Coronary Artery DiseaseNCT07207421
The Effect of Ultra-Fast-Track Cardiac Anesthesia in Coronary Artery Bypass Grafting Surgery
A study testing Ultra-Fast-Track Anesthesia and Standart care anesthesia in people with Coronary Artery Disease and Coronary Artery Bypass Graft (CABG), run by Adiyaman University Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled trial aims to evaluate the impact of Ultra-Fast-Track (UFT) anesthesia on postoperative recovery in patients undergoing elective coronary artery bypass grafting (CABG). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
- What is being tested?
- Ultra-Fast-Track Anesthesia and Standart care anesthesia
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Oct 2025to 31 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged ≥18 years undergoing elective coronary artery bypass grafting (CABG)
- Patients suitable for Ultra-Fast-Track anesthesia as determined by the anesthesia team
- Ability to provide written informed consent
Who cannot join
- Emergency CABG or combined cardiac procedures (e.g., valve surgery)
- Preoperative shock or requirement for mechanical ventilation
- Severe pulmonary disease (e.g., GOLD stage 3-4 COPD, home oxygen therapy)
- Severe hepatic failure or end-stage renal disease requiring dialysis
- Pregnancy
- Inability to provide informed consent or follow-up
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Adıyaman University Training and Research Hospital
Adıyaman, Adıyaman Province, 02200
About this study
This randomized controlled trial aims to evaluate the impact of Ultra-Fast-Track (UFT) anesthesia on postoperative recovery in patients undergoing elective coronary artery bypass grafting (CABG). UFT anesthesia targets extubation in the operating room or within the first hour after surgery, whereas standard care involves transfer to the intensive care unit (ICU) with subsequent extubation according to routine protocols. A total of 100 patients will be randomized in a 1:1 ratio. The primary outcome is the maximum Vaso-Inotropic Score (VIS) within the first 24 postoperative hours. Secondary outcomes include postoperative pain scores (VAS), Quality of Recovery-15 (QoR-15) scores, opioid and analgesic requirements, ICU and hospital length of stay, time to mobilization, and postoperative complications. This study seeks to determine whether UFT anesthesia can safely reduce inotropic support requirements and enhance early recovery following CABG.
Read the detailed description
Coronary artery bypass grafting (CABG) is the most frequently performed cardiac surgical procedure and remains the gold standard for the treatment of advanced coronary artery disease. While CABG restores myocardial perfusion and relieves ischemic symptoms, the postoperative period is often associated with prolonged mechanical ventilation, increased risk of complications, higher costs, and delayed recovery.
Ultra-Fast-Track (UFT) anesthesia is a perioperative strategy that aims to achieve extubation either in the operating room or within the first postoperative hour. Previous studies have demonstrated that fast-track and UFT protocols may shorten intensive care unit (ICU) length of stay, reduce postoperative complications, and improve recovery, without compromising patient safety. However, the influence of UFT anesthesia on inotropic support requirements, recovery quality, and analgesic needs in patients undergoing CABG has not been fully clarified.
In this prospective, randomized, controlled clinical trial, 100 patients scheduled for elective CABG will be randomly assigned to one of two groups:
UFT group: patients will undergo standard general anesthesia for cardiac surgery and will be extubated in the operating room or within one hour postoperatively before ICU transfer.
Standard care group: patients will undergo the same anesthesia protocol but will remain intubated upon ICU admission, with extubation performed according to routine ICU protocols.
The primary endpoint is the maximum Vaso-Inotropic Score (VIS) recorded during the first 24 hours after surgery. Secondary endpoints include postoperative pain scores (VAS), opioid and analgesic requirements, Quality of Recovery-15 (QoR-15) scores at 24 and 72 hours, ICU and hospital length of stay, time to mobilization, and the incidence of postoperative complications such as reintubation, pneumonia, atrial fibrillation, and acute kidney injury.
This study is designed to provide high-quality evidence on whether UFT anesthesia can safely decrease inotropic support requirements, enhance postoperative recovery, and reduce ICU stay in patients undergoing CABG.
- Being tested
- Ultra-Fast-Track Anesthesia, Standart care anesthesia
- Keywords
- Coronary Artery Bypass Graft (CABG), ultra- fast track anesthesia, Vaso-Inotropic Score (VIS), Postoperative recovery, Cardiac anesthesia
- Medical subject headings
- Coronary Artery Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultra-Fast-Track AnesthesiaProcedure or surgery
General anesthesia for cardiac surgery followed by planned extubation in the operating room or within the first postoperative hour before ICU transfer.
