Metabolic Dysfunction-Associated Steatotic Liver DiseasePhase 3NCT07165028
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
A Phase 3 study testing Tirzepatide and Retatrutide in people with Metabolic Dysfunction-Associated Steatotic Liver Disease, run by Eli Lilly and Company at 563 sites in 34 countries.
Trial summary
The main purpose of the SYNERGY-OUTCOMES study is to find out whether retatrutide and tirzepatide can prevent major adverse liver outcomes (MALO) in people with high-risk metabolic dysfunction-associated steatotic liver disease (MASLD). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Metabolic Dysfunction-Associated Steatotic Liver Disease
- What is being tested?
- Tirzepatide and Retatrutide
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 4,500 participants
- Where
- 563 sitesin 34 countries
- Study dates
- 15 Oct 2025to Aug 2032
- Phase
- Phase 3
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Have liver fat content ≥8%
- Have ELF score of ≥9 and ≤10.8 at screening
- Have VCTE LSM ≥10 kilopascal (kPa) and <20 kPa at screening
Who cannot join
- Have any other type of liver disease other than MASLD
- Have a body mass index (BMI) <25 kilogram per square meter (kg/m2)
- Prior decompensated liver disease (history of esophageal/gastric varices, ascites, hepatic encephalopathy)
- Have lost more than 11 pounds within the 3 months prior to screening
- Have a hemoglobin A1c (HbA1c) greater than 10%
- Have type 1 diabetes
Trial locations and contacts
563 sites in 34 countries. Contact the study team or a site near you to ask about taking part.
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or contact
Physicians interested in becoming principal investigators please contact contact
563 sites in 34 countries
United States141 sites, 141 recruiting
- Recruiting
Akron Gastro Research
Akron, Ohio, 44320
Ganesh Veerappan
- Recruiting
Southwest Gastroenterology Associates
Albuquerque, New Mexico, 87109
Antoine Jakiche
- Recruiting
University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045
303-724-4651
Neda Rasouli
- Recruiting
IMA Clinical Research Austin
Austin, Texas, 78745
512-649-0082
Nomita Kim
- Recruiting
American Research Corporation
Austin, Texas, 78757
210-253-3426
Carmen Landaverde
- Recruiting
Pinnacle Clinical Research
Austin, Texas, 78757
512-384-1460 x3001
Rohit Puskoor
- Recruiting
Mercy Medical Center - Baltimore
Baltimore, Maryland, 21202
410-332-9356
Paul Thuluvath
- Recruiting
Delta Research Partners of Bastrop, LLC
Bastrop, Louisiana, 71220
318-281-6040
Bal Raj Bhandari
- Recruiting
Dayton Gastroenterology - Beavercreek
Beavercreek, Ohio, 45440
937-320-5050
Rupa Fritz
- Recruiting
Bellaire Clinical Research
Bellaire, Texas, 77401
Michael Hansen
- Recruiting
Washington Gastroenterology - Bellevue
Bellevue, Washington, 98004
425-454-4768
Nicholas Procaccini
- Not yet recruiting
Clinical Research Institute of Ohio - Brooklyn
Brooklyn, Ohio, 44144
440-363-4000
Naim Alkhouri
- Recruiting
South Texas Research Institute - Brownsville
Brownsville, Texas, 78520
956-468-3360
Dimple Desai
- Recruiting
Headlands Horizons, LLC dba Headlands Research-Brownsville
Brownsville, Texas, 78526
Rani Rabah
- Recruiting
Research Foundation of SUNY - University of Buffalo
Buffalo, New York, 14203
716-535-1850
Ajay Chaudhuri
- Recruiting
San Fernando Valley Health Institute
Canoga Park, California, 91304
818-222-6868
Jeffrey London
- Recruiting
The Institute for Liver Health II dba Arizona Clinical Trials - Chandler
Chandler, Arizona, 85224
Yessica Sachdeva
- Recruiting
CAMC Health Education and Research Institute Inc
Charleston, West Virginia, 25304
304-388-9944
Ebubekir Daglilar
- Recruiting
Galen Medical Group - Galen Hepatology
Chattanooga, Tennessee, 37421
423-954-9015
Chirag Patel
- Recruiting
Capital Digestive Care - Chevy Chase
Chevy Chase, Maryland, 20815
301-841-6869
Mohammed Ali
- Not yet recruiting
University of Chicago Medical Center
Chicago, Illinois, 60637
Mary Rinella
- Recruiting
K2 Medical Research WINTER GARDEN
Clermont, Florida, 34711
407-426-9299
Beatriz Colon
- Recruiting
Clinical Research Institute of Michigan, LLC
Clinton Township, Michigan, 48038
586-598-3329
Kyle Antosiek
- Recruiting
Columbia Digestive Health Research
Columbia, South Carolina, 29204
Edward Kimbrough
- Recruiting
Gastro One (Walnut Run Road)
Cordova, Tennessee, 38018
Ziad Younes
- Recruiting
Southeast Clinical Research Center
Dalton, Georgia, 30720
706-913-1779
Pablo Perez
- Recruiting
K2 Medical Research - Daytona Beach
Daytona Beach, Florida, 32114
Joshua Eisenhut
- Recruiting
Care Access - Delray Beach
Delray Beach, Florida, 33484
401-773-7855
Sudhir Bansal
- Recruiting
Soma Clinical Trials
Denison, Texas, 75020
469-819-0228
Hesham Elgouhari
- Recruiting
Epic Medical Research - DeSoto
DeSoto, Texas, 75115
197-277-7695
HARESH BOGHARA
- Recruiting
AMR Clinical
Doral, Florida, 33172
Abid Chaudhry
- Recruiting
Duke University - Main Hospital and Clinics
Durham, North Carolina, 27710
Anastasia-Stefania Alexopoulos
- Recruiting
South Texas Research Institute
Edinburg, Texas, 78539
956-468-3360
Dimple Desai
- Recruiting
AMR Clinical
El Dorado, Kansas, 67042
316-600-5127 EXT 301
Michael Rausch
- Recruiting
South Denver Gastroenterology
Englewood, Colorado, 80113
Marcelo Kugelmas
- Recruiting
Dallas Research Institute
Farmers Branch, Texas, 75234
214-347-7577
Pedro Castillo
- Recruiting
US Digestive Health - Flourtown
Flourtown, Pennsylvania, 19031
215-664-4362
Victor Araya
- Recruiting
GI Associates - GIA and Endoscopy Center - Flowood
Flowood, Mississippi, 39232
601-863-0395
Ralph Vance
- Recruiting
Care United Research, LLC
Forney, Texas, 75126
972-564-0044
Shilpi Mittal
- Recruiting
Southwest General Healthcare Center
Fort Myers, Florida, 33907
239-931-3368
Jose Rodriguez
- Recruiting
GI Alliance - Fort Worth
Fort Worth, Texas, 76104
817-612-5575
Kumar Gutta
- Recruiting
Ark Clinical Research - Fountain Valley
Fountain Valley, California, 92708
714-988-2021
Mark Leibowitz
- Recruiting
Tandem Clinical Research - Freehold
Freehold, New Jersey, 07728
Colin Brown
- Recruiting
Fresno Clinical Research Center
Fresno, California, 93720
559-970-3441
Muhammad Sheikh
- Recruiting
University of Florida College of Medicine
Gainesville, Florida, 32610
352-273-8662
Kenneth Cusi
- Recruiting
Spectrum Research Institute
Gilbert, Arizona, 85297
Donna DeSantis
- Recruiting
Medical Research Center of Connecticut
Hamden, Connecticut, 06518
Paul Feuerstadt
- Recruiting
Encore Medical Research
Hollywood, Florida, 33024
954-400-1725
Rodolfo Perez
- Recruiting
HRI- Medical Center
Houston, Texas, 77004
Joseph Galati
- Recruiting
Care Access - Houston
Houston, Texas, 77054
877-791-0656
Ali Bajwa
- Recruiting
Houston Research Institute
Houston, Texas, 77079
281-809-3234
David Huang
- Recruiting
Biopharma Informatic, LLC
Houston, Texas, 77084
281-944-3610
James Arthur Maher Jr., MD
- Recruiting
Research Physicians Network, LLC
Houston, Texas, 77089
281-944-3610
Amir Hassan
- Recruiting
Indiana University Health University Hospital
Indianapolis, Indiana, 46202
317-278-1652
Raj Vuppalanchi
- Recruiting
Nature Coast Clinical Research - Inverness
Inverness, Florida, 34452
352-341-2100
Paul Hellstern
- Recruiting
