Healthy Older AdultsNCT07039708
A Computer-based Memory Strategy Training Program for Older Adults
A study testing E-MinD Life Semantic and Cognitive stimulation in people with Healthy Older Adults and Memory Complaints, run by The Hong Kong Polytechnic University at 1 site in Hong Kong.
Trial summary
A computer-based cognitive rehabilitation program based on daily tasks utilising the semantic or perceptual encoding strategies called Enhancing Memory in Daily Life (E-MinD Life) has been developed for Chinese people. Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy Older Adults, Memory Complaints, Mild Cognitive Impairment (MCI)
- What is being tested?
- E-MinD Life Semantic and Cognitive stimulation
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteHong Kong
- Study dates
- 10 Feb 2025to Dec 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- Group 1: healthy older adults aged 65 years or above Group 2: older adults aged 65 years or above with memory complaints Group 3: older adults aged 65 or above with mild cognitive impairment
Who cannot join
- have depression and other clinical conditions that may affect their cognition.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Computer-based Memory Strategy Training Program to Promote Everyday Performance in Healthy Older Adults, Older Adults With Memory Complaints, Mild Cognitive Impairment and Mild Dementia
A computer-based cognitive rehabilitation program based on daily tasks utilising the semantic or perceptual encoding strategies called Enhancing Memory in Daily Life (E-MinD Life) has been developed for Chinese people. The aim of the E-MinD Life is to delay functional deterioration associated with possible cognitive changes in healthy older adults, older adults with memory complaints, mild cognitive impairment (MCI) and mild dementia. This project will pilot-test the E-MinD Life in Chinese healthy older adults, older adults with memory complaints, MCI and mild dementia.
Read the detailed description
The objectives of the study are to investigate the feasibility and pilot-test the benefits of the computer-based E-MinD Life (Semantic) or (Perceptual) program to promote everyday performance in healthy older adults, older adults with memory complaints, mild cognitive impairment (MCI) and mild dementia in Hong Kong using a randomised control trial.
Three groups of participants will be recruited: (1) 15 healthy older adults, (2) 15 older adults aged over 65 years with memory complaints, or older adults aged over 65 years, meeting the diagnostic criteria for MCI with a Clinical Dementia Rating score of 0 or having mild dementia with a Clinical Dementia Rating score of 1. All participants will have no depression and other clinical conditions that may affect their cognition. Their scores on the Montreal Cognitive Assessment will be recorded. Their carers or family members are invited to participate.
- Being tested
- E-MinD Life Semantic, Cognitive stimulation
- Keywords
- computer-based, memory training, activities of daily living, older adults, feasibility
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
E-MinD Life SemanticBehavioural
The E-MinD Life programme is designed to teach semantic or perceptual memory strategies. The memory strategies are applied to 12 common daily activities required for community living, e.g. meal preparation, laundry activities, and built into the E-MinD Life programme on a computer-based platform. The intervention runs over 9 weeks with one 45-minute individual face-to-face or online healthcare-professional-led session and two 30-minute, family-assisted home sessions per week. During the home sessions, participants will complete the same activities as those learnt during the healthcare-professional-led sessions. Family members or carers will be invited to join the healthcare-professional-led sessions as observers and support the participants in the home sessions if needed.
Cognitive stimulationBehavioural
Participants will receive stimulation for visual attention and memory through online cognitive activities. The intervention will adopt a similar structure as the E-MinD Life group, with one 45-minute individual face-to-face or online healthcare-professional-led session and two 30-minute, family-assisted home sessions per week for 9 weeks.
| Study group | Role | What they receive |
|---|---|---|
| E-MinD Life | Experimental | Participants receive the E-MinD Life (Semantic or Perceptual) programme. Receives: Behavioral: E-MinD Life Semantic |
| Cognitive stimulation | Active comparator | Participants will receive cognitive stimulation. Receives: Behavioral: Cognitive stimulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Accceptability
Acceptability is measured using a structured questionnaire divided into five sections: (1) the therapist-led group sessions, (2) the self-administered individual sessions, and (3) the computer program interface and iPad usability, (4) the overall program design and structure and (5) overall satisfaction. Participants are invited to give quantitative ratings on four dimensions under each section: (a) perceived effectiveness (e.g., whether the program improved cognitive strategy use), (b) relevance (e.g., how applicable the activities were to daily life), (c) convenience (e.g., ease) and (d) clarity. Responses are collected using a 4-point Likert scale, ranging from 1 "Completely disagree" to 4 "Completely agree," with higher scores indicating greater acceptability.
