HealthyNCT07210099
The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation
A study testing Concentrated olive fruit water and Anhydrous caffeine in people with Healthy, run by Anglia Ruskin University at 1 site in United Kingdom.
Trial summary
There is current research interest in the use of fruit and plant-based food products containing high levels of natural antioxidants and their impact on exercise, which may be particularly beneficial for recreationally or low-active populations. Read more about this study
- Who is it for?
- Ages 21 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Concentrated olive fruit water and Anhydrous caffeine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 40 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 30 May 2025to 30 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Men and women, UK based, above 21 years of age with a body mass index (BMI) >18 and <30 kg·m2 determined during baseline testing
- Considered to be recreationally active i.e. approximately 150mins of general physical activity/ exercise per week (meeting the WHO physical activity guidelines); and a VO2peak (fitness) score >20 and <50 mL·kg-1·min-1 determined during baseline testing.
- No known history (including family history) of heart abnormalities, hypertension, coronary heart disease or diabetes (determined from pre-study health screen questionnaire).
- Not currently suffering from any musculoskeletal injury, or any other reason that may prevent participation in cardiovascular exercise.
- Have not suffered from recent viral infections ie: influenza (defined within the prior 2 months).
- Not taking any prescribed or over-the-counter medication which may influence exercise training (with the exception of inhalers for exercise induced asthma or contraceptive pill).
- Not consuming or prepared to refrain from consumption, any commercial supplementation which conflicts with the study parameters ie: antioxidants.
- No known allergy or intolerance to olives or prune/grape juice, or any known side effects from caffeine ingestion.
Who cannot join
- If any of the above criteria is not met.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site, 1 recruiting
- Recruiting
Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University,
Cambridge, CB1 1PT
Justin D Roberts, PhD, 07794122020, justin.roberts@aru.ac.uk
Joseph B Lillis, MSc, 07713870153, JBL115@pgr.aru.ac.uk
About this study
Official title: The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation in Recreationally Active Volunteers
There is current research interest in the use of fruit and plant-based food products containing high levels of natural antioxidants and their impact on exercise, which may be particularly beneficial for recreationally or low-active populations. One such product is an olive extract drink (called OliPhenolia®) produced by Fattoria La Vialla (an organic farm based in Northern Italy) and commercially available for the general public. Whilst previous research from the investigators (at Anglia Ruskin University) using this product has demonstrated potential antioxidant benefits and reduced oxygen cost during aerobic exercise, there are to date no studies investigating whether the short-term consumption of OliPhenolia® can benefit fat oxidation during exercise or whether such effects can be further enhanced employing a pre workout caffeinated beverage.
Therefore the aim of this study is two-fold:
- to assess the impact of short-term supplementation (8 days) of OliPhenolia® relative to body mass on fat oxidation during aerobic cycling exercise in comparison to placebo in healthy recreationally active volunteers; and ii) whether potential benefits of OliPhenolia® on fat oxidation are enhanced with a pre-workout caffeinated beverage in comparison to placebo in healthy recreationally active volunteers.
Read the detailed description
This exploratory study will involve initial recruitment of approximately 30-40 healthy volunteers to undertake an initial study briefing pre-screening health questionnaire, informed written consent and familiarisation to exercise equipment, before returning to the human physiology laboratory at Anglia Ruskin University on a separate occasion (Visit 1) to undertake a standard exercise test for maximal fitness capacity.
Following this, Visit 2 will see participants undertake a standard fat oxidation exercise test (aerobic exercise on a cycle ergometer) to ascertain maximal fat oxidation (Fatmax) with increasing exercise intensity, as well as a steady state exercise bout (30mins at FATmax).
After this participants will begin a short-term (8 days) supplementation period of either OliPhenolia or Placebo before returning for a follow up fat oxidation assessment (Visit 3) as above. Fat oxidation will be assessed by standard respiratory measures (breath to breath for oxygen and carbon dioxide). On the follow up test (Visit 3), a pre-exercise workout drink will be provided containing either caffeine flavoured water or placebo. This is to assess whether fat oxidation can be enhanced from short-term polyphenol supplementation (OliPhenolia) with or without additional caffeine prior to exercise.
Participants will therefore be randomised into 1 of 4 groups for this study (Placebo product for 8 days + placebo beverage at follow up; Oliphenolia for 8 days + placebo beverage at follow up; and OliPhenolia for 8 days plus caffeinated beverage at follow up; and placebo product for 8 days plus caffeinated beverage at follow up).