Encore Borland-Groover Clinical Research
Jacksonville, Florida, 32256
904-680-0871
Nikhil Kapila
- Recruiting
Health Awareness
Jupiter, Florida, 33458
Mitchell Davis
- Recruiting
AMR Clinical
Kansas City, Missouri, 64114
Martha Fanning
- Recruiting
UCSD - Altman Clinical and Translational Research Institute (ACTRI)
La Jolla, California, 92037
858-246-2227
Rohit Loomba
- Recruiting
K2 MEDICAL Research THE VILLAGES
Lady Lake, Florida, 32159
352-500-5252
Craig Curtis
- Recruiting
Orange County Research Center
Lake Forest, California, 92630
714-550-9990
JOEL NEUTEL
- Recruiting
Florida Research Institute
Lakewood Rch, Florida, 34211
941-727-7772
Manuel Rodriguez
- Recruiting
Om Research LLC
Lancaster, California, 93534
661-388-2239
Jatinder Pruthi
- Recruiting
Tampa Bay Medical Research - Largo
Largo, Florida, 33777
727-724-3316
Sureka Bollepalli
- Recruiting
Jubilee Clinical Research NV. LLC
Las Vegas, Nevada, 89106
702-631-5000
Elliot Shin
- Recruiting
Excel Clinical Research, LLC
Las Vegas, Nevada, 89109
702-680-1500
Robby Quintos
- Recruiting
Johnson County Clinical Trials
Lenexa, Kansas, 66219
Thomas Kreamer
- Recruiting
AMR Clinical
Lexington, Kentucky, 40509
Peter Akpunonu
- Recruiting
Ark Clinical Research
Long Beach, California, 90815
562-997-1000
Apinya Vutikullird
- Recruiting
Los Angeles Institute for Metabolic Research
Los Angeles, California, 90015
213-373-8380
Juan Frias
- Recruiting
Gastrointestinal Specialists of Georgia
Marietta, Georgia, 30060
404-786-3100
Aasim Sheikh
- Recruiting
Tandem Clinical Research
Marrero, Louisiana, 70072
504-934-8424
Gary Reiss
- Recruiting
Biopharma Informatic, LLC
McAllen, Texas, 78503
281-944-3610
Ralph Alhalel, MD
- Recruiting
DHR Health Institute for Research and Development (Administrative Office & Laboratory)
McAllen, Texas, 78504
956-362-2390
Henry Herrera
- Recruiting
Southern Endocrinology Associates
Mesquite, Texas, 75149
214-693-0904
Sumana Gangi
- Recruiting
Evolution Clinical Trials
Miami, Florida, 33122-1722
786-706-1216
Gilberto Perez
- Recruiting
Floridian Clinical Research, LLC
Miami Lakes, Florida, 33016-1518
305-330-9977
William Sanchez
- Recruiting
MNGI Digestive Health
Minneapolis, Minnesota, 55413
Ibrahim Hanouneh
- Recruiting
Monroe Biomedical Research
Monroe, North Carolina, 28112
704-283-7359
Awawu Igbinadolor
- Recruiting
Carteret Medical Group
Morehead City, North Carolina, 28557
252-499-8623
Mary Lawrence
- Not yet recruiting
Atlantic Health System Morristown Medical Center
Morristown, New Jersey, 07960
973-971-7507
Ravish Parekh
- Recruiting
United Medical Doctors - Murrieta
Murrieta, California, 92563
951-566-5229
John Jong Bae Hong
- Recruiting
GI PROS Research
Naples, Florida, 34102
239-571-0899
Raymond Phillips
- Recruiting
Gastroenterology Health Partners
New Albany, Indiana, 47150
812-206-1702
Jonathan Obert
- Recruiting
Lucida Clinical Trials
New Bedford, Massachusetts, 02740
Jason Reich
- Recruiting
Care Access - New Iberia
New Iberia, Louisiana, 70560
813-851-0135
Son Nguyen
- Recruiting
NYU Langone Health
New York, New York, 10016
646-501-2948
Ira Jacobson
- Recruiting
IMA Clinical Research Manhattan
New York, New York, 10036
Samar Hameed
- Recruiting
New York Gastroenterology Associates
New York, New York, 10075
Jennifer Leong
- Recruiting
Deaconess Clinic- Gateway
Newburgh, Indiana, 47630
812-490-4505
Mia Hindi
- Recruiting
Eximia Research - Norfolk
Norfolk, Virginia, 23502
John Smith
- Recruiting
Arkansas Gastroenterology - North Little Rock
North Little Rock, Arkansas, 72117
Samuel Dunn
- Recruiting
Care Access - Ogden
Ogden, Utah, 84403
801-614-0010
Chad Gonzales
- Recruiting
Knowledge Research Center
Orange, California, 92868
657-247-0087
Alaa Abousaif
- Recruiting
Charter Research - Orlando
Orlando, Florida, 32803
Mary Quarterman
- Recruiting
Headlands Research Orlando
Orlando, Florida, 32806
407-705-3471
Uzma Khan
- Recruiting
California Liver Research Center
Pasadena, California, 91105
626-795-5769
Edward Mena
- Recruiting
HRI Pasadena
Pasadena, Texas, 77505
832-847-1727
Rukan Daccak, MD
- Recruiting
Clinical Research of Philadelphia
Pennington, New Jersey, 08534
215-676-6696
Taher Modarressi
- Recruiting
The Institute for Liver Health II dba Arizona Liver Health - Peoria
Peoria, Arizona, 85381
480-470-4000
Justin Reynolds
- Recruiting
Penn Medicine: University of Pennsylvania Health System
Philadelphia, Pennsylvania, 19104
Ethan Weinberg
- Recruiting
Progressive Medical Research
Port Orange, Florida, 32127
386-304-7070
Bhanu Visvalingam
- Recruiting
University Gastroenterology
Providence, Rhode Island, 02905
Eric Newton
- Recruiting
Richmond Veterans Affairs Medical Center (Richmond VA Medical Center)
Richmond, Virginia, 23249
Michael Fuchs
- Not yet recruiting
Virginia Commonwealth University (VCU) Medical Center
Richmond, Virginia, 23298
804-828-4060
Amon Asgharpour
- Recruiting
The Cognitive and Research Center of New Jersey - Ridgewood
Ridgewood, New Jersey, 07450
201-850-4622
Ritu Suri
- Recruiting
Artemis Institute for Clinical Research
Riverside, California, 92503
951-374-1190
Jack Vu
- Recruiting
Covenant Metabolic Specialists - Riverview
Riverview, Florida, 33578
941-894-2014
Guy Neff
- Recruiting
Gastroenterology Consultants of Southwest Virginia
Roanoke, Virginia, 24014
Farhad Sahebjam
- Recruiting
American Research Corporation at Texas Liver Institute
San Antonio, Texas, 78215
210-253-3426
Eric Lawitz
- Recruiting
Clinical Trials of Texas, LLC dba Flourish Research
San Antonio, Texas, 78229
210-949-0122
Douglas Denham
- Recruiting
IMA Clinical Research San Antonio
San Antonio, Texas, 78229
210-692-7157
Lisa Blair
- Recruiting
Medical Associates Research Group
San Diego, California, 92123
858-277-5678
Cainan Foltz
- Recruiting
Quest Clinical Research
San Francisco, California, 94115
415-353-0800
Maurizio Bonacini
- Recruiting
Advanced Research Institute - Sandy
Sandy City, Utah, 84070
801-409-2040
Robert Barnett
- Recruiting
UW Medicine Diabetes Institute
Seattle, Washington, 98109
Arthi Thirumalai
- Recruiting
Consano Clinical Research, LLC
Shavano Park, Texas, 78231
210-545-4900
Michelle Welch
- Recruiting
Louisiana Research Center
Shreveport, Louisiana, 71105
318-525-3233
John Provenza
- Recruiting
Digestive Research Alliance of Michiana
South Bend, Indiana, 46635
574-904-9617
Pankaj Patel
- Recruiting
Great Lakes Research Institute
Southfield, Michigan, 48075
248-864-5242
Derrick Williamson
- Recruiting
GI Alliance - Southlake
Southlake, Texas, 76092
940-367-2316
Timothy Ritter
- Recruiting
Care Access - St. Petersburg
St. Petersburg, Florida, 33710
877-791-0656
Gigi Lefebvre
- Recruiting
Houston Research Institute (HRI) - Sugar Land
Sugar Land, Texas, 77479
Sushovan Guha
- Recruiting
Epic Medical Research-Sun City
Sun City, Arizona, 85351
Rachel Greatwood
- Recruiting
Washington Gastroenterology - Tacoma
Tacoma, Washington, 98405
253-272-5127
Elizabeth Rosenblatt
- Recruiting
Care Access - Tamarac
Tamarac, Florida, 33321
877-791-0656
Brad Lipson
- Recruiting
Cotton O'Neil Digestive Health Center
Topeka, Kansas, 66606
785-368-0477
Curtis Baum
- Recruiting
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, 48098
248-312-0025
Neil Fraser
- Recruiting
The Institute for Liver Health II dba Arizona Clinical Trials - Tucson
