Median NerveNCT07154017
Efficacy of Combining Movement Representation Techniques to Active Neural Mobilization in the Mechanosensitivity of the Median Nerve in Asymptomatic Volunteers.
A study testing Combination of Movement Representation Techniques with neural mobilization exercises and Neural mobilization exercises in people with Median Nerve, run by University of Gran Rosario at 1 site in Argentina.
Trial summary
The objective of this study will be to determine whether the combination of movement imaging techniques with neural mobilization (NM) exercises works to modify median nerve sensitivity to mechanical stimuli. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Median Nerve
- What is being tested?
- Combination of Movement Representation Techniques with neural mobilization exercises and Neural mobilization exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteArgentina
- Study dates
- Sep 2025to Dec 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- asymptomatic volunteers of both sexes
- aged 18 to 45
- with no symptoms or history of disease in the cervical region, shoulder girdle, or upper limb.
Who cannot join
- history of surgery or trauma to the cervical spine, shoulder girdle, or upper limb;
- nonspecific shoulder pain;
- presenting symptoms of chronic pain in any region of the body;
- aphantasia (inability to create mental images);
- hypermobility;
- history of cancer or active disease;
Show all 15Show fewer
- current infection;
- rheumatological disease;
- neurological and/or psychiatric disorders;
- altered sensation;
- current pregnancy;
- consumption of centrally acting medications;
- undergoing physiotherapy treatment in the last month;
- inability to understand the informed consent document;
- previous experience with median nerve provocation testing.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Argentina1 site
University of Gran Rosario
Rosario, Santa Fe Province, 2000
Leonardo Intelangelo, Doctor-Physiotherapist, +5493416758135, lintelangelo@ugr.edu.ar
Mauro S Barone, Doctor-Physiotherapist, +5493412123037, mbarone@ugr.edu.ar
About this study
Official title: Efficacy of Combining Movement Representation Techniques to Active Neural Mobilization in the Mechanosensitivity of the Median Nerve: A Pilot Study, Single-blind,Randomized, Crossover.
The objective of this study will be to determine whether the combination of movement imaging techniques with neural mobilization (NM) exercises works to modify median nerve sensitivity to mechanical stimuli. Movement Representation Techniques (MRTs) are defined as therapeutic or training systems that neurophysiologically evoke a perceptual-cognitive representation of movement. They can be combined with the execution of actual movement or with afferent sensory stimulation (motor command). There is evidence demonstrating positive results in pain reduction and improved range of motion using MRTs alone.
The study will be evaluated in 10 randomly selected asymptomatic volunteers, considering the following variables: pressure pain threshold, elbow extensor range of motion, and sensory responses before and after the intervention, in both the experimental and control groups. The period between interventions will be 72 hours.
Read the detailed description
The objective of this pilot study will be to determine the efficacy of combining movement representation techniques with neural mobilization (NM) exercises on median nerve mechanosensitivity. Movement representation techniques (MRTs) are defined as therapeutic or training systems that neurophysiologically evoke a perceptual-cognitive representation of movement through imagery or observation of motor actions. They can be combined with actual movement execution or with afferent sensory stimulation (motor command). There is evidence demonstrating positive results in pain reduction and range of motion gains using MRTs alone.
The study will be designed as a randomized, single-blind, crossover pilot clinical trial. In this study, 10 asymptomatic volunteers will be randomly selected and measured in the following variables: pressure pain threshold (PPT), elbow extensor range of motion (EROM), and the spatiotemporal distribution of pre- and post-intervention sensory responses in both the experimental group (RMM + MN) and the control group (MN). The washout period between interventions will be 72 hours.
- Conditions
- Median Nerve
- Being tested
- Combination of Movement Representation Techniques with neural mobilization exercises, Neural mobilization exercises
- Keywords
- Movement Representation Techniques, Neural Mobilization, Mechanosensitivity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combination of Movement Representation Techniques with neural mobilization exercisesOther
The experimental intervention will be an exposition of movement representation techniques in an established sequential order, consisting of action observation, implicit/explicit motor imagery and visual feedback with a mirror in combination with neural mobilization exercises.
Neural mobilization exercisesOther
Also called Neurodinamics excercises
The control intervention will consist in three series of active neural mobilization exercises
| Study group | Role | What they receive |
|---|---|---|
| Combination of Movement Representation Techniques with Neural Mobilization Exercises (experimental) | Experimental | Combination of Movement Representation Techniques (Action observation, Motor imagery and Mirror therapy) with Neural Mobilization Exercises (Active neural mobilization of Median nerve) Receives: Other: Combination of Movement Representation Techniques with neural mobilization exercises |
| Neural Mobilization Excercises (control) | Active comparator | Neural Mobilization Exercises (Active neural mobilization of Median nerve) Receives: Other: Neural mobilization exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Elbow Extensor Range of Motion
The elbow extension movement will be measured during the median nerve provocation test, through digital inclinometry of both the dominant and non-dominant arm by an experienced Physiotherapist.
