Peripheral Arterial DiseasePhase 3ATTAIN-PADNCT07223593
Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
A Phase 3 study testing Orforglipron in people with Peripheral Arterial Disease, run by Eli Lilly and Company at 170 sites in 18 countries.
Trial summary
The purpose of this study is to evaluate the effect and safety of orforglipron once daily in participants with Fontaine II peripheral arterial disease (PAD). Participation in the study will last about 58 weeks. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Peripheral Arterial Disease
- What is being tested?
- Orforglipron
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 1,205 participants
- Where
- 170 sitesin 18 countries
- Study dates
- 31 Oct 2025to Jun 2028
- Phase
- Phase 3
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Have symptomatic PAD with intermittent claudication of Fontaine Stage II
- Have an Ankle Brachial Index (ABI) of 0.9 or less
Who cannot join
- Have a body mass index (BMI) less than 23 kilogram per square meter (kg/m2)
- Have Hemoglobin A1c (HbA1c) greater than 10%
- Have walking ability limited by conditions other than PAD
- Have a planned lower limb surgery or any other surgery affecting walking ability
- Had peripheral revascularization procedure within 90 days prior to the day of screening or planning to undergo peripheral revascularization during the clinical trial
- Had stroke, transient ischemic attack, myocardial infarction, coronary or carotid revascularization, or hospitalization for unstable angina pectoris within 60 days prior to screening
- Have heart failure presently classified as being in New York Heart Association class III - IV
Trial locations and contacts
170 sites in 18 countries. Contact the study team or a site near you to ask about taking part.
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or contact
Physicians interested in becoming principal investigators please contact contact
170 sites in 18 countries
United States36 sites, 36 recruiting
- Not yet recruiting
Rocky Mountain Regional VA Medical Center
Aurora, Colorado, 80045
David Saxon
- Recruiting
St. Vincent's Birmingham Hospital
Birmingham, Alabama, 35205
Christopher DeGroat
- Recruiting
Flourish Research - Bowie
Bowie, Maryland, 20715
410-824-1341
Sara Collins
- Recruiting
Capital Area Research, LLC
Camp Hill, Pennsylvania, 17011
717-441-1725
Venkatesh Nadar
- Recruiting
Alpine Research Organization
Clinton, Utah, 84015
801-791-2206
Justin Mansfield
- Recruiting
Mercy Gilbert Medical Center
Gilbert, Arizona, 85297
602-214-0886
Nabil Dib, MD, Msc,
- Recruiting
ASHA Clinical Research - Munster, LLC
Hammond, Indiana, 46324
219-803-6649
Mohan Kesani
- Recruiting
Biopharma Informatic, LLC
Houston, Texas, 77084
281-944-3610
Imran Ahmed Dar, MD
- Recruiting
Research Physicians Network, LLC
Houston, Texas, 77089
832-847-1724
Nadish Garg, MD
- Recruiting
Indiana University Health Methodist Hospital
Indianapolis, Indiana, 46202
Rolf Kreutz
- Recruiting
The Jackson Clinic
Jackson, Tennessee, 38305
731-660-8396
Antwan Robinson
- Recruiting
East Coast Institute for Research - Jefferson City
Jefferson City, Tennessee, 37760
Pragnesh Patel
- Not yet recruiting
Capitol Cardiology Associates - Lanham Office
Lanham, Maryland, 20706
561-906-0904
Vineet Venugopal
- Recruiting
Lakeview Institute of Clinical Research
Leesburg, Florida, 34748
352-782-0606
Khai Chang
- Not yet recruiting
Angel City Research Inc.
