Acute Uncomplicated AppendicitisE-APPENDNCT07230379
Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated Appendicitis
A study testing Direct Visualization Endoscopic Retrograde Appendicitis Therapy and Laparoscopic appendectomy in people with Acute Uncomplicated Appendicitis, run by Changhai Hospital at 14 sites in China.
Trial summary
This study compares two ways of treating acute uncomplicated appendicitis, which is a mild form of appendicitis. In the Direct Visualization ERAT group, participants will receive Endoscopic Retrograde Appendicitis Therapy (ERAT). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Uncomplicated Appendicitis
- What is being tested?
- Direct Visualization Endoscopic Retrograde Appendicitis Therapy and Laparoscopic appendectomy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 376 participants
- Where
- 14 sitesChina
- Study dates
- 10 Dec 2025to Nov 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years.
- Diagnosis of first-episode acute uncomplicated appendicitis (AUA) confirmed by CT scan of the lower abdomen. AUA is defined as acute appendicitis without evidence of abscess, perforation, gangrene, or tumor.
- Provision of written informed consent.
Who cannot join
- Complicated appendicitis, defined as acute appendicitis with perforation, gangrene, periappendiceal abscess or phlegmon, generalized peritonitis, or radiologic evidence of extraluminal appendicolith, extraluminal air, periappendiceal fat stranding, or appendiceal mass.
- Severe intestinal adhesions or bowel obstruction.
- Intolerance or contraindication to bowel preparation or colonoscopy (e.g., intestinal perforation or bowel obstruction).
- Poor general condition precluding tolerance of abdominal surgery.
- Abdominal pain caused by other diseases as confirmed by CT or other diagnostic examinations, including inflammatory bowel disease, urinary tract disease, or gynecological disease.
- Pregnancy.
Show all 9Show fewer
- Severe dysfunction of major organ systems, including but not limited to cardiac, pulmonary, renal, hepatic, or hematologic systems.
- Current enrollment in another clinical trial.
- Any condition that may prevent the participant from completing all study requirements.
Trial locations and contacts
14 sites in 1 country. Contact the study team or a site near you to ask about taking part.
14 sites in 1 country
China14 sites, 14 recruiting
- Recruiting
Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital
Changsha, Hunan, 410005
Chao-Wu Chen, MD, PhD, 008613298682898, dr.chencw@hunnu.edu.cn
Chao-Wu Chen, MD, PhD
- Recruiting
Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University
Changsha, Hunan, 410008
Wei-Dong Liu, MD, PhD, 008613873124855, davidcsu@foxmail.com
Weo-Dong iu, MD, PhD
- Recruiting
Department of Gastrointestinal Surgery, Fourth West China Hospital, Sichuan University
Chengdu, Sichuan, 610041
Juan Liao, MD, PhD, 00618780267956, juanliao@scu.edu.cn
Juan Liao, MD, PhD
- Not yet recruiting
Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chingqing, 400010
Song He, MD, PhD, 13808336120, hedoctor65@cqmu.edu.cn
Song he, MD, PhD
- Recruiting
Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, 510655
Zhen He, MD, PhD
Zhen He, MD, PhD
- Recruiting
Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou
Ji-Chao Qin, MD, PhD, 008613628683363, jcqin2024@zju.edu.cn
Ji-Chao Qin, MD, PhD
- Recruiting
Department of Gastroenterology, Jilin City People's Hospital
Jilin City, Jilin, 132011
Hong-Guang Wang, MD, PhD, 008618904421817, wanghongguang1817@163.com
Liying Tao, MD, PhD, 13689866436, 406346148@qq.com
- Recruiting
Department of Gastroenterology, The First Affiliated Hospital of Henan University,
Kaifeng, Henan, 475001
Wen-Yi Yang, MD, PhD, 008615890922163, baoca4621210@163.com
Wen-Yi Yang, MD, PhD
- Recruiting
Department of Gastroenterology, Linyi People's Hospital
Linyi, Shandong, 276000
Ling-Jian Kong, MD, PhD, 0086157 1369 8818, konggewww@163.com
Ling-Jian Kong, MD, PhD
- Recruiting
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006
Yin Zhu, MD, PhD, 008613970841464, zhuyin27@sina.com
Yin Zhu, MD, PhD
- Recruiting
Department of Gastroenterology, Changhai Hospital, Naval Medical University
Shanghai, 200433
Zhuan Liao, MD, PhD, liaozhuan@smmu.edu.cn
Zhuan Liao, MD, PhD
- Recruiting
Department of Gastroenterology, South China Hospital, Medical School, Shenzhen University
Shenzhen, Guangdong, 518116
Si-Lin Huang, MD, PhD, 13512756686, silinhuang@szu.edu.cn
Si-Lin Huang, MD, PhD
- Not yet recruiting
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215008
Yong-You Wu, MD, PhD, 008613338706607, wuyongyou72@126.com
Yong-You Wu, MD, PhD
- Recruiting
Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000
Bing-Rong Liu, MD, PhD, 008613313695959, fccliubr@zzu.edu.cn