Measured: Pre- and post-interventions with a 72-hour washout period, for both control and experimental.
Pressure Pain Threshold
Pressure pain thresholds (PPTs) will be performed at two sites, the dominant and non-dominant side, in asymptomatic participants: 1) the upper trapezius muscle, and 2) the proximal third of the forearm. A pressure algometer will be used. The device has a rod at one end with a 1 cm2 flat, circular rubber tip. Pressure will be applied progressively in a perpendicular direction at a rate of 0.5 kgf/cm2 per second to the assessment sites. Volunteers will be asked to verbally report the moment they feel the pressure exerted with the pressure algometer begin to change to a sensation of pain (first painful sensation). At that moment, the evaluator will stop applying pressure and a value will be obtained. Three measurements will be taken at each site, 30 seconds apart. The PPT will be determined as the arithmetic mean of the three measurements.
Measured: Pre and post interventions, both control and experimentalPre- and post-interventions with a 72-hour washout period, for both control and experimental.
Spatiotemporal distribution of sensory responses
Humanoid software (University Center of Assistance, Teaching and Investigation, CUADI, Argentina) will be used to evaluate the spatiotemporal distribution of pain intensity and/or perceived sensations. To mark the sensations that subject feel during the arm stretch test. To do this, the subjects will mark the area on the touchscreen where they perceive tension or stretching. The sensations will be representated by different colours: yellow is used for mild sensations, orange for moderate sensations, and red for intense sensations.
Measured: Pre- and post-interventions with a 72-hour washout period, for both control and experimental.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Sep 2025
- Study startSep 2025 (estimated)
- Primary completionDec 2025 (estimated)
- Study completionDec 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Median NerveStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- A Pilot Study, Single-blind,Randomized, Crossover.
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 10 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Gran Rosario
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Maximiliano Venosta, University of Gran Rosario
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07154017
- Sponsor's protocol ID
- 886/2024
- Status last verified
- Aug 2025
- First submitted
- 18 Aug 2025
- Last updated
- 4 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Yes, the statistical analysis and consent form
Publications
Matesanz-Garcia L, Caceres-Pajuelo JE, Cuenca-Martinez F, La Touche R, Goicoechea-Garcia C, Fernandez-Carnero J. Effects of neural mobilizations through movement representation techniques for the improvement of neural mechanosensitivity of the median nerve region: a randomized controlled trial. Somatosens Mot Res. 2021 Dec;38(4):267-276. doi: 10.1080/08990220.2021.1964463. Epub 2021 Aug 17.
PubMed 34404324
Study at a glance
From the registry record, last updated by the sponsor on 4 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy of Combining Movement Representation Techniques to Active Neural Mobilization in the Mechanosensitivity of the Median Nerve: A Pilot Study, Single-blind,Randomized, Crossover.
- ClinicalTrials.gov ID
- NCT07154017
- Acronym / sponsor ID
- 886/2024
- Conditions
- Median Nerve
- Keywords
- Movement Representation Techniques, Neural Mobilization, Mechanosensitivity
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 10 participants (estimated)
- Lead sponsor
- University of Gran RosarioUniversity, hospital or other
- Study start
- Sep 2025 (estimated)
- Primary completion
- Dec 2025 (estimated)
- Study completion
- Dec 2025 (estimated)
- First posted
- 4 Sep 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this study will be to determine whether the combination of movement imaging techniques with neural mobilization (NM) exercises works to modify median nerve sensitivity to mechanical stimuli. Movement Representation Techniques (MRTs) are defined as therapeutic or training systems that neurophysiologically evoke a perceptual-cognitive representation of movement. They can be combined with the execution of actual movement or with afferent sensory stimulation (motor command). There is evidence demonstrating positive results in pain reduction and improved range of motion using MRTs alone.
The study will be evaluated in 10 randomly selected asymptomatic volunteers, considering the following variables: pressure pain threshold, elbow extensor range of motion, and sensory responses before and after the intervention, in both the experimental and control groups. The period between interventions will be 72 hours.
Detailed description
The objective of this pilot study will be to determine the efficacy of combining movement representation techniques with neural mobilization (NM) exercises on median nerve mechanosensitivity. Movement representation techniques (MRTs) are defined as therapeutic or training systems that neurophysiologically evoke a perceptual-cognitive representation of movement through imagery or observation of motor actions. They can be combined with actual movement execution or with afferent sensory stimulation (motor command). There is evidence demonstrating positive results in pain reduction and range of motion gains using MRTs alone.
