesis of Periodontal Diseases: A Narrative Review. Ann Glob Health. 2025 Oct 3;91(1):69. doi: 10.5334/aogh.4861. eCollection 2025.
- Individual participant dataSharing planned: Yes. microplastic findings
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Periodontal Diseases and Periodontitis, run by Sigmund Freud PrivatUniversitat.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Hady Haririan, Univ.-Prof., Dr., PhD, MSc (+4317201966, hady.haririan@med.sfu.ac.at), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Microplastics (time frame: one year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07231198, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Nov 2025.