AsthmaNCT07110116
Alternate Nostril Breathing With Incentive Spirometry on Lung Function Among Asthma Patients
A study testing Alternate nostril breathing with Incentive Spirometery and Incentive spirometery in people with Asthma, run by Riphah International University at 1 site in Pakistan.
Trial summary
To compare effects of Alternate Nostril Breathing exercise with incentive spirometer on lung functions (forced vital capacity, forced expiratory volume, and peak expiratory flow rate) in Asthma patients. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Asthma
- What is being tested?
- Alternate nostril breathing with Incentive Spirometery and Incentive spirometery
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 sitePakistan
- Study dates
- 20 Aug 2025to Nov 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Diagnosed male \& female asthma patients of age 18-60 years.
- Patients with mild to moderate asthma having predicted FEV1 between 60-80%.
- Stable asthma condition without recent exacerbations.
- Able to perform spirometry and follow instructions for the interventions.
- No recent respiratory infections.
Who cannot join
- Patients with severe asthma (FEV1 \< 60% predicted).
- Patients having respiratory infections, recent exacerbations or other comorbidities.
- Inability to perform breathing exercises or spirometry.
- Patients using medications like oral steroids, beta blockers.
- Pregnant women due to potential risks with breathing exercises.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Allied Specialist Hospital & Clinics
Abbottābād, Khyber PkahtoonKhwa, 22020
Hira Qazi, MSPT, +92 319 5523996, hiraqazi5sem@gmail.com
Hira Qazi, MSPT
About this study
Official title: Comparison of Effects of Alternate Nostril Breathing Exercise With Incentive Spirometer Technique on Lung Functions Among Asthma Patients
To compare effects of Alternate Nostril Breathing exercise with incentive spirometer on lung functions (forced vital capacity, forced expiratory volume, and peak expiratory flow rate) in Asthma patients.
- Conditions
- Asthma
- Being tested
- Alternate nostril breathing with Incentive Spirometery, Incentive spirometery
- Medical subject headings
- Asthma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Alternate nostril breathing with Incentive SpirometeryOther
Participants in experimental group were instructed to close their left nostril by left index finger and inhale through their right nostril for six seconds, then closing the right nostril and holding breath for six seconds. Afterward, they exhaled through the left nostril slowly for six seconds. Next, they inhaled through left nostril, keeping the right nostril closed for six seconds then hold the breath by closing both nostrils for six seconds subsequently, and then exhaled through the right nostril, keeping the left closed for six seconds repeating these steps several times for 10 minutes
Incentive spirometeryOther
The control group participants were asked to do breathing exercise with incentive spirometry. The subject is asked to create a tight seal around the mouthpiece and asked to inhale deeply and slowly and the subject would observe the flow meter for visual feedback of his/her effort. At the end of the inspiration the subject is asked to sustain the inhalation 2-3 seconds to facilitate the Inspiratory hold. Subject relaxes the seal around the mouthpiece and exhales. Normal breathing is taken, then the exhalation phase in the incentive spirometry is done and the whole cycle is repeated 5 - 10 times thrice a day over a period 6 weeks
| Study group | Role | What they receive |
|---|---|---|
| Alternate nostril breathing with Incentive Spirometery | Experimental | Not described Receives: Other: Alternate nostril breathing with Incentive Spirometery |
| Incentive Spirometery | Active comparator | Not described Receives: Other: Incentive spirometery |
What is being measured
The primary outcome is the main question the study is designed to answer.
Forced expiratory volume in 1 second
Forced Expiratory Volume in 1 second (FEV1) is a measurement of how much air a person can forcefully exhale from their lungs in one second
Measured: 6 week
Forced Vital Capicity
Forced vital capacity (FVC) is a measurement of lung function that quantifies the maximum amount of air a person can forcefully exhale after taking the deepest breath possible
Measured: 6 week
Peak Expiratory Flow Rate
Peak expiratory flow rate (PEFR) measures the maximum speed of air that a person can forcefully exhale in one breath
Measured: 6 week
Asthama Control Test
The Asthma Control Test (ACT) is scored by assigning a value from 1 to 5 to each response in the 5-question survey, then summing these values for a total score ranging from 5 to 25. A higher score indicates better asthma control. A score of 20 or higher generally suggests well-controlled asthma.
Measured: 6 week
Asthama Quality of Life Questionaire with standardized Activities
The Standardized Asthma Quality of Life Questionnaire (AQLQ(S)) is a 32-item questionnaire used to assess the impact of asthma on an individual's quality of life, specifically focusing on the physical, emotional, and social aspects. 7-point Likert scale (7 = not impaired at all - 1 = severely impaired). Scores range 1-7, with higher scores indicating better quality of life.
