Primary Knee OsteoarthritisNCT07066215
Effects of Balance and Muscle Strength in Knee Osteoarthritis
An observational study of Primary Knee Osteoarthritis, run by Bezmialem Vakif University at 1 site in Turkey (Türkiye).
Trial summary
Knee osteoarthritis (OA) is a chronic and progressive joint disease characterized by the degeneration of articular cartilage, subchondral bone sclerosis, and the formation of osteophytes. This condition leads to joint pain and stiffness, negatively affecting individuals' quality of life. Read more about this study
- Who is it for?
- Ages 45 to 75 years, women only
- Conditions the study is for
- Primary Knee Osteoarthritis
- How many people
- 64 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2025to 13 Mar 2026
- How long will I take part?
- 1 Day
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 75 years
- Women only
- No healthy volunteers
- Adult, Older adult
Study population: Patients who have diagnosed primary knee osteoarthritis will be included
Who may be able to join
- Primary knee osteoarthritis
Who cannot join
- Previous surgery in the lower extremity
- Neuromuscular disease
- Vestibular pathology
- Physiotherapy intervention or intra-articular injection within the last 6 months
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Balance and Muscle Strength on Functional Capacity in Knee Osteoarthritis
Knee osteoarthritis (OA) is a chronic and progressive joint disease characterized by the degeneration of articular cartilage, subchondral bone sclerosis, and the formation of osteophytes. This condition leads to joint pain and stiffness, negatively affecting individuals' quality of life. Joint stiffness, decreased quadriceps strength, and impaired proprioceptive sensation result in functional limitations. Due to these symptoms, individuals experience difficulties in performing daily activities such as rising from a chair, walking, and climbing stairs. The aim of this study is to evaluate the effects of balance, and muscle strength on functional capacity in patients with knee osteoarthritis.
Read the detailed description
In knee OA, structural changes in the cartilage and the formation of peripheral osteophytes contribute to joint stiffness and a reduction in the range of motion, which adversely affects physical function, particularly in older adults. Activities such as stair climbing, sitting and standing, and walking require the contribution of core muscles as well as lower extremity muscles, particularly the knee extensors. In knee OA, there is a reported decrease in lower extremity muscle strength, especially in the quadriceps femoris muscle, which further impairs functional activities in the advanced stages of the disease.
Arthritic damage to joint mechanoreceptors in osteoarthritis leads to a decline in motor control and proprioceptive sensitivity. These sensorimotor deficits result in decreased stability and impaired balance function. Additionally, reduced muscle strength can hinder neuromuscular control, leading to postural instability and an increased risk of falls, especially in older patients.
Identifying the factors that contribute to the decline in functional capacity is crucial for planning appropriate exercise programs. The aim of this study is to evaluate the effects of balance, and muscle strength on functional capacity in patients with knee osteoarthritis.
- Conditions
- Primary Knee Osteoarthritis
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle strength
Muscles strength measurement with 5 time sit-to-stand test
Measured: Baseline
Balance
Biodex Balance System will be used for postural stability evaluation. Lower scores indicate better stability and higher scores mean poor balance.
Measured: Baseline
6-minute walk test
Walking distance will be measured
Measured: Baseline
Stair climb test
Test completion time will be evaluated
Measured: Baseline
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Function subscale consisting of 17 items will be used for evaluation. Higher scores indicate greater functional limitation.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jul 2025
- Study start1 Aug 2025
- Primary completion28 Feb 2026
- Study completion13 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Primary Knee OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 64 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Bezmialem Vakif University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kübra Alpay, Bezmialem Vakif University
- Investigators
- Kubra Alpay, PhD, Principal investigator, Bezmialem Vakif University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07066215
- Sponsor's protocol ID
- KA25-1
- Status last verified
- Apr 2026
- First submitted
- 14 Jul 2025
- Last updated
- 28 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No