Dan Liu, MD, PhD, 0086183 3980 0019, wilmawell@163.com
About this study
Official title: Direct Visualization Endoscopic Retrograde Appendicitis Therapy (ERAT) Versus Laparoscopic Appendectomy (LA) for Acute Uncomplicated Appendicitis in Adults (E-APPEND): An Open-Label, Multicenter, Randomized Controlled Non-Inferiority Trial
This study compares two ways of treating acute uncomplicated appendicitis, which is a mild form of appendicitis. In the Direct Visualization ERAT group, participants will receive Endoscopic Retrograde Appendicitis Therapy (ERAT). This is a minimally invasive, non-surgical treatment that uses a flexible endoscope passed through the colon to reach the appendix, clear the blockage, and drain the infection. In the Surgery group, participants will undergo Laparoscopic Appendectomy (LA), which is the current standard surgical treatment to remove the appendix. The purpose of this study is to determine whether ERAT is as safe and effective as standard surgery for treating uncomplicated appendicitis.
Before treatment, each participant will have a CT scan of the lower abdomen with contrast to confirm uncomplicated appendicitis and to rule out any signs of more serious infection. Participants will then be randomly assigned to either the ERAT group or the surgery group, and they will be informed of which treatment they will receive. Regardless of the group, all participants will receive the same supportive care, including pain relief, close monitoring, and a single dose of antibiotics before treatment. After the procedure, participants will stay in the hospital for at least 24 hours for observation. Follow-up will include an outpatient visit at 2 weeks, and telephone follow-ups at 1 month, 3 months, 6 months, and 1 year to monitor recovery and ensure that appendicitis does not recur.
Read the detailed description
This is a multicenter, open-label, randomized, non-inferiority trial comparing Direct Visualization Endoscopic Retrograde Appendicitis Therapy (ERAT) with Laparoscopic Appendectomy (LA) for the treatment of adult acute uncomplicated appendicitis (AUA). A total of 376 participants will be enrolled across 14 hospitals in China, and randomized in a 1:1 ratio to either ERAT or LA after providing informed consent.
Adults aged 18 years or older with CT-confirmed first-episode AUA are eligible. Key exclusions include complicated appendicitis, bowel obstruction, intolerance to colonoscopy or bowel preparation, poor operative candidacy, pregnancy, severe organ dysfunction, or concurrent participation in another clinical trial.
Interventions will be performed within 24 hours of admission. ERAT involves the use of a direct visualization appendicoscope to access the appendiceal lumen, irrigate pus and debris, and remove or fragment appendicoliths under direct vision. A short plastic stent may be placed if drainage is required. LA will be performed according to standard laparoscopic surgical techniques. Follow-up assessments will include an outpatient visit at 2 weeks and telephone follow-ups at 1, 3, 6, and 12 months.
The primary outcome is 30-day treatment success, defined as successful completion of the assigned procedure, resolution of symptoms, discharge without further surgery, and absence of recurrence. This study aims to provide robust evidence supporting the safety and effectiveness of ERAT and to inform future clinical guidelines for the management of acute uncomplicated appendicitis.
- Conditions
- Acute Uncomplicated Appendicitis
- Being tested
- Direct Visualization Endoscopic Retrograde Appendicitis Therapy, Laparoscopic appendectomy
- Keywords
- ERAT, Endoscopic retrograde appendicitis therapy, Appendicitis, LA, Laparoscopic appendectomy
- Medical subject headings
- Appendicitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Direct Visualization Endoscopic Retrograde Appendicitis TherapyProcedure or surgery
Also called ERAT
Direct visualization ERAT will be performed by experienced endoscopists (≥ 30 prior ERAT cases) under conscious sedation or general anesthesia as needed. A colonoscope with a transparent cap will be advanced to the cecum to expose the appendiceal orifice, and a direct visualization appendicoscope will be introduced through the working channel. The appendiceal lumen will be inspected and irrigated with saline to clear pus and debris, with negative pressure applied for aspiration. Small appendicoliths will be flushed out, while larger ones will be removed using a retrieval basket, stone extractor, or laser lithotripsy. When narrowing or heavy purulence is present, a stent will be inserted for drainage. After confirming adequate drainage, the scope will be withdrawn. If ERAT fails, conversion to laparoscopic or open appendectomy will be performed.
