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Meniscus RuptureNCT07079254

Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy

An observational study of Meniscus Rupture and Meniscus Injury, run by Region Skane at 2 sites in Sweden.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The menisci of the knee joint are structures composed of cartilage and connective tissue, whose primary functions are to stabilize the joint and distribute weight across joint surfaces. In doing so, it helps protect the joint from osteoarthritis - a form of joint failure commonly referred to as "joint wear". Read more about this study

Who is it for?
Ages 15 years and older
What is being tested?
Meniscus suture and Partial meniscectomy
Type of treatment
Surgery or procedure
How many people
300 participants
Where
2 sitesSweden
Study dates
7 Oct 2023to Dec 2045
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 15 years and older
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Study population: Patients who present to the emergency department or the orthopaedic outpatient clinics at our hospitals with a knee extension deficit after trauma, with a clinically suspected bucket-handle meniscus rupture, are referred to a magnetic resonance imaging (MRI) within a week. Patients with a bucket-handle tear on the MRI, and no younger than 15 years, will be invited to participate in the study. Recruitment takes place at the outpatient clinic at the orthopaedic department at Skåne University Hospital in Malmö and the orthopaedic department at Hässleholm hospital.

Who may be able to join

  • 15 years or above.
  • Displaced longitudinal bucket-handle tear including the posterior horn on MRI and a knee extension deficit.

Who cannot join

  • Patient younger than 15 years.
  • Insufficient knowledge of the Swedish language.
  • Per-operative findings including a bucket-handle rupture in combination with a complete radial rupture

Trial locations and contacts

2 sites in 1 country. Contact the study team or a site near you to ask about taking part.

Sofie Alerskans, MD contact

+46 768-487639

sofie.alerskans@med.lu.se

Ola Svejme, MD, PhD contact

+46 722-106158

ola.svejme@skane.se

Sweden2 sites, 2 recruiting
  • Region Skåne, Orthopaedic department Kristianstad/Hässleholm

    Hässleholm, Skåne County

    Sofie Alerskans, MD, +46768487639, sofie.alerskans@med.lu.se

    Recruiting
  • Region Skåne, Skåne University Hospital

    Malmö, Skåne County

    Ola Svejme, MD, PhD, +722 106158, ola.svejme@skane.se

    Recruiting

Other trials in Sweden

About this study

Official title: Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy: A 10-year Observational Study

The menisci of the knee joint are structures composed of cartilage and connective tissue, whose primary functions are to stabilize the joint and distribute weight across joint surfaces. In doing so, it helps protect the joint from osteoarthritis - a form of joint failure commonly referred to as "joint wear". Meniscal surgeries are among the most common orthopaedic procedures performed both in Sweden and globally. Historically, damaged menisci were treated by removing the injured part. However, this approach is linked to early-onset osteoarthritis. Osteoarthritis affects approximately one-third of individuals over the age of 45 and ranks among the ten most common diagnoses in Europe based on years lived with disability. The knee is the most frequently affected joint, and the importance of the menisci in preserving knee function has become increasingly recognized.

In recent years, advances in surgical techniques have led to a shift towards meniscus-preserving procedures. A typical injury is the displaced meniscus, in which a large portion of the meniscus becomes detached from the joint capsule and wedges itself inside the joint, causing mechanical locking and preventing full extension. A displaced meniscus often loses its blood supply and suffers mechanical damage from being compressed between the joint surfaces. To preserve the meniscus and prevent irreversible damage, early surgical intervention is required. If the injury is too old or the tissue too damaged, the injured part of the meniscus must be removed, which significantly increases the risk of developing early knee osteoarthritis.

Read more

It remains unclear how soon surgery must be performed to successfully preserve the meniscus, and this likely depends on various other factors, including patient age, presence of additional joint injuries, and surgical technique. There is currently no reliable data on the proportion of displaced menisci that heal after meniscus-preserving surgery. However, studies suggest that 20-30% of repaired menisci require reoperation due to failed healing.

Given that displaced menisci are considered surgical emergencies, they pose a significant burden on healthcare systems already strained by limited access to urgent surgery. Meanwhile, ongoing development of surgical techniques raise ethical and logistical questions for health providers - especially as the scientific evidence for the benefits of some advanced treatments remains inconclusive.

Therefore, more research is needed to guide the optimal management of displaced bucket-handle lesions across a diverse patient population, taking into account age, activity level, and concurrent injuries. A key priority is to identify predictors of healing potential, particularly the time window during which surgical repair remains a viable option. With better knowledge, more menisci could potentially be preserved - reducing both the number of unnecessary re-operations and the long-term incidence of knee osteoarthritis.

Being tested
Meniscus suture, Partial meniscectomy
Keywords
Meniscus, Re-operation, Bucket-handle, Osteoarthritis
Medical subject headings
Osteoarthritis, Knee, Osteoarthritis

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Meniscus sutureProcedure or surgery

    The meniscus bucket-handle injury will either be treated with meniscus suture or partial meniscectomy

  • Partial meniscectomyProcedure or surgery

    The meniscus bucket-handle injury wil be treated with either meniscus suture or partial meniscectomy

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Re-operation

    Re-operation for meniscus injury/lesion

    Measured: 2-10 years

Secondary outcomes (2)
  1. Knee Injury and Osteoarthritis Outcome Score (KOOS)

    Patient reported outcome measure in the form of Knee Injury and Outcome Score (KOOS). A total score, called KOOS4, without the ADL scale, will be calculated. The scale ranges from 0 (worst) to 100 (best).

    Measured: From 6 months to 10 years

  2. Osteoarthritis in the knee

    Radiological osteoarthritis

    Measured: 10 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted22 Jul 2025
  2. Study start7 Oct 2023
  3. Primary completionDec 2035 (estimated)
  4. Study completionDec 2045 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
300 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07079254
Sponsor's protocol ID
2023-00059-01
Other IDs
2023
Status last verified
Aug 2026
First submitted
13 Jul 2025
Last updated
13 Aug 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: Contains sensitive data such as social security number and surgery references, etc

Questions about this trial

What is this clinical trial studying?

An observational study of Meniscus Rupture and Meniscus Injury, run by Region Skane at 2 sites in Sweden.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 13 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 2 sites in Sweden. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Sofie Alerskans, MD (+46 768-487639, sofie.alerskans@med.lu.se), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Re-operation (time frame: 2-10 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2026.

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