Los Angeles, California, 90010
213-365-0793
Parham Parto
- Recruiting
Stroobants Cardiovascular Center
Lynchburg, Virginia, 24501
Supawat Ratanapo
- Not yet recruiting
ERA Health Research - CardioNow - Lynnwood
Lynnwood, Washington, 98036
425-869-6828
Mahesh Mulumudi
- Not yet recruiting
Carient Heart & Vascular - Manassas
Manassas, Virginia, 20109
703-335-8750
Hamid Taheri
- Recruiting
Inpatient Research Clinic
Miami Lakes, Florida, 33014
786-502-4303
Alexis Gutierrez
- Recruiting
Floridian Clinical Research, LLC
Miami Lakes, Florida, 33016-1518
305-330-9977
Gilberto Concepcion
- Not yet recruiting
Cardiovascular Research of Northwest Indiana
Munster, Indiana, 46321
219-934-4200
Wail Asfour
- Recruiting
Deaconess Clinic- Gateway
Newburgh, Indiana, 47630
812-490-4505
Sridhar Banuru
- Recruiting
Valley Clinical Trials, LLC dba Flourish Research
Northridge, California, 91325
818-280-4220
Christopher Chow
- Recruiting
The Cardiovascular Center
Redding, California, 96001
281-944-3610
Mohamed Hussein Khan, MD
- Recruiting
Eastside Research Associates
Redmond, Washington, 98052
425-869-6828
Christopher Price
- Recruiting
Clinical Research Partners, LLC
Richmond, Virginia, 23226
804-477-3045
Robert Call
- Recruiting
St Johns Center for Clinical Research
Saint Augustine, Florida, 32086
904-209-0043
Ameeth Vedre
- Recruiting
Sherman Clinical Research
Sherman, Texas, 75090
903-771-4093
Tariq Yousuf
- Not yet recruiting
Emvera Health at Peak Heart & Vascular Surprise
Surprise, Arizona, 85378
844-290-2273
Frank Lovecchio
- Recruiting
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, 48098
248-312-0025
Neil Fraser
- Recruiting
Del Sol Research Management, LLC
Tucson, Arizona, 85715
520-257-3881
Carl Diener
- Recruiting
InvivoCure
Van Nuys, California, 91405
859-509-0084
Rodney Samaan
- Recruiting
Gershon Pain Specialists
Virginia Beach, Virginia, 23454
757-496-2050
Steven Gershon
- Recruiting
NextStage Clinical Research - Waco
Waco, Texas, 76712
Donald Cross
- Recruiting
Interventional Cardiology Medical Group
West Hills, California, 91307
818-702-8800
Farhad Rafii
- Not yet recruiting
Guardian Research Organization, LLC
Winter Park, Florida, 32792
407-645-1847
Ashish Gupta
Japan25 sites, 25 recruiting
- Recruiting
University of Yamanashi Hospital
Chūō, 409-3898
81120023812
Takamitsu Nakamura
- Recruiting
Fukuyama City Hospital
Fukuyama, 721-8511
81120023812
Akihiro Oka
- Recruiting
Hakodate Municipal Hospital
Hakodate, 041-8680
81120023812
masami shingaki
- Not yet recruiting
Mito Medical Center
Higashiibaraki, 311-3117
81120023812
Tomomi Koizumi
- Recruiting
Medical Corporation Sapporo Heart Center Sapporo Cardio Vascular Clinic
Higashiku, 007-0849
81120023812
Takuya Haraguchi
- Recruiting
National Hospital Organization Kanazawa Medical Center
Kanazawa, 920-8650
81120023812
Fuminori Kasashima
- Recruiting
Shinyurigaoka General Hospital
Kawasaki, 215-0026
81120023812
KENJIRO KANEKO
- Recruiting
Kokura Memorial Hospital
Kitakyushu, 802-8555
81120023812
Kenji Ando
- Recruiting
Kobe City Medical Center General Hospital
Kobe, 650-0047
81120023812
Yuta Azumi
- Recruiting
Omi Medical Center
Kusatsu, 525-0066
81120023812
Masaharu Okada
- Recruiting
Seikeikai Medical Corporation New Tokyo Heart Clinic
Matsudo, 271-0077
81120023812
Haruhito Yuki
- Recruiting
