AsthmaCON-PONCT07134686

Implementation of a Joint Pulmonologist and ENT Consultation in the Care Pathway of Patients Suffering From Asthma and Chronic Rhinosinusitis With Nasal Polyposis: Effectiveness Compared With Consultations by Specialty (CON-PO Study).

A study testing Joint consultation, Mucus sampling and Nasal brushing in people with Asthma and Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), run by Assistance Publique Hopitaux De Marseille at 1 site in France.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts

Official record

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Trial summary

Asthma affects the lower respiratory tract (bronchi), whereas chronic rhinosinusitis with nasal polyposis (CRSwNP) involves the upper airways. Despite this anatomical distinction, the upper and lower airways form a continuous respiratory tract and share common pathophysiological mechanisms. Read more about this study

Who is it for?: Ages 18 years and older
Conditions the study is for: Asthma, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
What is being tested?: Joint consultation, Mucus sampling and Nasal brushing
Type of treatment: Surgery or procedure
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 195 participants
Where: 1 siteFrance
Study dates: 28 Jul 2026to Nov 2029
Phase: Interventional
Are there results?: Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 years and older
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

Male or female, 18 years of age or older;
With a diagnosis of asthma;
With a diagnosis of chronic rhinosinusitis with nasal polyposis;
Whose asthma and/or chronic rhinosinusitis is/are not controlled according to SNOT-22 and ACQ-6 scores;
Having used systemic corticosteroids in the previous year to treat symptoms related to one of these conditions at least;

Who cannot join

Patient in a period of exclusion from another research protocol at the time of consent signature;
Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code (adult patients under guardianship or curatorship, patients deprived of their liberty, pregnant or breast-feeding women);
Patients who do not read and/or understand French

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

France1 site, 1 recruiting

AP-HM
Marseille
Laurie Pahus, +334 91 96 45 33, promotion.interne@ap-m.fr
Recruiting

Other trials in France

About this study

Given these overlaps, we hypothesize that a multidisciplinary consultation involving both a pulmonologist and an ENT specialist could be more effective than separate consultations for patient care. We also believe that this innovative organization that would benefit the healthcare system.

To test this hypothesis, we are conducting a study whose primary objective is to assess whether joint consultations lead to a reduction in oral corticosteroid need over the year following the initial consultation, by enabling more personalized treatment strategies.

Secondary outcomes will include the frequency of asthma exacerbations, frequency of ENT-related events, respiratory symptoms, quality of life, and healthcare ressources utilization.

We will compare outcomes between two patient groups: one receiving joint consultation from both specialists, and the other managed through standard, separate consultations as per current clinical practice.

Conditions: Asthma, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Being tested: Joint consultation, Mucus sampling, Nasal brushing
Keywords: Asthma, Care pathway, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Medical subject headings: Asthma

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Joint consultationOther
Joint consultation with pneumologist and ENT at baseline.
Mucus samplingProcedure or surgery
Mucus sampling at baseline and one year follow-up
Nasal brushingProcedure or surgery
Nasal brushing at baseline and one year follow-up

Study groups in NCT07134686
Study group	Role	What they receive
Joint consultation	Experimental	Multi-disciplinary consultation with a pulmonologist and ENT specialist at the baseline visit Receives: Other: Joint consultation; Procedure: Mucus sampling; Procedure: Nasal brushing
Separate consultations	Active comparator	Separate consultations with a pulmonologist and ENT specialist at the baseline visit as standard care Receives: Procedure: Mucus sampling; Procedure: Nasal brushing

What is being measured

The primary outcome is the main question the study is designed to answer.

Effectiveness of joint ENT and pulmonologist consultation on relative change in cumulative annual dose of oral corticosteroids from the year before Baseline to the year between Baseline and 12 months visit.
Self reported cumulative annual dose of oral corticosteroids.
Measured: From the year before Baseline to the 12 months visit.

Secondary outcomes (7)

Reduction of asthma exacerbations frequency. Relative change from the year before Baseline to the year between baseline and 12 months visit in number of asthma exacerbations.
self-reported number of asthma exacerbations
Measured: From the year before Baseline to the 12 months visit.
Reduction of ENT events frequency. Relative change from the year before baseline to the year between baseline and 12 month visit in number of ENT events.
Self reported number of ENT events
Measured: From the year before Baseline to the 12 months visit.
Improvement of asthma control. Relative change from baseline to 12 months visit in ACQ-6 score
Self-administered questionnaire
Measured: Baseline and 12 months visit.
Improvement of chronic rhinosinusitis with nasal polyposis control . Relative change from baseline to 12 months visit in SNOT-22 score
Self-administered questionnaire
Measured: Baseline and 12 months visit.
Reduction in endoscopic polyp score. Relative change from baseline to 12 months visit in the polyp endoscopic score (mean of measures of both nostrils)
Evaluated with nasal endoscopy
Measured: Baseline and 12 months visit.
Improvement of patient's quality of life. Relative change from baseline to 12 months visit in EQ-5D-5L score
Self-administered questionnaire
Measured: Baseline and 12 months visit.
Reduction of healthcare ressource use . Relative change from baseline to 12 months visit in number of consultations with a specialist, general practitionner, emergency visits and hospitalizations
Self-reported number of consultations with a specialist, general practicionner, emergency visits and hospitalizations
Measured: From Baseline to the 12 months visit

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

28 Jul 2026Nov 2029

First posted21 Aug 2025
Study start28 Jul 2026
Primary completionNov 2029 (estimated)
Study completionNov 2029 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for AsthmaStudies of the same condition, open and under way.
More trials run by Assistance Publique Hopitaux De MarseilleThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Other
Allocation: Randomised
Intervention model: Parallel groups
Model description: Model Description
Masking: None (open label)
Enrolment: 195 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07134686
Sponsor's protocol ID: 2024-A02003-44
Acronym: CON-PO
Status last verified: Jul 2026
First submitted: 14 Aug 2025
Last updated: 3 Aug 2026
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

Interested in taking part?