- Conditions
- Healthy
- Being tested
- Concentrated olive fruit water, Placebo, Anhydrous caffeine, Placebo beverage
- Keywords
- FatMax, Fat Oxidation, Polyphenols, Caffeine
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Concentrated olive fruit waterDietary supplement
Also called OliPhenolia
Supplementation of OliPhenolia twice daily for eight days. Dose equivalent to ≤1.0mg∙kg-1 of hydroxytyrosol.
PlaceboDietary supplement
Placebo matched for taste and appearance consumed twice daily for eight days in the equivalent volume to the experimental product.
Anhydrous caffeineDietary supplement
A single bolus of flavoured water (150mL) containing 6mg/kg anhydrous caffeine taken as a pre-exercise beverage
Placebo beverageDietary supplement
A single bolus of flavoured water (150mL) containing 6mg/kg microcrystalline cellulose
| Study group | Role | What they receive |
|---|---|---|
| OliPhenolia® plus placebo beverage | Experimental | OliPhenolia® is to be consumed twice daily, away from food and separated by ≥4 hours, for a period of 8 days.
Note each serving of OliPhenolia® is a volume equivalent to ≤1.0mg∙kg-1 of Hydroxytyrosol.
At the follow up test participants will also be provided with a 150mL placebo (microcrystalline cellulose at a dose of 6mg/kg) beverage pre-exercise. Receives: Dietary Supplement: Concentrated olive fruit water; Dietary Supplement: Placebo beverage |
| Placebo product plus placebo beverage | Placebo comparator | A taste and appearance matched placebo will be used within this research, conforming to the recipe utilised in previously published OliPhenolia® research. Recipe as follows; equal ratio [1:1:1] of prune juice, diet cola, and tonic water. The placebo formula will be provided in matched 28mL sterilised jars provided order to match OliPhenolia® original packaging.
At the follow up test participants will also be provided with a 150mL placebo (microcrystalline cellulose at a dose of 6mg/kg) beverage pre-exercise. Receives: Dietary Supplement: Placebo; Dietary Supplement: Placebo beverage |
| OliPhenolia® +Caffeine (pre workout) | Experimental | OliPhenolia® is to be consumed twice daily, away from food and separated by ≥4 hours, for a period of 8 days.
Note each serving of OliPhenolia® is a volume equivalent to ≤1.0mg∙kg-1 of Hydroxytyrosol.
For the pre workout beverage this will be a single serve drink (150mL) containing flavoured water with 6mg/kg anhydrous caffeine based on previous research. The product will only be used pre-exercise as a single bolus. Receives: Dietary Supplement: Concentrated olive fruit water; Dietary Supplement: Anhydrous caffeine |
| Placebo +Caffeine (pre workout) | Active comparator | A taste and appearance matched placebo will be used within this research, conforming to the recipe utilised in previously published OliPhenolia® research. Recipe as follows; equal ratio [1:1:1] of prune juice, diet cola, and tonic water. The placebo formula will be provided in matched 28mL sterilised jars provided order to match OliPhenolia® original packaging.
For the pre workout beverage this will be a single serve drink (150mL) containing flavoured water with 6mg/kg anhydrous caffeine based on previous research. The product will only be used pre-exercise as a single bolus. Receives: Dietary Supplement: Placebo; Dietary Supplement: Anhydrous caffeine |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximal fat oxidation (g/min)
Assessment of total fat oxidation from stochiometrics (based on oxygen and carbon dioxide breath to breath measurements during exercise)
Measured: Pre and post main intervention (8 days)
Secondary outcomes (1)
Expired oxygen (L/min)
Assessment of oxygen cost based on expired air analysis during submaximal exercise
Measured: Pre and post main intervention (8 days)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Oct 2025
- Study start30 May 2025
- Primary completion28 Feb 2027 (estimated)
- Study completion30 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Participants will be randomly assigned to one of the 2 main experimental groups in a double-blinded manner. Following completion of the first round of testing, those participants consuming OliPhenolia will return after a 1 week wash out period and repeat the process but taking placebo, and vice versa. Therefore all participants will have consumed either test product or placebo. For the pre-follow up test beverage, participants will be randomly assigned to either placebo or caffeine in block manner. This exploratory study will only involve a single cross over.
