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HomelessnessCARE-VASHNCT07141394

Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

A study testing Medication for Addiction Treatment (MAT) and Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD) in people with Homelessness and Substance Use Disorder (SUD), run by VA Office of Research and Development at 1 site in United States.

Enrolling by invitation

Enrolling by invitation. The study team selects and invites participants, usually from an existing group of patients.

Sites and contacts
Official record

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Trial summary

The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program provides subsidized permanent housing with case management to homeless-experienced Veterans (HEVs). Read more about this study

Who is it for?
Any ageHealthy volunteers can take part
Conditions the study is for
Homelessness, Substance Use Disorder (SUD)
What is being tested?
Medication for Addiction Treatment (MAT) and Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
Could I receive a placebo?
No, everyone receives an active treatment
How many people
7,908 participants
Where
1 siteUnited States
Study dates
15 Sep 2026to 30 Sep 2030
Phase
Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • Healthy volunteers accepted
  • Child, Adult, Older adult

Who may be able to join

  • Homeless-experienced Veterans (HEVs) enrolled in the Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program.

Who cannot join

  • None

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

United States1 site
  • VA Greater Los Angeles Healthcare System, West Los Angeles, CA

    West Los Angeles, California, 90073-1003

Other trials in United States

About this study

Official title: Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing (CARE-VASH) (QUE 25-013)

The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program provides subsidized permanent housing with case management to homeless-experienced Veterans (HEVs). Up to 40% of Veterans exit HUD-VASH within two years of attaining housing; substance use disorders (SUDs) are one of the largest causes of returns to homelessness for HEVs. CARE-VASH QUERI proposes to implement and evaluate two evidence-based SUD services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in HUD-VASH.

Read the detailed description

The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) program provides subsidized, permanent housing and supports to Veterans experiencing homelessness. Substance use disorders (SUDs) are a common primary or contributing factor to negative exits from HUD-VASH. The Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing (CARE-VASH) QUERI will implement two evidence-based practices (EBPs) for SUDs-Medications for Addiction Treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD)-in 12 HUD-VASH sites. The investigators will use the Replicating Effective Programs (REP) implementation bundle to support EBP implementation at all 12 sites. Half the sites (n=6) will also receive 9 months of consumer engagement (REP+CE). In a type 3 hybrid trial, the investigators will use mixed methods to examine the impacts of REP vs. REP+CE. Using our trial data, the investigators will develop a budget impact analysis and implementation playbook for our program partners to spread and sustain MAT and CBT-SUD in HUD-VASH.

Being tested
Medication for Addiction Treatment (MAT), Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
Keywords
Homeless, Substance Use Disorder, Permanent Supportive Housing, Implementation Science
Medical subject headings
Substance-Related Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Medication for Addiction Treatment (MAT)Drug

    Also called MAT

    MAT includes medications for alcohol use disorder (MAUD) and medications for opioid use disorder (MAUD). It reduces substance use, increases SUD treatment engagement, enhances quality of life, and reduces overdoses.

  • Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)Behavioural

    Also called CBT-SUD

    An evidence-based psychotherapy that uses cognitive behavioral therapy to further recovery goals across SUD diagnoses.

Study groups in NCT07141394
Study groupRoleWhat they receive
Replicating Effective Programs (REP)ExperimentalA stakeholder-informed training and technical assistance implementation strategy
Receives: Drug: Medication for Addiction Treatment (MAT); Behavioral: Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
REP + Consumer Engagement (CE)Active comparatorREP plus CE package (educational materials, peer coaching, toolkit) to support MAT and CBT-SUD implementation.
Receives: Drug: Medication for Addiction Treatment (MAT); Behavioral: Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
Control GroupNo interventionNo MAT or CBT-SUD implementation

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Reach of MAT (Medications for Addiction Treatment)

    • (percent of) Veterans who used Medications for Opioid Use Disorder (MOUD) for OUD, ≥1 prescription
    • (percent of) Veterans who used MOUD for OUD for 180 days since initial prescription (without a break ≥14 days in supply)
    • (percent of) Veterans who used Medications for Alcohol Use Disorder (MAUD) for AUD, ≥1 prescription
    • (percent of) Veterans who used MAUD for AUD for 180 days since initial prescription (without a break ≥14 days in supply)