Tucson, Arizona, 85712
Anita Kohli
- Recruiting
Del Sol Research Management, LLC
Tucson, Arizona, 85715
520-257-3881
Bassel Kisso
- Recruiting
MFA Clinical Research
Tuscaloosa, Alabama, 35405
205-331-4963
Adisesha Reddy
- Recruiting
Rophe Adult and Pediatric Medicine/SKYCRNG
Union City, Georgia, 30291
470-317-3604
Dwight Blake
- Recruiting
Covenant Metabolic Specialists, LLC
University Park, Florida, 34201
941-894-2014
Guy Neff
- Recruiting
IMA Clinical Research Warren
Warren Township, New Jersey, 07059
Nancy Phillips
- Recruiting
Texas Valley Clinical Research
Weslaco, Texas, 78596
956-431-8090
Eduardo Luna
- Recruiting
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, 50266
Amy Keller
- Recruiting
Delta Research Partners of West Monroe
West Monroe, Louisiana, 71291
Clarence Dunn
- Recruiting
CRIOH
Westlake, Ohio, 44145
440-363-4000
Naim Alkhouri
- Recruiting
Medrasa Clinical Research
Wylie, Texas, 75098
469-449-3645
Tanvir Ahmad
- Recruiting
US Digestive Health - Wyomissing
Wyomissing, Pennsylvania, 19610
610-374-4401
Nirav Shah
- Recruiting
Care Access - Yonkers
Yonkers, New York, 10701
Peter Wayne
Japan65 sites, 65 recruiting
- Recruiting
Kansai Rosai Hospital
Amagasaki, 660-8511
81120023812
Shinjiro Yamaguchi
- Recruiting
Hyogo Prefectural Amagasaki General Medical Center
Amagasaki, 660-8550
81120023812
Makoto Umeda
- Recruiting
Asahikawa Medical University Hospital
Asahikawa, 078-8510
81120023812
Koji Sawada
- Recruiting
Institute of Science Tokyo Hospital
Bunkyō, 113-8519
81120023812
Yasuhiro Asahina
- Recruiting
Juntendo University Hospital
Bunkyō City, 113-8431
81120023812
Kenichi Ikejima
- Recruiting
The University of Tokyo Hospital
Bunkyō City, 113-8654
81120023812
Ryosuke Tateishi
- Recruiting
Tokyo Metropolitan Komagome Hospital
Bunkyō City, 113-8677
81120023812
Jun Imamura
- Recruiting
Fukuoka University Chikushi Hospital
Chikushino-shi, 818-0067
81120023812
Toru Maruo
- Recruiting
Hamanomachi Hospital
Fukuoka, 810-8539
81120023812
Toshifumi Gushima
- Recruiting
Fukuoka University Hospital
Fukuoka, 814-0180
81120023812
Keiji Yokoyama
- Recruiting
Gifu Municipal Hospital
Gifu, 500-8513
81120023812
Hideki Hayashi
- Recruiting
University of the Ryukyus Hospital
Ginowan, 901-2725
81120023812
Tatsuji Maeshiro
- Recruiting
Hamamatsu University Hospital
Hamamatsu, 431-3192
81120023812
Kazuhito Kawata
- Recruiting
Hiroshima University Hospital
Hiroshima, 734-8551
81120023812
Masataka Tsuge
- Recruiting
National Kohnodai Medical Center
Ichikawa, 272-8516
81120023812
Tatsuya Kanto
- Recruiting
Nihon University Itabashi Hospital
Itabashiku, 173-8610
81120023812
Hirofumi Kogure
- Recruiting
Shimane University Hospital
Izumo, 693-8501
81120023812
Hiroshi Tobita
- Recruiting
Juntendo University Shizuoka Hospital
Izunokuni, 410-2211
81120023812
Takuya Genda
- Recruiting
Kagoshima University Hospital
Kagoshima, 890-8520
81120023812
Seiichi Mawatari
- Recruiting
Nara Medical University Hospital
Kashihara, 634-0813
81120023812
Norihisa Nishimura
- Recruiting
St. Marianna University Hospital
Kawasaki, 216-8511
81120023812
Tsunamasa Watanabe
- Recruiting
Kagawa University Hospital
Kita-ku, 761-0701
81120023812
Asahiro Morishita
- Recruiting
Yamanashi Prefectural Central Hospital
Kofu, 400-8506
81120023812
Masao Omata
- Recruiting
Kumamoto University Hospital
Kumamoto, 860-8556
81120023812
Yasuhito Tanaka
- Recruiting
Kumamoto Shinto General Hospital
Kumamoto, 862-8655
81120023812
Shigetoshi Fujiyama
- Recruiting
Kurume University Hospital
Kurume, 830-0011
81120023812
Masahito Nakano
- Recruiting
University Hospital,Kyoto Prefectural University of Medicine
Kyoto, 602-8566
81120023812
Kanji Yamaguchi
- Recruiting
Saiseikai Maebashi Hospital
Maebashi, 371-0821
81120023812
Takeshi Hatanaka
- Recruiting
Toranomon Hospital
Minatoku, 105-8470
81120023812
Norio Akuta
- Recruiting
Tokyo Saiseikai Central Hospital
Minatoku, 108-0073
81120023812
Atsushi Nakazawa
- Recruiting
Japanese Red Cross Musashino Hospital
Musashino-shi, 180-8610
81120023812
Nobuharu Tamaki
- Recruiting
Nagasaki University Hospital
Nagasaki, 852-8501
81120023812
hisamitsu miyaaki
- Recruiting
Meitetsu Hospital
Nagoya, 451-8511
81120023812
Tomohiko Obayashi
- Recruiting
Nagoya City University Hospital
Nagoya, 467-8602
81120023812
Kei Fujiwara
- Recruiting
International University of Health and Welfare Narita Hospital
Narita, 286-8520
81120023812
Hirotoshi Ebinuma
- Recruiting
Hyogo Medical University Hospital
Nishinomiya, 663-8501
81120023812
Hirayuki Enomoto
- Recruiting
Ogaki Municipal Hospital
Ōgaki, 503-0864
81120023812
Hidenori Toyoda
- Recruiting
Abe Clinic
Ōita, 870-0039
81120023812
Katsushige Abe
- Recruiting
Oita Cardiovascular Hospital
Ōita, 870-0837
81120023812
Masataka Seike
- Recruiting
Okayama University Hospital
Okayama, 700-8558
81120023812
Miwa Kawanaka
- Recruiting
National Hospital Organization Nagasaki Medical Center
Ōmura, 856-8562
81120023812
Atsumasa Komori
- Recruiting
National Hospital Organization Osaka National Hospital
Osaka, 540-0006
81120023812
Ryotaro Sakamori
- Recruiting
Osaka Keisatsu Hospital
Osaka, 543-0042
81120023812
Masanori Miyazaki
- Recruiting
Osaka Metropolitan University Hospital
Osaka, 545-8586
81120023812
Atsushi Hagihara
- Recruiting
Osaka General Medical Center
Osaka, 558-8558
81120023812
Takayuki Yakushijin
- Recruiting
Saga University Hospital
Saga, 849-8501
81120023812
Hirokazu Takahashi
- Recruiting
Osaka Rosai Hospital
Sakai, 591-8025
81120023812
Atsushi Hosui
- Recruiting
Bell Land General Hospital
Sakai, 599-8247
81120023812
TATSUICHI AN
- Recruiting
Hokkaido University Hospital
Sapporo, 060-8648
81120023812
Goki Suda
- Recruiting
Jichi Medical University Hospital
Shimotsuke, 329-0498
81120023812
Koichi Miura
- Recruiting
Tokyo Medical University Hospital
Shinjuku-ku, 160-0023
81120023812
Hirohito Takeuchi
- Recruiting
National Center for Global Health and Medicine
Shinjyuku-ku, 162-8655
81120023812
Yasuo Tanaka
- Recruiting
Iwate Medical University Hospital
Shiwa-gun Yahaba-cho, 028-3695
81120023812
Hidekatsu Kuroda
- Recruiting
Osaka Saiseikai Suita hospital
Suita, 564-0013
81120023812
Toshihide Shima
- Recruiting
The University of Osaka Hospital
Suita, 565-0871
81120023812
takahiro kodama
- Recruiting
Kagawa Prefectural Central Hospital
Takamatsu, 760-8557
81120023812
Takuya Nagano
- Recruiting
National Hospital Organization Takasaki General Medical Center
Takasaki, 370-0829
81120023812
Atsushi Naganuma
- Recruiting
Tokyo Women's Medical University
Tokyo, 162-8666
81120023812
Yosuke Nakai
- Recruiting
Nagano Municipal Hospital
Tomitake, 381-8551
81120023812
Hideo Kunimoto
- Recruiting
Ehime University Hospital
Tōon, 791-0295
81120023812
Yoichi Hiasa
- Recruiting
Sekino Hospital
Toshimaku, 171-0014
81120023812
Hisakuni Sekino
- Recruiting
Mie University Hospital
Tsu, 514-8507
81120023812
Hayato Nakagawa
- Recruiting
National Hospital Organization Ureshino Medical Center
Ureshino, 843-0393
81120023812
Keisuke Ario
- Recruiting
Yamagata University Hospital
Yamagata, 990-9585
81120023812
Kyoko Hoshikawa
- Recruiting
Yokohama City University Hospital
Yokohama, 236-0004
81120023812
Masato Yoneda
China40 sites, 40 recruiting
- Recruiting
Beijing Ditan Hospital
Beijing, 100015
Minghui Li