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Anglia Ruskin University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Justin Roberts, Anglia Ruskin University
- Investigators
- Justin D Roberts, Professor, Principal investigator, Anglia Ruskin University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07210099
- Sponsor's protocol ID
- ETH2425-5668
- Status last verified
- Oct 2026
- First submitted
- 3 Jun 2025
- Last updated
- 28 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation in Recreationally Active Volunteers
- ClinicalTrials.gov ID
- NCT07210099
- Acronym / sponsor ID
- ETH2425-5668
- Conditions
- Healthy
- Keywords
- FatMax, Fat Oxidation, Polyphenols, Caffeine
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Anglia Ruskin UniversityUniversity, hospital or other
- Study start
- 30 May 2025 (actual)
- Primary completion
- 28 Feb 2027 (estimated)
- Study completion
- 30 Mar 2027 (estimated)
- First posted
- 7 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
There is current research interest in the use of fruit and plant-based food products containing high levels of natural antioxidants and their impact on exercise, which may be particularly beneficial for recreationally or low-active populations. One such product is an olive extract drink (called OliPhenolia®) produced by Fattoria La Vialla (an organic farm based in Northern Italy) and commercially available for the general public. Whilst previous research from the investigators (at Anglia Ruskin University) using this product has demonstrated potential antioxidant benefits and reduced oxygen cost during aerobic exercise, there are to date no studies investigating whether the short-term consumption of OliPhenolia® can benefit fat oxidation during exercise or whether such effects can be further enhanced employing a pre workout caffeinated beverage.
Therefore the aim of this study is two-fold:
- to assess the impact of short-term supplementation (8 days) of OliPhenolia® relative to body mass on fat oxidation during aerobic cycling exercise in comparison to placebo in healthy recreationally active volunteers; and ii) whether potential benefits of OliPhenolia® on fat oxidation are enhanced with a pre-workout caffeinated beverage in comparison to placebo in healthy recreationally active volunteers.
Detailed description
This exploratory study will involve initial recruitment of approximately 30-40 healthy volunteers to undertake an initial study briefing pre-screening health questionnaire, informed written consent and familiarisation to exercise equipment, before returning to the human physiology laboratory at Anglia Ruskin University on a separate occasion (Visit 1) to undertake a standard exercise test for maximal fitness capacity.
Following this, Visit 2 will see participants undertake a standard fat oxidation exercise test (aerobic exercise on a cycle ergometer) to ascertain maximal fat oxidation (Fatmax) with increasing exercise intensity, as well as a steady state exercise bout (30mins at FATmax).
After this participants will begin a short-term (8 days) supplementation period of either OliPhenolia or Placebo before returning for a follow up fat oxidation assessment (Visit 3) as above. Fat oxidation will be assessed by standard respiratory measures (breath to breath for oxygen and carbon dioxide). On the follow up test (Visit 3), a pre-exercise workout drink will be provided containing either caffeine flavoured water or placebo. This is to assess whether fat oxidation can be enhanced from short-term polyphenol supplementation (OliPhenolia) with or without additional caffeine prior to exercise.
Participants will therefore be randomised into 1 of 4 groups for this study (Placebo product for 8 days + placebo beverage at follow up; Oliphenolia for 8 days + placebo beverage at follow up; and OliPhenolia for 8 days plus caffeinated beverage at follow up; and placebo product for 8 days plus caffeinated beverage at follow up).
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 4
- Model description
- Participants will be randomly assigned to one of the 2 main experimental groups in a double-blinded manner. Following completion of the first round of testing, those participants consuming OliPhenolia will return after a 1 week wash out period and repeat the process but taking placebo, and vice versa. Therefore all participants will have consumed either test product or placebo. For the pre-follow up test beverage, participants will be randomly assigned to either placebo or caffeine in block manner. This exploratory study will only involve a single cross over.
