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Facial Wrinkles and Rhytides ReductionNCT07067086

Cream Short-term Efficacy Clinical Study

A study testing Test Cream in people with Facial Wrinkles and Rhytides Reduction, run by ChinaNorm at 1 site in China.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This study aimed to evaluate the short-term efficacy of a facial cream (Formula# 899675 44A) on improving various skin quality and wrinkle parameters after a single application. A total of 44 healthy Chinese women aged 20 to 50 years, with all skin types including 50% sensitive skin, were enrolled. Read more about this study

Who is it for?
Ages 20 to 50 years, women onlyHealthy volunteers can take part
Conditions the study is for
Facial Wrinkles and Rhytides Reduction
What is being tested?
Test Cream
Could I receive a placebo?
No, everyone receives an active treatment
How many people
42 participants
Where
1 siteChina
Study dates
11 Dec 2024to 16 Dec 2024
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 50 years
  • Women only
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • 1.Chinese female with 20-50 years old (Must have 20-30 years old). 2.In general, good health at the time of the study. 3.All skin types, with 50% sensitive skin. 4.Regular users for cleanser, anti-aging cream and sunscreen product. 5.Self-declare with plumpness, smoothness and wrinkles problems. 6.Clinical grading by dermatologist in terms of: Underneath eye wrinkles: 2≤grade≤4; Forehead wrinkles: 1 <grade≤ 4; Crow's feet wrinkles: grade > 1; Skin smoothness: 3≤ grade≤ 6 (0-9 scale); Skin plumpness: 3≤ grade≤ 6 (0-9 scale); 7.Did not participate any clinical test or cosmetic product test on skin within 3 months.
  • 8.Did not participate any chemical/beauty procedures for previous 6 months. 9.No disagreement of dermatologist because of other reasons that exclude the participation of the subject.
  • 10.Were willing and able to participate as evidenced by signing of informed consent and photo release form.
  • 11.Must be willing to comply with all study protocol requirements.

Who cannot join

  • 1.Pregnant or breast-feeding woman or woman planning pregnancy during the study.
  • 2.Subject deprived of rights by a court or administrative order. 3.Major subject to a guardianship order. 4.Subject residing in a health or social care establishment. 5.Patient in an emergency setting. 6.Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema).
  • 7.Subject presenting a stable or progressive serious disease (per investigator's assessment).
  • 8.Immuno-compromised subject. 9.Subject with history of allergy to cosmetic or personal care products or ingredients.
  • 10.Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
  • 11.Subjects regularly practicing aquatic or nautical sports. 12.Subjects regularly attending a sauna. 13.Subject with physical highly sensitive constitution. 14.Subject with cardiovascular or circulatory history. 15.Subject with a history of skin cancer or malignant melanoma. 16.Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune-suppressants in the last 6 months before study.

Trial locations and contacts

1 site in 1 country.

China1 site

  • Shanghai China-norm Quality Technical Service Co., Ltd., Shanghai, Shanghai 200072

    Shanghai

Other trials in China

About this study

This study aimed to evaluate the short-term efficacy of a facial cream (Formula# 899675 44A) on improving various skin quality and wrinkle parameters after a single application. A total of 44 healthy Chinese women aged 20 to 50 years, with all skin types including 50% sensitive skin, were enrolled. Participants applied the cream once to the full face and neck under supervision, and outcomes were assessed at baseline (T0), 10 hours (T10h), and 24 hours (T24h) post-application. Clinical evaluations and photo-based imaging were used to assess skin plumpness, smoothness, radiance, and multiple types of wrinkles. At the end of the study, 42 participants completed the protocol.

Being tested
Test Cream

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Test CreamOther

    A facial cream (Formula# 899675 44A, 30 mL) was applied once by participants under supervision. 1g of cream was spread over the entire face and neck, followed by targeted massage on wrinkle-prone areas including forehead, crow's feet, underneath eyes, nasolabial folds, and neck folds. Clinical and photo-based evaluations were conducted at baseline (T0), 10 hours (T10h), and 24 hours (T24h) after application.

Study groups in NCT07067086
Study groupRoleWhat they receive
Test Cream Single Application GroupExperimentalParticipants applied the test cream (Formula# 899675 44A, 30 mL) once to the full face and neck under staff supervision. Application was followed by massaging designated wrinkle-prone areas including the forehead, crow's feet, underneath eyes, nasolabial folds, and neck folds. Clinical assessments and imaging analysis were performed at T0, T10h, and T24h post-application.
Receives: Other: Test Cream

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time effect of cheek plumpness (Visual)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  2. Time effect of skin smoothness (Visual)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  3. Time effect of skin radiance (Visual)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  4. Time effect of skin elasticity (Tactile)

    Measured: Compare to baseline, 10h, 24h

Secondary outcomes (9)

  1. Time effect of global fine lines (Visual)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  2. Time effect of forehead wrinkles (Photo analysis)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  3. Time effect of crow's feet wrinkles (Photo analysis)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  4. Time effect of skin firmness (Visual)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  5. Time effect of nasolabial folds (Photo analysis)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  6. Time effect of skin hydration (Corneometer)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  7. Time effect of skin TEWL (Tewameter)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  8. Time effect of skin glossiness (Glossymeter)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

  9. Time effect of skin redness (Chromameter)

    Measured: Compare to baseline, Time point at 10 hours, Time point at 24 hours.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted16 Jul 2025
  2. Study start11 Dec 2024
  3. Primary completion16 Dec 2024
  4. Study completion16 Dec 2024

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
42 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07067086
Sponsor's protocol ID
C24005077
Status last verified
Jul 2025
First submitted
4 Jul 2025
Last updated
16 Jul 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: This Data Sharing Plan (DSP) aims to promote the open exchange and reuse of de-identified individual participant data (IPD) from cosmetic clinical research, including study protocols, case report forms (CRFs), and statistical analysis plans (SAPs). The shared data will be made available through compliant platforms to eligible researchers in dermatology, cosmetic science, and related fields, following ethical principles and data protection regulations. Users must sign a Data Use Agreement (DUA) to ensure data security, privacy protection, and compliance with research purposes.

Questions about this trial

What is this clinical trial studying?

A study testing Test Cream in people with Facial Wrinkles and Rhytides Reduction, run by ChinaNorm at 1 site in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 16 Jul 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time effect of cheek plumpness (Visual) (time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07067086.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jul 2025.

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