Hemophilia AHemophilia ANCT07116993
Effects of Ultrasound and Infrared on Joint Pain and Movement in Hemophilia A Patients.
A study testing theraputic ultrasound and infrared radiation in people with Hemophilia A, run by Danyal Ahmad at 1 site in Pakistan.
Trial summary
The study aims to compare the effectiveness of therapeutic ultrasound and infrared in managing hemarthrosis in patients with Hemophilia A, focusing on specific outcomes like joint pain, swelling, muscle atrophy, and range of motion.The main question to it is either one from both of the modalities are effective for… Read more about this study
- Who is it for?
- Any age, men only
- Conditions the study is for
- Hemophilia A
- What is being tested?
- theraputic ultrasound and infrared radiation
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Mar 2024to 15 Jun 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Men only
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Patients with hemophilia A (Eid \& Aly, 2015) .
- Who had the Bleeding frequency of atleast once per week (Eid \& Aly, 2015).
- Males with hemophilia A
- Irrespective of their therapeutic regime administered by their hematologists (Donoso-Úbeda, Meroño-Gallut, López-Pina, \& Cuesta Barriuso, 2020) .
Who cannot join
- Patients who had surgical procedures (Eid \& Aly, 2015) .
- Patients who were suffering from co-morbidities along with Hemophilia A.
- Patients who had any other disability/deformity.
- Who were receiving other physiotherapy treatment (Donoso-Úbeda et al., 2020) .
- Who failed to sign the informed consent (Donoso-Úbeda et al., 2020)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Effects of Ultrasound and Infrared on Pain, Range of Motion and Joint Health in Knee, Elbow and Ankle Joints in Patients With Hemophilia A: a Randomized Clinical Trial
The study aims to compare the effectiveness of therapeutic ultrasound and infrared in managing hemarthrosis in patients with Hemophilia A, focusing on specific outcomes like joint pain, swelling, muscle atrophy, and range of motion.The main question to it is either one from both of the modalities are effective for hemophilia patients or not? comparison will be done to check the effectiveness of ultrasound and infrared on patients of both groups.
participants will:
- get the treatment according to their respective groups
- Both groups were given 4 sessions for 4 weeks.
Read the detailed description
The data collection was started by the consent of the participants through the consent form. Then we randomly divided the patients into Group A and Group B. Group A participants were given Ultrasound therapy for 10 minutes with intensity of 1.5 W/m2 along with the conventional physiotherapy as well as home plan. Group B participants were given Infrared therapy for 10 minutes with moderate intensity along with the conventional physiotherapy as well as home plan. Both groups were given 4 sessions for 4 weeks.
- Conditions
- Hemophilia A
- Being tested
- theraputic ultrasound, infrared radiation
- Keywords
- hemophilia A, ultrasound, infrared, joint health
- Medical subject headings
- Hemophilia A
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
theraputic ultrasoundDevice
Ultrasound is a mechanical sound wave with frequencies above human hearing, requiring a medium like air or tissue to travel, commonly used in imaging.
infrared radiationDevice
Infrared, in contrast, is electromagnetic radiation associated with heat, doesn't need a medium, and is used in applications like thermal imaging and remote controls.
| Study group | Role | What they receive |
|---|---|---|
| ultrasound | Experimental | ultrasound group containing 15 participants who were given ultrasound therapy for 10 minutes along with the conventional physiotherapy. Receives: Device: theraputic ultrasound |
| infrared radiation | Experimental | infrared radiation group containing 15 participants who were treated with infrared therapy for 10 minutes along with the conventional physiotherapy. Receives: Device: infrared radiation |
What is being measured
The primary outcome is the main question the study is designed to answer.
joint pain
Joint Pain: Measured using the Numerical Pain Rating Scale (NPRS) to quantify changes in pain severity. 0 indicates no pain while 10 indicates severe pain
Measured: 3 weeks
ROM
Range of Motion (ROM): Measured using a goniometer to assess improvements in flexion and extension angles, measured in degrees, in the joint.
Measured: 3 weeks
Swelling
Assessed based on circumference measurements around knee, elbow and ankle joint using inelastic tape measure in centimeters around the affected joint to detect reductions in swelling.