- Recruiting
Peking University People's Hospital
Beijing, 100034
Huiying Rao
- Recruiting
Beijing Friendship Hospital Affiliate of Capital University
Beijing, 100050
Jidong Jia
- Recruiting
Beijing Youan Hospital
Beijing, 100069
13391859683
Jing Zhang
- Recruiting
Hunan Provincial People's Hospital
Changsha, 410005
Zheng Zhang
- Recruiting
Xiangya Hospital Central South University
Changsha, 410008
Fei Liu
- Recruiting
The Second Xiangya Hospital of Central South University
Changsha, 410011
Kaizhong Luo
- Recruiting
Sichuan Provincial People's Hospital
Chengdu, 610072
+86 18981388263
Jianmei Lin
- Recruiting
2nd Affiliated Hospital Chongqing Medical Universi
Chongqing, 400000
Song He
- Recruiting
The First People's Hospital of Foshan
Foshan, 528041
18038861118
Honglian Bai
- Recruiting
Fujian Medical University Mengchao Hepatobiliary Hospital (Fuzhou Infectious Disease Hospital)
Fuzhou, 350025
Ping Zhang
- Recruiting
The First Affiliated Hospital Of Fujian Medical University
Fuzhou, 350207
Su Lin
- Recruiting
Guangzhou 8th People's Hospital
Guangzhou, 510060
13632293277
Yujuan Guan
- Recruiting
Southern Medical University Nanfang Hospital
Guangzhou, 510515
Jinlin Hou
- Recruiting
Guizhou Provincial People's Hospital
Guiyang, 550002
13885035037
Hong Peng
- Recruiting
The Affiliated Hospital of Guizhou Medical University
Guiyang, 550004
18685183363
Quan Zhang
- Recruiting
Affiliated Hospital of Hangzhou Normal University
Hangzhou, 310015
13957121199
Junping Shi
- Recruiting
Jinhua Central Hospital
Jinhua, 321000
Haijun Chen
- Recruiting
Liaocheng People's Hospital
Liaocheng, 252000
sikui wang
- Recruiting
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, 471003
Yanli Bai
- Recruiting
The Affiliated Hospital of Southwest Medical University
Luzhou, 646000
Yunjian Sheng
- Recruiting
The Second Affiliated Hospital of Nanchang University
Nanchang, 330006
Shuilin Sun
- Recruiting
The First affiliated hospital of Nanchang University (Xianghu campus)
Nanchang, 330209
Na Cheng
- Recruiting
Jiangsu Province Hospital
Nanjing, 210029
Li Dong
- Recruiting
The First Affiliated Hospital of Nanyang Medical College
Nanyang
Yu Zhang
- Recruiting
Ningbo 2nd Hospital
Ningbo, 315000
Hong shan Li
- Recruiting
The first affiliated hospital of Ningbo university
Ningbo, 315010
Lei Xu
- Recruiting
Ningbo Medical Center
Ningbo, 315041
Hua Ye
- Recruiting
Pingxiang People's Hospital
Pingxiang, 337055
13979936681
Xing Li
- Recruiting
Ruijin Hospital Shanghai Jiaotong University School of Medicine
Shanghai, 200025
+86 13651804273
Qing Xie
- Recruiting
Zhongshan Hospital,Fudan University
Shanghai, 200032
13817923359
Shengdi Wu
- Recruiting
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Shanghai, 200092
Chao Sun
- Recruiting
Shengjing Hospital of China Medical University
Shenyang, 110022
Yang Ding
- Recruiting
Peking University Shenzhen Hospital
Shenzhen, 518036
13510880598
Jing Wu
- Recruiting
The Third Hospital of Hebei Medical University
Shijiazhuang, 050051
Yuemin Nan
- Recruiting
Tianjin People' s Hospital
Tianjin, 300121
Tao Han
- Recruiting
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000
+86 13967781644
Minghua Zheng
- Recruiting
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, 710061
Yingli He
- Recruiting
General Hospital of Ningxia Medical University
Yinchuan, 750004
Xiangchun Ding
- Recruiting
Zhoukou Central Hospital
Zhoukou, 466000
Ming Zhao
Brazil26 sites, 24 recruiting
- Recruiting
NewData Clinical Research - Aracaju
Aracaju, 49075-000
+55 79 98825-9395
Alex Callado França
- Recruiting
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, 14784400
1733216637
Larissa Sargentini
- Suspended
Hospital Universitário João de Barros Barreto
Belém, 66073-000
- Recruiting
NUPEC - Cardio
Belo Horizonte, 30220-140
55-31-3307-9255
Claudia Couto
- Recruiting
Faculdade de Medicina da UNESP
Botucatu, 18618-686
1438801171
Giovanni Silva
- Recruiting
Centro de Pesquisa Clinica do Brasil
Brasília, 71625-175
556133643364
Joao Lindolfo Borges
- Recruiting
Chronos Pesquisa Clínica
Brasília, 72145-450
61999780700
Cintia Mendes Clemente
- Recruiting
Instituto de Pesquisa clinica de Campinas
Campinas, 13060-080
55 19 3267 0023
Sylka Rodovalho
- Recruiting
Cline Research Center
Curitiba, 80030-480
+554130273930
Silmara Leite
- Recruiting
Hospital Universitario Walter Cantidio
Fortaleza, 60430-270
Renan Montenegro
- Recruiting
Universidade Federal de Goias
Goiânia, 74605-020
Daniela Antunes
- Recruiting
Hospital Brasilia
Lago Sul, 71635580
+556133058208
Natalia Trevizoli
- Recruiting
CHN - Complexo Hospitalar de Niterói
Niterói, 24020-096
Rodrigo Luz
- Recruiting
Hospital de Clinicas de Porto Alegre
Porto Alegre, 90035-903
Mario Reis Alvares da Silva
- Recruiting
Hospital Moinhos de Vento
Porto Alegre, 90560032
55 51 9249-0979
Fernando Wolff
- Recruiting
IMV Pesquisa Cardiologica - Porto Alegre - Rua Orfanotrofio
Porto Alegre, 90840-440
Cristiano Jaeger
- Recruiting
Instituto do Fígado e Tranplantes de Pernambuco
Recife, 50100-130
Leila Pereira
- Recruiting
IBPClin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, 20241-180
+55 (21) 2527-7979
Gabriela Beserra
- Suspended
Universidade Federal do Rio de Janeiro
Rio de Janeiro, 21941-913
- Recruiting
Ruschel Medicina e Pesquisa Clínica
Rio de Janeiro, 22270-060
552134892340
Cynthia Valerio
- Recruiting
Inovace Pesquisa Clínica
Salvador, 41820-000
+5571988221340
Mauricio Barreto
- Recruiting
Centro Multidisciplinar de Estudos Clinicos
São Bernardo do Campo, 09715-090
55 11 4930 4243
Claudia Brito
- Recruiting
CPHosp Medicina, Ensino e Pesquisa (CPQuali)
São Paulo, 01228-000
+55 (11) 2776-6801
Rafael Lages
- Recruiting
Clínica Hepatogastro JK
São Paulo, 04543-011
5511999158070
Rodrigo Andrey Rocco
- Recruiting
Hospital das Clinicas FMUSP
São Paulo, 05403-000
1130617301
Claudia Oliveira
- Recruiting
CEDOES
Vitória, 29055450
55 27 99933-3330
Queulla Santos
India21 sites, 21 recruiting
- Recruiting
Avron Hospitals
Ahmedabad, 380013
Tanmay Vyas
- Not yet recruiting
All India Institute of Medical Sciences
Bhubaneswar, 751019
+91 9438884267
Manas Panigarhi
- Not yet recruiting
Postgraduate Institute of Medical Education & Research
Chandigarh, 160012
Ajay Duseja
- Recruiting
Amrita Institute of Medical Sciences and Research Center
Ernākulam, 682041
08411051156
Arun Valsan
- Not yet recruiting
Endolife Speciality Hospitals
Guntur, 522001
9849945577
Kongara Srikanth
- Recruiting
Asian Institute of Gastroenterology
Hyderabad, 500032
Anand Kulkarni
- Recruiting
SR Kalla Memorial Gastro & General Hospital
Jaipur, 302006
0141-4039432
Mukesh Kalla
- Recruiting
Lisie Hospital
Kochi, 682018
9846045469
Mathew Philip
- Recruiting
John C. Martin Centre for Liver Research & Innovations (JCMLRI)
Kolkata, 700150
ABHIJIT CHOWDHURY
- Not yet recruiting
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow, 226014
Amit Goel
- Not yet recruiting
Dayanand Medical College and Hospital
Ludhiana, 141001
09815528289
Vandana Midha
- Recruiting
Fortis Hospital - Mohali
Mohali, 160062
Kiran Singh
- Recruiting
Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
Mumbai, 400008
Shubham Jain
- Recruiting
Mysore Medical College
Mysore, 570001
Dharmendra L
- Recruiting
Midas Multispeciality Hospital Pvt.Ltd.
