Cerebral Palsy Spastic DiplegiaNCT07072533
Effect of Blood Flow Restriction With Aerobic Training on Chest Muscles in Diaplegic Cerebral Palsy
A study testing blood flow restriction training in people with Cerebral Palsy Spastic Diplegia, run by Cairo University.
Trial summary
To evaluate the effect of blood flow restriction combined with aerobic training on chest muscle strength in individual with diaplegic cerebral palsy Read more about this study
- Who is it for?
- Ages 12 to 25 years
- Conditions the study is for
- Cerebral Palsy Spastic Diplegia
- What is being tested?
- blood flow restriction training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- No sites listed yet
- Study dates
- Aug 2025to Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 25 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- diaplegic cerebral palsy. GMFCS level I-III. medically stable.
Who cannot join
- severe cognitive impairment. cardio respiratory contraindication. previous thoracic surgery or musculoskeletal deformities affecting chest.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
To evaluate the effect of blood flow restriction combined with aerobic training on chest muscle strength in individual with diaplegic cerebral palsy
Read the detailed description
combining blood flow restriction with aerobic training may enhance muscle function and endurance by increasing localized metabolic stress and systemic cardiovascular effects inducing muscular hypertrophy and strength gaining with low load training especially chest muscles which affected in individuals with diaplegic cerebral palsy.
- Conditions
- Cerebral Palsy Spastic Diplegia
- Being tested
- blood flow restriction training
- Medical subject headings
- Cerebral Palsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
blood flow restriction trainingOther
Also called aerobic training
individual will do aerobic training .
| Study group | Role | What they receive |
|---|---|---|
| blood flow restriction combined with aerobic training | Experimental | individual will do blood flow restriction aerobic training Receives: Other: blood flow restriction training |
| aerobic training only | Active comparator | individual will do aerobic training Receives: Other: blood flow restriction training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Chest muscle strength
chest muscle strength will be measured by handheld dynamometry measured in Newton
Measured: 3 months
Secondary outcomes (4)
pulmonary function tests
pulmonary function tests in the form of forced vital capacity and forced expiratory volume in one second will be measured in Liters
Measured: 3 months
sub-maximal aerobic capacity
sub-maximal aerobic capacity will be measured using six minute walk test measured in seconds
Measured: 3 months
quality f life
quality f life will be measured using the pediatric quality of life inventory measured in scores from zero point to four points
Measured: 3 months
oxygen saturation and heart rate response
oxygen saturation and heart rate response will be measured using pulse oximeter measured in percentage for oxygen saturation and pulses per minute for heart rate
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Jul 2025
- Study startAug 2025 (estimated)
- Primary completionDec 2025 (estimated)
- Study completionFeb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebral Palsy Spastic DiplegiaStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Group A which is the experimental group treated with blood flow restriction plus aerobic training and group B which is the control group treated with aerobic trainin only.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Salah Eid Ahmed Ali, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07072533
- Sponsor's protocol ID
- SREC.PT.SUE(11)625
- Status last verified
- Jul 2025
- First submitted
- 28 Jun 2025
- Last updated
- 18 Jul 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 Jul 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Blood Flow Restriction With Aerobic Training on Chest Muscles in Diaplegic Cerebral Palsy
- ClinicalTrials.gov ID
- NCT07072533
- Acronym / sponsor ID
- SREC.PT.SUE(11)625
- Conditions
- Cerebral Palsy Spastic Diplegia
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- Aug 2025 (estimated)
- Primary completion
- Dec 2025 (estimated)
- Study completion
- Feb 2026 (estimated)
- First posted
- 18 Jul 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To evaluate the effect of blood flow restriction combined with aerobic training on chest muscle strength in individual with diaplegic cerebral palsy
Detailed description
combining blood flow restriction with aerobic training may enhance muscle function and endurance by increasing localized metabolic stress and systemic cardiovascular effects inducing muscular hypertrophy and strength gaining with low load training especially chest muscles which affected in individuals with diaplegic cerebral palsy.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Group A which is the experimental group treated with blood flow restriction plus aerobic training and group B which is the control group treated with aerobic trainin only.
| Arm | Type | Receives |
|---|---|---|
| blood flow restriction combined with aerobic training | Experimental | Other: blood flow restriction trainingindividual will do blood flow restriction aerobic training |
| aerobic training only | Active comparator | Other: blood flow restriction trainingindividual will do aerobic training |
Who may qualify
- Ages
- 12 to 25 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (1 listed)
- diaplegic cerebral palsy. GMFCS level I-III. medically stable.
Key exclusion criteria (1 listed)
- severe cognitive impairment. cardio respiratory contraindication. previous thoracic surgery or musculoskeletal deformities affecting chest.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| blood flow restriction trainingAlso: aerobic trainingindividual will do aerobic training . | Other | aerobic training only, blood flow restriction combined with aerobic training |
Primary outcome
Chest muscle strength
Time frame: 3 months
chest muscle strength will be measured by handheld dynamometry measured in Newton
4 secondary outcomes
pulmonary function tests
Time frame: 3 months
sub-maximal aerobic capacity
Time frame: 3 months
quality f life
Time frame: 3 months
oxygen saturation and heart rate response
Time frame: 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Jul 2025.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing blood flow restriction training in people with Cerebral Palsy Spastic Diplegia, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 18 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Salah Eid Ahmed Ali, Assis Lect (01158125773, Salah.Eid@sue.edu.eeg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Chest muscle strength (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Jul 2025.