    Measured: 18 months post-implementation

  2. Reach of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)

    • (percent of) Veterans with stimulant use disorder who had ≥1 visit for Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD) or contingency management
    • (percent of) Veterans with substance use disorder with ≥1 CBT-SUD visit
    • (percent of) Veterans with substance use disorder with ≥9 CBT-SUD visits

    Measured: 18 months post-implementation

  3. Adoption of MAT (Medications for Addiction Treatment)

    % (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) and mental health prescribers engaged with Veterans who ordered Medications for Opioid Use Disorder (MOUD) / Medications for Alcohol Use Disorder (MAUD) at least once

    Measured: 18 months post-implementation

  4. Adoption of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)

    % (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) case managers who delivered ≥1 CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders) session

    Measured: 18 months post-implementation

  5. Sustainment of MAT (Medications for Addiction Treatment)

    • (percent of) Veterans who used Medications for Opioid Use Disorder (MOUD) for OUD, ≥1 prescription
    • (percent of) Veterans who used MOUD for OUD for 180 days since initial prescription (without a break ≥14 days in supply)
    • (percent of) Veterans who used Medications for Alcohol Use Disorder (MAUD) for AUD, ≥1 prescription
    • (percent of) Veterans who used MAUD for AUD for 180 days since initial prescription (without a break ≥14 days in supply)
    • (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) and mental health prescribers engaged with Veterans who ordered Medications for Opioid Use Disorder (MOUD) / Medications for Alcohol Use Disorder (MAUD) at least once

    Measured: 18-27 months post-implementation

  6. Sustainment of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)

    • (percent of) Veterans with stimulant use disorder who had ≥1 visit for Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD) or contingency management
    • (percent of) Veterans with substance use disorder with ≥1 CBT-SUD visit
    • (percent of) Veterans with substance use disorder with ≥9 CBT-SUD visits
    • (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) case managers who delivered ≥1 CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders) session

    Measured: 18-27 months post-implementation

Secondary outcomes (4)
  1. Housing retention

    Difference in the mean days homeless over 1 year of follow-up for Veterans enrolled in trial sites that received the base versus enhanced implementation strategy, versus the expected number of days homeless had they enrolled in a comparison group of all sites not engaged in the trial

    Measured: 1 year after implementation by cohort

  2. Provider experience

    Experiences of and satisfaction with providing HUD-VASH services to HEVs with SUDs pre- and post- implementation, which will be assessed using semi-structured qualitative interviews (data will be coded from key findings in the narratives provided during the interviews).

    Measured: Baseline and 18 months post-implementation

  3. Cost impact of Medications for Addiction Treatment (MAT) and Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD)

    The predominant cost of delivering MAT in the Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) programs is prescriber time; for CBT-SUD, the predominant cost is case manager time. The investigators will use VA administrative data to identify visits in which MAT was prescribed or CBT-SUD was delivered. Interviews with HUD-VASH prescribers will be used to estimate minutes/visit spent on MAT, including visits in which MAT was discussed but not prescribed; at implementation sites, the investigators will add a mandated field to templated CBT-SUD notes that indicates time spent outside the encounter (e.g., preparing for the visit).

    Measured: 18 months (during the course of implementation)

  4. Acute care utilization

    Emergency department visits and hospitalizations associated with primary SUD diagnoses

    Measured: 1 year after implementation by cohort

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted26 Aug 2025
  2. Study start15 Sep 2026
  3. Primary completion30 Sep 2030 (estimated)
  4. Study completion30 Sep 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Other
Allocation
Randomised
Intervention model
Parallel groups
Model description
Investigators are implementing two evidence-based Substance Use Disorder (SUD) services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in the Department of Housing and Urban Development-VA Supportive Housing Program (HUD-VASH).
Masking
None (open label)
Enrolment
7,908 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07141394
Sponsor's protocol ID
QUX 25-001
Other IDs
QUE 25-013
Acronym
CARE-VASH
Status last verified
Sep 2026
First submitted
6 Aug 2025
Last updated
30 Sep 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes

Publications

  • Gabrielian S, Chang ET, Treichler EBH, Barnard J, Nelson RE, Wong MS, Jackson NJ, Finley EP. Comparing two strategies to support the implementation of evidence-based practices for substance use disorders in VA's permanent supportive housing program: a protocol for a type 3 hybrid cluster-randomized controlled trial. Implement Sci. 2026 Mar 24;21(1):30. doi: 10.1186/s13012-026-01498-z.

    PubMed 41877142

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