Acute Ischemic StrokePC-CBSNCT07122934
Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score
An observational study of Acute Ischemic Stroke and Posterior Circulation Brain Infarction, run by Centre Hospitalier Universitaire Vaudois.
Trial summary
Posterior circulation strokes (PCS) represent ~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Ischemic Stroke, Posterior Circulation Brain Infarction, Arterial Occlusion Disease
- What is being tested?
- Assessment of cervico-cerebral arterial occlusion pattern
- How many people
- 1,828 participants
- Where
- No sites listed yet
- Study dates
- 1 Feb 2003to 8 Aug 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients suffering from an acute ischemic stroke (AIS) clinically and/or radiologically attributable to a posterior circulation arterial occlusion
Who may be able to join
- age >18 years old
- admitted within 24h from last known well
- symptomatic arterial occlusion. The following arterial occlusions were eligible for inclusion: the extracranial vertebral artery between the V0 and V3 segments; the intracranial portion of the vertebral artery; the basilar artery either in its proximal, mid and/or distal segment, the P1 and/or the P2 segments of the posterior cerebral artery.
Who cannot join
- simultaneous clinical and/or radiological strokes in the posterior and anterior circulation
About this study
Posterior circulation strokes (PCS) represent ~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.
- Being tested
- Assessment of cervico-cerebral arterial occlusion pattern
- Medical subject headings
- Ischemic Stroke, Brain Infarction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Assessment of cervico-cerebral arterial occlusion patternDiagnostic test
Assessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score
| Study group | Role | What they receive |
|---|---|---|
| Development and Internal validation cohort | Not described Receives: Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern | |
| External validation cohort | Not described Receives: Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern |
What is being measured
The primary outcome is the main question the study is designed to answer.
Modified rankin scale at three months
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Aug 2025
- Study start1 Feb 2003
- Primary completion31 Mar 2023
- Study completion8 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Ischemic StrokeStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire VaudoisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 1,828 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire Vaudois
- Sponsor type
- University, hospital or other
- Collaborators
- Insel Gruppe AG, University Hospital Bern, Hospital de Egas Moniz, University Hospital Heidelberg, IRCCS Istituto delle Scienze Neurologiche di Bologna, The University of Texas Health Science Center, Houston, Azienda Ospedaliero-Universitaria di Modena, Hospital Vall d'Hebron, Boston University, Università degli Studi di Brescia, Medical University of Graz, Hôpital Rothschild, Medical University of Vienna, Hebrew University of Jerusalem, Michigan State University, Medical University Innsbruck, Ludwig-Maximilians - University of Munich, Ospedale Policlinico San Martino, EOC Lugano CH, University Hospital, Basel, Switzerland, Aristotle University Of Thessaloniki, Technische Universität Dresden
- Responsible party
- Principal investigator, Dr. med. Alexander Salerno, MD-PhD, Centre Hospitalier Universitaire Vaudois
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07122934
- Sponsor's protocol ID
- PC-CBS
- Acronym
- PC-CBS
- Status last verified
- Aug 2025
- First submitted
- 8 Aug 2025
- Last updated
- 14 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score
- ClinicalTrials.gov ID
- NCT07122934
- Acronym / sponsor ID
- PC-CBS / PC-CBS
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 1,828 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire VaudoisUniversity, hospital or other
- Collaborators
- Insel Gruppe AG, University Hospital Bern, Hospital de Egas Moniz, University Hospital Heidelberg, IRCCS Istituto delle Scienze Neurologiche di Bologna, The University of Texas Health Science Center, Houston, Azienda Ospedaliero-Universitaria di Modena, Hospital Vall d'Hebron, Boston University, Università degli Studi di Brescia, Medical University of Graz, Hôpital Rothschild, Medical University of Vienna, Hebrew University of Jerusalem, Michigan State University, Medical University Innsbruck, Ludwig-Maximilians - University of Munich, Ospedale Policlinico San Martino, EOC Lugano CH, University Hospital, Basel, Switzerland, Aristotle University Of Thessaloniki, Technische Universität Dresden
- Study start
- 1 Feb 2003 (actual)
- Primary completion
- 31 Mar 2023 (actual)
- Study completion
- 8 Aug 2025 (actual)
- First posted
- 14 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Posterior circulation strokes (PCS) represent ~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Development and Internal validation cohort | – | Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern |
| External validation cohort | – | Diagnostic Test: Assessment of cervico-cerebral arterial occlusion pattern |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients suffering from an acute ischemic stroke (AIS) clinically and/or radiologically attributable to a posterior circulation arterial occlusion
Key inclusion criteria (3 listed)
- age >18 years old
- admitted within 24h from last known well
- symptomatic arterial occlusion. The following arterial occlusions were eligible for inclusion: the extracranial vertebral artery between the V0 and V3 segments; the intracranial portion of the vertebral artery; the basilar artery either in its proximal, mid and/or distal segment, the P1 and/or the P2 segments of the posterior cerebral artery.
Key exclusion criteria (1 listed)
- simultaneous clinical and/or radiological strokes in the posterior and anterior circulation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Assessment of cervico-cerebral arterial occlusion patternAssessment of cervico-cerebral arterial occlusion pattern for the development of a radiological score | Diagnostic test | Development and Internal validation cohort, External validation cohort |
Primary outcome
Modified rankin scale at three months
Time frame: 3 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Aug 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Ischemic Stroke and Posterior Circulation Brain Infarction, run by Centre Hospitalier Universitaire Vaudois.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Modified rankin scale at three months (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Aug 2025.