Japanese Red Cross Musashino Hospital
Musashino-shi, 180-8610
81120023812
Toshihiro Nozato
- Recruiting
Koujunkai Daido Clinic
Nagoya, 457-8511
81120023812
Sumio Morita
- Recruiting
Nakakinen clinic
Naka, 311-0113
81120023812
Takeshi Osonoi
- Not yet recruiting
Oita Oka Hospital
Ōita, 870-0192
81120023812
Hidenori Sako
- Recruiting
National Hospital Organization Osaka National Hospital
Osaka, 540-0006
81120023812
Yasunori Ueda
- Recruiting
Osaka Keisatsu Hospital
Osaka, 543-0042
81120023812
Osamu Iida
- Recruiting
Kansai Electric Power Hospital
Osaka, 553-0003
81120023812
Shuichiro Kaji
- Recruiting
Osaka General Medical Center
Osaka, 558-8558
81120023812
Mitsutoshi Asai
- Recruiting
Saitama City Hospital
Saitama, 336-8522
81120023812
Atsunori Asami
- Recruiting
Japan Community Healthcare Organization Hokkaido Hospital
Sapporo, 062-8618
81120023812
Masashige Takahashi
- Recruiting
Iwate Medical University Hospital
Shiwa-gun Yahaba-cho, 028-3695
81120023812
Yuki Matsumoto
- Recruiting
Municipal Toyonaka Hospital
Toyonaka, 560-0055
81120023812
Hironobu Fujimura
- Recruiting
Yamagata University Hospital
Yamagata, 990-9585
81120023812
Masafumi Watanabe
- Recruiting
Yokohama City Minato Red Cross Hospital
Yokohama, 231-0801
81120023812
Yasuteru Yamauchi
China18 sites, 18 recruiting
- Recruiting
Xuanwu Hospital Capital Medical University
Beijing, 100053
Lianrui Guo
- Recruiting
Peking University Third Hospital
Beijing, 100091
13810103532
Dan Zhu
- Recruiting
Beijing Pinggu District Hospital
Beijing, 101200
13911080328
yufeng li
- Recruiting
Sichuan Provincial People's Hospital
Chengdu, 610072
Limin Tian
- Recruiting
Guangdong Provincial People's Hospital
Guangzhou, 510000
Jiyan Chen
- Recruiting
The Fourth Affiliated Hospital of Harbin Medical University
Harbin, 150001
18903602198
ZhiFeng Cheng
- Recruiting
Heilongjiang Provincial Hospital
Harbin, 150036
weimin wang
- Recruiting
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, 471003
13653880139
Hongwei Jiang
- Recruiting
Nanjing First Hospital
Nanjing, 210006
Qian Li
- Recruiting
Nanjing First Hospital
Nanjing, 210012
Jianping Gu
- Recruiting
Jiangsu Province Hospital
Nanjing, 210029
Xiwei Zhang
- Recruiting
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, 200023
Xinwu Lu
- Recruiting
Zhongshan Hospital,Fudan University
Shanghai, 200032
Weiguo Fu
- Recruiting
Tianjin Medical University General Hospital
Tianjin, 300052
Xiangchen Dai
- Recruiting
Tianjin People' s Hospital
Tianjin, 300121
Li Li
- Recruiting
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000
Jingyong Huang
- Recruiting
Wuhan University Medical College - Hubei Zhongshan Hospital
Wuhan, 430000
15307151800
Jingyi Zhang
- Recruiting
The First Affiliated Hospital of Xi'an Medical University
Xi'an, 710077
Ya Li
Argentina13 sites, 13 recruiting
- Recruiting
CIPREC
Buenos Aires, 1061
5491128690843
Fernando Guerlloy
- Recruiting
CIPREC
Buenos Aires, C1119ACN
5491165496764
Angela Romero Zarante
- Recruiting
Sanatorio Finochietto
Buenos Aires, C1187AAN
+5491164424757
Nicolás Gonzalez
- Recruiting
CEMEDIC
Buenos Aires, C1407GTN
54 11 46356624
Claudio Majul
- Recruiting
Instituto de Investigaciones Clínicas Córdoba
Córdoba, 5000
543514253456
Ines Bartolacci
- Not yet recruiting
MICA - Medicina e Investigación Cardiometabólica
Del Viso, 1669
54 11 3845-9542