Each site lists its own contact. Pick the site nearest to you.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See sites and contacts

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All Asthma trials

Study at a glance

From the registry record, last updated by the sponsor on 3 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Implementation of a Joint Pulmonologist and ENT Consultation in the Care Pathway of Patients Suffering From Asthma and Chronic Rhinosinusitis With Nasal Polyposis: Effectiveness Compared With Consultations by Specialty (CON-PO Study).
ClinicalTrials.gov ID: NCT07134686
Acronym / sponsor ID: CON-PO / 2024-A02003-44
Conditions: Asthma, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Keywords: Asthma, Care pathway, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Study type: Interventional
Recruitment status: Recruiting
Enrolment: 195 participants (estimated)
Lead sponsor: Assistance Publique Hopitaux De MarseilleUniversity, hospital or other
Study start: 28 Jul 2026 (actual)
Primary completion: Nov 2029 (estimated)
Study completion: Nov 2029 (estimated)
First posted: 21 Aug 2025 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Secondary outcomes will include the frequency of asthma exacerbations, frequency of ENT-related events, respiratory symptoms, quality of life, and healthcare ressources utilization.

Study design

Primary purpose: Other
Allocation: Randomised
Intervention model: Parallel groups
Masking: None (open label)
Number of arms: 2
Model description: Model Description

Arm	Type	Receives
Joint consultation	Experimental	Other: Joint consultation, Procedure: Mucus sampling, Procedure: Nasal brushingMulti-disciplinary consultation with a pulmonologist and ENT specialist at the baseline visit
Separate consultations	Active comparator	Procedure: Mucus sampling, Procedure: Nasal brushingSeparate consultations with a pulmonologist and ENT specialist at the baseline visit as standard care

Who may qualify

Ages: 18 years and older
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult, Older adult

Key inclusion criteria (5 listed)

Male or female, 18 years of age or older;
With a diagnosis of asthma;
With a diagnosis of chronic rhinosinusitis with nasal polyposis;
Whose asthma and/or chronic rhinosinusitis is/are not controlled according to SNOT-22 and ACQ-6 scores;
Having used systemic corticosteroids in the previous year to treat symptoms related to one of these conditions at least;

Key exclusion criteria (3 listed)

Patient in a period of exclusion from another research protocol at the time of consent signature;
Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code (adult patients under guardianship or curatorship, patients deprived of their liberty, pregnant or breast-feeding women);
Patients who do not read and/or understand French

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Joint consultationJoint consultation with pneumologist and ENT at baseline.	Other	Joint consultation
Mucus samplingMucus sampling at baseline and one year follow-up	Procedure or surgery	Joint consultation, Separate consultations
Nasal brushingNasal brushing at baseline and one year follow-up	Procedure or surgery	Joint consultation, Separate consultations

Primary outcome

Effectiveness of joint ENT and pulmonologist consultation on relative change in cumulative annual dose of oral corticosteroids from the year before Baseline to the year between Baseline and 12 months visit.
Time frame: From the year before Baseline to the 12 months visit.
Self reported cumulative annual dose of oral corticosteroids.

7 secondary outcomes

Reduction of asthma exacerbations frequency. Relative change from the year before Baseline to the year between baseline and 12 months visit in number of asthma exacerbations.
Time frame: From the year before Baseline to the 12 months visit.
Reduction of ENT events frequency. Relative change from the year before baseline to the year between baseline and 12 month visit in number of ENT events.
Time frame: From the year before Baseline to the 12 months visit.
Improvement of asthma control. Relative change from baseline to 12 months visit in ACQ-6 score
Time frame: Baseline and 12 months visit.
Improvement of chronic rhinosinusitis with nasal polyposis control . Relative change from baseline to 12 months visit in SNOT-22 score
Time frame: Baseline and 12 months visit.
Reduction in endoscopic polyp score. Relative change from baseline to 12 months visit in the polyp endoscopic score (mean of measures of both nostrils)
Time frame: Baseline and 12 months visit.
Improvement of patient's quality of life. Relative change from baseline to 12 months visit in EQ-5D-5L score
Time frame: Baseline and 12 months visit.
Reduction of healthcare ressource use . Relative change from baseline to 12 months visit in number of consultations with a specialist, general practitionner, emergency visits and hospitalizations
Time frame: From Baseline to the 12 months visit

Results and safety

This study is still under way. Results are not available in the source record yet.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 3 Aug 2026.

Related trials for Asthma

RecruitingPhase 1
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation
Asthma
RecruitingPhase 1
A Study to Compare the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152a to HFA-134a in Mild Asthmatics Aged 18 to 65 Inclusive
Asthma, Mild Asthma
RecruitingPhase 3
A Study Assessing the Effect of Dupilumab on Inducing Clinical Remission in Asthma
Asthma Control
Active, not recruitingPhase 2/3
Local Antibiotic Delivery for Community Acquired Pneumonia
Community Acquired Pneumonia (CAP)
RecruitingPhase 2
A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma
Asthma

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.

AP-HM

Marseille, France

+334 91 96 45 33

promotion.interne@ap-m.fr

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 3 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Effectiveness of joint ENT and pulmonologist consultation on relative change in cumulative annual dose of oral corticosteroids from the year before Baseline to the year between Baseline and 12 months visit. (time frame: From the year before Baseline to the 12 months visit.). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07134686.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Aug 2026.