Hemispatial NeglectNCT07228871
The Effectiveness of Transcranial Magnetic Stimulation and Mirror Therapy in Hemispatial Neglect
A study testing Mirror Therapy, cTBS and Cognitive rehabilitation in people with Hemispatial Neglect, run by Ankara Etlik City Hospital at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to evaluate the effectiveness of continuous Theta Burst Stimulation added to mirror therapy on neglect associated with stroke. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Hemispatial Neglect
- What is being tested?
- Mirror Therapy, cTBS and Cognitive rehabilitation
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 22 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2026to 31 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Ischemic/haemorrhagic stroke
- Right hemisphere lesion
- Patients with a duration of more than 7 days but less than 1 year from the date of the event
- Aged between 18 and 75 years
- Patients with a Mini Mental Test Score ≥ 24
Who cannot join
- History of recurrent stroke
- Presence of vision or hearing problems
- Use of medication affecting cognitive function
- History of epilepsy
- Pregnancy or breastfeeding
- History of malignancy
Show all 10Show fewer
- Pacemaker
- Presence of metallic implants in the brain or scalp (including cochlear implant)
- History of premorbid dementia
- Presence of psychiatric or additional neurological disease
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Ankara Etlik City Hospital
Ankara, Yenimahalle, 06010
Ayşe Naz Kalem Özgen, +90 0312 797 00 00, kalemnaz@gmail.com
About this study
Official title: Evaluation of the Effectiveness of Transcranial Magnetic Stimulation and Mirror Therapy in Hemispatial Neglect Developing After Stroke
The aim of this study is to evaluate the effectiveness of continuous Theta Burst Stimulation added to mirror therapy on neglect associated with stroke.
- Conditions
- Hemispatial Neglect
- Being tested
- Mirror Therapy, cTBS, Cognitive rehabilitation
- Keywords
- neglect, mirror therapy, theta burst stimulation
- Medical subject headings
- Perceptual Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mirror TherapyOther
Mirror therapy will be administered 5 days a week for 2 weeks.
cTBSDevice
Patients received cTBS applied to the P3 region according to the 10/20 electroencephalogram system for 5 days a week, totalling 10 sessions over 2 weeks.
Cognitive rehabilitationOther
Methods that facilitate adaptation in daily life activities will be taught.
| Study group | Role | What they receive |
|---|---|---|
| Active cTBS + mirror therapy group | Experimental | Not described Receives: Other: Mirror Therapy; Device: cTBS; Other: Cognitive rehabilitation |
| Sham cTBS + mirror therapy | Sham comparator | Not described Receives: Other: Mirror Therapy; Other: Cognitive rehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Catherine Bergego Scale
Measured: Before Treatment and 2nd week of treatment
Secondary outcomes (3)
Verbal and Nonverbal Cancellation Test
Measured: Before Treatment and 2nd week of treatment
Line Bisection Test
Measured: Before Treatment and 2nd week of treatment
Barthel Index
Measured: Before Treatment and 2nd week of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Nov 2025
- Study start1 Jan 2026
- Primary completion31 Jan 2027 (estimated)
- Study completion31 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hemispatial NeglectStudies of the same condition, open and under way.
- More trials run by Ankara Etlik City HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 22 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ankara Etlik City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Ayse Naz Kalem, Ankara Etlik City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07228871
- Sponsor's protocol ID
- AEŞH-EK-2025-164
- Status last verified
- Nov 2025
- First submitted
- 13 Nov 2025
- Last updated
- 24 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Effectiveness of Transcranial Magnetic Stimulation and Mirror Therapy in Hemispatial Neglect Developing After Stroke
- ClinicalTrials.gov ID
- NCT07228871
- Acronym / sponsor ID
- AEŞH-EK-2025-164
- Conditions
- Hemispatial Neglect
- Keywords
- neglect, mirror therapy, theta burst stimulation
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 22 participants (estimated)
- Lead sponsor
- Ankara Etlik City HospitalOther government
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 31 Jan 2027 (estimated)
- Study completion
- 31 Jan 2027 (estimated)
- First posted
- 14 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to evaluate the effectiveness of continuous Theta Burst Stimulation added to mirror therapy on neglect associated with stroke.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Active cTBS + mirror therapy group | Experimental | Other: Mirror Therapy, Device: cTBS, Other: Cognitive rehabilitation |
| Sham cTBS + mirror therapy | Sham comparator | Other: Mirror Therapy, Other: Cognitive rehabilitation |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Ischemic/haemorrhagic stroke
- Right hemisphere lesion
- Patients with a duration of more than 7 days but less than 1 year from the date of the event
- Aged between 18 and 75 years
- Patients with a Mini Mental Test Score ≥ 24
Key exclusion criteria (10 listed)
- History of recurrent stroke
- Presence of vision or hearing problems
- Use of medication affecting cognitive function
- History of epilepsy
- Pregnancy or breastfeeding
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mirror TherapyMirror therapy will be administered 5 days a week for 2 weeks. | Other | Active cTBS + mirror therapy group, Sham cTBS + mirror therapy |
| cTBSPatients received cTBS applied to the P3 region according to the 10/20 electroencephalogram system for 5 days a week, totalling 10 sessions over 2 weeks. | Device | Active cTBS + mirror therapy group |
| Cognitive rehabilitationMethods that facilitate adaptation in daily life activities will be taught. | Other | Active cTBS + mirror therapy group, Sham cTBS + mirror therapy |
Primary outcome
Catherine Bergego Scale
Time frame: Before Treatment and 2nd week of treatment
3 secondary outcomes
Verbal and Nonverbal Cancellation Test
Time frame: Before Treatment and 2nd week of treatment
Line Bisection Test
Time frame: Before Treatment and 2nd week of treatment
Barthel Index
Time frame: Before Treatment and 2nd week of treatment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mirror Therapy, cTBS and Cognitive rehabilitation in people with Hemispatial Neglect, run by Ankara Etlik City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ayşe Naz Kalem Özgen, specialist (+90 0312 797 00 00, kalemnaz@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Catherine Bergego Scale (time frame: Before Treatment and 2nd week of treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Feb 2026.