Multiple SclerosisNCT07123272
Usability of the MeTime MS App
A study testing Self-guided smartphone application for relaxing acupressure and Self-guided smartphone application for stimulating acupressure in people with Multiple Sclerosis and Pain, run by University of Michigan at 1 site in United States.
Trial summary
The Me Time MS Application was designed to enable self-administration of acupressure. Two forms of acupressure - either "relaxing" or "stimulating" protocols - are administered through the Me Time MS app. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Multiple Sclerosis, Pain, Fatigue Symptom
- What is being tested?
- Self-guided smartphone application for relaxing acupressure and Self-guided smartphone application for stimulating acupressure
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 10 participants
- Where
- 1 siteUnited States
- Study dates
- 17 Mar 2025to 16 May 2025
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- MS diagnosis (all MS subtypes included)
- Age 18 years or older
- Average Fatigue Severity Scale (FSS) score ≥ 4 at screening coupled with the opinion of the volunteer that the fatigue has interfered with their daily activities for ≥ 3 months
- Presence of chronic pain defined as moderate to severe pain for ≥ 3-month duration that is ≥ 4 on average using a 0-10 numerical rating scale
- Home access to internet via Wi-Fi or cellular data
- Active email account
Who cannot join
- Not fluent in English
- Pregnancy or breast feeding, or anticipate pregnancy in next 6 months
- Inability to use smartphone/tablet and/or MeTime MS mobile app
- Anything at the discretion of the PI or study team that would preclude participation in the study
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Usability of the MeTime MS Acupressure Mobile Application in Adults With MS
The Me Time MS Application was designed to enable self-administration of acupressure. Two forms of acupressure - either "relaxing" or "stimulating" protocols - are administered through the Me Time MS app.
The goal of this study is to assess the usability of the Me Time MS app in a sample of 10 adults with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Pain, Fatigue Symptom
- Being tested
- Self-guided smartphone application for relaxing acupressure, Self-guided smartphone application for stimulating acupressure
- Keywords
- chronic pain, acupressure, digital health, fatigue, usability, feasibility
- Medical subject headings
- Multiple Sclerosis, Pain, Fatigue, Chronic Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Self-guided smartphone application for relaxing acupressureBehavioural
Also called Me Time MS
Relaxing Acupressure entails applying pressure with either a finger, pencil, or similar object to acupressure points. For the relaxing protocol, there is a total of 9 acupoints (1 unilateral and 4 bilateral). Each point will be stimulated for 3 minutes, yielding a total treatment time of 27 minutes each day. The acupoints are:
- Yin Tang (Unilaterally): Located on the forehead, between the eyebrows.
- Anmian (Right and Left/bilaterally): Located on the posterior aspect of the neck, in a slight depression along the bone directly behind the ear.
- Heart 7 (HT7) (Right and Left/bilaterally): Located on the palmer surface of the hands on the wrist crease; in line with the pinky.
- Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
- Liver 3 (LIV3) (Right and Left/bilaterally): This point is located on the foot, near the big and second toes.
Self-guided smartphone application for stimulating acupressureBehavioural
Also called Me Time MS
There is a total of 10 acupoints (2 unilateral and 4 bilateral). Each point is stimulated for 3 minutes, yielding a total treatment time of 30 minutes each day. The acupoints are:
- Du 20 (Unilaterally): Located at the top of the head.
- Large Intestine 4 (LI4) (Right and Left/bilaterally): Located on the back of the hand, between your thumb and index finger.
- Conception Vessel 6 (CV6) (Unilaterally): Located two finger widths below the navel on the centerline.
- Stomach 36 (ST36) (Right and Left/bilaterally): Located on the lower leg below the knee on the outside of the leg.
- Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle.
- Kidney 3 (K3) (Right and Left/bilaterally): Located on the inside of the ankle.
| Study group | Role | What they receive |
|---|---|---|
| Relaxing Self-Acupressure | Experimental | Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks. Receives: Behavioral: Self-guided smartphone application for relaxing acupressure |
| Stimulating Self-Acupressure | Experimental | Self-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks. Receives: Behavioral: Self-guided smartphone application for stimulating acupressure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Participant Perception of Me Time MS App Usability
Qualitative descriptions of positive, negative, and neutral aspects of usability of the Me Time MS app, gathered through one-on-one, open-ended interviews after 6 weeks of access to the app. Results reflect the total number of comments across all participants that were provided for each category. Participants could submit multiple types of comments.
Measured: Up to 2 weeks after the 6-week app usage period ended
Secondary outcomes (1)
System Usability Scale (SUS) Adapted for the MeTime MS App
SUS is a custom, 10-item survey to assess the participant's perception of the usability of the MeTime MS app. Possible total score ranges from 0 (lowest usability) to 40 (highest usability).
Measured: Up to 2 weeks after the 6-week app usage period ended
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Aug 2025
- Study start17 Mar 2025
- Primary completion16 May 2025
- Study completion16 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- More trials run by University of MichiganThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 10 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Michigan
- Sponsor type
- University, hospital or other
- Collaborators
- National Center for Complementary and Integrative Health (NCCIH)
- Responsible party
- Principal investigator, Anna Kratz, University of Michigan
- Investigators
- Anna Kratz, PhD, Principal investigator, University of Michigan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07123272
- Sponsor's protocol ID
- HUM00268311
- Other IDs
- K24AT012644
- Status last verified
- Nov 2025
- First submitted
- 7 Aug 2025
- Last updated
- 20 Nov 2025
- Results posted
- Yes, on ClinicalTrials.gov
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: This study's limited qualitative data focused on digital health tool usability is not relevant outside of our efforts to optimize the digital health tool (Me Time MS); therefore release of qualitative data is not planned.
