PterygiumNCT07198126
Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft Transplantation
A study testing Pterygium Excision with Conjunctival Autograft in people with Pterygium and Corneal Astigmatism, run by Mughal Eye Trust Hospital at 1 site in Pakistan.
Trial summary
Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea. This growth can cause redness, irritation, blurred vision, and, in advanced cases, changes in the curvature of the cornea leading to distorted… Read more about this study
- Who is it for?
- Ages 30 to 70 years
- Conditions the study is for
- Pterygium, Corneal Astigmatism
- What is being tested?
- Pterygium Excision with Conjunctival Autograft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 130 participants
- Where
- 1 sitePakistan
- Study dates
- 30 Aug 2025to 28 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults of either sex aged >30 to 70 years.
- Phakic eyes.
- Primary pterygium, Grade II or Grade III (as per protocol grading).
- Presence of corneal astigmatism on pre-operative assessment.
- Scheduled for pterygium excision with conjunctival autograft transplantation at the study site.
- Able to provide written informed consent and to attend the 1-month postoperative assessment.
Who cannot join
- Pseudophakic or aphakic eyes.
- Recurrent pterygium.
- Prior keratoplasty or trabeculectomy in the study eye.
- Keratoconus or other corneal pathologies that can independently induce astigmatism.
- Lenticular astigmatism or significant lens pathology affecting refraction.
- Eyes planned for simple pterygium excision without conjunctival autograft.
- Any ocular condition or systemic illness judged likely to interfere with keratometric or refractive measurements, follow-up, or surgical safety.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea. This growth can cause redness, irritation, blurred vision, and, in advanced cases, changes in the curvature of the cornea leading to distorted vision (astigmatism). The condition is more frequent in people exposed to sunlight, dust, and dry environments.
The standard treatment for symptomatic pterygium is surgical removal. However, simple removal has a high chance of recurrence. To reduce this risk, surgeons commonly use a technique called conjunctival autograft transplantation, where a small piece of the patient's own conjunctiva is placed over the area after excision. This method not only lowers the recurrence rate but may also improve vision by reducing corneal irregularities.
Read more
This study is designed to measure the changes in corneal curvature (keratometric readings) before and after pterygium excision with conjunctival autograft transplantation. By comparing preoperative and postoperative measurements, the study aims to determine how much this surgery improves corneal shape and reduces astigmatism.
The hypothesis is that pterygium excision with conjunctival autograft transplantation will lead to a significant improvement in keratometric readings and reduce irregular astigmatism, thereby improving visual quality.
This research will provide local evidence of the effectiveness of this procedure and help guide treatment strategies for patients suffering from pterygium-related visual problems.
- Conditions
- Pterygium, Corneal Astigmatism
- Being tested
- Pterygium Excision with Conjunctival Autograft
- Keywords
- Pterygium excision, Astigmatism correction, Conjunctival autograft transplantation, Refractive error
- Medical subject headings
- Pterygium, Astigmatism, Refractive Errors
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Pterygium Excision with Conjunctival AutograftProcedure or surgery
Excision of primary Grade II or Grade III pterygium Conjunctival autograft harvested and transplanted at the excision site Graft secured with sutures
| Study group | Role | What they receive |
|---|---|---|
| Group Pterygium Excision with Conjunctival Autograft | Experimental | Patients will undergo surgical excision of pterygium followed by conjunctival autograft transplantation. The autograft will be harvested from the superior bulbar conjunctiva and secured at the excision site using sutures. Receives: Procedure: Pterygium Excision with Conjunctival Autograft |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Keratometric Readings (K1 and K2)
Keratometric readings, including the flat meridian (K1) and steep meridian (K2) of the anterior corneal surface, will be measured using a manual keratometer. The mean change in K-readings (measured in diopters) from baseline (pre-operative) to post-operative assessment will be calculated to evaluate corneal curvature improvement following pterygium excision with conjunctival autograft.
Measured: Baseline (pre-operative) and 1 month post-operative.
Secondary outcomes (1)
Change in Astigmatism
Astigmatism will be measured using an automated refractometer. Both type (regular/irregular, with-the-rule/against-the-rule) and degree of astigmatism (in diopters) will be recorded. The reduction in astigmatism from baseline to post-operative follow-up will be assessed.