Measured: End of the intervention at 9 weeks
Secondary outcomes (6)
Feasibility by measuring the attendance rate
Feasibility by measuring the intervention attendance rate
Measured: Through the intervention for 9 weeks, attendance at each session
Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB)
The CERAD-NAB provides a profile on cognitive function by assessing cognitive deficits and was validated in a Chinese version. This study will use all subtests, including Verbal Fluency (J1), Boston's Naming (J2), Mini-Mental State Examination (MMSE, J3), Word List Memory (J4), Constructional Praxis (J5), Word List Recall (J6), Word List Recognition (J7) and Recall of Constructional Praxis (J8). The total score ranges from 0 -115 with a higher score indicating better performance.
Measured: From enrollment to the end of intervention at 9 weeks
Digit Span Test
The Digit Span Test consists of Digit Span Forward (DSF) and Digit Span Backward (DSB), measures immediate verbal recall, attentional capacity and working memory. The score is the number of digits in the longest successfully recalled sequence. A higher score indicates a better performance.
Measured: From enrollment to the end of intervention at 9 weeks
Lawton Instrumental Activities of Daily Living Scale
The self-reported Lawton Instrumental Activities of Daily Living Scale-Chinese version (IADLS) assesses one's ability to independently perform eight domains of instrumental daily activities such as meal preparation, laundry work, and shopping. The scale consists of nine items, each rated on a 3-point or 4-point scale, with a total score ranging from 0 to 18 or higher. A higher score indicates a better performance
Measured: From enrollment to the end of intervention at 9 weeks
Disability Assessment for Dementia (DAD)
The Chinese version of the Disability Assessment for Dementia (DAD) is a survey, completed by a proxy/carer, that evaluates the level of independence in daily activities for a person who has dementia or cognitive impairment. The DAD is scored based on a "yes/no" system, where "yes" indicates the person performed the activity without help, and "no" indicates they did not. The number of "yes" responses is totalled, and then converted to a percentage score out of 100. Higher percentage scores indicate better functional ability.
Measured: From enrollment to the end of intervention at 9 weeks
EuroQoL- 5 Dimensions - 5 Levels Hong Kong version (EQ-5D-5L_HK)
The EQ-5D-5L HK measures health-related quality of life in five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, using five rating levels (33). The 5-level health status is converted to a utility value, ranging from 0 (death) to 1 (full health). The EQ-5D-5L HK includes a Visual Analogue Scale where respondents rate their overall health on a scale of 0 to 100.
Measured: From enrollment to the end of intervention at 9 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jun 2025
- Study start10 Feb 2025
- Primary completionDec 2026 (estimated)
- Study completionDec 2026 (estimated)
Why it stopped: Because of the funding issue and the time limitation, the project has recruited healthy older adults. In the future, the project will resume to recruit older adults with memory complaints and mild cognitive impairments.
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy Older AdultsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- The Hong Kong Polytechnic University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, LIU Karen, The Hong Kong Polytechnic University
- Investigators
- Karen Liu, Principal investigator, The Hong Kong Polytechnic University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07039708
- Sponsor's protocol ID
- HongKongPU_E-MinD Life
- Status last verified
- Sep 2026
- First submitted
- 18 Jun 2025
- Last updated
- 17 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The project is applying for external funding. The IPD will not be shared at this stage.
Study at a glance
From the registry record, last updated by the sponsor on 17 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Computer-based Memory Strategy Training Program to Promote Everyday Performance in Healthy Older Adults, Older Adults With Memory Complaints, Mild Cognitive Impairment and Mild Dementia
- ClinicalTrials.gov ID
- NCT07039708
- Acronym / sponsor ID
- HongKongPU_E-MinD Life
- Keywords
- computer-based, memory training, activities of daily living, older adults, feasibility
- Study type
- Interventional
- Recruitment status
- SuspendedReason stopped: Because of the funding issue and the time limitation, the project has recruited healthy older adults. In the future, the project will resume to recruit older adults with memory complaints and mild cognitive impairments.
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- The Hong Kong Polytechnic UniversityUniversity, hospital or other
- Study start
- 10 Feb 2025 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 26 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A computer-based cognitive rehabilitation program based on daily tasks utilising the semantic or perceptual encoding strategies called Enhancing Memory in Daily Life (E-MinD Life) has been developed for Chinese people. The aim of the E-MinD Life is to delay functional deterioration associated with possible cognitive changes in healthy older adults, older adults with memory complaints, mild cognitive impairment (MCI) and mild dementia. This project will pilot-test the E-MinD Life in Chinese healthy older adults, older adults with memory complaints, MCI and mild dementia.
