Acute Effects of Exercise in Healthy PeopleNCT07101341
Acute Effects of Aerobic Exercise and High-intensity Interval Exercise With Immersive Virtual Reality
A study testing Traditional aerobic training, High Intensity Interval Training (HIIT) and Aerobic training performed with a immersive virtual reality application in people with Acute Effects of Exercise in Healthy People and Health Adult Subjects, run by University of Valencia at 1 site in Spain.
Trial summary
This study aims to compare the acute effects at the cardiovascular (heart rate, blood pressure) and physiological (lactate) levels, as well as the perception of effort and fatigue, of four exercise modalities, one based on the traditional aerobic training methodology, another based on high-intensity interval training… Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Acute Effects of Exercise in Healthy People, Health Adult Subjects
- What is being tested?
- Traditional aerobic training, High Intensity Interval Training (HIIT) and Aerobic training performed with a immersive virtual reality application
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteSpain
- Study dates
- 25 Feb 2026to Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy people between 18 and 35 years old
Who cannot join
- Current or recent injury that affects training
- Condition that prevents exercise (decompensated heart disease, decompensated respiratory disease, significant mobility difficulties, etc.)
- Visual problems that prevent exercise with virtual reality headsets
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Spain1 site, 1 recruiting
- Recruiting
Faculty of Physiotherapy, University of Valencia
Valencia, Valencia, 46010
Adrian Escriche-Escuder, PhD, +34 963 98 38 55, adrian.escriche@uv.es
Adrian Escriche-Escuder, PhD
About this study
Official title: Analysis of the Acute Effects of Aerobic Exercise and High-intensity Interval Exercise, With and Without the Simultaneous Application of Immersive Virtual Reality
This study aims to compare the acute effects at the cardiovascular (heart rate, blood pressure) and physiological (lactate) levels, as well as the perception of effort and fatigue, of four exercise modalities, one based on the traditional aerobic training methodology, another based on high-intensity interval training (HIIT), another consisting of aerobic exercise performed in conjunction with an immersive virtual reality (VR) application, and a last one consisting of exercise with HIIT-type parameters but also performed in conjunction with an immersive VR application.
All participants will complete one session of each of the four exercise modalities, analyzing the variables studied in each for subsequent analysis and comparison.
- Being tested
- Traditional aerobic training, High Intensity Interval Training (HIIT), Aerobic training performed with a immersive virtual reality application, High Intensity Interval Training (HIIT) performed with a immersive virtual reality application
- Keywords
- virtual reality, immersive virtual reality, exergame
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Traditional aerobic trainingProcedure or surgery
5 minutes of warm-up at increasing intensity up to 60% of maximum heart rate (HRmax) + 20 minutes between 60-80% of HRmax + 5 minutes of cool-down at decreasing intensity (30-60% HRmax)
High Intensity Interval Training (HIIT)Procedure or surgery
5 minutes warm-up at increasing intensity up to 60% maximum heart rate (HRmax) + 20 minutes main part consisting of 10 repetitions of the combination of 1 minute at 75-90% HRmax and 2 minutes of active rest with light pedaling (50% HRmax) + 5 minutes cool-down at decreasing intensity (30-60% HRmax)
Aerobic training performed with a immersive virtual reality applicationProcedure or surgery
5 minutes of warm-up at increasing intensity up to 60% Maximum heart rate (HRmax) + 20 minutes between 60-80% of HRmax + 5 minutes of cooling at decreasing intensity (30-60% HRmax), with the use of virtual reality glasses and an immersive virtual reality application
High Intensity Interval Training (HIIT) performed with a immersive virtual reality applicationProcedure or surgery
5 minutes warm-up at increasing intensity up to 60% Maximum heart rate (HRmax) + 20 minutes main part consisting of 10 repetitions of the combination of 1 minute at 75-90% HRmax and 2 minutes of active rest with light pedaling (50% HRmax) + 5 minutes cool-down at decreasing intensity (30-60% HRmax), with the use of virtual reality glasses for an immersive virtual reality application
| Study group | Role | What they receive |
|---|---|---|
| Traditional aerobic exercise | Experimental | Not described Receives: Procedure: Traditional aerobic training |
| High-intensity interval training | Experimental | A single session of exercise Receives: Procedure: High Intensity Interval Training (HIIT) |
| Aerobic exercise applied with reality virtual | Experimental | A single session of exercise Receives: Procedure: Aerobic training performed with a immersive virtual reality application |
| High-intensity interval training applied with virtual reality | Experimental | A single session of exercise Receives: Procedure: High Intensity Interval Training (HIIT) performed with a immersive virtual reality application |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood lactate
Analysis of blood lactate concentration
Measured: During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Secondary outcomes (5)
Heart rate pattern
Heart rate pattern, measured with a heart rate monitor
Measured: During each exercise session (Days 1, 8, 15 and 22 from the start of the study)
Systolic and diastolic blood pressure
Systolic and diastolic blood pressure, measured with a sphygmomanometer
Measured: During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Perception of effort
Individual perception of effort during exercise, assessed with a modified Borg scale (0-10), where 0 is "no effort" and 10 corresponds to the "maximum possible perception of effort".
Measured: During the first minute after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Perception of fatigue
Individual perception of fatigue, with a numerical scale from 0 to 10, where 0 is "no fatigue" and 10 corresponds to the "maximum perception of fatigue possible"
Measured: During the first minute after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Physical performance
Physical performance, assessed by calculating the sets, repetitions and kg mobilized during the exercise time.
