Brain ActivityNUMWORDNCT07133230
Neurocognitive Correlates of the Influence of Number Word Syntax on Magnitude Processing
An observational study of Brain Activity, run by Centre Hospitalier St Anne at 1 site in France.
Trial summary
Linguistic irregularities in number naming systems, such as the inversion of number words, affect the processing of Arabic numerals. Recently, it has been claimed that there is even a syntactic representation of number words. Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Brain Activity
- How many people
- 84 participants
- Where
- 1 siteFrance
- Study dates
- Sep 2025to 30 Oct 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Adult
Study population: In the experimental phase, 42 adult volunteers (a total of 84), selected according to strict criteria, will undergo an MRI scan, each comprising: - anatomical acquisition, - functional acquisition of activation during a number processing task (Phase 1: two-digit number magnitude comparison; Phase 2: multi-digit mental arithmetic).
Who may be able to join
- Subject aged 18 to 45 years;
- Female or male;
- Right-handed preference;
- Subject, or legal representative, who has given consent to participate;
- Native language: French
- Subject affiliated with a social security system;
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- Having signed their consent to participate (and their legal representative if applicable),
- Subjects have read the information letter and given their free and informed consent;
- Normal medical, neurological, and neuroradiological examinations
- For women of childbearing age, be on effective contraception
Who cannot join
- Not corresponding to the targeted age range;
- Subject with contraindications to an MRI examination (pacemaker or neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign bodies in the eyes or brain near neural structures, metal prostheses, patient agitation: non-cooperative or agitated patients, minors, claustrophobic subjects, pregnant women, ventriculoperitoneal neurosurgical shunt valves, dental braces);
- Subject with chronic alcohol or drug use;
- Abuse or dependence on substances (except nicotine) or toxic substances for more than 5 years or having led to comas (overdoses);
- Subject with sudden-onset cognitive disorders that could indicate a stroke; a history of head trauma with loss of consciousness for more than 1 hour, or encephalitis;
- Subject with chronic neurological, psychiatric, endocrine, hepatic, or infectious conditions;
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- Subject with a history of major illness (diabetes, chronic lung disease, severe cardiac, metabolic, hematological, endocrine, or immunological disorder, cancer);
- Subject on medication: taking medications likely to interfere with brain imaging measurements (psychotropics, anxiolytic hypnotics, neuroleptics, anti-Parkinsonians, benzodiazepines, steroidal anti-inflammatories, antiepileptics, central analgesics, and muscle relaxants);
- Color blindness;
- Inability to comply with the study for geographical or psychiatric reasons;
- Tattoo incompatible with MRI;
- Cerebral palsy;
- Fine motor skills disorder;
- Pregnant women at the time of inclusion;
- Adult subjects under legal protection or unable to give consent (article L.1121-8 of the French Public Health Code) (under guardianship or curatorship);
- Children and parents under legal protection measures
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Linguistic irregularities in number naming systems, such as the inversion of number words, affect the processing of Arabic numerals. Recently, it has been claimed that there is even a syntactic representation of number words. participant investigate the neurofunctional correlates of the syntactic processing of number words by examining different levels of place-value processing in a study with two complementary successive phases (Group 1 and Group 2) in healthy adults. In the first phase with Group 1, participant evaluate the unit-decade compatibility effect (UDCE) in two-digit magnitude comparisons. In the second phase with Group 2, participant investigate the carry-over effect in two-digit addition problems.
Read the detailed description
Selection visit
- Call for participants for pre-selection
- Sending of information forms by mail
- Making an appointment for the inclusion visit at GHU Paris
- Information on the modalities, constraints and foreseeable risks of the study
- Collection of informed consent
- Verification of inclusion/non-inclusion criteria
- Clinical examination:
- Verification of medical history and drug treatments
- Psychiatric pathology
- Consumption of toxic substances (nicotine, alcohol, cannabis, etc.)
- Manual lateralization will be assessed by the score on the Edinburgh questionnaire (Oldfield, 1971)
- Collection of main medical history and concomitant treatments
- Explanation of study procedures
- MRI examination
- Conditions
- Brain Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Participants recruited (phase 1) | In each experimental phase (2 in total), 42 adult volunteers will be recruited (a total of 84 participants), selected based on the following criteria: * Aged 18-45 * Female or male * Right-handed * Signed informed consent * Normal medical, neurological, and neuroradiological examinations * Affiliated with a social security system * For women of childbearing age: under effective contraception; a urine pregnancy test will be administered * MRI examination compatible Participants will be recruited in the Paris region. | |
| Participants recruited (phase 2) | In each experimental phase (2 in total), 42 adult volunteers will be recruited (a total of 84 participants), selected based on the following criteria: * Aged 18-45 * Female or male * Right-handed * Signed informed consent * Normal medical, neurological, and neuroradiological examinations * Affiliated with a social security system * For women of childbearing age: under effective contraception; a urine pregnancy test will be administered * MRI examination compatible Participants will be recruited in the Paris region. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Neurofunctional variables (fMRI)
the comparison of pairs of incompatible numbers compared to pairs of compatible numbers during the comparison of numbers.
Measured: Day 1
Structural variables (structural MRI)
the comparison of problems of addition with and without restraint during mental arithmetic.
Measured: Day 1
Behavioral variables,
we compare performance to the post-imaging reading test
Measured: Day 1
structural variables
recording of morphological and brain morphometric characteristics.
