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Cervical ProprioceptionNCT07181798

Evaluation of Cervical Position and Movement Sense Using a Novel Computer Vision-Based Software

An observational study of Cervical Proprioception, run by Nevsehir Haci Bektas Veli University at 1 site in Turkey (Türkiye).

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record
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Trial summary

This observational study evaluates cervical proprioception using a computer vision-based system developed with OpenCV and MediaPipe. Healthy adults will perform a series of head movements while their nose tip is tracked by a camera. Read more about this study

Who is it for?
Ages 18 years and olderHealthy volunteers can take part
Conditions the study is for
Cervical Proprioception
How many people
74 participants
Where
1 siteTurkey (Türkiye)
Study dates
Sep 2025to Apr 2026
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Study population: The study population will consist of healthy adult volunteers aged 18 years and older, without any history of neck pain, spinal disorders, or other conditions affecting cervical mobility. Participants will be recruited from the general population.

Who may be able to join

  • Healthy individuals over 18 years of age
  • No neck pain

Who cannot join

  • Neck or spinal symptoms
  • History of cervical/spinal trauma or surgery
  • Chronic conditions affecting mobility
  • Visual or vestibular impairments

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Mustafa GÜVEN, Master of Science contact

0 384 471 45 75 ext. 31002

mguven1389@gmail.com

Turkey (Türkiye)1 site
  • Nevşehir Hacı Bektaş Veli University

    Nevşehir, Kozakli, 50600

    Mustafa Güven, Master of Science, 90 384 471 45 75 ext. 31002, mguven1389@gmail.com

Other trials in Turkey (Türkiye)

About this study

Official title: Evaluation of Cervical Position and Movement Sense Using Computer Vision Technology in Healthy Individuals

This observational study evaluates cervical proprioception using a computer vision-based system developed with OpenCV and MediaPipe. Healthy adults will perform a series of head movements while their nose tip is tracked by a camera. The primary objective is to assess the accuracy of neck position and movement perception. Data will be analyzed to determine the reliability of the tracking system. The study is non-invasive, involves no interventions, and poses minimal risk to participants. Findings may support the development of accessible diagnostic tools for clinical and research applications.

Read the detailed description

This study aims to assess the test-retest reliability of computer-based cervical proprioception evaluations in healthy adults using OpenCV and MediaPipe for motion tracking. Participants will be seated in a controlled environment with a computer screen at eye level. The following four evaluations will be conducted:

Cervical Joint Position Sense (Head Relocation Error): Participants attempt to reposition their head to a perceived neutral position after flexion, extension, and rotation movements. The software records the deviation in pixels between actual and perceived head positions. Six trials per movement direction will be performed, with retesting after one hour.

Cervical Movement Sense - Patterned Tracking: Participants trace on-screen shapes (e.g., F8, ZZ) with their nose tip to evaluate movement accuracy. The total deviation from the ideal path in pixels will be measured. One practice trial and recorded attempts will be conducted, with retesting after one hour.

Cervical Movement Sense - Target Tracking: Participants follow a moving on-screen target with their nose tip. Tracking accuracy and time spent inside the target will be recorded. Three trials will be performed, with retesting after one week.

Sensorimotor Control Assessment: Participants align their head with randomly appearing visual targets for one minute. Performance will be evaluated based on the number of correct alignments and response accuracy. Three trials will be conducted, with retesting after one hour.

All data will be anonymized and analyzed for reliability using Intraclass Correlation Coefficient (ICC), Standard Error of Measurement (SEM), and Minimal Detectable Change (MDC). This non-invasive, computer-based methodology aims to provide a reliable and low-cost approach to assessing cervical joint position sense, movement perception, and sensorimotor control, contributing to future clinical and research applications.

