Pressor ResponseNCT07164326
Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients
A study testing Dexmedetomidine and Saline in people with Pressor Response, run by Assiut University.
Trial summary
Dexmedetomidine nebulization in sever preeclamptic patients Read more about this study
- Who is it for?
- Ages 18 to 40 years, women only
- Conditions the study is for
- Pressor Response
- What is being tested?
- Dexmedetomidine and Saline
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 100 participants
- Where
- No sites listed yet
- Study dates
- 15 Oct 2025to 15 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
- ASA II, III
Who cannot join
- sever obesity (BMI ≥ 40)
- Cardiac patients
- History of diabetes mellitus
- Renal dysfunction (elevated serum creatinine > 2mg\dl)
- hepatic dysfunction (elevated hepatic enzyme three times above normal)
- History to hypersensitivity to the tested drug.
- Emergency surgery
- Known fetal anomalies
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Fatma Nabil contact
About this study
Official title: Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients Undergoing Caesarean Section Under General Anaesthesia
Dexmedetomidine nebulization in sever preeclamptic patients
Read the detailed description
Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.
- Conditions
- Pressor Response
- Being tested
- Dexmedetomidine, Saline
- Keywords
- Preeclampsia, Nebulization
- Medical subject headings
- Pre-Eclampsia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
DexmedetomidineDrug
Nebulization of dexmedetomidine
SalineDrug
Nebulization of normal saline
| Study group | Role | What they receive |
|---|---|---|
| Dexmedetomidine | Experimental | Nebulization of dexmedetomidine Receives: Drug: Dexmedetomidine |
| Saline | Placebo comparator | Nebulization of saline Receives: Drug: Saline |
What is being measured
The primary outcome is the main question the study is designed to answer.
Systolic blood pressure in response to endotracheal intubation
the change in systolic blood pressure in response to endotracheal intubation
Measured: Intraoperative
Secondary outcomes (3)
Optic nerve sheath diameter
the change in optic nerve sheath diameter in response to endotracheal intubation
Measured: Intraoperative
Incidence of maternal postoperative sore throat
Measured: 1 hour Postoperative
Incidence of maternal postoperative hoarseness of voice
Measured: 1 hour Postoperative
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Sep 2025
- Study start15 Oct 2025 (estimated)
- Primary completion15 Nov 2026 (estimated)
- Study completion15 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pressor ResponseStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohamed Sayed Hussein Hassan, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07164326
- Sponsor's protocol ID
- Dexmedetomidine nebulization
- Status last verified
- Aug 2025
- First submitted
- 30 Aug 2025
- Last updated
- 10 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients Undergoing Caesarean Section Under General Anaesthesia
- ClinicalTrials.gov ID
- NCT07164326
- Acronym / sponsor ID
- Dexmedetomidine nebulization
- Conditions
- Pressor Response
- Keywords
- Preeclampsia, Nebulization
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 15 Oct 2025 (estimated)
- Primary completion
- 15 Nov 2026 (estimated)
- Study completion
- 15 Dec 2026 (estimated)
- First posted
- 10 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Dexmedetomidine nebulization in sever preeclamptic patients
Detailed description
Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Dexmedetomidine | Experimental | Drug: DexmedetomidineNebulization of dexmedetomidine |
| Saline | Placebo comparator | Drug: SalineNebulization of saline |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
- ASA II, III
Key exclusion criteria (8 listed)
- sever obesity (BMI ≥ 40)
- Cardiac patients
- History of diabetes mellitus
- Renal dysfunction (elevated serum creatinine > 2mg\dl)
- hepatic dysfunction (elevated hepatic enzyme three times above normal)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| DexmedetomidineNebulization of dexmedetomidine | Drug | Dexmedetomidine |
| SalineNebulization of normal saline | Drug | Saline |
Primary outcome
Systolic blood pressure in response to endotracheal intubation
Time frame: Intraoperative
the change in systolic blood pressure in response to endotracheal intubation
3 secondary outcomes
Optic nerve sheath diameter
Time frame: Intraoperative
Incidence of maternal postoperative sore throat
Time frame: 1 hour Postoperative
Incidence of maternal postoperative hoarseness of voice
Time frame: 1 hour Postoperative
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2025.
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Effect of Dexmedetomidine on Hemodynamic Response to Endotracheal Intubation in Hypertensive Patients
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Fatma Nabil contact
Questions about this trial
What is this clinical trial studying?
A study testing Dexmedetomidine and Saline in people with Pressor Response, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mohamed S. Hussein (+201028586836, mohamedmsh4274@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Systolic blood pressure in response to endotracheal intubation (time frame: Intraoperative). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2025.