HomelessnessCARE-VASHNCT07141394
Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing
A study testing Medication for Addiction Treatment (MAT) and Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD) in people with Homelessness and Substance Use Disorder (SUD), run by VA Office of Research and Development at 1 site in United States.
Trial summary
The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program provides subsidized permanent housing with case management to homeless-experienced Veterans (HEVs). Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Homelessness, Substance Use Disorder (SUD)
- What is being tested?
- Medication for Addiction Treatment (MAT) and Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 7,908 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Sep 2026to 30 Sep 2030
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Homeless-experienced Veterans (HEVs) enrolled in the Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program.
Who cannot join
- None
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, 90073-1003
About this study
Official title: Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing (CARE-VASH) (QUE 25-013)
The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program provides subsidized permanent housing with case management to homeless-experienced Veterans (HEVs). Up to 40% of Veterans exit HUD-VASH within two years of attaining housing; substance use disorders (SUDs) are one of the largest causes of returns to homelessness for HEVs. CARE-VASH QUERI proposes to implement and evaluate two evidence-based SUD services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in HUD-VASH.
Read the detailed description
The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) program provides subsidized, permanent housing and supports to Veterans experiencing homelessness. Substance use disorders (SUDs) are a common primary or contributing factor to negative exits from HUD-VASH. The Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing (CARE-VASH) QUERI will implement two evidence-based practices (EBPs) for SUDs-Medications for Addiction Treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD)-in 12 HUD-VASH sites. The investigators will use the Replicating Effective Programs (REP) implementation bundle to support EBP implementation at all 12 sites. Half the sites (n=6) will also receive 9 months of consumer engagement (REP+CE). In a type 3 hybrid trial, the investigators will use mixed methods to examine the impacts of REP vs. REP+CE. Using our trial data, the investigators will develop a budget impact analysis and implementation playbook for our program partners to spread and sustain MAT and CBT-SUD in HUD-VASH.
- Conditions
- Homelessness, Substance Use Disorder (SUD)
- Being tested
- Medication for Addiction Treatment (MAT), Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)
- Keywords
- Homeless, Substance Use Disorder, Permanent Supportive Housing, Implementation Science
- Medical subject headings
- Substance-Related Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Medication for Addiction Treatment (MAT)Drug
Also called MAT
MAT includes medications for alcohol use disorder (MAUD) and medications for opioid use disorder (MAUD). It reduces substance use, increases SUD treatment engagement, enhances quality of life, and reduces overdoses.
Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD)Behavioural
Also called CBT-SUD
An evidence-based psychotherapy that uses cognitive behavioral therapy to further recovery goals across SUD diagnoses.
| Study group | Role | What they receive |
|---|---|---|
| Replicating Effective Programs (REP) | Experimental | A stakeholder-informed training and technical assistance implementation strategy Receives: Drug: Medication for Addiction Treatment (MAT); Behavioral: Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD) |
| REP + Consumer Engagement (CE) | Active comparator | REP plus CE package (educational materials, peer coaching, toolkit) to support MAT and CBT-SUD implementation. Receives: Drug: Medication for Addiction Treatment (MAT); Behavioral: Cognitive Behavioral Therapy for Substance Use Disorders (CBT-SUD) |
| Control Group | No intervention | No MAT or CBT-SUD implementation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Reach of MAT (Medications for Addiction Treatment)
- (percent of) Veterans who used Medications for Opioid Use Disorder (MOUD) for OUD, ≥1 prescription
- (percent of) Veterans who used MOUD for OUD for 180 days since initial prescription (without a break ≥14 days in supply)
- (percent of) Veterans who used Medications for Alcohol Use Disorder (MAUD) for AUD, ≥1 prescription
- (percent of) Veterans who used MAUD for AUD for 180 days since initial prescription (without a break ≥14 days in supply)
Measured: 18 months post-implementation
Reach of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)
- (percent of) Veterans with stimulant use disorder who had ≥1 visit for Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD) or contingency management
- (percent of) Veterans with substance use disorder with ≥1 CBT-SUD visit
- (percent of) Veterans with substance use disorder with ≥9 CBT-SUD visits
Measured: 18 months post-implementation
Adoption of MAT (Medications for Addiction Treatment)
% (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) and mental health prescribers engaged with Veterans who ordered Medications for Opioid Use Disorder (MOUD) / Medications for Alcohol Use Disorder (MAUD) at least once