Study at a glance
From the registry record, last updated by the sponsor on 20 Nov 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Usability of the MeTime MS Acupressure Mobile Application in Adults With MS
- ClinicalTrials.gov ID
- NCT07123272
- Acronym / sponsor ID
- HUM00268311
- Conditions
- Multiple Sclerosis, Pain, Fatigue Symptom
- Keywords
- chronic pain, acupressure, digital health, fatigue, usability, feasibility
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 10 participants (actual)
- Lead sponsor
- University of MichiganUniversity, hospital or other
- Collaborators
- National Center for Complementary and Integrative Health (NCCIH)
- Study start
- 17 Mar 2025 (actual)
- Primary completion
- 16 May 2025 (actual)
- Study completion
- 16 May 2025 (actual)
- First posted
- 14 Aug 2025 (actual)
- Results
- Posted 20 Nov 2025
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Me Time MS Application was designed to enable self-administration of acupressure. Two forms of acupressure - either "relaxing" or "stimulating" protocols - are administered through the Me Time MS app.
The goal of this study is to assess the usability of the Me Time MS app in a sample of 10 adults with multiple sclerosis (MS).
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Relaxing Self-Acupressure | Experimental | Behavioral: Self-guided smartphone application for relaxing acupressureSelf-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks. |
| Stimulating Self-Acupressure | Experimental | Behavioral: Self-guided smartphone application for stimulating acupressureSelf-guided use of a smartphone app that informs users how to administer relaxing acupressure each day for 6 weeks. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- MS diagnosis (all MS subtypes included)
- Age 18 years or older
- Average Fatigue Severity Scale (FSS) score ≥ 4 at screening coupled with the opinion of the volunteer that the fatigue has interfered with their daily activities for ≥ 3 months
- Presence of chronic pain defined as moderate to severe pain for ≥ 3-month duration that is ≥ 4 on average using a 0-10 numerical rating scale
- Home access to internet via Wi-Fi or cellular data
Key exclusion criteria (4 listed)
- Not fluent in English
- Pregnancy or breast feeding, or anticipate pregnancy in next 6 months
- Inability to use smartphone/tablet and/or MeTime MS mobile app
- Anything at the discretion of the PI or study team that would preclude participation in the study
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Self-guided smartphone application for relaxing acupressureAlso: Me Time MSRelaxing Acupressure entails applying pressure with either a finger, pencil, or similar object to acupressure points. For the relaxing protocol, there is a total of 9 acupoints (1 unilateral and 4 bilateral). Each point will be stimulated for 3 minutes, yielding a total treatment time of 27 minutes each day. The acupoints are: 1. Yin Tang (Unilaterally): Located on the forehead, between the eyebrows. 2. Anmian (Right and Left/bilaterally): Located on the posterior aspect of the neck, in a slight depression along the bone directly behind the ear. 3. Heart 7 (HT7) (Right and Left/bilaterally): Located on the palmer surface of the hands on the wrist crease; in line with the pinky. 4. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle. 5. Liver 3 (LIV3) (Right and Left/bilaterally): This point is located on the foot, near the big and second toes. | Behavioural | Relaxing Self-Acupressure |
| Self-guided smartphone application for stimulating acupressureAlso: Me Time MSThere is a total of 10 acupoints (2 unilateral and 4 bilateral). Each point is stimulated for 3 minutes, yielding a total treatment time of 30 minutes each day. The acupoints are: 1. Du 20 (Unilaterally): Located at the top of the head. 2. Large Intestine 4 (LI4) (Right and Left/bilaterally): Located on the back of the hand, between your thumb and index finger. 3. Conception Vessel 6 (CV6) (Unilaterally): Located two finger widths below the navel on the centerline. 4. Stomach 36 (ST36) (Right and Left/bilaterally): Located on the lower leg below the knee on the outside of the leg. 5. Spleen 6 (SP6) (Right and Left/bilaterally): Located on the inside of the lower leg, approximately 4 fingers width above the bone of the ankle. 6. Kidney 3 (K3) (Right and Left/bilaterally): Located on the inside of the ankle. | Behavioural | Stimulating Self-Acupressure |
Primary outcome
Participant Perception of Me Time MS App Usability
Time frame: Up to 2 weeks after the 6-week app usage period ended
Qualitative descriptions of positive, negative, and neutral aspects of usability of the Me Time MS app, gathered through one-on-one, open-ended interviews after 6 weeks of access to the app. Results reflect the total number of comments across all participants that were provided for each category. Participants could submit multiple types of comments.
1 secondary outcome
System Usability Scale (SUS) Adapted for the MeTime MS App
Time frame: Up to 2 weeks after the 6-week app usage period ended
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Nov 2025.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Individual participant dataSharing planned: No. This study's limited qualitative data focused on digital health tool usability is not relevant outside of our efforts to optimize the digital health tool (Me Time MS); therefore release of qualitative data is not planned.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anna Kratz, PhD principal investigator
University of Michigan
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Self-guided smartphone application for relaxing acupressure and Self-guided smartphone application for stimulating acupressure in people with Multiple Sclerosis and Pain, run by University of Michigan at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 20 Nov 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Participant Perception of Me Time MS App Usability (time frame: Up to 2 weeks after the 6-week app usage period ended). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Nov 2025.