Micaela Mirada
- Recruiting
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, 2152
5493412106243
Juan Dominguez
- Recruiting
DIM Clínica Privada
Ramos Mejía, B1704ETD
54011 46562828
Oscar Montaña
- Recruiting
Fundacion Estudios Clinicos
Rosario, 2000
543412384171
María Schiavoni
- Recruiting
INECO Neurociencias Oroño
Rosario, 2000
543415004351
Dana Miralles
- Recruiting
Instituto de Investigaciones Clinicas Rosario
Rosario, S2000CVD
5493415109204
Carolina Chacón
- Recruiting
Go Centro Medico San Nicolás
San Nicolás, 2900
5493364571637
Paulina Lanchiotti
- Recruiting
Centro de Salud e Investigaciones Médicas
Santa Rosa, L6300
542954244444
Marcos Mayer
India11 sites, 11 recruiting
- Recruiting
Jawaharlal Nehru Medical College
Aligarh, 202002
8126320218
Md. Azharuddin Malik
- Recruiting
Priyanka Hospital & Cardiac Center
Jaipur, 302020
Piyush Joshi
- Recruiting
M. P. Birla Group - Belle Vue Clinic
Kolkata, 700017
Santanu Dutta
- Recruiting
Government Medical College - Kozhikode
Kozhikode, 673008
Dr. Rajesh S
- Recruiting
Central India Cardiology and Research Institute
Nagpur, 440015
9822220936
Anil Jawahirani
- Recruiting
Lata Mangeshkar Hospital - Digdoh
Nagpur, 440019
Hitendra Bhagwatkar
- Recruiting
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, 441108
9209197577
Frankleena Parage
- Recruiting
Vijan Hospital & Research Centre
Nashik, 422005
Vikrant Vijan
- Recruiting
Sir Ganga Ram Hospital
New Delhi, 110060
Sawhney Jitendra Pal Singh
- Recruiting
All India Institute of Medical Sciences - Rishikesh
Rishikesh, 249203
9935615903
Raja Lahiri
- Recruiting
Nirmal Hospital Pvt Ltd.
Surat, 395002
Atul Abhyankar
Australia9 sites, 9 recruiting
- Recruiting
Box Hill Hospital
Box Hill, 3128
Ming Li Yee
- Recruiting
Core Research Group
Brisbane, 4064
61738765688
David Colquhoun
- Not yet recruiting
Heart of Australia
Brisbane, 4068
61 409497358
Rolf Gomes
- Recruiting
Canberra Hospital
Canberra, 2605
Peter Scott
- Not yet recruiting
Barwon Health
Geelong, 3220
Kay Hau (Aaron) Choy
- Recruiting
University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook
Meadowbrook, 4131
Ivan Lim
- Recruiting
Royal Perth Hospital
Perth, 6000
Nishath Altaf
- Recruiting
Gold Coast University Hospital
Southport, 4215
0438083132
Jessica Triay
- Not yet recruiting
Royal North Shore Hospital
St Leonards, 2065
Sarah Glastras
Brazil8 sites, 8 recruiting
- Recruiting
Centro de Pesquisa Clinica do Coracao
Aracaju, 49055-530
557999987-0794
FÁBIO SILVEIRA
- Recruiting
Hospital Universitário João de Barros Barreto
Belém, 66073-000
559132291329
Joao Felicio
- Recruiting
Instituto de Pesquisa clinica de Campinas
Campinas, 13060-080
1932670023
Jose Saraiva
- Recruiting
Centro de Pesquisa Sao Lucas
Campinas, 13060-803
55 19 3343-8688
Danilo Villagelin Neto
- Recruiting
Universidade Federal de Goias
Goiânia, 74605-020
55 62 36448186
Aguinaldo Freitas
- Recruiting
Hospital de Clinicas de Porto Alegre
Porto Alegre, 90035-903
Adamastor Pereira
- Recruiting
Centro Avançado De Pesquisa, Estudos E Diagnóstico (CAPED) - Centro Médico RibeirãoShopping
Ribeirão Preto, 14026-020
55 16 99118-2046
Pedro Schwartzmann
- Recruiting
Instituto de Molestias Cardiovasculares de Tatui
Tatuí, 18270-170
+551534511300
Wladmir Saporito
Poland8 sites, 8 recruiting
- Recruiting
Centrum Medyczne INTERCOR Sp. z o.o.