The study will be designed as a randomized, single-blind, crossover pilot clinical trial. In this study, 10 asymptomatic volunteers will be randomly selected and measured in the following variables: pressure pain threshold (PPT), elbow extensor range of motion (EROM), and the spatiotemporal distribution of pre- and post-intervention sensory responses in both the experimental group (RMM + MN) and the control group (MN). The washout period between interventions will be 72 hours.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- A Pilot Study, Single-blind,Randomized, Crossover.
| Arm | Type | Receives |
|---|---|---|
| Combination of Movement Representation Techniques with Neural Mobilization Exercises (experimental) | Experimental | Other: Combination of Movement Representation Techniques with neural mobilization exercisesCombination of Movement Representation Techniques (Action observation, Motor imagery and Mirror therapy) with Neural Mobilization Exercises (Active neural mobilization of Median nerve) |
| Neural Mobilization Excercises (control) | Active comparator | Other: Neural mobilization exercisesNeural Mobilization Exercises (Active neural mobilization of Median nerve) |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- asymptomatic volunteers of both sexes
- aged 18 to 45
- with no symptoms or history of disease in the cervical region, shoulder girdle, or upper limb.
Key exclusion criteria (15 listed)
- history of surgery or trauma to the cervical spine, shoulder girdle, or upper limb;
- nonspecific shoulder pain;
- presenting symptoms of chronic pain in any region of the body;
- aphantasia (inability to create mental images);
- hypermobility;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combination of Movement Representation Techniques with neural mobilization exercisesThe experimental intervention will be an exposition of movement representation techniques in an established sequential order, consisting of action observation, implicit/explicit motor imagery and visual feedback with a mirror in combination with neural mobilization exercises. | Other | Combination of Movement Representation Techniques with Neural Mobilization Exercises (experimental) |
| Neural mobilization exercisesAlso: Neurodinamics excercisesThe control intervention will consist in three series of active neural mobilization exercises | Other | Neural Mobilization Excercises (control) |
Primary outcome
Elbow Extensor Range of Motion
Time frame: Pre- and post-interventions with a 72-hour washout period, for both control and experimental.
The elbow extension movement will be measured during the median nerve provocation test, through digital inclinometry of both the dominant and non-dominant arm by an experienced Physiotherapist.
Pressure Pain Threshold
Time frame: Pre and post interventions, both control and experimentalPre- and post-interventions with a 72-hour washout period, for both control and experimental.
Pressure pain thresholds (PPTs) will be performed at two sites, the dominant and non-dominant side, in asymptomatic participants: 1) the upper trapezius muscle, and 2) the proximal third of the forearm. A pressure algometer will be used. The device has a rod at one end with a 1 cm2 flat, circular rubber tip. Pressure will be applied progressively in a perpendicular direction at a rate of 0.5 kgf/cm2 per second to the assessment sites. Volunteers will be asked to verbally report the moment they feel the pressure exerted with the pressure algometer begin to change to a sensation of pain (first painful sensation). At that moment, the evaluator will stop applying pressure and a value will be obtained. Three measurements will be taken at each site, 30 seconds apart. The PPT will be determined as the arithmetic mean of the three measurements.
Spatiotemporal distribution of sensory responses
Time frame: Pre- and post-interventions with a 72-hour washout period, for both control and experimental.
Humanoid software (University Center of Assistance, Teaching and Investigation, CUADI, Argentina) will be used to evaluate the spatiotemporal distribution of pain intensity and/or perceived sensations. To mark the sensations that subject feel during the arm stretch test. To do this, the subjects will mark the area on the touchscreen where they perceive tension or stretching. The sensations will be representated by different colours: yellow is used for mild sensations, orange for moderate sensations, and red for intense sensations.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2025.
- Results publication: PubMed 34404324Matesanz-Garcia L, Caceres-Pajuelo JE, Cuenca-Martinez F, La Touche R, Goicoechea-Garcia C, Fernandez-Carnero J. Effects of neural mobilizations through movement representation techniques for the improvement of neural mechanosensitivity of the median nerve region: a randomized controlled trial. Somatosens Mot Res. 2021 Dec;38(4):267-276. doi: 10.1080/08990220.2021.1964463. Epub 2021 Aug 17.
- Individual participant dataSharing planned: Yes. Yes, the statistical analysis and consent form
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combination of Movement Representation Techniques with neural mobilization exercises and Neural mobilization exercises in people with Median Nerve, run by University of Gran Rosario at 1 site in Argentina.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 4 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Argentina. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Maximiliano Venosta, Physiotherapist (+5493412114064, mvenosta@ugr.edu.ar), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Elbow Extensor Range of Motion (time frame: Pre- and post-interventions with a 72-hour washout period, for both control and experimental.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07154017, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2025.