Measured: 6 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Aug 2025
- Study start20 Aug 2025
- Primary completionNov 2025 (estimated)
- Study completionNov 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AsthmaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 54 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Muhammad Iqbal Tariq, PhD*, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07110116
- Sponsor's protocol ID
- REC/02192 Hira Qazi
- Status last verified
- Aug 2025
- First submitted
- 31 Jul 2025
- Last updated
- 5 Sep 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Effects of Alternate Nostril Breathing Exercise With Incentive Spirometer Technique on Lung Functions Among Asthma Patients
- ClinicalTrials.gov ID
- NCT07110116
- Acronym / sponsor ID
- REC/02192 Hira Qazi
- Conditions
- Asthma
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 54 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 20 Aug 2025 (actual)
- Primary completion
- Nov 2025 (estimated)
- Study completion
- Nov 2025 (estimated)
- First posted
- 7 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To compare effects of Alternate Nostril Breathing exercise with incentive spirometer on lung functions (forced vital capacity, forced expiratory volume, and peak expiratory flow rate) in Asthma patients.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Alternate nostril breathing with Incentive Spirometery | Experimental | Other: Alternate nostril breathing with Incentive Spirometery |
| Incentive Spirometery | Active comparator | Other: Incentive spirometery |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Diagnosed male \& female asthma patients of age 18-60 years.
- Patients with mild to moderate asthma having predicted FEV1 between 60-80%.
- Stable asthma condition without recent exacerbations.
- Able to perform spirometry and follow instructions for the interventions.
- No recent respiratory infections.
Key exclusion criteria (5 listed)
- Patients with severe asthma (FEV1 \< 60% predicted).
- Patients having respiratory infections, recent exacerbations or other comorbidities.
- Inability to perform breathing exercises or spirometry.
- Patients using medications like oral steroids, beta blockers.
- Pregnant women due to potential risks with breathing exercises.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Alternate nostril breathing with Incentive SpirometeryParticipants in experimental group were instructed to close their left nostril by left index finger and inhale through their right nostril for six seconds, then closing the right nostril and holding breath for six seconds. Afterward, they exhaled through the left nostril slowly for six seconds. Next, they inhaled through left nostril, keeping the right nostril closed for six seconds then hold the breath by closing both nostrils for six seconds subsequently, and then exhaled through the right nostril, keeping the left closed for six seconds repeating these steps several times for 10 minutes | Other | Alternate nostril breathing with Incentive Spirometery |
| Incentive spirometeryThe control group participants were asked to do breathing exercise with incentive spirometry. The subject is asked to create a tight seal around the mouthpiece and asked to inhale deeply and slowly and the subject would observe the flow meter for visual feedback of his/her effort. At the end of the inspiration the subject is asked to sustain the inhalation 2-3 seconds to facilitate the Inspiratory hold. Subject relaxes the seal around the mouthpiece and exhales. Normal breathing is taken, then the exhalation phase in the incentive spirometry is done and the whole cycle is repeated 5 - 10 times thrice a day over a period 6 weeks | Other | Incentive Spirometery |
Primary outcome
Forced expiratory volume in 1 second
Time frame: 6 week
Forced Expiratory Volume in 1 second (FEV1) is a measurement of how much air a person can forcefully exhale from their lungs in one second
Forced Vital Capicity
Time frame: 6 week
Forced vital capacity (FVC) is a measurement of lung function that quantifies the maximum amount of air a person can forcefully exhale after taking the deepest breath possible
Peak Expiratory Flow Rate
Time frame: 6 week
Peak expiratory flow rate (PEFR) measures the maximum speed of air that a person can forcefully exhale in one breath
Asthama Control Test
Time frame: 6 week
The Asthma Control Test (ACT) is scored by assigning a value from 1 to 5 to each response in the 5-question survey, then summing these values for a total score ranging from 5 to 25. A higher score indicates better asthma control. A score of 20 or higher generally suggests well-controlled asthma.
Asthama Quality of Life Questionaire with standardized Activities
Time frame: 6 week
The Standardized Asthma Quality of Life Questionnaire (AQLQ(S)) is a 32-item questionnaire used to assess the impact of asthma on an individual's quality of life, specifically focusing on the physical, emotional, and social aspects. 7-point Likert scale (7 = not impaired at all - 1 = severely impaired). Scores range 1-7, with higher scores indicating better quality of life.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Sep 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Muhammad Iqbal Tariq, PhD* principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Alternate nostril breathing with Incentive Spirometery and Incentive spirometery in people with Asthma, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Muhammad Iqbal Tariq, PhD* (03338236752, iqbal.tariq@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Forced expiratory volume in 1 second (time frame: 6 week). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Sep 2025.