Laparoscopic appendectomyProcedure or surgery
Also called LA
Laparoscopic appendectomy will be performed under general anesthesia by surgeons with experience in > 20 procedures, according to standard clinical practice. The resected appendix will be examined for gross features and sent for histopathological confirmation of acute uncomplicated appendicitis. If laparoscopic appendectomy is unsuccessful, conversion to open appendectomy will be performed.
| Study group | Role | What they receive |
|---|---|---|
| Direct Visualization ERAT | Experimental | Undergo direct visualization endoscopic retrograde appendicitis therapy Receives: Procedure: Direct Visualization Endoscopic Retrograde Appendicitis Therapy |
| Laparoscopic Appendectomy | Active comparator | Undergo laparoscopic appendectomy Receives: Procedure: Laparoscopic appendectomy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Treatment Success
ERAT arm: Treatment success is defined as successful completion of the ERAT procedure, resolution of acute uncomplicated appendicitis symptoms, discharge from the hospital without appendectomy, and absence of recurrence within 30 days.
LA arm: Treatment success is defined as successful completion of laparoscopic appendectomy without conversion to open appendectomy, histopathological confirmation of acute appendicitis characterized by the presence of neutrophilic infiltration within the appendiceal muscularis propria, resolution of acute uncomplicated appendicitis symptoms, and absence of recurrence within 30 days.
Measured: 30 days
Secondary outcomes (17)
Recurrence
Recurrent appendicitis defined as the occurrence of clinical symptoms consistent with appendicitis, leading to appendectomy after initial intervention, with histopathological confirmation of appendicitis in the resected appendix.
Measured: 1 year
Technical success
ERAT arm: Successful endoscopic cannulation of the appendiceal orifice with appendicoscope insertion.
LA arm: Completion of laparoscopic appendectomy without conversion to open surgery.
Measured: Intraoperative
Timing to procedure
Measured in hours from the time of CT-confirmed diagnosis of AUA to the start of the procedure, as documented in the operative note.
Measured: Pre-operative
Total procedure time
Represents the total time patient spent in the OR. Measured in minutes from the time the patient is wheeled into the operating room to the time the patient is wheeled out.
Measured: Intraoperative
Intervention time
Measured in minutes from the beginning to the end of the intervention procedure, based on the operative note. For ERAT: from endoscope insertion to complete scope withdrawal. For LA: from skin incision to skin closure.
Measured: Intraoperative
Preparation time
Defined as total procedure time minus intervention time. This duration includes time spent on equipment setup, administration of anesthesia, patient positioning, and draping.
Measured: Intraoperative
Self-reported pain score
Assessed using the Visual Analogue Scale (VAS) ranging from 0 (no pain) to 10 (worst imaginable pain).
Measured: 1 month
Time to soft diet resumption
Number of days from the end of the procedure to patient-reported good tolerance of a soft diet. If soft diet is tolerated on the same day as the procedure, it will be recorded as 0 days.
Measured: 1 week
Post-intervention narcotics used
Total amount of narcotics received during the primary hospitalization, both oral and intravenous, converted into intravenous morphine equivalents per kilogram of body weight.
Measured: 1 week
Duration of analgesics used
Number of days from the end of the procedure to the last dose of analgesics (oral or intravenous) used for procedure-related abdominal pain.
Measured: 2 weeks
Duration of post-intervention antibiotics used
Number of days from the end of the procedure to the last dose of prescribed antibiotics. Antibiotics may include both intravenous and oral forms. The day of the procedure is counted as Day 0.
Measured: 1 week
Sick leave
Number of days participants are absent from work due to disease-related reasons, including post-intervention recovery.
Measured: 1 month
Time to return to normal daily activities
The number of days it takes for participants to resume their normal everyday activities without significant discomfort after receiving the treatment.
Measured: 1 month
Cost of treatment
Total direct hospital cost is calculated as the sum of all charges incurred, based on the hospital billing record.
Measured: 1 year
Quality of Life of the Participants
Measured using the Chinese-validated EQ-5D-5L questionnaire.
