MeditationNCT07165795
Pilot Study to Evaluate the Effect of Transcendental Meditation on Telomere Activity and Well-Being Among Nurse Managers
A study testing Transcendental Meditation in people with Meditation, run by Sarasota Memorial Health Care System at 1 site in United States.
Trial summary
The objective of this study is to evaluate the impact of a health and coping strategy (Transcendental Meditation, or TM) on Telomere Length and Telomerase Activity (known markers of physiological and psychological stress and aging), Perceived Stress, Work Life Balance, Flourishing, Power as Knowing Participation in… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Meditation
- What is being tested?
- Transcendental Meditation
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 18 May 2025to May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Nurse managers within the Sarasota Memorial Health Care System (SMHCS);
- Stable for at least two months on any prescribed medications (for example, anti-anxiety or anti-depressant medications)
Who cannot join
- prior instruction in the TM technique
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
Sarasota Memorial Health Care System
Sarasota, Florida, 34239
About this study
The objective of this study is to evaluate the impact of a health and coping strategy (Transcendental Meditation, or TM) on Telomere Length and Telomerase Activity (known markers of physiological and psychological stress and aging), Perceived Stress, Work Life Balance, Flourishing, Power as Knowing Participation in Change, and Burnout, among nurse managers.
Aim 1: To evaluate the effects of TM compared to usual care delayed instruction on TL and TA.
Aim 2: To evaluate the effects of TM compared to usual care delayed instruction on work life climate, flourishing, perceived stress, burnout, and power as knowing participation in change.
- Conditions
- Meditation
- Being tested
- Transcendental Meditation
- Keywords
- nurse manager, well-being, telomere, meditation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transcendental MeditationBehavioural
Standard TM instruction by certified TM teachers, including 4 days of initial training (60-90 min/day), then follow-up sessions (60-90 min) every 2-4 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Immediate TM Instruction | Experimental | This group will receive initial TM instruction within three weeks of baseline assessments with follow-up interventions every 2-4 weeks and an expectation of home practice of two 20min meditation sessions per day. Receives: Behavioral: Transcendental Meditation |
| Control Group (delayed instruction) | No intervention | This group will be eligible to receive TM instruction upon completion of the final 4-month assessments, and asked to continue with routine activities throughout study. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Telomere Length
T/S ratio; processed by UCSF Blackburn Labs SOP #104D
Measured: baseline, 1-month, 4-months
Telomerase Activity
(# positive copies/10,000 input cells) ; processed by UCSF Blackburn Labs SOP #104D
Measured: baseline, 1-month, 4-months
Secondary outcomes (5)
Work-Life Climate Scale
(Sexton, et al., 2017); measures work/life balance; responses range from 0-4; survey scores range 0-32, with lower scores reflecting better work/life balance.
Measured: baseline, 1-month, 4-months
Secure Flourishing Index, SFI
(Weziak-Bialowolska et al., 2019); measures multidimensional well-being; survey scores range from 0-120, with higher scores reflecting a higher level of flourishing.
Measured: baseline, 1-month, 4-months
Perceived Stress Scale-10 (PSS10)
(Cohen, 1988); measures the perception of stressful thoughts and feelings in preceding month; responses range from 0-40 with higher scores indicating higher levels of stress.
Measured: baseline, 1-month, 4-months
Maslach Burnout Inventory Human Services Survey for Medical Personnel
(Maslach \& Jackson, 1984); Consists of three subscales: Emotional Exhaustion (9-items, score range 0-54, higher scores indicate more emotional exhaustion); Depersonalization (5-items, score range 0-18, higher scores indicate more depersonalization); and Personal Accomplishment (8-items, score range 0-48, higher scores indicate higher level of personal accomplishment).
Measured: baseline, 1-month, 4-months
Power as Knowing Participation in Change (PKPCT)
Barrett (1983, 1984, 2010); Scores range from 48-336 in four subscales with higher scores indicating higher levels of perceived power.
