Pulp Exposure, DentalNCT07041905
Effects of Total and Selective Caries Removal - Requiring or Avoiding Vital Pulp Therapy - on Pulp Vitality and Postoperative Pain in Deep Carious Mature Permanent Teeth: A Split-Mouth Clinical Study
A study testing Total Caries Removal and Selective Caries Removal in people with Pulp Exposure, Dental and Deep Dental Caries, run by Cukurova University at 1 site in Turkey (Türkiye).
Trial summary
The effect of selective caries cleaning and total caries cleaning on pulp health and post operative pain in teeth with deep caries will be investigated. Read more about this study
- Who is it for?
- Ages 15 to 55 years
- Conditions the study is for
- Pulp Exposure, Dental, Deep Dental Caries
- What is being tested?
- Total Caries Removal and Selective Caries Removal
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 15 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jul 2025to 1 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 55 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Patients aged ≥15 years with bilateral deep carious mature permanent teeth.
- Positive vitality test (cold sensitivity).
- No spontaneous pain or periapical radiolucency.
- Willingness to attend 6- and 12-month follow-ups
Who cannot join
- Uncontrolled systemic diseases Pregnancy or allergy to dental materials used Teeth with irreversible pulpitis (spontaneous pain, necrosis) Non-restorable teeth (fractures, extensive decay)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Cukurova University
Adana
Cukurova University Cukurova University Faculty of Dentistry, 0322 338 73 30, dhf@cu.edu.tr
About this study
The effect of selective caries cleaning and total caries cleaning on pulp health and post operative pain in teeth with deep caries will be investigated.
- Conditions
- Pulp Exposure, Dental, Deep Dental Caries
- Being tested
- Total Caries Removal, Selective Caries Removal
- Medical subject headings
- Dental Pulp Exposure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Total Caries RemovalProcedure or surgery
Arm 1: "Total caries removal (complete excavation to hard dentin)"
Selective Caries RemovalProcedure or surgery
Partial removal leaving affected dentin near pulp.
| Study group | Role | What they receive |
|---|---|---|
| Arm 1 | Active comparator | Complete caries excavation Receives: Procedure: Total Caries Removal |
| Arm 2 | Experimental | Partial caries excavation Receives: Procedure: Selective Caries Removal |
What is being measured
The primary outcome is the main question the study is designed to answer.
Early postoperative pain intensity (VAS) after total vs. selective excavation
The patient will be asked to rate his/her pain on day 1, 3 and 7 according to VAS
Measured: first week
dentin bridge formation
no dentin bridge formation is expected in selective caries cleaning, while dentin bridge formation will be observed radiologically in total cleaning
Measured: twelve months
pulp survival at twelve months
The pulp is expected to remain vital, with no percussion tenderness and no spontaneous pain
Measured: twelve months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jun 2025
- Study start1 Jul 2025
- Primary completion1 Feb 2026
- Study completion1 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pulp Exposure, DentalStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 15 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cukurova University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zehra SUSGUN YILDIRIM, Cukurova University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07041905
- Sponsor's protocol ID
- D-SCR-2025-01
- Status last verified
- Mar 2026
- First submitted
- 19 Jun 2025
- Last updated
- 30 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Total and Selective Caries Removal - Requiring or Avoiding Vital Pulp Therapy - on Pulp Vitality and Postoperative Pain in Deep Carious Mature Permanent Teeth: A Split-Mouth Clinical Study
- ClinicalTrials.gov ID
- NCT07041905
- Acronym / sponsor ID
- D-SCR-2025-01
- Conditions
- Pulp Exposure, Dental, Deep Dental Caries
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 15 participants (estimated)
- Lead sponsor
- Cukurova UniversityUniversity, hospital or other
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- 1 Feb 2026 (actual)
- Study completion
- 1 Aug 2026 (estimated)
- First posted
- 27 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The effect of selective caries cleaning and total caries cleaning on pulp health and post operative pain in teeth with deep caries will be investigated.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Arm 1 | Active comparator | Procedure: Total Caries RemovalComplete caries excavation |
| Arm 2 | Experimental | Procedure: Selective Caries RemovalPartial caries excavation |
Who may qualify
- Ages
- 15 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- Patients aged ≥15 years with bilateral deep carious mature permanent teeth.
- Positive vitality test (cold sensitivity).
- No spontaneous pain or periapical radiolucency.
- Willingness to attend 6- and 12-month follow-ups
Key exclusion criteria (1 listed)
- Uncontrolled systemic diseases Pregnancy or allergy to dental materials used Teeth with irreversible pulpitis (spontaneous pain, necrosis) Non-restorable teeth (fractures, extensive decay)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Total Caries RemovalArm 1: "Total caries removal (complete excavation to hard dentin)" | Procedure or surgery | Arm 1 |
| Selective Caries RemovalPartial removal leaving affected dentin near pulp. | Procedure or surgery | Arm 2 |
Primary outcome
Early postoperative pain intensity (VAS) after total vs. selective excavation
Time frame: first week
The patient will be asked to rate his/her pain on day 1, 3 and 7 according to VAS
dentin bridge formation
Time frame: twelve months
no dentin bridge formation is expected in selective caries cleaning, while dentin bridge formation will be observed radiologically in total cleaning
pulp survival at twelve months
Time frame: twelve months
The pulp is expected to remain vital, with no percussion tenderness and no spontaneous pain
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Mar 2026.
Related trials for Pulp Exposure, Dental
Not yet recruiting
Effect of Hemostatic Agents on TheraCal PT Pulpotomy Success in Primary Molars
Reversible Pulpitis, Dental Caries
Recruiting
Pomegranate Peel Extract for Primary Molar Pulpotomy
Pulpitis Reversible, Pulp Exposure, Dental
Not yet recruiting
Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars
Pulp Disease, Dental, Pulp Therapy in Primary Molars
Not yet recruitingPhase 1
Comparative Evaluation of Clinical and Radiographic Outcomes of Mustard Gel (Brassica Nigra) and Mineral Trioxide Aggregate (MTA) as Pulpotomy Agents in Deciduous Molars- A Randomized Controlled Trial
Dental Pulp Exposure
Active, not recruitingObservational study
The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy
Pulp Exposure, Dental, Pulp Disease, Dental
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Total Caries Removal and Selective Caries Removal in people with Pulp Exposure, Dental and Deep Dental Caries, run by Cukurova University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zehra Zehra Susgun Yıldırım, Principal investigator (0553 454 1123, susgunzehra@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Early postoperative pain intensity (VAS) after total vs. selective excavation (time frame: first week). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Mar 2026; AzTrials last refreshed its copy on 26 Oct 2026.