Measured: Day 1
Secondary outcomes (2)
Handedness score
Measuring the lateralization of the hand will allow to recognize, based on the proposed activities, the dominant hand.
Measured: Day 1
Demographics questionnaire
this questionnaire which will allow the collection of all the precise information about the participant
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Aug 2025
- Study startSep 2025 (estimated)
- Primary completionOct 2027 (estimated)
- Study completion30 Oct 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Brain ActivityStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier St AnneThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 84 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier St Anne
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07133230
- Sponsor's protocol ID
- D24-P010
- Acronym
- NUMWORD
- Status last verified
- May 2025
- First submitted
- 12 Jun 2025
- Last updated
- 20 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neurocognitive Correlates of the Influence of Number Word Syntax on Magnitude Processing
- ClinicalTrials.gov ID
- NCT07133230
- Acronym / sponsor ID
- NUMWORD / D24-P010
- Conditions
- Brain Activity
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 84 participants (estimated)
- Lead sponsor
- Centre Hospitalier St AnneUniversity, hospital or other
- Study start
- Sep 2025 (estimated)
- Primary completion
- Oct 2027 (estimated)
- Study completion
- 30 Oct 2027 (estimated)
- First posted
- 20 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Linguistic irregularities in number naming systems, such as the inversion of number words, affect the processing of Arabic numerals. Recently, it has been claimed that there is even a syntactic representation of number words. participant investigate the neurofunctional correlates of the syntactic processing of number words by examining different levels of place-value processing in a study with two complementary successive phases (Group 1 and Group 2) in healthy adults. In the first phase with Group 1, participant evaluate the unit-decade compatibility effect (UDCE) in two-digit magnitude comparisons. In the second phase with Group 2, participant investigate the carry-over effect in two-digit addition problems.
Detailed description
Selection visit
- Call for participants for pre-selection
- Sending of information forms by mail
- Making an appointment for the inclusion visit at GHU Paris
- Information on the modalities, constraints and foreseeable risks of the study
- Collection of informed consent
- Verification of inclusion/non-inclusion criteria
- Clinical examination:
- Verification of medical history and drug treatments
- Psychiatric pathology
- Consumption of toxic substances (nicotine, alcohol, cannabis, etc.)
- Manual lateralization will be assessed by the score on the Edinburgh questionnaire (Oldfield, 1971)
- Collection of main medical history and concomitant treatments
- Explanation of study procedures
- MRI examination
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Participants recruited (phase 1) | – | –In each experimental phase (2 in total), 42 adult volunteers will be recruited (a total of 84 participants), selected based on the following criteria: * Aged 18-45 * Female or male * Right-handed * Signed informed consent * Normal medical, neurological, and neuroradiological examinations * Affiliated with a social security system * For women of childbearing age: under effective contraception; a urine pregnancy test will be administered * MRI examination compatible Participants will be recruited in the Paris region. |
| Participants recruited (phase 2) | – | –In each experimental phase (2 in total), 42 adult volunteers will be recruited (a total of 84 participants), selected based on the following criteria: * Aged 18-45 * Female or male * Right-handed * Signed informed consent * Normal medical, neurological, and neuroradiological examinations * Affiliated with a social security system * For women of childbearing age: under effective contraception; a urine pregnancy test will be administered * MRI examination compatible Participants will be recruited in the Paris region. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Age groups
- Adult
- Study population
- In the experimental phase, 42 adult volunteers (a total of 84), selected according to strict criteria, will undergo an MRI scan, each comprising: - anatomical acquisition, - functional acquisition of activation during a number processing task (Phase 1: two-digit number magnitude comparison; Phase 2: multi-digit mental arithmetic).
Key inclusion criteria (10 listed)
- Subject aged 18 to 45 years;
- Female or male;
- Right-handed preference;
- Subject, or legal representative, who has given consent to participate;
- Native language: French
Key exclusion criteria (16 listed)
- Not corresponding to the targeted age range;
- Subject with contraindications to an MRI examination (pacemaker or neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign bodies in the eyes or brain near neural structures, metal prostheses, patient agitation: non-cooperative or agitated patients, minors, claustrophobic subjects, pregnant women, ventriculoperitoneal neurosurgical shunt valves, dental braces);
- Subject with chronic alcohol or drug use;
- Abuse or dependence on substances (except nicotine) or toxic substances for more than 5 years or having led to comas (overdoses);
- Subject with sudden-onset cognitive disorders that could indicate a stroke; a history of head trauma with loss of consciousness for more than 1 hour, or encephalitis;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Neurofunctional variables (fMRI)
Time frame: Day 1
the comparison of pairs of incompatible numbers compared to pairs of compatible numbers during the comparison of numbers.
Structural variables (structural MRI)
Time frame: Day 1
the comparison of problems of addition with and without restraint during mental arithmetic.
Behavioral variables,
Time frame: Day 1
we compare performance to the post-imaging reading test
structural variables
Time frame: Day 1
recording of morphological and brain morphometric characteristics.
2 secondary outcomes
Handedness score
Time frame: Day 1
Demographics questionnaire
Time frame: Day 1
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Aug 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Brain Activity, run by Centre Hospitalier St Anne at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 16 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Elise Klein (+49 175 2042210, elise.klein@u-paris.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Neurofunctional variables (fMRI) (time frame: Day 1). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Aug 2025.