Measured: 3 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Aug 2025
- Study start1 Mar 2024
- Primary completion30 Mar 2024
- Study completion15 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hemophilia AStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Danyal Ahmad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Danyal Ahmad, University of Management and Technology Sialkot Pakistan
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07116993
- Sponsor's protocol ID
- kuhs/dpt/umt-skt-017
- Acronym
- Hemophilia A
- Status last verified
- Aug 2025
- First submitted
- 30 Oct 2024
- Last updated
- 12 Aug 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Effects of Ultrasound and Infrared on Pain, Range of Motion and Joint Health in Knee, Elbow and Ankle Joints in Patients With Hemophilia A: a Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07116993
- Acronym / sponsor ID
- Hemophilia A / kuhs/dpt/umt-skt-017
- Conditions
- Hemophilia A
- Keywords
- hemophilia A, ultrasound, infrared, joint health
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Danyal AhmadUniversity, hospital or other
- Study start
- 1 Mar 2024 (actual)
- Primary completion
- 30 Mar 2024 (actual)
- Study completion
- 15 Jun 2024 (actual)
- First posted
- 12 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study aims to compare the effectiveness of therapeutic ultrasound and infrared in managing hemarthrosis in patients with Hemophilia A, focusing on specific outcomes like joint pain, swelling, muscle atrophy, and range of motion.The main question to it is either one from both of the modalities are effective for hemophilia patients or not? comparison will be done to check the effectiveness of ultrasound and infrared on patients of both groups.
participants will:
- get the treatment according to their respective groups
- Both groups were given 4 sessions for 4 weeks.
Detailed description
The data collection was started by the consent of the participants through the consent form. Then we randomly divided the patients into Group A and Group B. Group A participants were given Ultrasound therapy for 10 minutes with intensity of 1.5 W/m2 along with the conventional physiotherapy as well as home plan. Group B participants were given Infrared therapy for 10 minutes with moderate intensity along with the conventional physiotherapy as well as home plan. Both groups were given 4 sessions for 4 weeks.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ultrasound | Experimental | Device: theraputic ultrasoundultrasound group containing 15 participants who were given ultrasound therapy for 10 minutes along with the conventional physiotherapy. |
| infrared radiation | Experimental | Device: infrared radiationinfrared radiation group containing 15 participants who were treated with infrared therapy for 10 minutes along with the conventional physiotherapy. |
Who may qualify
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (4 listed)
- Patients with hemophilia A (Eid \& Aly, 2015) .
- Who had the Bleeding frequency of atleast once per week (Eid \& Aly, 2015).
- Males with hemophilia A
- Irrespective of their therapeutic regime administered by their hematologists (Donoso-Úbeda, Meroño-Gallut, López-Pina, \& Cuesta Barriuso, 2020) .
Key exclusion criteria (5 listed)
- Patients who had surgical procedures (Eid \& Aly, 2015) .
- Patients who were suffering from co-morbidities along with Hemophilia A.
- Patients who had any other disability/deformity.
- Who were receiving other physiotherapy treatment (Donoso-Úbeda et al., 2020) .
- Who failed to sign the informed consent (Donoso-Úbeda et al., 2020)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| theraputic ultrasoundUltrasound is a mechanical sound wave with frequencies above human hearing, requiring a medium like air or tissue to travel, commonly used in imaging. | Device | ultrasound |
| infrared radiationInfrared, in contrast, is electromagnetic radiation associated with heat, doesn't need a medium, and is used in applications like thermal imaging and remote controls. | Device | infrared radiation |
Primary outcome
joint pain
Time frame: 3 weeks
Joint Pain: Measured using the Numerical Pain Rating Scale (NPRS) to quantify changes in pain severity. 0 indicates no pain while 10 indicates severe pain
ROM
Time frame: 3 weeks
Range of Motion (ROM): Measured using a goniometer to assess improvements in flexion and extension angles, measured in degrees, in the joint.
Swelling
Time frame: 3 weeks
Assessed based on circumference measurements around knee, elbow and ankle joint using inelastic tape measure in centimeters around the affected joint to detect reductions in swelling.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing theraputic ultrasound and infrared radiation in people with Hemophilia A, run by Danyal Ahmad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
joint pain (time frame: 3 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2025.