Keywords
Proprioception, Computer-Assisted Image Interpretation

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT07181798
Study groupRoleWhat they receive
Healthy Volunteer CohortA single cohort of 74 healthy adult volunteers will undergo an observational test-retest reliability study of four cervical proprioception assessments using computer-vision tracking. No medical interventions will be administered. Two distinct assessment protocols control for learning effects and follow literature-based retest intervals: Protocol A (n=37): Cervical Movement Sense Target Tracking at baseline and again after one week to assess longer-term reliability. Protocol B (n=37): Head Relocation Test in 32 participants at baseline and again after one hour. Cervical Movement Sense Patterned Tracking and Cervical Proprioceptive Function Test in all 37 participants at baseline and again after one hour to minimize short-term learning effects. Separate participant groups prevent cross-test learning, and retest intervals (1 hour vs. 1 week) align with prior studies.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Cervical Joint Position Sense (Head Relocation Error)

    With the help of algorithms, the initial position of the participant's nose tip on the screen will be recorded. Following flexion, extension, or rotation movements, the final position will be obtained, and the difference between the initial and final positions will be calculated in pixels and reported as the error score. While the primary output will be in pixels, this difference can also be expressed in degrees with the necessary conversions. Rotational movements performed during the measurement will be simultaneously recorded using the CROM device, and the values from the screen will be compared with those from the CROM to assess criterion validity, which provides the error magnitude directly in degrees. Measurements performed on the same group at two different time points will be analyzed using the Intraclass Correlation Coefficient (ICC), the Standard Error of Measurement (SEM), and Bland-Altman methods.

    Measured: The test will be repeated at 1-hour intervals.

  2. Cervical Movement Sense - Patterned Tracking

    During the test, an F8 or ZZ shaped pattern will be displayed on the screen, and the participant will trace the pattern starting from the center using their nose tip. The algorithm will track the nose tip's position in each camera frame throughout the test: if the nose tip remains within the shape, the error score will be 0; if it moves outside, the distance to the nearest point of the shape will be calculated in pixels and recorded as the instantaneous error score. At the end of the test, all instantaneous error scores will be summed to obtain the total error score. The start and finish times of the test will also be recorded to determine the total test duration. Total error scores from measurements performed on the same group at different time points will be analyzed using the Intraclass Correlation Coefficient (ICC), the Standard Error of Measurement (SEM), and Bland-Altman methods.

    Measured: The test will be repeated at 1-hour intervals.

  3. Cervical Movement Sense - Target Tracking:

    During the test, a rectangle will appear on the screen and move at a constant speed along the ZZ or F8 paths. The participant will attempt to keep their nose tip inside this moving rectangle. Since the speed is fixed, the test duration is the same for all participants.

    Scoring Methods

    Time-Based Score: The total time the nose tip remains inside the rectangle is divided by the total test duration. The resulting ratio ranges from 0 to 1:

    1 → Best score (nose tip always inside)

    0 → Worst score (nose tip never inside)

    Distance-Based Score: For each frame, the algorithm calculates the distance from the nose tip to the rectangle:

    Inside = 0

    Outside = distance in pixels to the nearest edge

    At the end, all distances are summed to obtain the total deviation score. Both scores from measurements performed on the same group at different time points will be analyzed using the Intraclass Correlation Coefficient (ICC), the Standard Error of Measurement (SEM), and Bland-Altman methods.

    Measured: The test will be repeated at 1-week intervals.

  4. Sensorimotor Control Assessment

    The test duration is 60 seconds. During this time, individual points will appear on the screen at random locations.

    The participant's task is to move their nose tip over these points. When the nose tip correctly reaches a point:

    The point will disappear,

    A new point will appear at a different location on the screen.

    At the end of the test, the number of points the participant successfully matched with their nose tip within the 60 seconds will be counted, and this value will be recorded as the test score.

    The test score obtained from measurements performed on the same group at different time points will be analyzed using the Intraclass Correlation Coefficient (ICC), the Standard Error of Measurement (SEM), and Bland-Altman methods.

    Measured: The test will be repeated at 1-hour intervals.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted18 Sep 2025
  2. Study startSep 2025 (estimated)
  3. Primary completionDec 2025 (estimated)
  4. Study completionApr 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
74 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07181798
Sponsor's protocol ID
NEVSEHIRHBVU-KMYO-MG-001
Status last verified
Sep 2025
First submitted
18 May 2025
Last updated
24 Sep 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Zou GY. Sample size formulas for estimating intraclass correlation coefficients with precision and assurance. Stat Med. 2012 Dec 20;31(29):3972-81. doi: 10.1002/sim.5466. Epub 2012 Jul 4.

    PubMed 22764084
  • Mondal D, Vanbelle S, Cassese A, Candel MJ. Review of sample size determination methods for the intraclass correlation coefficient in the one-way analysis of variance model. Stat Methods Med Res. 2024 Mar;33(3):532-553. doi: 10.1177/09622802231224657. Epub 2024 Feb 6.