| Arm | Type | Receives |
|---|---|---|
| OliPhenolia® plus placebo beverage | Experimental | Dietary Supplement: Concentrated olive fruit water, Dietary Supplement: Placebo beverageOliPhenolia® is to be consumed twice daily, away from food and separated by ≥4 hours, for a period of 8 days. Note each serving of OliPhenolia® is a volume equivalent to ≤1.0mg∙kg-1 of Hydroxytyrosol. At the follow up test participants will also be provided with a 150mL placebo (microcrystalline cellulose at a dose of 6mg/kg) beverage pre-exercise. |
| Placebo product plus placebo beverage | Placebo comparator | Dietary Supplement: Placebo, Dietary Supplement: Placebo beverageA taste and appearance matched placebo will be used within this research, conforming to the recipe utilised in previously published OliPhenolia® research. Recipe as follows; equal ratio [1:1:1] of prune juice, diet cola, and tonic water. The placebo formula will be provided in matched 28mL sterilised jars provided order to match OliPhenolia® original packaging. At the follow up test participants will also be provided with a 150mL placebo (microcrystalline cellulose at a dose of 6mg/kg) beverage pre-exercise. |
| OliPhenolia® +Caffeine (pre workout) | Experimental | Dietary Supplement: Concentrated olive fruit water, Dietary Supplement: Anhydrous caffeineOliPhenolia® is to be consumed twice daily, away from food and separated by ≥4 hours, for a period of 8 days. Note each serving of OliPhenolia® is a volume equivalent to ≤1.0mg∙kg-1 of Hydroxytyrosol. For the pre workout beverage this will be a single serve drink (150mL) containing flavoured water with 6mg/kg anhydrous caffeine based on previous research. The product will only be used pre-exercise as a single bolus. |
| Placebo +Caffeine (pre workout) | Active comparator | Dietary Supplement: Placebo, Dietary Supplement: Anhydrous caffeineA taste and appearance matched placebo will be used within this research, conforming to the recipe utilised in previously published OliPhenolia® research. Recipe as follows; equal ratio [1:1:1] of prune juice, diet cola, and tonic water. The placebo formula will be provided in matched 28mL sterilised jars provided order to match OliPhenolia® original packaging. For the pre workout beverage this will be a single serve drink (150mL) containing flavoured water with 6mg/kg anhydrous caffeine based on previous research. The product will only be used pre-exercise as a single bolus. |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Men and women, UK based, above 21 years of age with a body mass index (BMI) >18 and <30 kg·m2 determined during baseline testing
Key exclusion criteria (1 listed)
- If any of the above criteria is not met.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Concentrated olive fruit waterAlso: OliPhenoliaSupplementation of OliPhenolia twice daily for eight days. Dose equivalent to ≤1.0mg∙kg-1 of hydroxytyrosol. | Dietary supplement | OliPhenolia® +Caffeine (pre workout), OliPhenolia® plus placebo beverage |
| PlaceboPlacebo matched for taste and appearance consumed twice daily for eight days in the equivalent volume to the experimental product. | Dietary supplement | Placebo +Caffeine (pre workout), Placebo product plus placebo beverage |
| Anhydrous caffeineA single bolus of flavoured water (150mL) containing 6mg/kg anhydrous caffeine taken as a pre-exercise beverage | Dietary supplement | OliPhenolia® +Caffeine (pre workout), Placebo +Caffeine (pre workout) |
| Placebo beverageA single bolus of flavoured water (150mL) containing 6mg/kg microcrystalline cellulose | Dietary supplement | OliPhenolia® plus placebo beverage, Placebo product plus placebo beverage |
Primary outcome
Maximal fat oxidation (g/min)
Time frame: Pre and post main intervention (8 days)
Assessment of total fat oxidation from stochiometrics (based on oxygen and carbon dioxide breath to breath measurements during exercise)
1 secondary outcome
Expired oxygen (L/min)
Time frame: Pre and post main intervention (8 days)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Oct 2026.
- Individual participant dataSharing planned: No
Related trials for Healthy
Recruiting
THE EFFECTS OF GAME-BASED EXERCISE PROGRAMS
Physical Activity, Body Image
Not yet recruitingPhase 1
A Phase I Study of GLR2053 Tablets in Chinese Healthy Adult Participants
Atopic Dermatitis
Recruiting
Colon-delivered Riboflavin and Gut Microbiota Composition
Microbiome Dysbiosis, Gut Health
Not yet recruiting
Neuroergonomic Analysis of a Brain-Computer Interface Device (BCI)
Healthy Volunteers - Male and Female
RecruitingPhase 1
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis
Healthy Volunteer, Atopic Dermatitis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Justin D Roberts, Professor principal investigator
Anglia Ruskin University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Concentrated olive fruit water and Anhydrous caffeine in people with Healthy, run by Anglia Ruskin University at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 28 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Justin D Roberts, Professor (07794122020, justin.roberts@aru.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximal fat oxidation (g/min) (time frame: Pre and post main intervention (8 days)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Oct 2026.