Tobacco Use DisorderNCT07164404
Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients
A study testing EHR alert in people with Tobacco Use Disorder, run by Medical University of South Carolina at 1 site in United States.
Trial summary
Investigators are evaluating an EHR-based, non-interruptive alert to increase NRT prescribing in the hospital and at discharge for hospitalized patients. Investigators will investigate two randomized groups of resident physicians to evaluate their prescribing behaviors when the tool is introduced. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Tobacco Use Disorder
- What is being tested?
- EHR alert
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 92 participants
- Where
- 1 siteUnited States
- Study dates
- 17 Nov 2025to 1 Sep 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Hospitalized patients admitted to a General Medicine Service at MUSC Charleston
- Identified as actively smoking tobacco via nursing admission screening
- Admitted by a resident physician participating in the study (as indicated by the H\&P note)
- Internal medicine resident physicians rotating on the hospitalist service at MUSC Health Charleston
Who cannot join
- None
- Resident Physicians:
- None
Trial locations and contacts
1 site in 1 country.
United States1 site
Medical University of South Carolina
Charleston, South Carolina, 29407
About this study
Official title: Increasing Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients Using an Innovative Non-Interruptive Alert Within the Electronic Health Record Provider Note
Investigators are evaluating an EHR-based, non-interruptive alert to increase NRT prescribing in the hospital and at discharge for hospitalized patients. Investigators will investigate two randomized groups of resident physicians to evaluate their prescribing behaviors when the tool is introduced.
Read the detailed description
Efforts to decrease cancer-related morbidity and mortality include increasing smoking cessation, however smoking remains prevalent. Classically, alerts within the electronic health record (EHR) are implemented to address gaps in care, yet studies suggest typical EHR alerts are often overridden and ignored. In this study, the investigators aim to decrease the incidence and burden of disease by including hospitalists as part of the multidisciplinary care team by implementing and evaluating a novel non-interruptive EHR alert embedded within a provider note as a tool to increase prescription of nicotine replacement therapy to patients who smoke upon admission to and discharge from the hospital. Investigators will investigate two randomized groups of resident physicians to evaluate their prescribing behaviors when the tool is introduced.
- Conditions
- Tobacco Use Disorder
- Being tested
- EHR alert
- Medical subject headings
- Tobacco Use Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EHR alertOther
EHR embedded alert into the admission note template, where it automatically inserts smoking history, prompts NRT prescribing in the hospital, and offers referral to outpatient follow up.
| Study group | Role | What they receive |
|---|---|---|
| EHR alert | Experimental | Group will have access to the EHR embedded alert into the admission note template, where it automatically inserts smoking history, prompts NRT prescribing in the hospital, and offers referral to outpatient follow up. Receives: Other: EHR alert |
| Control | No intervention | Routine care, no access to the EHR embedded alert |
What is being measured
The primary outcome is the main question the study is designed to answer.
Nicotine Replacement Therapy (NRT) prescribing rates during hospitalization
Measured: During hospitalization, assessed from admission to discharge (average of 3-7 days)
Nicotine Replacement Therapy (NRT) prescribing rates at discharge
Measured: During hospitalization, assessed from admission to discharge (average of 3-7 days)
Rate of referral to outpatient tobacco cessation clinic
Measured: During hospitalization, assessed from admission to discharge (average of 3-7 days)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Sep 2025
- Study start17 Nov 2025
- Primary completion1 Sep 2026
- Study completion1 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tobacco Use DisorderStudies of the same condition, open and under way.
- More trials run by Medical University of South CarolinaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 92 participants (actual)
Sponsor and investigators
- Lead sponsor
- Medical University of South Carolina
- Sponsor type
- University, hospital or other
- Collaborators
- South Carolina Clinical & Translational Research Institute (SCTR)
- Responsible party
- Sponsor
- Investigators
- Ellen Esposito, MD, Principal investigator, Medical University of South Carolina
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07164404
- Sponsor's protocol ID
- Pro00146588
- Status last verified
- Oct 2026
- First submitted
- 28 Aug 2025
- Last updated
- 14 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Increasing Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients Using an Innovative Non-Interruptive Alert Within the Electronic Health Record Provider Note
- ClinicalTrials.gov ID
- NCT07164404
- Acronym / sponsor ID
- Pro00146588
- Conditions
- Tobacco Use Disorder
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 92 participants (actual)
- Lead sponsor
- Medical University of South CarolinaUniversity, hospital or other
- Collaborators
- South Carolina Clinical & Translational Research Institute (SCTR)
- Study start
- 17 Nov 2025 (actual)
- Primary completion
- 1 Sep 2026 (actual)
- Study completion
- 1 Sep 2026 (actual)
- First posted
- 10 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Investigators are evaluating an EHR-based, non-interruptive alert to increase NRT prescribing in the hospital and at discharge for hospitalized patients. Investigators will investigate two randomized groups of resident physicians to evaluate their prescribing behaviors when the tool is introduced.
Detailed description
Efforts to decrease cancer-related morbidity and mortality include increasing smoking cessation, however smoking remains prevalent. Classically, alerts within the electronic health record (EHR) are implemented to address gaps in care, yet studies suggest typical EHR alerts are often overridden and ignored. In this study, the investigators aim to decrease the incidence and burden of disease by including hospitalists as part of the multidisciplinary care team by implementing and evaluating a novel non-interruptive EHR alert embedded within a provider note as a tool to increase prescription of nicotine replacement therapy to patients who smoke upon admission to and discharge from the hospital. Investigators will investigate two randomized groups of resident physicians to evaluate their prescribing behaviors when the tool is introduced.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| EHR alert | Experimental | Other: EHR alertGroup will have access to the EHR embedded alert into the admission note template, where it automatically inserts smoking history, prompts NRT prescribing in the hospital, and offers referral to outpatient follow up. |
| Control | No intervention | –Routine care, no access to the EHR embedded alert |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Hospitalized patients admitted to a General Medicine Service at MUSC Charleston
- Identified as actively smoking tobacco via nursing admission screening
- Admitted by a resident physician participating in the study (as indicated by the H\&P note)
- Internal medicine resident physicians rotating on the hospitalist service at MUSC Health Charleston
Key exclusion criteria (3 listed)
- None
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EHR alertEHR embedded alert into the admission note template, where it automatically inserts smoking history, prompts NRT prescribing in the hospital, and offers referral to outpatient follow up. | Other | EHR alert |
Primary outcome
Nicotine Replacement Therapy (NRT) prescribing rates during hospitalization
Time frame: During hospitalization, assessed from admission to discharge (average of 3-7 days)
Nicotine Replacement Therapy (NRT) prescribing rates at discharge
Time frame: During hospitalization, assessed from admission to discharge (average of 3-7 days)
Rate of referral to outpatient tobacco cessation clinic
Time frame: During hospitalization, assessed from admission to discharge (average of 3-7 days)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ellen Esposito, MD principal investigator
Medical University of South Carolina
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing EHR alert in people with Tobacco Use Disorder, run by Medical University of South Carolina at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Nicotine Replacement Therapy (NRT) prescribing rates during hospitalization (time frame: During hospitalization, assessed from admission to discharge (average of 3-7 days)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Oct 2026.