Nagpur, 440010
Shrikant Mukewar
- Recruiting
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, 441108
8475000331
Rutwik Loya
- Recruiting
All India Institute of Medical Sciences
New Delhi, 110029
Shalimar Sushil Kumar
- Recruiting
Sir Ganga Ram Hospital
New Delhi, 110060
Ashish Kumar
- Recruiting
All India Institute of Medical Sciences - Rishikesh
Rishikesh, 249203
8279488824
Rohit Gupta
- Not yet recruiting
Surat Institute of Digestive Sciences Hospitals
Surat, 395002
09879863510
Rajiv Mehta
- Recruiting
Acharya Vinoba Bhave Rural Hospital
Wardha, 442004
Vijendra Kirnake
South Korea20 sites, 20 recruiting
- Recruiting
Korea University Ansan Hospital
Ansan-si, 15355
Young Kul Jung
- Recruiting
Soon Chun Hyang University Bucheon Hospital
Bucheon-si, 14584
Sang Gyune Kim
- Recruiting
Pusan National University Yangsan Hospital
Busan, 50612
82-55-360-2362
Ki Tae Yoon
- Recruiting
Yeungnam Univeristy Medical Center
Daegu, 42415
Jung Gil Park
- Recruiting
Keimyung University Dongsan Hospital
Daegu, 42601
Byoung Kuk Jang
- Recruiting
Chung-Ang University Hospital
Dongjak-gu, 06973
Hyung Joon Kim
- Recruiting
Boramae Medical Center
Dongjak-gu, 07061
+82-28702233
Won Kim
- Recruiting
Hanyang University Guri Hospital
Guri-si, 11923
Sangmo Hong
- Recruiting
Inha University Hospital
Incheon, 22332
82328902548
Jin-Woo Lee
- Recruiting
Gyeongsang National University Hospital
Jinju, 52727
+82 10 9494 4022
HYUN CHIN CHO
- Recruiting
Kyungpook National University Hospital
Junggu, 41944
Won Young Tak
- Recruiting
Seoul National University Hospital
Seoul, 03080
Yoon Jun Kim
- Recruiting
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Seoul, 03312
Hyun Yang
- Recruiting
Severance Hospital, Yonsei University Health System
Seoul, 03722
Seung Up Kim
- Recruiting
Severance Hospital, Yonsei University Health System
Seoul, 03722
Byung Wan Lee
- Recruiting
Hanyang University Seoul Hospital
Seoul, 04763
+82-2-2290-8338
Dae won Jun
- Recruiting
Asan Medical Center
Seoul, 05505
82-2-3010-0048
Won-Mook Choi
- Recruiting
Samsung Medical Center
Seoul, 06351
Yong Han Paik
- Recruiting
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, 06591
Pil Soo Sung
- Recruiting
Wonju Severance Christian Hospital
Wŏnju, 26426
Moon Young Kim
Mexico19 sites, 19 recruiting
- Recruiting
Medical Center Metas
Chihuahua City, 31110
52 614 423 5956
Luis Nevarez
- Recruiting
Centro de Investigación y Gastroenterología
Cuauhtémoc, 06700
5510546591
Alma Ladron de Guevara Cetina
- Recruiting
Instituto de Diabetes, Obesidad y Nutricion
Cuernavaca, 62250
7771022899
Leobardo Sauque Reyna
- Not yet recruiting
Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
Guadalajara, 44340
+ 52 33 3986 9435
Jose Velarde Ruiz Velasco
- Recruiting
Private Practice - Dr. Arechavaleta Granell Maria del Rosario
Guadalajara, 44670
523336165410 400
Maria Arechavaleta Granell
- Not yet recruiting
Unidad de Investigación Clínica y Atención Médica HEPA S.C.
Guadalajara, 44670
523336422886
Marisol Herrera Marmolejo
- Not yet recruiting
Kohler & Milstein Research S.A. De C.V.
Mérida, 97070
+529999204004
Jesus Simon Campos
- Not yet recruiting
Centro Médico Lic. Arturo Montiel Rojas ISSEMYM
Metepec, 52170
7221084392
Eduardo Brea Andrés
- Not yet recruiting
Grupo Medico Camino Sc
Mexico City, 03310
5541689873
Jorge Rojas Serrano
- Not yet recruiting
Centro de Investigación y Gastroenterología - S.C.
Mexico City, 03330
5540455183
Graciela Torres Mendoza
- Recruiting
Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
Mexico City, 11650
52 5585340943
Melchor Alpizar Salazar
- Recruiting
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, 14080
Ricardo Macias Rodriguez
- Recruiting
CEINV Salud
Monterrey, 64020
52 8141916867
Jose Gerardo González González
- Recruiting
Clinica de Enfermedades Cronicas y Procedimientos Especiales, SC
Morelia, 58249
4433232828
Gustavo Gasca
- Recruiting
Oncare Vasconcelos
San Pedro Garza García, 66220
Genaro Vazquez Elizondo
- Not yet recruiting
Avant Sante Research Center
San Pedro Garza García, 66260
Federico Arguelles-Tello
- Not yet recruiting
Fundación Santos y de la Garza Evía I.B.P
San Pedro Garza García, 66278
Francisco Bosques PAdilla
- Not yet recruiting
Instituto Veracruzano en Investigación Clínica S.C.
Veracruz, 91900
2299323157
Rosa Luna Ceballos
- Not yet recruiting
Hospital General de Occidente
Zapopan, 45170
Raul Aguilar Orozco
Argentina17 sites, 17 recruiting
- Recruiting
Hospital Italiano de Buenos Aires
ABB, C1199ABB
Adrian Gadano
- Recruiting
CIPREC
Buenos Aires, 1061
+5491162723941
Fernando Gruz
- Recruiting
DOM Centro de Reumatología
Buenos Aires, 1111
+54 9 11 64720026
Nora Cejas
- Recruiting
Cicemo Srl
Buenos Aires, 1424
541160410129
Alejandro de Dios
- Recruiting
Glenny Corp. S.A.
Buenos Aires, 1430
5491133256886
Gabriel Aballay Soteras
- Recruiting
Centro de Investigaciones Metabólicas (CINME)
Buenos Aires, C1056ABI
(+5411) 3984-2826
Maria Anders
- Recruiting
Centro Médico Viamonte
Buenos Aires, C1120AAC
54 1149635650
Diego Aizenberg
- Recruiting
Mautalen Salud e Investigación
Buenos Aires, C1128AAF
+541145143408
Emiliano Tron
- Recruiting
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Buenos Aires, C1425AGC
5401148019001
Evelyn Blanc
- Recruiting
Fundación Respirar
Buenos Aires, C1426ABP
Matias Bori
- Recruiting
Instituto de Investigaciones Clínicas Córdoba
Córdoba, 5000
03515102154
Mauro Pautasso
- Recruiting
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, 2152
+54 9 3416 18-5727
Sebastian Ferretti
- Recruiting
Instituto de Investigaciones Clínicas Mar del Plata
Mar del Plata, B7600FZO
0223155189482
Natalia Cluigt
- Recruiting
DIM Clínica Privada
Ramos Mejía, B1704ETD
Soledad Perez
- Recruiting
INECO Neurociencias Oroño
Rosario, 2000
(0341) 425 8695
María Cappiello
- Recruiting
Instituto de Investigaciones Clinicas Rosario
Rosario, S2000CVD
Mariana LaGrutta
- Recruiting
Centro de Diagnóstico y Rehabilitación (CEDIR)
Santa Fe, 3000
5493424087292
Antonio Saleme
United Kingdom17 sites, 17 recruiting
- Recruiting
Aberdeen Royal Infirmary
Aberdeen, AB25 2ZN
01224558952
Ashis Mukhopadhya
- Recruiting
4 Medical Solutions, Ltd - Manchester
Clifton, M27 8FF
03300575838
Naveed Younis
- Recruiting
Panthera Biopartners - North London
Enfield, EN3 4GS
Saima Ajaz
- Recruiting
Panthera Biopartners - Glasgow
Glasgow, G51 4RY
0141 4284318
Rahul Mangalath Rajendra Prasad
- Recruiting
Ipswich Hospital
Ipswich, IP4 5PD
Sanjeev Sharma
- Recruiting
Liverpool University Hospitals NHS Foundation Trust
Liverpool, L9 7AL
Vinay Balachandrakumar
- Recruiting
Royal London Hospital
London, E1 1FR
William Alazawi
- Recruiting
4 Medical Solutions, Ltd - London
London, IG1 4HP
03300575838
Fazel Butt
- Recruiting
Royal Free Hospital
London, NW32QG
Emmanouil Tsochatzis
- Recruiting
King's College Hospital
London, SE5 9RL
02032997615
Philip Newsome
- Recruiting
Freeman Hospital
Newcastle upon Tyne, NE7 7DN
Preya Patel
- Recruiting
The John Radcliffe Hospital
Oxford, OX3 9DU
01865228756
Jeremy Cobbold
- Recruiting
Atlantic Medical
Penzance, TR18 3DX
Alex Dewdney
- Recruiting
Panthera Biopartners - Preston
Preston, PR2 9QB
01772237822
Samin Chowdhury
- Recruiting
Panthera Biopartners - Manchester
Rochdale, OL11 4AU
01706 436278
Henrique Freitas
- Recruiting
Panthera Biopartners - Sheffield
Sheffield, S2 5FX
01143503730
Hannah Collins
- Recruiting
Panthera Clinic - York
York, YO24 4LJ
01772 237822
Mahadev Ramjee
Australia16 sites, 16 recruiting
- Recruiting
Nightingale Research
Adelaide, 5000
Andrew Hamilton
- Recruiting
Flinders Medical Centre