    PubMed 38320802
  • Basteris A, Pedler A, Sterling M. Evaluating the neck joint position sense error with a standard computer and a webcam. Man Ther. 2016 Dec;26:231-234. doi: 10.1016/j.math.2016.04.008. Epub 2016 Apr 23.

    PubMed 27161883
  • Peng B, Yang L, Li Y, Liu T, Liu Y. Cervical Proprioception Impairment in Neck Pain-Pathophysiology, Clinical Evaluation, and Management: A Narrative Review. Pain Ther. 2021 Jun;10(1):143-164. doi: 10.1007/s40122-020-00230-z. Epub 2021 Jan 12.

    PubMed 33464539
  • Sarig-Bahat H, Weiss PL, Laufer Y. Cervical motion assessment using virtual reality. Spine (Phila Pa 1976). 2009 May 1;34(10):1018-24. doi: 10.1097/BRS.0b013e31819b3254.

    PubMed 19404177
  • Pinsault N, Fleury A, Virone G, Bouvier B, Vaillant J, Vuillerme N. Test-retest reliability of cervicocephalic relocation test to neutral head position. Physiother Theory Pract. 2008 Sep-Oct;24(5):380-91. doi: 10.1080/09593980701884824.

    PubMed 18821444
  • Strimpakos N, Sakellari V, Gioftsos G, Kapreli E, Oldham J. Cervical joint position sense: an intra- and inter-examiner reliability study. Gait Posture. 2006 Jan;23(1):22-31. doi: 10.1016/j.gaitpost.2004.11.019.

    PubMed 16311191
  • Werner IM, Ernst MJ, Treleaven J, Crawford RJ. Intra and interrater reliability and clinical feasibility of a simple measure of cervical movement sense in patients with neck pain. BMC Musculoskelet Disord. 2018 Oct 5;19(1):358. doi: 10.1186/s12891-018-2287-0.

    PubMed 30290759
  • Kristjansson E, Oddsdottir GL. "The Fly": a new clinical assessment and treatment method for deficits of movement control in the cervical spine: reliability and validity. Spine (Phila Pa 1976). 2010 Nov 1;35(23):E1298-305. doi: 10.1097/BRS.0b013e3181e7fc0a.

    PubMed 20975484
  • Kristjansson E, Hardardottir L, Asmundardottir M, Gudmundsson K. A new clinical test for cervicocephalic kinesthetic sensibility: "the fly". Arch Phys Med Rehabil. 2004 Mar;85(3):490-5. doi: 10.1016/s0003-9993(03)00619-1.

    PubMed 15031839
  • Hage R, Ancenay E. Identification of a relationship between cervical spine function and rotational movement control. Ann Phys Rehabil Med. 2009 Nov;52(9):653-67. doi: 10.1016/j.rehab.2009.04.003. Epub 2009 Sep 10. English, French.

    PubMed 19783494
  • Goncalves C, Silva AG. Reliability, measurement error and construct validity of four proprioceptive tests in patients with chronic idiopathic neck pain. Musculoskelet Sci Pract. 2019 Oct;43:103-109. doi: 10.1016/j.msksp.2019.07.010. Epub 2019 Jul 28.

    PubMed 31376618
  • English DJ, Zacharias A, Green RA, Weerakkody N. Reliability of Cervicocephalic Proprioception Assessment: A Systematic Review. J Manipulative Physiol Ther. 2022 Jun;45(5):346-357. doi: 10.1016/j.jmpt.2022.08.005. Epub 2022 Oct 19.

    PubMed 36270904
  • Sarig Bahat H, Sprecher E, Sela I, Treleaven J. Neck motion kinematics: an inter-tester reliability study using an interactive neck VR assessment in asymptomatic individuals. Eur Spine J. 2016 Jul;25(7):2139-48. doi: 10.1007/s00586-016-4388-5. Epub 2016 Jan 30.

    PubMed 26831536

Questions about this trial

What is this clinical trial studying?

An observational study of Cervical Proprioception, run by Nevsehir Haci Bektas Veli University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 24 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Mustafa GÜVEN, Master of Science (0 384 471 45 75 ext. 31002, mguven1389@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Cervical Joint Position Sense (Head Relocation Error) (time frame: The test will be repeated at 1-hour intervals.). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07181798, which also lists 14 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Sep 2025.

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