Thyroid NodulesNCT07226804
Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
An observational study of Thyroid Nodules and Pulsed Field Ablation, run by M.D. Anderson Cancer Center at 1 site in United States.
Trial summary
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Thyroid Nodules, Pulsed Field Ablation
- What is being tested?
- Questionnaire
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 14 Nov 2025to 31 Aug 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: MD Anderson Cancer Center
Who may be able to join
None listed.
Who cannot join
- Age <18
- Patients considered unsuitable for nsPFA by the treating physician
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
MD Anderson Cancer Center
Houston, Texas, 77030
Victoria E Banuchi, MD, 346-217-8668, vebanuchi@mdanderson.org
Victoria E Banuchi, MD
About this study
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
Read the detailed description
Primary Objectives
- To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care
Secondary Objectives
- To determine changes in health-related quality of life changes following ultrasound-guided nsPFA
- To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA.
- To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.
- Conditions
- Thyroid Nodules, Pulsed Field Ablation
- Being tested
- Questionnaire
- Medical subject headings
- Thyroid Nodule
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
QuestionnaireOther
patient-reported outcomes questionnaire
What is being measured
The primary outcome is the main question the study is designed to answer.
Quality-of-life Questionnaire
Measured: Through study completion; an average of 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Nov 2025
- Study start14 Nov 2025
- Primary completion31 Aug 2028 (estimated)
- Study completion31 Aug 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Thyroid NodulesStudies of the same condition, open and under way.
- More trials run by M.D. Anderson Cancer CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- M.D. Anderson Cancer Center
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Victoria E Banuchi, MD, Principal investigator, M.D. Anderson Cancer Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07226804
- Sponsor's protocol ID
- 2025-0483
- Other IDs
- NCI-2025-08362
- Status last verified
- May 2026
- First submitted
- 7 Nov 2025
- Last updated
- 1 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
- ClinicalTrials.gov ID
- NCT07226804
- Acronym / sponsor ID
- 2025-0483
- Conditions
- Thyroid Nodules, Pulsed Field Ablation
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- M.D. Anderson Cancer CenterUniversity, hospital or other
- Study start
- 14 Nov 2025 (actual)
- Primary completion
- 31 Aug 2028 (estimated)
- Study completion
- 31 Aug 2030 (estimated)
- First posted
- 10 Nov 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
Detailed description
Primary Objectives
- To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care
Secondary Objectives
- To determine changes in health-related quality of life changes following ultrasound-guided nsPFA
- To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA.
- To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- MD Anderson Cancer Center
Key inclusion criteria (0 listed)
Key exclusion criteria (2 listed)
- Age <18
- Patients considered unsuitable for nsPFA by the treating physician
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Questionnairepatient-reported outcomes questionnaire | Other | – |
Primary outcome
Quality-of-life Questionnaire
Time frame: Through study completion; an average of 1 year
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jun 2026.
- MD Anderson Cancer CenterLink provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Victoria E Banuchi, MD principal investigator
M.D. Anderson Cancer Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Thyroid Nodules and Pulsed Field Ablation, run by M.D. Anderson Cancer Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 1 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Victoria E Banuchi, MD (346-217-8668, vebanuchi@mdanderson.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quality-of-life Questionnaire (time frame: Through study completion; an average of 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jun 2026.