Adelaide, 5042
Kate Muller
- Recruiting
Box Hill Hospital
Box Hill, 3128
+ 61 3 9094 9555
Alex Hodge
- Recruiting
Royal Brisbane and Women's Hospital
Brisbane, 4029
+61 7 36468111
Richard Skoien
- Recruiting
Core Research Group
Brisbane, 4064
61738765688
David Colquhoun
- Recruiting
Mater Misericordiae Limited
Brisbane, 4101
Katerina Liew
- Recruiting
Gallipoli Medical Research Ltd
Brisbane, 4120
0733947284
Darrell Crawford
- Recruiting
Genesis Research Services
Broadmeadow, 2292
Lay Theng Gan
- Not yet recruiting
Barwon Health
Geelong, 3220
Anna Anderson
- Recruiting
Austin Health
Heidelberg, 3084
61 3 9496 2787
Marie Sinclair
- Recruiting
Ipswich Hospital
Ipswich, 4305
0402112100
Thomas Dover
- Recruiting
Fiona Stanley Hospital
Murdoch, 6150
Oyekoya Ayonrinde
- Recruiting
TrialsWest - Osborne Park
Osborne Park, 6017
John Olynyk
- Recruiting
The Royal Melbourne Hospital
Parkville, 3050
Ashok Raj
- Recruiting
Gold Coast University Hospital
Southport, 4215
Rupert Cox
- Recruiting
Westmead Hospital
Westmead, 2145
0288907705
Jacob George
France16 sites, 16 recruiting
- Recruiting
CHU d'Amiens-Picardie - Hôpital Sud
Amiens, 80054
Eric Nguyen-Khac
- Recruiting
Centre Hospitalier Universitaire d'Angers
Angers, 49933
Jérôme Boursier
- Recruiting
CHU Besançon
Besançon, 25000
Vincent Di Martino
- Recruiting
Hôpital Beaujon
Clichy, 92110
Laurent Castera
- Recruiting
Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand
Dijon, 21079
Thomas Mouillot
- Recruiting
CHD Vendee
La Roche-sur-Yon, 85000
Ludovic Lagin
- Recruiting
Hopital Claude Huriez - CHU de Lille
Lille, 59037
Philippe Mathurin
- Recruiting
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
Limoges, 87042
0555058726
Marilyne Gratien
- Recruiting
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet
Nice, 06200
Rodolphe Anty
- Recruiting
Pitie Salpetriere University Hospital
Paris, 75013
+33142161020
Vlad RATZIU
- Recruiting
Hôpital Saint Antoine
Paris, 75571
0149283154
Marie Lequoy
- Recruiting
CHU Bordeaux Haut-Leveque
Pessac, 33600
Juliette Foucher
- Recruiting
Centre Hospitalier Lyon Sud
Pierre-Bénite, 69494 Cédex
Cyrielle Caussy
- Recruiting
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
Rennes, 35000
Edouard BARDOU-JACQUET
- Recruiting
Nouvel Hôpital Civil (NHC)
Strasbourg, 67091
0369550024
Lawrence SERFATY
- Recruiting
CHU Rangueil
Toulouse, 31059
+33561322960
Christophe Bureau
Canada15 sites, 15 recruiting
- Not yet recruiting
Heritage Medical Research Clinic
Calgary, T2N 4Z6
4032109240
Mark Swain
- Recruiting
Ecogene-21
Chicoutimi, G7H 7K9
418-545-1252
Daniel Gaudet
- Recruiting
Wells Research Group
Edmonton, T5L 4G4
5879863393
Malcolm Wells
- Not yet recruiting
University Of Alberta Hospital
Edmonton, T6G 2C8
Ellina Lytvyak
- Not yet recruiting
QEII Health Sciences Centre - Victoria General Site
Halifax, B3H 2Y9
Julie Zhu
- Recruiting
University Hospital - London Health Sciences Centre
London, N6A 5A5
Mohammad Qasim Khan
- Recruiting
Private Practice - Dr. Stephane M. Gauthier
North Bay, P1B 2H3
7054767737
Stephane Gauthier
- Recruiting
Diex Recherche Quebec
Québec, G1V 4T3
Marie-Philippe Morin
- Recruiting
Clinical Research of Ontario
Toronto, M1S 4T7
18002474525
Gerald Chan
- Not yet recruiting
Toronto General Hospital
Toronto, M5G 2C4
4163403312
Keyur Patel
- Not yet recruiting
St. Joseph's Health Centre
Toronto, M6R 1B5
Ian Bookman
- Recruiting
Diex Recherche Inc. Division Trois-Rivieres
Trois-Rivières, G9A 4P3
Jean-francois Naud
- Not yet recruiting
Vancouver General Hospital
Vancouver, V5Z 1M9
Peter W.C. Kwan
- Not yet recruiting
(G.I.R.I.) GI Research Institute Foundation
Vancouver, V5Z 2K5
Alnoor Ramji
- Not yet recruiting
Health Sciences Centre Winnipeg
Winnipeg, R3A 1R9
204 789 3950
Nabiha Faisal
Poland15 sites, 15 recruiting
- Recruiting
KRESMED Sp. z o.o.
Bialystok, 15-481
Iwona Mikolajczyk
- Recruiting
Centrum Badan Klinicznych PI-House sp. z o.o.
Gdansk, 80-546
48603790004
Monika Lukaszewicz
- Recruiting
Centrum Medyczne Pratia Katowice
Katowice, 40-081
Elzbieta Blach
- Recruiting
Gyncentrum sp. z o.o. NZOZ Holsamed - oddział Libero
Katowice, 40-600
Marek Olakowski
- Recruiting
Santa Familia PTG Lodz
Lodz, 90-302
508489097
Maciej Jablkowski
- Recruiting
ID Clinic
Mysłowice, 41-400
48502338571
Ewa Janczewska
- Recruiting
Uniwersyteckie Centrum Stomatologii i Medycyny Specjalistycznej
Poznan, 60-354
Michal Chojnicki
- Not yet recruiting
Private Practice - Dr. Lukasz Krupa
Rzeszów, 35-055
Lukasz Krupa
- Recruiting
NZOZ GynCentrum - Oddział Warszawa
Warsaw, 00-124
Adam Parfienczyk
- Recruiting
Przychodnie Care Access
Warsaw, 00-719
48 221524931
Dorota Knychas
- Recruiting
Szpital Czerniakowski
Warsaw, 00-737
Kamil Wrzosek
- Recruiting
MTZ Clinical Research Powered by Pratia
Warsaw, 02-172
+48 513419850
Maciej Murawski
- Recruiting
Państwowy Instytut Medyczny MSWiA
Warsaw, 02-507
477221885
Jakub Klapaczynski
- Recruiting
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
Warsaw, 04-501
500111648
Jaroslaw Kierkus
- Recruiting
ETG Zamość
Zamość, 22-400
48606930022
Katarzyna Wojcik
Taiwan15 sites, 15 recruiting
- Recruiting
Chiayi Christian Hospital
Chiayi City, 600
886-5-2765041
Chu-Kuang Chou
- Recruiting
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807
Ming-Lung Yu
- Recruiting
E-Da hospital
Kaohsiung City, 82445
Yao-Chun Hsu
- Recruiting
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, 83301
Jing-Houng Wang
- Recruiting
Taipei Tzu Chi General Hospital
New Taipei City, 231
Chia-Chi Wang
- Not yet recruiting
Fu Jen Catholic University Hospital
New Taipei City, 24352
+866920052653
Chi-Yang Chang
- Recruiting
China Medical University Hospital
Taichung, 404332
Cheng-Yuan Peng
- Recruiting
Taichung Veterans General Hospital
Taichung, 407
Teng-Yu Lee
- Recruiting
National Cheng Kung University Hospital
Tainan, 704
Pin-Nan Cheng
- Recruiting
Chi Mei Medical Center
Tainan, 71004
hsingtao Kuo
- Recruiting
National Taiwan University Hospital
Taipei, 10002
Jia-Horng Kao
- Recruiting
Cathay General Hospital
Taipei, 106
Hai-Hua Chuang
- Recruiting
Taipei Medical University Hospital
Taipei, 110
Wei-Yu Kao
- Recruiting
Taipei Veterans General Hospital
Taipei, 11217
+886228757506
Yi-Hsiang Huang
- Recruiting
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, 333
Chao Wei Hsu
Germany13 sites, 13 recruiting
- Recruiting
Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen
Bad Oeynhausen, 32545
0495731973700
Susanne Reger-Tan
- Not yet recruiting
Charité Campus Virchow-Klinikum
Berlin, 13353
+49 30 450 665318
Münevver Demir
- Not yet recruiting
Universitätsklinikum Brandenburg an der Havel
Brandenburg, 14770
03381 411600
Stefan Lueth
- Recruiting
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
Dresden, 01307
0049-351 45819719
Marco Berning
- Recruiting
Deutsches Diabetes-Zentrum (DDZ)
Düsseldorf, 40225
0049 3382 698
Sabine Kahl
- Not yet recruiting
Universitätsklinikum Frankfurt Goethe-Universität
Frankfurt, 60590
0049 69 6301 87769
Anita Pathil-Warth
- Recruiting
Medizinische Hochschule Hannover
Hanover, 30625
495115323306
Hans-Heinrich Wedemeyer
- Recruiting
Universitaetsklinikum Heidelberg
Heidelberg, 69120
0622156311960
Alba Sulaj
- Recruiting
Universitaetsklinikum des Saarlandes
Homburg, 66424
+4968411615027
Joern Schattenberg
- Recruiting
Eugastro GmbH
Leipzig, 04103
00493414935720
Ingolf Schiefke
- Recruiting
Universitätsklinikum Leipzig
Leipzig, 04103
Thomas Berg
- Recruiting
Universitätsmedizin Johannes Gutenberg Universität Mainz
Mainz, 55131
06131176831
Christian Labenz
- Recruiting