Detailed description
The objectives of the study are to investigate the feasibility and pilot-test the benefits of the computer-based E-MinD Life (Semantic) or (Perceptual) program to promote everyday performance in healthy older adults, older adults with memory complaints, mild cognitive impairment (MCI) and mild dementia in Hong Kong using a randomised control trial.
Three groups of participants will be recruited: (1) 15 healthy older adults, (2) 15 older adults aged over 65 years with memory complaints, or older adults aged over 65 years, meeting the diagnostic criteria for MCI with a Clinical Dementia Rating score of 0 or having mild dementia with a Clinical Dementia Rating score of 1. All participants will have no depression and other clinical conditions that may affect their cognition. Their scores on the Montreal Cognitive Assessment will be recorded. Their carers or family members are invited to participate.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| E-MinD Life | Experimental | Behavioral: E-MinD Life SemanticParticipants receive the E-MinD Life (Semantic or Perceptual) programme. |
| Cognitive stimulation | Active comparator | Behavioral: Cognitive stimulationParticipants will receive cognitive stimulation. |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (1 listed)
- Group 1: healthy older adults aged 65 years or above Group 2: older adults aged 65 years or above with memory complaints Group 3: older adults aged 65 or above with mild cognitive impairment
Key exclusion criteria (1 listed)
- have depression and other clinical conditions that may affect their cognition.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| E-MinD Life SemanticThe E-MinD Life programme is designed to teach semantic or perceptual memory strategies. The memory strategies are applied to 12 common daily activities required for community living, e.g. meal preparation, laundry activities, and built into the E-MinD Life programme on a computer-based platform. The intervention runs over 9 weeks with one 45-minute individual face-to-face or online healthcare-professional-led session and two 30-minute, family-assisted home sessions per week. During the home sessions, participants will complete the same activities as those learnt during the healthcare-professional-led sessions. Family members or carers will be invited to join the healthcare-professional-led sessions as observers and support the participants in the home sessions if needed. | Behavioural | E-MinD Life |
| Cognitive stimulationParticipants will receive stimulation for visual attention and memory through online cognitive activities. The intervention will adopt a similar structure as the E-MinD Life group, with one 45-minute individual face-to-face or online healthcare-professional-led session and two 30-minute, family-assisted home sessions per week for 9 weeks. | Behavioural | Cognitive stimulation |
Primary outcome
Accceptability
Time frame: End of the intervention at 9 weeks
Acceptability is measured using a structured questionnaire divided into five sections: (1) the therapist-led group sessions, (2) the self-administered individual sessions, and (3) the computer program interface and iPad usability, (4) the overall program design and structure and (5) overall satisfaction. Participants are invited to give quantitative ratings on four dimensions under each section: (a) perceived effectiveness (e.g., whether the program improved cognitive strategy use), (b) relevance (e.g., how applicable the activities were to daily life), (c) convenience (e.g., ease) and (d) clarity. Responses are collected using a 4-point Likert scale, ranging from 1 "Completely disagree" to 4 "Completely agree," with higher scores indicating greater acceptability.
6 secondary outcomes
Feasibility by measuring the attendance rate
Time frame: Through the intervention for 9 weeks, attendance at each session
Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB)
Time frame: From enrollment to the end of intervention at 9 weeks
Digit Span Test
Time frame: From enrollment to the end of intervention at 9 weeks
Lawton Instrumental Activities of Daily Living Scale
Time frame: From enrollment to the end of intervention at 9 weeks
Disability Assessment for Dementia (DAD)
Time frame: From enrollment to the end of intervention at 9 weeks
EuroQoL- 5 Dimensions - 5 Levels Hong Kong version (EQ-5D-5L_HK)
Time frame: From enrollment to the end of intervention at 9 weeks
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Sep 2026.
- Individual participant dataSharing planned: No. The project is applying for external funding. The IPD will not be shared at this stage.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Karen Liu principal investigator
The Hong Kong Polytechnic University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing E-MinD Life Semantic and Cognitive stimulation in people with Healthy Older Adults and Memory Complaints, run by The Hong Kong Polytechnic University at 1 site in Hong Kong.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: paused, as of the sponsor's last update on 17 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Hong Kong. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Accceptability (time frame: End of the intervention at 9 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Sep 2026.