Measured: baseline, 1-month, 4-months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Sep 2025
- Study start18 May 2025
- Primary completionMay 2027 (estimated)
- Study completionMay 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MeditationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study is a two-group randomized clinical trial (intervention and control groups) pilot study consisting of 30 nurse managers, with 15 nursing managers randomly assigned to each group.
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sarasota Memorial Health Care System
- Sponsor type
- University, hospital or other
- Collaborators
- Florida Atlantic University
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07165795
- Sponsor's protocol ID
- 2288149-1
- Status last verified
- Sep 2025
- First submitted
- 30 Jun 2025
- Last updated
- 10 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pilot Study to Evaluate the Effect of Transcendental Meditation on Telomere Activity and Well-Being Among Nurse Managers
- ClinicalTrials.gov ID
- NCT07165795
- Acronym / sponsor ID
- 2288149-1
- Conditions
- Meditation
- Keywords
- nurse manager, well-being, telomere, meditation
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Sarasota Memorial Health Care SystemUniversity, hospital or other
- Collaborators
- Florida Atlantic University
- Study start
- 18 May 2025 (actual)
- Primary completion
- May 2027 (estimated)
- Study completion
- May 2027 (estimated)
- First posted
- 10 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this study is to evaluate the impact of a health and coping strategy (Transcendental Meditation, or TM) on Telomere Length and Telomerase Activity (known markers of physiological and psychological stress and aging), Perceived Stress, Work Life Balance, Flourishing, Power as Knowing Participation in Change, and Burnout, among nurse managers.
Aim 1: To evaluate the effects of TM compared to usual care delayed instruction on TL and TA.
Aim 2: To evaluate the effects of TM compared to usual care delayed instruction on work life climate, flourishing, perceived stress, burnout, and power as knowing participation in change.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This study is a two-group randomized clinical trial (intervention and control groups) pilot study consisting of 30 nurse managers, with 15 nursing managers randomly assigned to each group.
| Arm | Type | Receives |
|---|---|---|
| Immediate TM Instruction | Experimental | Behavioral: Transcendental MeditationThis group will receive initial TM instruction within three weeks of baseline assessments with follow-up interventions every 2-4 weeks and an expectation of home practice of two 20min meditation sessions per day. |
| Control Group (delayed instruction) | No intervention | –This group will be eligible to receive TM instruction upon completion of the final 4-month assessments, and asked to continue with routine activities throughout study. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Nurse managers within the Sarasota Memorial Health Care System (SMHCS);
- Stable for at least two months on any prescribed medications (for example, anti-anxiety or anti-depressant medications)
Key exclusion criteria (1 listed)
- prior instruction in the TM technique
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transcendental MeditationStandard TM instruction by certified TM teachers, including 4 days of initial training (60-90 min/day), then follow-up sessions (60-90 min) every 2-4 weeks. | Behavioural | Immediate TM Instruction |
Primary outcome
Telomere Length
Time frame: baseline, 1-month, 4-months
T/S ratio; processed by UCSF Blackburn Labs SOP #104D
Telomerase Activity
Time frame: baseline, 1-month, 4-months
(# positive copies/10,000 input cells) ; processed by UCSF Blackburn Labs SOP #104D
5 secondary outcomes
Work-Life Climate Scale
Time frame: baseline, 1-month, 4-months
Secure Flourishing Index, SFI
Time frame: baseline, 1-month, 4-months
Perceived Stress Scale-10 (PSS10)
Time frame: baseline, 1-month, 4-months
Maslach Burnout Inventory Human Services Survey for Medical Personnel
Time frame: baseline, 1-month, 4-months
Power as Knowing Participation in Change (PKPCT)
Time frame: baseline, 1-month, 4-months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2025.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Transcendental Meditation in people with Meditation, run by Sarasota Memorial Health Care System at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 10 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Telomere Length (time frame: baseline, 1-month, 4-months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2025.