Bydgoszcz, 85-605
48 603 127 021
Grzegorz Grzesk
- Recruiting
NZOZ Twoje Zdrowie EL Sp. z o. o.
Elblag, 82-300
Waldemar Bieniek
- Recruiting
Przychodnie Grudziądz
Grudziądz, 86-300
Piotr Kubalski
- Recruiting
Centrum Medyczne Komorniki
Komorniki, 62-052
Marta Karczewska-Mastalerz
- Recruiting
Poliklinika Kardiologiczna Serce
Leszno, 64-100
Witold Piotrowski
- Not yet recruiting
KO-MED Centra Kliniczne
Puławy, 24-100
MAREK KONIECZNY
- Not yet recruiting
Centrum Badań Klinicznych Piotr Napora lekarze sp.p.
Wroclaw, 51-162
48713267900
Piotr Napora
- Not yet recruiting
Pracownia Badań Klinicznych Salus
Wroclaw, 53-034
Maciej Rabczynski
Canada7 sites, 7 recruiting
- Recruiting
THEO Medical Concorde
Laval, H7G 2E6
438-320-7171
Mohamed Medhi Khider
- Recruiting
Alpha Recherche Clinique - Lévis
Lévis, G6V 0C9
418-380-1112
Steeve Kwan Tat
- Recruiting
KMH Cardiology Centres - Stoney Creek
Stoney Creek, L8J 3W2
905 855 1860
Fatima Merali
- Recruiting
Corcare
Toronto, M1B 5N1
416-284-4744
Paul Galiwango
- Not yet recruiting
Unity Health Toronto, St. Michael's Hospital
Toronto, M5B 1W8
Beth Abramson
- Not yet recruiting
Toronto General Hospital
Toronto, M5G 2C4
Thomas Lindsay
- Recruiting
Cardio 1 Medical Clinic
Winnipeg, R3L 1Z5
204-287-5222 ext 104
Peiman Malek Marzban
France7 sites, 7 recruiting
- Recruiting
Centre Hospitalier Universitaire d'Angers
Angers, 49933
+33241353610
pierre ABRAHAM
- Recruiting
CHRU Troussau
Chambray-lès-Tours, 37170
+33247479054
Jean Baptiste de Freminville
- Recruiting
Hôpital Saint Philibert
Lomme, 59160
Marjolaine TALBOT
- Recruiting
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, 06000
10.00
Georges LEFTHERIOTIS
- Recruiting
Groupe hospitalier Paris saint Joseph
Paris, 75014
Yann Goueffic
- Recruiting
Hôpital Européen Georges Pompidou
Paris, 75015
Tristan Mirault
- Recruiting
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
Rennes, 35033
Guillaume Mahe
Greece6 sites, 6 recruiting
- Not yet recruiting
General Hospital of Athens Laiko
Athens, 11527
302132061248
Alexandros Kokkinos
- Not yet recruiting
Athens Medical Center
Athens, 151 25
302106862530
Georgia Argyrakopoulou
- Not yet recruiting
Attikon General University Hospital
Chaïdári, 12462
00302105831148
Vaia Lambadiari
- Not yet recruiting
University General Hospital of Heraklion
Heraklion, 71500
302813405438
Theodosios Filippatos
- Not yet recruiting
University Hospital of Ioannina
Ioannina, 45500
302651099846
Vasileios Tsimichodimos
- Not yet recruiting
European Interbalkan Medical Center
Thessaloniki, 570 01
+302310994838
Georgios Giannakoulas
United Kingdom5 sites, 5 recruiting
- Recruiting
Imperial College Healthcare NHS Trust, Charing Cross Hospital
London, W6 8RF
Alun Davies
- Recruiting
Derriford Hospital
Plymouth, Pl6 8DH
01752431822
Devender Mittapalli
- Recruiting
Royal Stoke University Hospital
Stoke-on-Trent, ST4 6QG
Arun Pherwani
- Recruiting
Swansea University
Swansea, SA2 8PP
07710641345
Stephen Bain
- Recruiting
Moorgreen Hospital
West End, SO30 3JB
Sarah Brewster
Israel4 sites, 4 recruiting
- Not yet recruiting
Rambam Health Care Campus
Haifa, 3109601
97247773476
Oren Caspi
- Not yet recruiting
Hadassah Medical Center
Jerusalem, 9112001
Sagi Levental
- Not yet recruiting
Meir Medical Center
Kfar Saba, 4428164
adi bachar
- Not yet recruiting
Rabin Medical Center
Petah Tikva, 4941492
Katia Orvin
South Korea4 sites, 4 recruiting
- Recruiting
Daegu Catholic University Medical Center
Daegu, 42472
Kihyuk Park
- Recruiting
Korea University Anam Hospital
Seoul, 02841