Measured: During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Aug 2025
- Study start25 Feb 2026
- Primary completionJun 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Effects of Exercise in Healthy PeopleStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 45 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Valencia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Adrián Escriche Escuder, University of Valencia
- Investigators
- Adrian Escriche-Escuder, PhD, Principal investigator, University of Valencia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07101341
- Sponsor's protocol ID
- 2024-FIS-3483189
- Status last verified
- Jun 2026
- First submitted
- 22 Jul 2025
- Last updated
- 10 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: The data that support the findings of this study will be available from the corresponding author upon reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 10 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Analysis of the Acute Effects of Aerobic Exercise and High-intensity Interval Exercise, With and Without the Simultaneous Application of Immersive Virtual Reality
- ClinicalTrials.gov ID
- NCT07101341
- Acronym / sponsor ID
- 2024-FIS-3483189
- Keywords
- virtual reality, immersive virtual reality, exergame
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 45 participants (estimated)
- Lead sponsor
- University of ValenciaUniversity, hospital or other
- Study start
- 25 Feb 2026 (actual)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 3 Aug 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare the acute effects at the cardiovascular (heart rate, blood pressure) and physiological (lactate) levels, as well as the perception of effort and fatigue, of four exercise modalities, one based on the traditional aerobic training methodology, another based on high-intensity interval training (HIIT), another consisting of aerobic exercise performed in conjunction with an immersive virtual reality (VR) application, and a last one consisting of exercise with HIIT-type parameters but also performed in conjunction with an immersive VR application.
All participants will complete one session of each of the four exercise modalities, analyzing the variables studied in each for subsequent analysis and comparison.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (investigator, outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Traditional aerobic exercise | Experimental | Procedure: Traditional aerobic training |
| High-intensity interval training | Experimental | Procedure: High Intensity Interval Training (HIIT)A single session of exercise |
| Aerobic exercise applied with reality virtual | Experimental | Procedure: Aerobic training performed with a immersive virtual reality applicationA single session of exercise |
| High-intensity interval training applied with virtual reality | Experimental | Procedure: High Intensity Interval Training (HIIT) performed with a immersive virtual reality applicationA single session of exercise |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Healthy people between 18 and 35 years old
Key exclusion criteria (3 listed)
- Current or recent injury that affects training
- Condition that prevents exercise (decompensated heart disease, decompensated respiratory disease, significant mobility difficulties, etc.)
- Visual problems that prevent exercise with virtual reality headsets
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Traditional aerobic training5 minutes of warm-up at increasing intensity up to 60% of maximum heart rate (HRmax) + 20 minutes between 60-80% of HRmax + 5 minutes of cool-down at decreasing intensity (30-60% HRmax) | Procedure or surgery | Traditional aerobic exercise |
| High Intensity Interval Training (HIIT)5 minutes warm-up at increasing intensity up to 60% maximum heart rate (HRmax) + 20 minutes main part consisting of 10 repetitions of the combination of 1 minute at 75-90% HRmax and 2 minutes of active rest with light pedaling (50% HRmax) + 5 minutes cool-down at decreasing intensity (30-60% HRmax) | Procedure or surgery | High-intensity interval training |
| Aerobic training performed with a immersive virtual reality application5 minutes of warm-up at increasing intensity up to 60% Maximum heart rate (HRmax) + 20 minutes between 60-80% of HRmax + 5 minutes of cooling at decreasing intensity (30-60% HRmax), with the use of virtual reality glasses and an immersive virtual reality application | Procedure or surgery | Aerobic exercise applied with reality virtual |
| High Intensity Interval Training (HIIT) performed with a immersive virtual reality application5 minutes warm-up at increasing intensity up to 60% Maximum heart rate (HRmax) + 20 minutes main part consisting of 10 repetitions of the combination of 1 minute at 75-90% HRmax and 2 minutes of active rest with light pedaling (50% HRmax) + 5 minutes cool-down at decreasing intensity (30-60% HRmax), with the use of virtual reality glasses for an immersive virtual reality application | Procedure or surgery | High-intensity interval training applied with virtual reality |
Primary outcome
Blood lactate
Time frame: During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Analysis of blood lactate concentration
5 secondary outcomes
Heart rate pattern
Time frame: During each exercise session (Days 1, 8, 15 and 22 from the start of the study)
Systolic and diastolic blood pressure
Time frame: During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Perception of effort
Time frame: During the first minute after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Perception of fatigue
Time frame: During the first minute after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Physical performance
Time frame: During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jun 2026.
- Individual participant dataSharing planned: Undecided. The data that support the findings of this study will be available from the corresponding author upon reasonable request.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Adrian Escriche-Escuder, PhD principal investigator
University of Valencia
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Traditional aerobic training, High Intensity Interval Training (HIIT) and Aerobic training performed with a immersive virtual reality application in people with Acute Effects of Exercise in Healthy People and Health Adult Subjects, run by University of Valencia at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 10 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Adrian Escriche-Escuder, PhD (+34 963 98 38 55, adrian.escriche@uv.es), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood lactate (time frame: During the 5 minutes after finishing the exercise session of each intervention modality (Days 1, 8, 15 and 22 from the start of the study)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jun 2026.