StrokeNCT07106619
Effectiveness of Isokinetic Exercises in Proprioception for Post-stroke Patients
A study testing Isokinetic Exercises and Conventional rehabilitation program in people with Stroke, run by Ankara Etlik City Hospital at 1 site in Turkey (Türkiye).
Trial summary
Somatosensory dysfunction including the sense of movement and position, i.e. proprioception, is observed in approximately 65% of patients after stroke. Loss of muscle strength, especially in the lower extremities, and impaired proprioception lead to significant loss of function in stroke patients. Read more about this study
- Who is it for?
- Ages 35 to 75 years
- Conditions the study is for
- Stroke
- What is being tested?
- Isokinetic Exercises and Conventional rehabilitation program
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2025to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- At least 3 months and no more than 1 year must have passed since the date of the incident
- Be between 35 and 75 years of age
- Manual muscle testing of the affected lower extremity shows at least 3 in ankle dorsiflexion and knee extension
- No limitation in passive joint range of motion in the lower extremity
- Mini mental test score > 23
Who cannot join
- Presence of spasticity according to the modified Ashworth scale > 1+
- Presence of neurological disease other than stroke
- Presence of other medical conditions that may cause sensorimotor dysfunction in the lower extremities (e.g., diabetic polyneuropathy)
- Presence of orthopaedic problems affecting lower extremity function
- Previous history of stroke or ischaemic attack
- Poor general health status (e.g. severe heart failure, COPD)
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Ankara Etlik City Hospital
Ankara, Yenimahalle
About this study
Official title: Evaluation of the Effect of Knee Isokinetic Strengthening Exercises on Proprioception and Balance in Stroke Patients
Somatosensory dysfunction including the sense of movement and position, i.e. proprioception, is observed in approximately 65% of patients after stroke. Loss of muscle strength, especially in the lower extremities, and impaired proprioception lead to significant loss of function in stroke patients. In addition, recent studies have emphasised that sensory information obtained by target-oriented exercises plays an important role in neuroplasticity and proprioception is an important element. The aim of this study was to evaluate the effect of knee isokinetic muscle strengthening exercises on proprioception and balance in stroke patients.
- Conditions
- Stroke
- Being tested
- Isokinetic Exercises, Conventional rehabilitation program
- Keywords
- stroke rehabilitation, proprioception, isokinetic exercise
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Isokinetic ExercisesDevice
Exercises will be performed at three different angular speeds (90 ̊/sec, 5 repetitions, 5 sets; 120 ̊/sec, 8 repetitions, 5 sets; 150 ̊/sec, 10 repetitions, 5 sets).
Conventional rehabilitation programOther
Ambulation and balance exercises
| Study group | Role | What they receive |
|---|---|---|
| Conventional Rehabilitation | Active comparator | Patients will receive 15 sessions of conventional rehabilitation Receives: Other: Conventional rehabilitation program |
| isokinetic Exercise | Experimental | Patients will receive 15 sessions of conventional rehabilitation and 10 sessions of knee isokinetic strengthening exercise therapy for the paretic lower extremity for 3 weeks. Isokinetic strengthening exercises will be performed using Cybex 770, Humac Norm dynamometer (CSMI, Stoughton, MA, USA). Receives: Device: Isokinetic Exercises; Other: Conventional rehabilitation program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Proprioception assessment with isokinetic test device
Measured: before treatment and at the 3rd week of treatment
Secondary outcomes (2)
Berg scale
Measured: Before treatment and at 3rd week of treatment
Time up and Go Test
Measured: Before treatment and at the 3rd week of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2025
- Study start1 Aug 2025
- Primary completion30 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by Ankara Etlik City HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 34 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara Etlik City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Ayse Naz Kalem, Ankara Etlik City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07106619
- Sponsor's protocol ID
- AEŞH-EK-2025-012
- Status last verified
- Jul 2025
- First submitted
- 23 Jul 2025
- Last updated
- 10 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Effect of Knee Isokinetic Strengthening Exercises on Proprioception and Balance in Stroke Patients
- ClinicalTrials.gov ID
- NCT07106619
- Acronym / sponsor ID
- AEŞH-EK-2025-012
- Conditions
- Stroke
- Keywords
- stroke rehabilitation, proprioception, isokinetic exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 34 participants (actual)
- Lead sponsor
- Ankara Etlik City HospitalOther government
- Study start
- 1 Aug 2025 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 6 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Somatosensory dysfunction including the sense of movement and position, i.e. proprioception, is observed in approximately 65% of patients after stroke. Loss of muscle strength, especially in the lower extremities, and impaired proprioception lead to significant loss of function in stroke patients. In addition, recent studies have emphasised that sensory information obtained by target-oriented exercises plays an important role in neuroplasticity and proprioception is an important element. The aim of this study was to evaluate the effect of knee isokinetic muscle strengthening exercises on proprioception and balance in stroke patients.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Conventional Rehabilitation | Active comparator | Other: Conventional rehabilitation programPatients will receive 15 sessions of conventional rehabilitation |
| isokinetic Exercise | Experimental | Device: Isokinetic Exercises, Other: Conventional rehabilitation programPatients will receive 15 sessions of conventional rehabilitation and 10 sessions of knee isokinetic strengthening exercise therapy for the paretic lower extremity for 3 weeks. Isokinetic strengthening exercises will be performed using Cybex 770, Humac Norm dynamometer (CSMI, Stoughton, MA, USA). |
Who may qualify
- Ages
- 35 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- At least 3 months and no more than 1 year must have passed since the date of the incident
- Be between 35 and 75 years of age
- Manual muscle testing of the affected lower extremity shows at least 3 in ankle dorsiflexion and knee extension
- No limitation in passive joint range of motion in the lower extremity
- Mini mental test score > 23
Key exclusion criteria (6 listed)
- Presence of spasticity according to the modified Ashworth scale > 1+
- Presence of neurological disease other than stroke
- Presence of other medical conditions that may cause sensorimotor dysfunction in the lower extremities (e.g., diabetic polyneuropathy)
- Presence of orthopaedic problems affecting lower extremity function
- Previous history of stroke or ischaemic attack
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Isokinetic ExercisesExercises will be performed at three different angular speeds (90 ̊/sec, 5 repetitions, 5 sets; 120 ̊/sec, 8 repetitions, 5 sets; 150 ̊/sec, 10 repetitions, 5 sets). | Device | isokinetic Exercise |
| Conventional rehabilitation programAmbulation and balance exercises | Other | Conventional Rehabilitation, isokinetic Exercise |
Primary outcome
Proprioception assessment with isokinetic test device
Time frame: before treatment and at the 3rd week of treatment
2 secondary outcomes
Berg scale
Time frame: Before treatment and at 3rd week of treatment
Time up and Go Test
Time frame: Before treatment and at the 3rd week of treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Isokinetic Exercises and Conventional rehabilitation program in people with Stroke, run by Ankara Etlik City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Proprioception assessment with isokinetic test device (time frame: before treatment and at the 3rd week of treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2026.