Ruppiner Kliniken
Neuruppin, 16816
0049 (0) 3391393210
Karsten Weylandt
Spain13 sites, 13 recruiting
- Recruiting
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, 15006
655624017
Alfonso Soto Gonzalez
- Recruiting
Hospital Germans Trias i Pujol
Badalona, 08916
(+34) 93 497 88 60
Núria Alonso Pedrol
- Recruiting
Hospital Universitari Vall d'Hebron
Barcelona, 08035
34697817352
ANDREEA CIUDIN
- Recruiting
Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
Ferrol, 15405
+34676692699
Ana Sanchez Bao
- Recruiting
Hospital Infanta Elena
Huelva, 21007
650762356
Manuel Jesús Romero-Jiménez
- Recruiting
Hospital General Universitario Gregorio Marañon
Madrid, 28007
Luis Ibañez Samaniego
- Recruiting
Hospital Universitario La Paz
Madrid, 28046
Antonio Olveira Martín
- Recruiting
Hospital Universitari Son Espases
Palma, 07120
34 871 205256
Santiago Tofe Povedano
- Recruiting
CHOP - Hospital Universitario Montecelo
Pontevedra, 36004
+34986800907
Juan Turnes Vazquez
- Recruiting
Hospital Universitario Marqués de Valdecilla
Santander, 39005
Maria Teresa Arias Loste
- Recruiting
Hospital Universitario Virgen Del Rocio
Seville, 41013
955012065
Manuel Romero Gomez
- Recruiting
Hospital Clinico de Valencia
Valencia, 46010
600511531
David Marti Aguado
- Recruiting
Hospital Universitari i Politecnic La Fe
Valencia, 46026
961245856
Marina Berenguer
Italy12 sites, 12 recruiting
- Recruiting
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
Bergamo, 24127
Mauro Viganò
- Recruiting
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, 40138
Fabio Piscaglia
- Recruiting
Azienda Ospedaliera Universitaria Careggi
Florence, 50134
+390557945425
Fabio Marra
- Recruiting
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Milan, 20122
02.5503.4192
Luca Valenti
- Recruiting
Azienda Ospedaliera Universitaria Federico II
Naples, 80131
Filomena Morisco
- Recruiting
Azienda Ospedale - Università Padova
Padova, 35128
Francesco Paolo Russo
- Recruiting
A.O.U. Policlinico Paolo Giaccone
Palermo, 90127
390916552106
Salvatore Petta
- Recruiting
Fondazione Policlinico Universitario Agostino Gemelli
Roma, 00168
08.30 - 09.30
Luca Miele
- Recruiting
Fondazione Policlinico Universitario Campus Bio-Medico
Rome, 00128
Umberto Vespasiani Gentilucci
- Recruiting
IRCCS Istituto Clinico Humanitas
Rozzano, 20089
Alessio Aghemo
- Not yet recruiting
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino
Torino, 10126
390116336224
Elisabetta Bugianesi
- Not yet recruiting
Policlinico GB Rossi Borgo Roma
Verona, 37136
Andrea Dalbeni
Belgium11 sites, 11 recruiting
- Recruiting
Centre Hospitalier Universitaire Brugmann
Brussels, 1020
+3224773619
Luc Lasser
- Recruiting
Université Libre de Bruxelles - Hôpital Erasme
Brussels, 1070
+3225554478
Christophe Moreno
- Not yet recruiting
UZ Brussel
Brussels, 1090
+32 2 477 68 11
Silke Francois
- Not yet recruiting
Cliniques universitaires Saint-Luc
Brussels, 1200
+3276470891
Nicolas Lanthier
- Not yet recruiting
Antwerp University Hospital
Edegem, 2650
3238213324
Sven Francque
- Recruiting
AZ Maria Middelares
Ghent, 9000
+3292467100
Christophe Van Steenkiste
- Not yet recruiting
UZ Gent
Ghent, 9000
3293324870
Anja Geerts
- Not yet recruiting
AZ Groeninge Campus Kennedylaan
Kortrijk, 8500
3256633300
Christophe George
- Recruiting
AZ Oostende vzw
Ostend, 8400
003259417970
Antoon Billiet
- Recruiting
AZ Delta vzw
Roeselare, 8800
+32 51 23 72 15
Charlotte De Vloo
- Not yet recruiting
VITAZ
Sint-Niklaas, B-9100
Wim Verlinden
Israel11 sites, 11 recruiting
- Recruiting
Barzilai Medical Center
Ashkelon, 7830604
+97286745468
Nave Firestein
- Recruiting
Soroka Medical Center
Beersheba, 8410101
972 8402330
Ohad Etzion
- Recruiting
Rambam Health Care Campus
Haifa, 3109601
+97247772947
Tarek Saadi
- Recruiting
Carmel Hospital
Haifa, 3436212
972-48250053
Eli Zuckerman
- Recruiting
Hadassah Medical Center
Jerusalem, 9112001
+972-2-6778705
Rifaat Safadi
- Recruiting
Shaare Zedek Medical Center
Jerusalem, 9778419
026555316
Gadi Lalazar
- Recruiting
Maccabi Health Services - Petah Tikva
Petah Tikva, 4925110
972-3-7958673
Yoav Lurie
- Recruiting
Rabin Medical Center
Petah Tikva, 4941492
97239377625
Marius Braun
- Recruiting
Sheba Medical Center
Ramat Gan, 5262100
+97235307179
Ehud Zigmond
- Recruiting
Sourasky Medical Center
Tel Aviv, 6423906
03-69758133
Helena Katchman
- Recruiting
Assuta Medical Center
Tel Aviv, 6971014
97235307177
Ziv Ben Ari
Ukraine11 sites, 11 recruiting
- Recruiting
Clinical Diagnostic Center
Ivano-Frankivsk, 76018
+380986445126
Vadym Berenfus
- Recruiting
Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
Kiev, 04050
+380979132763
Oksana Gerasymenko
- Recruiting
Edelweiss Medics
Kyiv, 02002
+380445949200
Oleksandra Tymofeieva
- Recruiting
Medical Center Ok!Clinic+
Kyiv, 02091
+380937694807
Nataliia Tsarynna
- Recruiting
Medbud Clinic
Kyiv, 03037
380445947078
Svitlana Postol
- Recruiting
Center of Family Medicine Plus
Kyiv, 04210
+380972094524
Liudmyla Chupryna
- Recruiting
Progastro Clinic
Lviv, 79019
0933825853
Olha Ivanishyn
- Recruiting
Medical Center Salutem
Vinnytsia, 21001
+380995067456
Oksana Nyzkoshapka
- Recruiting
Limited liability company "Medical center Health Clinic"
Vinnytsia, 21009
+380960992929
Oleksandr Golovchenko
- Recruiting
Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia Regio -T
Vinnytsia, 21018
Mykola Stanislavchuk
- Recruiting
CRZ Vidnovlennya
Zhytomyr, 10014
Tetiana Bevz
Turkey (Türkiye)8 sites, 8 recruiting
- Recruiting
Adana Sehir Egitim ve Arastirma Hastanesi
Adana, 01370
05326466586
Hilmi Sumbul
- Recruiting
Çukurova Üniversitesi Tıp Fakültesi Adana Hastanesi
Adana, 01790
+90 505 279 81 37
Umit KARAOGULLARINDAN
- Recruiting
Hacettepe Universitesi
Ankara, 06230
+905332344232
Hatice Yasemin Balaban
- Recruiting
Ankara Bilkent Şehir Hastanesi
Ankara, 06800
Meral Akdogan Kayhan
- Recruiting
Bursa Şehir Hastanesi
Bursa, 16110
111111111
Nizameddin Koca
- Recruiting
T.C. Sağlik Bakanliği- Marmara Üniversitesi İstanbul Pendik Eğitim Ve Araştirma Hastanesi
Pendik, 34899
+905059176112
Coskun Demirtas
- Recruiting
Recep Tayyip Erdogan University Training and Research Hospital
Rize, 53100
Yusuf Yilmaz
- Recruiting
Karadeniz Teknik Universitesi Tip Fakultesi
Trabzon, 61080
05324844131
arif mansur cosar
Netherlands6 sites, 6 recruiting
- Not yet recruiting
Progress Clinical Research - Den Bosch
's-Hertogenbosch, 5223 LA
0621262456
Manuel Castro Cabezas
- Not yet recruiting
Amsterdam UMC, locatie AMC
Amsterdam, 1105 AZ
Onno Holleboom
- Not yet recruiting
Radboudumc
Nijmegen, 6525 GA
+31 243619190
Eric Tjwa
- Not yet recruiting
Erasmus Medisch Centrum
Rotterdam, 3015 GD
0031630383443
Willem Pieter Brouwer
- Recruiting
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX
0887559793
Suzanne van Meer
- Not yet recruiting
Progress Clinical Research - Zwolle
Zwolle, 8025 AZ
0621262456
Manuel Castro Cabezas
Austria5 sites, 5 recruiting
- Recruiting
Medizinische Universität Graz
Graz, 8036
0043 316 385 82432
Vanessa Stadlbauer-Koellner
- Recruiting
Uniklinikum Salzburg
Salzburg, 5020
00435725525410
Elmar Aigner
- Recruiting
Klinik Landstraße
Vienna, 1030
43 1 71165 2101
Bernhard Ludvik
- Recruiting
Medizinische Universität Wien
Vienna, 1090
Mattias Mandorfer
- Recruiting
Landesklinikum Wiener Neustadt
Wiener Neustadt, 2700
00432622900412601
Thomas-Matthias Scherzer
Romania5 sites, 5 recruiting
- Recruiting
Delta Health Care
Bucharest, 014142
40745086735
Camelia Chioncel
- Recruiting
Spitalul Clinic Colentina
Bucharest, 020125
0213152590
Bogdan Mateescu
- Recruiting
Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor
Cluj-Napoca, 400162
0727343098
Bogdan Procopet
- Recruiting
Constanta County Emergency Clinical Hospital Sf.Ap.Andrei
Constanța, 900591
+40744761454
Eugen Dumitru
- Recruiting
Spital Judetean de Urgenta
Satu Mare, 440055
+40747 170 170
Bogdan Pintea
Czechia4 sites, 4 recruiting
- Recruiting
Krajská nemocnice Liberec
Liberec, 460 01
+420485312679
Karel Dvorak
- Recruiting
Fakultni nemocnice Ostrava
Ostrava, 708 52
420737909949
Adam Vasura
- Recruiting
Mestska nemocnice Ostrava
Ostrava, 728 80
00420734261275
Jan Smid
- Not yet recruiting
Vseobecna fakultni nemocnice v Praze
Prague, 12808
+420224962506
Radan Bruha
Bulgaria3 sites, 3 recruiting
- Not yet recruiting
Saint Marina Hospital
Pleven, 5800
Zornica Gorcheva
- Not yet recruiting
UMHATEM 'N.I. Pirogov'
Sofia, 1606
Kamen Danov
- Not yet recruiting
Medical Center - Arcus Medical
Veliko Tarnovo, 5002
Ilko Kosturkov
Hong Kong3 sites, 3 recruiting
- Not yet recruiting
Queen Mary Hospital
Hksar
Lung-Yi Mak
- Not yet recruiting
Prince of Wales Hospital
Shatin, NT
852-35054205
Vincent Wong
- Not yet recruiting
Tuen Mun Hospital
Tuenmen, 999077
Tsz Fai Cheng
Hungary3 sites, 3 recruiting
- Recruiting
Óbudai Egészségügyi Centrum
Budapest, 1036
36 70 450 8040
Viktor Vass
- Recruiting
Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032
+36 30 4054993
Maria Papp
- Recruiting
Szabolcs Szatmár Bereg Vármegyei Oktatókórház
Nyíregyháza, 4400
0036209530430
Zsolt Zilahi
New Zealand3 sites, 3 recruiting
- Not yet recruiting
New Zealand Clinical Research (Auckland)
Auckland, 1010
+6421548371
Edward Gane
- Recruiting
Aotearoa Clinical Trials
Auckland, 2025
May Shan Lim
- Recruiting
Aotearoa Clinical Trials - Whangarei
Whangarei, 0110
+6494304100
Byron Theron
Norway2 sites, 2 recruiting
- Not yet recruiting
Oslo Universitetssykehus Ullevål
Oslo, 0450
Haavard Midgard
- Not yet recruiting
Universitetssykehuset Nord-Norge HF
Tromsø, 9038
+4746803566
Rasmus Goll
Portugal2 sites, 2 recruiting
- Not yet recruiting
Associação Protectora dos Diabéticos de Portugal
Lisbon, 1050-078
Rita Nortadas
- Recruiting
Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria
Lisbon, 1649-035
Helena Cortez-Pinto
Puerto Rico2 sites, 2 recruiting
- Recruiting
Isis Clinical Research Center
Guaynabo, 00968
7874045252
Paola Mansilla-Letelier
- Recruiting
Klinical Investigations Group
San Juan, 00909
7879197865
Federico Rodriguez-Perez
Switzerland2 sites, 2 recruiting
- Recruiting
University Hospital Basel
Basel, 4056
Fahim Ebrahimi
- Recruiting
Kantonsspital Olten
Olten, 4600
Thomas Zueger
Sweden1 site, 1 recruiting
- Not yet recruiting
Universitetssjukhuset i Linköping
Linköping, 581 85
Mattias Ekstedt
About this study
Official title: A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Who Are at Increased Risk of Developing Major Adverse Liver Outcomes
The main purpose of the SYNERGY-OUTCOMES study is to find out whether retatrutide and tirzepatide can prevent major adverse liver outcomes (MALO) in people with high-risk metabolic dysfunction-associated steatotic liver disease (MASLD). The study will enroll adults who have MASLD based on non-invasive tests (NITs), which indicate they are more likely to develop MALO. Participants will be randomly assigned within a Master Protocol to receive either retatrutide (N1T-MC-RT01), tirzepatide (N1T-MC-TZ01) or placebo. The trial plans to enroll about 4,500 adults and will run for approximately 224 weeks. Participants may have up to approximately 25 to 30 clinic visits throughout the study to monitor their health, complete study procedures, and assess liver function and disease progression.
Once the study is complete, eligible participants may participate in an optional 2-year extension study, in which all participants will receive either retatrutide or tirzepatide, even if they received placebo in the main study.
- Being tested
- Tirzepatide, Retatrutide, Placebo
- Keywords
- Nonalcoholic Steatohepatitis, NASH, Fatty Liver, Fatty Liver Disease, SLD, Metabolic Dysfunction-Associated Fatty Liver Disease, MAFLD, Non-alcoholic Fatty Liver Disease, NAFLD, Hepatic Steatosis, Liver Related Outcomes, GLP1, Incretin, Non-Invasive Test
- Medical subject headings
- Non-alcoholic Fatty Liver Disease, Fatty Liver
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
TirzepatideDrug
Also called LY3298176
Administered SC
RetatrutideDrug
Also called LY3437943
Administered SC
PlaceboDrug
Administered SC
| Study group | Role | What they receive |
|---|---|---|
| Tirzepatide (TZ01) | Experimental | Participants will receive tirzepatide subcutaneously (SC) Receives: Drug: Tirzepatide |
| Placebo (TZ01) | Placebo comparator | Participants will receive placebo SC Receives: Drug: Placebo |
| Retatrutide (RT01) | Experimental | Participants will receive retatrutide SC Receives: Drug: Retatrutide |
| Placebo (RT01) | Placebo comparator | Participants will receive placebo SC Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to First Occurrence of Any Component of the Composite Endpoint for Major Adverse Liver Outcomes (MALO)
Composite endpoint comprised of progression to cirrhosis, development of large esophageal varices, gastric varices or development of varices needing treatment, development of ascites, development of hepatic encephalopathy, evidence of active or recent variceal hemorrhage, increase in model for end-stage liver disease (MELD) from ≤12 to ≥15, liver transplantation, all-cause mortality
Measured: Baseline up to Study Completion (about 224 weeks)
Secondary outcomes (9)
Change from Baseline in Enhanced Liver Fibrosis (ELF) Score
Measured: Baseline, Week 104
Change from Baseline in Vibration-Controlled Transient Elastography Liver Stiffness Measurement (VCTE LSM)
Measured: Baseline, Week 104
Percent Change from Baseline in Liver Fat Content (LFC)
Measured: Baseline, Week 104
Time to Occurrence of Progression to Cirrhosis
Measured: Baseline up to Study Completion (about 224 weeks)
Change from Baseline in Aspartate Aminotransferase (AST)
Measured: Baseline, Study Completion (about 224 weeks)
Change from Baseline in Alanine Aminotransferase (ALT)
Measured: Baseline, Study Completion (about 224 weeks)
Change from Baseline in Body Weight
Measured: Baseline, Study Completion (about 224 weeks)
Change from Baseline in Non-Alcoholic Steatohepatitis-CHECK Score (NASH-CHECK)
Measured: Baseline, Week 104
Time to First Occurrence of Any Component Event of the Composite Endpoint of Major Adverse Cardiovascular Events (MACE-3)
MACE-3 composite endpoint includes nonfatal myocardial infarction, nonfatal stroke, cardiovascular death
Measured: Baseline up to Study Completion (about 224 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Sep 2025
- Study start15 Oct 2025
- Primary completionAug 2030 (estimated)
- Study completionAug 2032 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Metabolic Dysfunction-Associated Steatotic Liver DiseaseStudies of the same condition, open and under way.
- More trials run by Eli Lilly and CompanyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 4,500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Eli Lilly and Company
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Study director, Eli Lilly and Company
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07165028
- Sponsor's protocol ID
- 27610
- Other IDs
- 2025-522674-36-00, N1T-MC-MALO, N1T-MC-TZ01, N1T-MC-RT01, 2025
- Status last verified
- Oct 2026
- First submitted
- 28 Aug 2025
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.