Standart care anesthesiaProcedure or surgery
Extubation will be targeted in the ICU according to respiratory effort.
| Study group | Role | What they receive |
|---|---|---|
| Ultra-Fast-Track Anesthesia group | Experimental | Patients will receive standard general anesthesia for cardiac surgery. Extubation will be targeted in the operating room or within the first postoperative hour before ICU transfer. Receives: Procedure: Ultra-Fast-Track Anesthesia |
| Standard care group | Active comparator | Patients will receive standard general anesthesia for cardiac surgery. They will remain intubated upon ICU admission and will be extubated according to routine ICU protocols. Receives: Procedure: Standart care anesthesia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Vaso-Inotropic Score (VIS)
The Vaso-Inotropic Score (VIS) will be calculated hourly based on recorded inotrope and vasopressor infusion rates using the standard VIS calculation method. The primary outcome is the maximum (peak) VIS value observed during the first 24 postoperative hours. VIS values will be extracted from infusion charts and/or electronic medical records.
Measured: From the end of surgery (0 hour) up to 24 hours postoperatively, with hourly assessments
Secondary outcomes (2)
Quality of Recovery (QoR-15) score
Assessed using the validated QoR-15 questionnaire to evaluate patient-reported recovery, including physical comfort, emotional state, and pain.
Measured: 24 hour postoperatively
Postoperative pain score (VAS)
Visual Analog Scale (VAS); range: 0-10, where higher scores indicate worse pain.
Measured: Postoperative 2, 4, 6, 8, 12, and 24 hours (within the first 24 hours after surgery)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Oct 2025
- Study start1 Oct 2025
- Primary completion15 Dec 2025
- Study completion31 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Coronary Artery DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study is a prospective, randomized, controlled, parallel assignment trial with two groups. Participants undergoing elective coronary artery bypass grafting (CABG) will be randomized in a 1:1 ratio to either Ultra-Fast-Track anesthesia with early extubation (intervention group) or standard extubation in the intensive care unit (control group).
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- Adiyaman University Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nezir Yılmaz, Adiyaman University Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07207421
- Sponsor's protocol ID
- ADYU-ANS-NY-012
- Status last verified
- Feb 2026
- First submitted
- 19 Sep 2025
- Last updated
- 10 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 10 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Ultra-Fast-Track Cardiac Anesthesia in Coronary Artery Bypass Grafting Surgery
- ClinicalTrials.gov ID
- NCT07207421
- Acronym / sponsor ID
- ADYU-ANS-NY-012
- Keywords
- Coronary Artery Bypass Graft (CABG), ultra- fast track anesthesia, Vaso-Inotropic Score (VIS), Postoperative recovery, Cardiac anesthesia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- Adiyaman University Research HospitalUniversity, hospital or other
- Study start
- 1 Oct 2025 (actual)
- Primary completion
- 15 Dec 2025 (actual)
- Study completion
- 31 Dec 2025 (actual)
- First posted
- 6 Oct 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial aims to evaluate the impact of Ultra-Fast-Track (UFT) anesthesia on postoperative recovery in patients undergoing elective coronary artery bypass grafting (CABG). UFT anesthesia targets extubation in the operating room or within the first hour after surgery, whereas standard care involves transfer to the intensive care unit (ICU) with subsequent extubation according to routine protocols. A total of 100 patients will be randomized in a 1:1 ratio. The primary outcome is the maximum Vaso-Inotropic Score (VIS) within the first 24 postoperative hours. Secondary outcomes include postoperative pain scores (VAS), Quality of Recovery-15 (QoR-15) scores, opioid and analgesic requirements, ICU and hospital length of stay, time to mobilization, and postoperative complications. This study seeks to determine whether UFT anesthesia can safely reduce inotropic support requirements and enhance early recovery following CABG.
Detailed description
Coronary artery bypass grafting (CABG) is the most frequently performed cardiac surgical procedure and remains the gold standard for the treatment of advanced coronary artery disease. While CABG restores myocardial perfusion and relieves ischemic symptoms, the postoperative period is often associated with prolonged mechanical ventilation, increased risk of complications, higher costs, and delayed recovery.