Measured: 18 months post-implementation
Adoption of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)
% (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) case managers who delivered ≥1 CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders) session
Measured: 18 months post-implementation
Sustainment of MAT (Medications for Addiction Treatment)
- (percent of) Veterans who used Medications for Opioid Use Disorder (MOUD) for OUD, ≥1 prescription
- (percent of) Veterans who used MOUD for OUD for 180 days since initial prescription (without a break ≥14 days in supply)
- (percent of) Veterans who used Medications for Alcohol Use Disorder (MAUD) for AUD, ≥1 prescription
- (percent of) Veterans who used MAUD for AUD for 180 days since initial prescription (without a break ≥14 days in supply)
- (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) and mental health prescribers engaged with Veterans who ordered Medications for Opioid Use Disorder (MOUD) / Medications for Alcohol Use Disorder (MAUD) at least once
Measured: 18-27 months post-implementation
Sustainment of CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders)
- (percent of) Veterans with stimulant use disorder who had ≥1 visit for Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD) or contingency management
- (percent of) Veterans with substance use disorder with ≥1 CBT-SUD visit
- (percent of) Veterans with substance use disorder with ≥9 CBT-SUD visits
- (percent of) Department of Housing and Urban Development - VA Supportive Housing (HUD-VASH) case managers who delivered ≥1 CBT-SUD (Cognitive Behavioral Therapy-Substance Use Disorders) session
Measured: 18-27 months post-implementation
Secondary outcomes (4)
Housing retention
Difference in the mean days homeless over 1 year of follow-up for Veterans enrolled in trial sites that received the base versus enhanced implementation strategy, versus the expected number of days homeless had they enrolled in a comparison group of all sites not engaged in the trial
Measured: 1 year after implementation by cohort
Provider experience
Experiences of and satisfaction with providing HUD-VASH services to HEVs with SUDs pre- and post- implementation, which will be assessed using semi-structured qualitative interviews (data will be coded from key findings in the narratives provided during the interviews).
Measured: Baseline and 18 months post-implementation
Cost impact of Medications for Addiction Treatment (MAT) and Cognitive Behavioral Therapy-Substance Use Disorders (CBT-SUD)
The predominant cost of delivering MAT in the Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) programs is prescriber time; for CBT-SUD, the predominant cost is case manager time. The investigators will use VA administrative data to identify visits in which MAT was prescribed or CBT-SUD was delivered. Interviews with HUD-VASH prescribers will be used to estimate minutes/visit spent on MAT, including visits in which MAT was discussed but not prescribed; at implementation sites, the investigators will add a mandated field to templated CBT-SUD notes that indicates time spent outside the encounter (e.g., preparing for the visit).
Measured: 18 months (during the course of implementation)
Acute care utilization
Emergency department visits and hospitalizations associated with primary SUD diagnoses
Measured: 1 year after implementation by cohort
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2025
- Study start15 Sep 2026
- Primary completion30 Sep 2030 (estimated)
- Study completion30 Sep 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HomelessnessStudies of the same condition, open and under way.
- More trials run by VA Office of Research and DevelopmentThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Investigators are implementing two evidence-based Substance Use Disorder (SUD) services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in the Department of Housing and Urban Development-VA Supportive Housing Program (HUD-VASH).
- Masking
- None (open label)
- Enrolment
- 7,908 participants (estimated)
Sponsor and investigators
- Lead sponsor
- VA Office of Research and Development
- Sponsor type
- US federal agency
- Collaborators
- University of California, Los Angeles
- Responsible party
- Sponsor
- Investigators
- Sonya Emi Gabrielian, MD MPH, Principal investigator, VA Greater Los Angeles Healthcare System, West Los Angeles, CAEvelyn T Chang, MD MSHS, Principal investigator, VA Greater Los Angeles Healthcare System, Sepulveda, CAErin P Finley, PhD MPH, Principal investigator, VA Greater Los Angeles Healthcare System, West Los Angeles, CAEmily Treichler, PhD, Principal investigator, VA San Diego Healthcare System, San Diego, CA
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07141394
- Sponsor's protocol ID
- QUX 25-001
- Other IDs
- QUE 25-013
- Acronym
- CARE-VASH
- Status last verified
- Sep 2026
- First submitted
- 6 Aug 2025
- Last updated
- 30 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Gabrielian S, Chang ET, Treichler EBH, Barnard J, Nelson RE, Wong MS, Jackson NJ, Finley EP. Comparing two strategies to support the implementation of evidence-based practices for substance use disorders in VA's permanent supportive housing program: a protocol for a type 3 hybrid cluster-randomized controlled trial. Implement Sci. 2026 Mar 24;21(1):30. doi: 10.1186/s13012-026-01498-z.
PubMed 41877142