Out of Hospital Cardiac ArrestNCT07034170
Skeletal Muscle Mass on Prognosis and Recovery in Clinical Trial
A study testing Enhanced Rehabilitation Program in people with Out of Hospital Cardiac Arrest and Inhospital Cardiac Arrest, run by National Taiwan University Hospital at 1 site in Taiwan.
Trial summary
The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction model for patients who have experienced cardiac arrest and undergone resuscitation. Read more about this study
- Who is it for?
- Ages 18 to 99 years
- Conditions the study is for
- Out of Hospital Cardiac Arrest, Inhospital Cardiac Arrest
- What is being tested?
- Enhanced Rehabilitation Program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 Jun 2025to 31 Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 99 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Non-traumatic adult patients who experienced sudden cardiac arrest
- Achieved sustained return of spontaneous circulation (ROSC) for more than five minutes following successful resuscitation
- Admitted to the ICU
- Survived beyond 72 hours without successful weaning from mechanical ventilation
Who cannot join
- Age under 18 years
- Pregnancy
- Expected to be weaned from mechanical ventilation within 48 hours
- Terminal-stage cancer or unwillingness to receive aggressive treatment
- Unavailability of ICU care due to overcrowding in the emergency intensive care unit
- Refusal to participate in the study by the patient or family members
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- Presence of an implanted pacemaker or defibrillator
- Open wounds, severe edema, or deep vein thrombosis in the lower limbs
- Pre-arrest status limited to wheelchair use or bedridden, unable to ambulate
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site
Department of Emergency Medicine, National Taiwan University Hospital
Taipei, Taipei, 100
About this study
Official title: Comprehensive Interpretation of the Importance of Skeletal Muscle Mass on Prognosis and Recovery in Cardiac Arrest Survivors: From Machine Learning to Clinical Trial
The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction model for patients who have experienced cardiac arrest and undergone resuscitation. The model will be validated using multicenter registry data and medical imaging. Furthermore, a clinical trial involving core muscle rehabilitation for post-resuscitation patients will be conducted to evaluate both short-term and long-term outcomes, aiming to comprehensively understand the impact of muscle mass on the prognosis of patients after cardiac arrest.
- Being tested
- Enhanced Rehabilitation Program
- Keywords
- cardiac arrest, Skeletal muscle mass, rehabilitation
- Medical subject headings
- Out-of-Hospital Cardiac Arrest, Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Enhanced Rehabilitation ProgramBehavioural
Participants in the intervention group receive an enhanced rehabilitation program, including muscular electrical stimulation, guided active rehabilitation sessions, and structured physical engagement during periods of consciousness. The intervention is designed to promote functional improvement in post-cardiac arrest patients.
| Study group | Role | What they receive |
|---|---|---|
| control group | No intervention | Not described |
| Intervention Group | Experimental | Participants in the arm group only performed joint-assisted movement. Receives: Behavioral: Enhanced Rehabilitation Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
skeletal muscle mass
Muscle changes were measured weekly using a handheld ultrasound.
Measured: 21 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jun 2025
- Study start1 Jun 2025
- Primary completion30 May 2028 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Out of Hospital Cardiac ArrestStudies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- This is a parallel assignment trial in which participants are allocated to study arms based on the month of admission. Patients admitted during even-numbered months are assigned to the intervention group, while those admitted during odd-numbered months are assigned to the control group.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07034170
- Sponsor's protocol ID
- 202501085RIND
- Status last verified
- Jul 2026
- First submitted
- 5 Jun 2025
- Last updated
- 20 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comprehensive Interpretation of the Importance of Skeletal Muscle Mass on Prognosis and Recovery in Cardiac Arrest Survivors: From Machine Learning to Clinical Trial
- ClinicalTrials.gov ID
- NCT07034170
- Acronym / sponsor ID
- 202501085RIND
- Keywords
- cardiac arrest, Skeletal muscle mass, rehabilitation
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- 30 May 2028 (estimated)
- Study completion
- 31 Dec 2028 (estimated)
- First posted
- 24 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction model for patients who have experienced cardiac arrest and undergone resuscitation. The model will be validated using multicenter registry data and medical imaging. Furthermore, a clinical trial involving core muscle rehabilitation for post-resuscitation patients will be conducted to evaluate both short-term and long-term outcomes, aiming to comprehensively understand the impact of muscle mass on the prognosis of patients after cardiac arrest.
Study design
- Primary purpose
- Supportive care
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- This is a parallel assignment trial in which participants are allocated to study arms based on the month of admission. Patients admitted during even-numbered months are assigned to the intervention group, while those admitted during odd-numbered months are assigned to the control group.
| Arm | Type | Receives |
|---|---|---|
| control group | No intervention | – |
| Intervention Group | Experimental | Behavioral: Enhanced Rehabilitation ProgramParticipants in the arm group only performed joint-assisted movement. |
Who may qualify
- Ages
- 18 to 99 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Non-traumatic adult patients who experienced sudden cardiac arrest
- Achieved sustained return of spontaneous circulation (ROSC) for more than five minutes following successful resuscitation
- Admitted to the ICU
- Survived beyond 72 hours without successful weaning from mechanical ventilation
Key exclusion criteria (9 listed)
- Age under 18 years
- Pregnancy
- Expected to be weaned from mechanical ventilation within 48 hours
- Terminal-stage cancer or unwillingness to receive aggressive treatment
- Unavailability of ICU care due to overcrowding in the emergency intensive care unit
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Enhanced Rehabilitation ProgramParticipants in the intervention group receive an enhanced rehabilitation program, including muscular electrical stimulation, guided active rehabilitation sessions, and structured physical engagement during periods of consciousness. The intervention is designed to promote functional improvement in post-cardiac arrest patients. | Behavioural | Intervention Group |
Primary outcome
skeletal muscle mass
Time frame: 21 days
Muscle changes were measured weekly using a handheld ultrasound.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jul 2026.
- Individual participant dataSharing planned: No
Related trials for Out of Hospital Cardiac Arrest
Active, not recruitingPhase 3
The Danish Out-of-Hospital Cardiac Arrest Study
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
Not yet recruiting
Compression-Only Versus Standard Basic Life Support Training in Nursing Students
Cardiopulmonary Resuscitation, Out-of-Hospital Cardiac Arrest
Not yet recruiting
Execution of Prehospital Transesophageal Echocardiography During Cardiopulmonary Resuscitation in Patients With Out-of-hospital Cardiac Arrest
Out-of-hospital Cardiac Arrest (OHCA)
Active, not recruiting
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
Cardiac Arrest, Out-Of-Hospital
Active, not recruiting
RACE-CARS - RAndomized Cluster Evaluation of Cardiac ARrest Systems
Cardiac Arrest
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Enhanced Rehabilitation Program in people with Out of Hospital Cardiac Arrest and Inhospital Cardiac Arrest, run by National Taiwan University Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 20 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
skeletal muscle mass (time frame: 21 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jul 2026; AzTrials last refreshed its copy on 8 Nov 2026.