Measured: 1 year
Patient Satisfaction
Measured by the Global Assessment of Satisfaction, consisting of two questions:
- "How satisfied are you with the treatment you received for acute uncomplicated appendicitis?" Response on a 5-point Likert scale: very satisfied, satisfied, neutral, dissatisfied, very dissatisfied
- "Knowing how the treatment went, would you recommend it to someone else?" Response: Yes or No
Measured: 1 year
Complication
Complications are defined as any adverse event related to the intervention (ERAT or LA). They will be classified as major or minor based on severity, according to the Clavien-Dindo classification system, with major complications defined as Clavien-Dindo Grade II or higher.
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Nov 2025
- Study start10 Dec 2025
- Primary completionDec 2026 (estimated)
- Study completionNov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Uncomplicated AppendicitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 376 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Changhai Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- MICRO-TECH (Nanjing) Co., Ltd
- Responsible party
- Principal investigator, Zhuan Liao, Changhai Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07230379
- Sponsor's protocol ID
- E-APPEND
- Acronym
- E-APPEND
- Status last verified
- Nov 2025
- First submitted
- 13 Nov 2025
- Last updated
- 4 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Undecided
Study at a glance
From the registry record, last updated by the sponsor on 4 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Direct Visualization Endoscopic Retrograde Appendicitis Therapy (ERAT) Versus Laparoscopic Appendectomy (LA) for Acute Uncomplicated Appendicitis in Adults (E-APPEND): An Open-Label, Multicenter, Randomized Controlled Non-Inferiority Trial
- ClinicalTrials.gov ID
- NCT07230379
- Acronym / sponsor ID
- E-APPEND / E-APPEND
- Conditions
- Acute Uncomplicated Appendicitis
- Keywords
- ERAT, Endoscopic retrograde appendicitis therapy, Appendicitis, LA, Laparoscopic appendectomy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 376 participants (estimated)
- Lead sponsor
- Changhai HospitalUniversity, hospital or other
- Collaborators
- MICRO-TECH (Nanjing) Co., Ltd
- Study start
- 10 Dec 2025 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Nov 2027 (estimated)
- First posted
- 17 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study compares two ways of treating acute uncomplicated appendicitis, which is a mild form of appendicitis. In the Direct Visualization ERAT group, participants will receive Endoscopic Retrograde Appendicitis Therapy (ERAT). This is a minimally invasive, non-surgical treatment that uses a flexible endoscope passed through the colon to reach the appendix, clear the blockage, and drain the infection. In the Surgery group, participants will undergo Laparoscopic Appendectomy (LA), which is the current standard surgical treatment to remove the appendix. The purpose of this study is to determine whether ERAT is as safe and effective as standard surgery for treating uncomplicated appendicitis.
Before treatment, each participant will have a CT scan of the lower abdomen with contrast to confirm uncomplicated appendicitis and to rule out any signs of more serious infection. Participants will then be randomly assigned to either the ERAT group or the surgery group, and they will be informed of which treatment they will receive. Regardless of the group, all participants will receive the same supportive care, including pain relief, close monitoring, and a single dose of antibiotics before treatment. After the procedure, participants will stay in the hospital for at least 24 hours for observation. Follow-up will include an outpatient visit at 2 weeks, and telephone follow-ups at 1 month, 3 months, 6 months, and 1 year to monitor recovery and ensure that appendicitis does not recur.
Detailed description
This is a multicenter, open-label, randomized, non-inferiority trial comparing Direct Visualization Endoscopic Retrograde Appendicitis Therapy (ERAT) with Laparoscopic Appendectomy (LA) for the treatment of adult acute uncomplicated appendicitis (AUA). A total of 376 participants will be enrolled across 14 hospitals in China, and randomized in a 1:1 ratio to either ERAT or LA after providing informed consent.
Adults aged 18 years or older with CT-confirmed first-episode AUA are eligible. Key exclusions include complicated appendicitis, bowel obstruction, intolerance to colonoscopy or bowel preparation, poor operative candidacy, pregnancy, severe organ dysfunction, or concurrent participation in another clinical trial.
Interventions will be performed within 24 hours of admission. ERAT involves the use of a direct visualization appendicoscope to access the appendiceal lumen, irrigate pus and debris, and remove or fragment appendicoliths under direct vision. A short plastic stent may be placed if drainage is required. LA will be performed according to standard laparoscopic surgical techniques. Follow-up assessments will include an outpatient visit at 2 weeks and telephone follow-ups at 1, 3, 6, and 12 months.