Cheol Woong Yu
- Recruiting
Seoul National University Hospital
Seoul, 03080
Seung-Kee Min
- Recruiting
Asan Medical Center
Seoul, 05505
SEUNG WHAN LEE
Taiwan4 sites, 4 recruiting
- Recruiting
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807
886-7-3121101 ext 7741
Tsung-Hsien Lin
- Recruiting
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, 83301
Shu-Kai Hsueh
- Recruiting
National Taiwan University Hospital
Taipei, 10002
886 972651064
Hsien-Li Kao
- Recruiting
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, 333
Pao-Hsien Chu
Netherlands3 sites, 3 recruiting
- Recruiting
Albert Schweitzer Ziekenhuis, locatie Dordwijk
Dordrecht, 3318 AT
0786542686
Simone Hartong
- Not yet recruiting
Catharina Ziekenhuis
Eindhoven, 5623 EJ
0402397150
Marc van Sambeek
- Not yet recruiting
Radboudumc
Nijmegen, 6525 GA
31243615333
Michiel Warle
Puerto Rico1 site, 1 recruiting
- Recruiting
Research and Cardiovascular Corp.
Ponce, 00717
787-290-8585
Jose Vazquez-Tanus
Slovakia1 site, 1 recruiting
- Recruiting
MEDIVASA
Žilina, 01001
421414510419
Viliam Bugan
About this study
Official title: A Study to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants With Peripheral Artery Disease: A Randomized, Double-Blind, Placebo Controlled Trial
The purpose of this study is to evaluate the effect and safety of orforglipron once daily in participants with Fontaine II peripheral arterial disease (PAD). Participation in the study will last about 58 weeks.
- Conditions
- Peripheral Arterial Disease
- Being tested
- Orforglipron, Placebo
- Medical subject headings
- Peripheral Arterial Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
OrforglipronDrug
Also called LY3502970
Administered orally
PlaceboDrug
Administered orally
| Study group | Role | What they receive |
|---|---|---|
| Orforglipron | Experimental | Participants will receive orforglipron orally Receives: Drug: Orforglipron |
| Placebo | Placebo comparator | Participants will receive placebo orally Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Percent Change from Baseline in Maximum Walking Distance
On a constant load treadmill test
Measured: Baseline, Week 52
Secondary outcomes (5)
Percent Change from Baseline in Pain Free Walking Distance
On a constant load treadmill test
Measured: Baseline, Week 52
Change from Baseline in Vascular Quality of Life (VascuQoL-6) Questionnaire Score
Measured: Baseline, Week 52
Change from Baseline in 6 Minute Walk Test Distance (meters)
Measured: Baseline, Week 52
Percent Change from Baseline in High-Sensitivity C-Reactive Protein (hsCRP)
Measured: Baseline, Week 52
Change from Baseline in Systolic Blood Pressure (mmHg)
Measured: Baseline, Week 52
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Nov 2025
- Study start31 Oct 2025
- Primary completionJun 2028 (estimated)
- Study completionJun 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Peripheral Arterial DiseaseStudies of the same condition, open and under way.
- More trials run by Eli Lilly and CompanyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 1,205 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Eli Lilly and Company
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Study director, Eli Lilly and Company
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07223593
- Sponsor's protocol ID
- 27632
- Other IDs
- 2025-523283-21-00, J2A-MC-GZPR, 2025
- Acronym
- ATTAIN-PAD
- Status last verified
- Oct 2026
- First submitted
- 30 Oct 2025
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.