Ultra-Fast-Track (UFT) anesthesia is a perioperative strategy that aims to achieve extubation either in the operating room or within the first postoperative hour. Previous studies have demonstrated that fast-track and UFT protocols may shorten intensive care unit (ICU) length of stay, reduce postoperative complications, and improve recovery, without compromising patient safety. However, the influence of UFT anesthesia on inotropic support requirements, recovery quality, and analgesic needs in patients undergoing CABG has not been fully clarified.
In this prospective, randomized, controlled clinical trial, 100 patients scheduled for elective CABG will be randomly assigned to one of two groups:
UFT group: patients will undergo standard general anesthesia for cardiac surgery and will be extubated in the operating room or within one hour postoperatively before ICU transfer.
Standard care group: patients will undergo the same anesthesia protocol but will remain intubated upon ICU admission, with extubation performed according to routine ICU protocols.
The primary endpoint is the maximum Vaso-Inotropic Score (VIS) recorded during the first 24 hours after surgery. Secondary endpoints include postoperative pain scores (VAS), opioid and analgesic requirements, Quality of Recovery-15 (QoR-15) scores at 24 and 72 hours, ICU and hospital length of stay, time to mobilization, and the incidence of postoperative complications such as reintubation, pneumonia, atrial fibrillation, and acute kidney injury.
This study is designed to provide high-quality evidence on whether UFT anesthesia can safely decrease inotropic support requirements, enhance postoperative recovery, and reduce ICU stay in patients undergoing CABG.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This study is a prospective, randomized, controlled, parallel assignment trial with two groups. Participants undergoing elective coronary artery bypass grafting (CABG) will be randomized in a 1:1 ratio to either Ultra-Fast-Track anesthesia with early extubation (intervention group) or standard extubation in the intensive care unit (control group).
| Arm | Type | Receives |
|---|---|---|
| Ultra-Fast-Track Anesthesia group | Experimental | Procedure: Ultra-Fast-Track AnesthesiaPatients will receive standard general anesthesia for cardiac surgery. Extubation will be targeted in the operating room or within the first postoperative hour before ICU transfer. |
| Standard care group | Active comparator | Procedure: Standart care anesthesiaPatients will receive standard general anesthesia for cardiac surgery. They will remain intubated upon ICU admission and will be extubated according to routine ICU protocols. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Adults aged ≥18 years undergoing elective coronary artery bypass grafting (CABG)
- Patients suitable for Ultra-Fast-Track anesthesia as determined by the anesthesia team
- Ability to provide written informed consent
Key exclusion criteria (6 listed)
- Emergency CABG or combined cardiac procedures (e.g., valve surgery)
- Preoperative shock or requirement for mechanical ventilation
- Severe pulmonary disease (e.g., GOLD stage 3-4 COPD, home oxygen therapy)
- Severe hepatic failure or end-stage renal disease requiring dialysis
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultra-Fast-Track AnesthesiaGeneral anesthesia for cardiac surgery followed by planned extubation in the operating room or within the first postoperative hour before ICU transfer. | Procedure or surgery | Ultra-Fast-Track Anesthesia group |
| Standart care anesthesiaExtubation will be targeted in the ICU according to respiratory effort. | Procedure or surgery | Standard care group |
Primary outcome
Vaso-Inotropic Score (VIS)
Time frame: From the end of surgery (0 hour) up to 24 hours postoperatively, with hourly assessments
The Vaso-Inotropic Score (VIS) will be calculated hourly based on recorded inotrope and vasopressor infusion rates using the standard VIS calculation method. The primary outcome is the maximum (peak) VIS value observed during the first 24 postoperative hours. VIS values will be extracted from infusion charts and/or electronic medical records.
2 secondary outcomes
Quality of Recovery (QoR-15) score
Time frame: 24 hour postoperatively
Postoperative pain score (VAS)
Time frame: Postoperative 2, 4, 6, 8, 12, and 24 hours (within the first 24 hours after surgery)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Feb 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ultra-Fast-Track Anesthesia and Standart care anesthesia in people with Coronary Artery Disease and Coronary Artery Bypass Graft (CABG), run by Adiyaman University Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Vaso-Inotropic Score (VIS) (time frame: From the end of surgery (0 hour) up to 24 hours postoperatively, with hourly assessments). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Feb 2026; AzTrials last refreshed its copy on 26 Oct 2026.