The primary outcome is 30-day treatment success, defined as successful completion of the assigned procedure, resolution of symptoms, discharge without further surgery, and absence of recurrence. This study aims to provide robust evidence supporting the safety and effectiveness of ERAT and to inform future clinical guidelines for the management of acute uncomplicated appendicitis.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Direct Visualization ERAT | Experimental | Procedure: Direct Visualization Endoscopic Retrograde Appendicitis TherapyUndergo direct visualization endoscopic retrograde appendicitis therapy |
| Laparoscopic Appendectomy | Active comparator | Procedure: Laparoscopic appendectomyUndergo laparoscopic appendectomy |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age ≥ 18 years.
- Diagnosis of first-episode acute uncomplicated appendicitis (AUA) confirmed by CT scan of the lower abdomen. AUA is defined as acute appendicitis without evidence of abscess, perforation, gangrene, or tumor.
- Provision of written informed consent.
Key exclusion criteria (9 listed)
- Complicated appendicitis, defined as acute appendicitis with perforation, gangrene, periappendiceal abscess or phlegmon, generalized peritonitis, or radiologic evidence of extraluminal appendicolith, extraluminal air, periappendiceal fat stranding, or appendiceal mass.
- Severe intestinal adhesions or bowel obstruction.
- Intolerance or contraindication to bowel preparation or colonoscopy (e.g., intestinal perforation or bowel obstruction).
- Poor general condition precluding tolerance of abdominal surgery.
- Abdominal pain caused by other diseases as confirmed by CT or other diagnostic examinations, including inflammatory bowel disease, urinary tract disease, or gynecological disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Direct Visualization Endoscopic Retrograde Appendicitis TherapyAlso: ERATDirect visualization ERAT will be performed by experienced endoscopists (≥ 30 prior ERAT cases) under conscious sedation or general anesthesia as needed. A colonoscope with a transparent cap will be advanced to the cecum to expose the appendiceal orifice, and a direct visualization appendicoscope will be introduced through the working channel. The appendiceal lumen will be inspected and irrigated with saline to clear pus and debris, with negative pressure applied for aspiration. Small appendicoliths will be flushed out, while larger ones will be removed using a retrieval basket, stone extractor, or laser lithotripsy. When narrowing or heavy purulence is present, a stent will be inserted for drainage. After confirming adequate drainage, the scope will be withdrawn. If ERAT fails, conversion to laparoscopic or open appendectomy will be performed. | Procedure or surgery | Direct Visualization ERAT |
| Laparoscopic appendectomyAlso: LALaparoscopic appendectomy will be performed under general anesthesia by surgeons with experience in > 20 procedures, according to standard clinical practice. The resected appendix will be examined for gross features and sent for histopathological confirmation of acute uncomplicated appendicitis. If laparoscopic appendectomy is unsuccessful, conversion to open appendectomy will be performed. | Procedure or surgery | Laparoscopic Appendectomy |
Primary outcome
Treatment Success
Time frame: 30 days
ERAT arm: Treatment success is defined as successful completion of the ERAT procedure, resolution of acute uncomplicated appendicitis symptoms, discharge from the hospital without appendectomy, and absence of recurrence within 30 days. LA arm: Treatment success is defined as successful completion of laparoscopic appendectomy without conversion to open appendectomy, histopathological confirmation of acute appendicitis characterized by the presence of neutrophilic infiltration within the appendiceal muscularis propria, resolution of acute uncomplicated appendicitis symptoms, and absence of recurrence within 30 days.
17 secondary outcomes
Recurrence
Time frame: 1 year
Technical success
Time frame: Intraoperative
Timing to procedure
Time frame: Pre-operative
Total procedure time
Time frame: Intraoperative
Intervention time
Time frame: Intraoperative
Preparation time
Time frame: Intraoperative
Self-reported pain score
Time frame: 1 month
Time to soft diet resumption
Time frame: 1 week
Post-intervention narcotics used
Time frame: 1 week
Duration of analgesics used
Time frame: 2 weeks
Duration of post-intervention antibiotics used
Time frame: 1 week
Sick leave
Time frame: 1 month
Time to return to normal daily activities
Time frame: 1 month
Cost of treatment
Time frame: 1 year
Quality of Life of the Participants
Time frame: 1 year
Patient Satisfaction
Time frame: 1 year
Complication
Time frame: 1 year
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2026.
- Individual participant dataSharing planned: Undecided. Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
14 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Direct Visualization Endoscopic Retrograde Appendicitis Therapy and Laparoscopic appendectomy in people with Acute Uncomplicated Appendicitis, run by Changhai Hospital at 14 sites in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 14 sites in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zhuan Liao, MD, PhD (021-81873001, liaozhuan@smmu.edu.cn), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Treatment Success (time frame: 30 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2026.