Measured: Baseline (pre-operative) and 1 month post-operative.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Sep 2025
- Study start30 Aug 2025
- Primary completion28 Feb 2026 (estimated)
- Study completion28 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PterygiumStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 130 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mughal Eye Trust Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ayeza Nadeem Butt, Mughal Eye Trust Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07198126
- Sponsor's protocol ID
- MughalETH1
- Status last verified
- Sep 2025
- First submitted
- 21 Sep 2025
- Last updated
- 30 Sep 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Of Keratometric Readings Pre and Post Pterygium Excision With Conjunctival Autograft Transplantation
- ClinicalTrials.gov ID
- NCT07198126
- Acronym / sponsor ID
- MughalETH1
- Conditions
- Pterygium, Corneal Astigmatism
- Keywords
- Pterygium excision, Astigmatism correction, Conjunctival autograft transplantation, Refractive error
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 130 participants (estimated)
- Lead sponsor
- Mughal Eye Trust HospitalUniversity, hospital or other
- Study start
- 30 Aug 2025 (actual)
- Primary completion
- 28 Feb 2026 (estimated)
- Study completion
- 28 Feb 2026 (estimated)
- First posted
- 30 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Pterygium, often called "surfer's eye," is a common eye condition in which a raised, fleshy growth of tissue extends from the white part of the eye onto the clear cornea. This growth can cause redness, irritation, blurred vision, and, in advanced cases, changes in the curvature of the cornea leading to distorted vision (astigmatism). The condition is more frequent in people exposed to sunlight, dust, and dry environments.
The standard treatment for symptomatic pterygium is surgical removal. However, simple removal has a high chance of recurrence. To reduce this risk, surgeons commonly use a technique called conjunctival autograft transplantation, where a small piece of the patient's own conjunctiva is placed over the area after excision. This method not only lowers the recurrence rate but may also improve vision by reducing corneal irregularities.
This study is designed to measure the changes in corneal curvature (keratometric readings) before and after pterygium excision with conjunctival autograft transplantation. By comparing preoperative and postoperative measurements, the study aims to determine how much this surgery improves corneal shape and reduces astigmatism.
The hypothesis is that pterygium excision with conjunctival autograft transplantation will lead to a significant improvement in keratometric readings and reduce irregular astigmatism, thereby improving visual quality.
This research will provide local evidence of the effectiveness of this procedure and help guide treatment strategies for patients suffering from pterygium-related visual problems.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Group Pterygium Excision with Conjunctival Autograft | Experimental | Procedure: Pterygium Excision with Conjunctival AutograftPatients will undergo surgical excision of pterygium followed by conjunctival autograft transplantation. The autograft will be harvested from the superior bulbar conjunctiva and secured at the excision site using sutures. |
Who may qualify
- Ages
- 30 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Adults of either sex aged >30 to 70 years.
- Phakic eyes.
- Primary pterygium, Grade II or Grade III (as per protocol grading).
- Presence of corneal astigmatism on pre-operative assessment.
- Scheduled for pterygium excision with conjunctival autograft transplantation at the study site.
Key exclusion criteria (7 listed)
- Pseudophakic or aphakic eyes.
- Recurrent pterygium.
- Prior keratoplasty or trabeculectomy in the study eye.
- Keratoconus or other corneal pathologies that can independently induce astigmatism.
- Lenticular astigmatism or significant lens pathology affecting refraction.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Pterygium Excision with Conjunctival AutograftExcision of primary Grade II or Grade III pterygium Conjunctival autograft harvested and transplanted at the excision site Graft secured with sutures | Procedure or surgery | Group Pterygium Excision with Conjunctival Autograft |
Primary outcome
Change in Keratometric Readings (K1 and K2)
Time frame: Baseline (pre-operative) and 1 month post-operative.
Keratometric readings, including the flat meridian (K1) and steep meridian (K2) of the anterior corneal surface, will be measured using a manual keratometer. The mean change in K-readings (measured in diopters) from baseline (pre-operative) to post-operative assessment will be calculated to evaluate corneal curvature improvement following pterygium excision with conjunctival autograft.
1 secondary outcome
Change in Astigmatism
Time frame: Baseline (pre-operative) and 1 month post-operative.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Sep 2025.
Related trials for Pterygium
Not yet recruiting
Video-Assisted Patient Education and Eye Fixation Training in Pterygium Surgery
Pterygium, Preoperative Anxiety
Not yet recruitingPhase 4
Emerging Indications for Hyperbaric Oxygen Treatment
Post-COVID-19 Condition, Ulcerative Colitis
Active, not recruitingPhase 1
Air-Dried Human Amniotic Membrane Terminally Sterilized by Gamma Irradiation for Multidisciplinary Clinical Application
Diabetic Foot Ulcer (DFU), Ocular Disorder
RecruitingObservational study
Development of a Mobile Terminal-Based Intelligent Detection System for Multiple Anterior Segment Diseases of the Eye
Artifical Intelligence, Cataract
Recruiting
Conjunctival Transpositional Surgery for Primary Pterygium
Pterygium of the Conjunctiva and Cornea
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Pterygium Excision with Conjunctival Autograft in people with Pterygium and Corneal Astigmatism, run by Mughal Eye Trust Hospital at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 30 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Keratometric Readings (K1 and K2) (time frame: Baseline (pre-operative) and 1 month post-operative.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2025.