Aerobic ExerciseNCT07016594
Acute Cardiovascular Responses to Two Types of Exercise
A study testing Aerobic exercise in people with Aerobic Exercise, run by University of Manitoba at 1 site in Canada.
Trial summary
The purpose of this research was to explore potential differences in acute cardiovascular responses between two conditions: 1) moderate-intensity cycle ergometer exercise; and 2) moderate-intensity cycle ergometer exercise with NMES. Young, healthy, physically active participants were recruited for this study. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Aerobic Exercise
- What is being tested?
- Aerobic exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteCanada
- Study dates
- 25 Jan 2022to 1 Jun 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- healthy
- performing aerobic activity greater than or equal to three times per week at any intensity
Who cannot join
- had lower body musculoskeletal injuries recently (within the past 6 months)
- health conditions that may place risk to the individual such as those with respiratory issues, hypertension, chronic atrial fibrillation, valvular diseases, heart disease; or obstructive cardiomyopathy
- if taking pharmacological drugs, performance-enhancing drugs, recreational drugs, nutritional supplements, or smoked nicotine
Trial locations and contacts
1 site in 1 country.
Canada1 site
Active Living Centre/Applied Research Centre
Winnipeg, Manitoba, R3T2N2
About this study
Official title: The Effect of Aerobic Exercise With and Without Neuromuscular Electrical Stimulation on Acute Cardiovascular Responses Between Biological Sexes
The purpose of this research was to explore potential differences in acute cardiovascular responses between two conditions: 1) moderate-intensity cycle ergometer exercise; and 2) moderate-intensity cycle ergometer exercise with NMES. Young, healthy, physically active participants were recruited for this study.
- Conditions
- Aerobic Exercise
- Being tested
- Aerobic exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Aerobic exerciseBehavioural
Aerobic exercise was done with and without neuromuscular electrical stimulation
| Study group | Role | What they receive |
|---|---|---|
| Aerobic exercise alone | Active comparator | Participants completed aerobic exercise acutely Receives: Behavioral: Aerobic exercise |
| Aerobic exercise with neuromuscular electrical stimulation of the leg musculature | Experimental | Participants completed aerobic exercise with neuromuscular electrical stimulation Receives: Behavioral: Aerobic exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Oxygen consumption
L/min
Measured: 20 minutes
Secondary outcomes (7)
Carbon dioxide production
L/min
Measured: 20 minutes
Heart rate
bpm
Measured: 20 minutes
Respiratory exchange ratio
RER (0.70-1.00)
Measured: 20 minutes
Rating of perceived exertion
RPE (6-20)
Measured: 20 minutes
Kilocalories utilized
kcal/min
Measured: 20 minutes
Carbohydrate utilized
g/min
Measured: 20 minutes
Fats utilized
g/min
Measured: 20 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2025
- Study start25 Jan 2022
- Primary completion1 Jun 2023
- Study completion1 Jun 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Aerobic ExerciseStudies of the same condition, open and under way.
- More trials run by University of ManitobaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Manitoba
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr. Stephen Mark Cornish, University of Manitoba
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07016594
- Sponsor's protocol ID
- HE2021-0209
- Status last verified
- Jun 2025
- First submitted
- 4 Jun 2025
- Last updated
- 15 Jun 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Will decide if asked by other investigators.
Study at a glance
From the registry record, last updated by the sponsor on 15 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Aerobic Exercise With and Without Neuromuscular Electrical Stimulation on Acute Cardiovascular Responses Between Biological Sexes
- ClinicalTrials.gov ID
- NCT07016594
- Acronym / sponsor ID
- HE2021-0209
- Conditions
- Aerobic Exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- University of ManitobaUniversity, hospital or other
- Study start
- 25 Jan 2022 (actual)
- Primary completion
- 1 Jun 2023 (actual)
- Study completion
- 1 Jun 2023 (actual)
- First posted
- 11 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research was to explore potential differences in acute cardiovascular responses between two conditions: 1) moderate-intensity cycle ergometer exercise; and 2) moderate-intensity cycle ergometer exercise with NMES. Young, healthy, physically active participants were recruited for this study.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Aerobic exercise alone | Active comparator | Behavioral: Aerobic exerciseParticipants completed aerobic exercise acutely |
| Aerobic exercise with neuromuscular electrical stimulation of the leg musculature | Experimental | Behavioral: Aerobic exerciseParticipants completed aerobic exercise with neuromuscular electrical stimulation |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- healthy
- performing aerobic activity greater than or equal to three times per week at any intensity
Key exclusion criteria (3 listed)
- had lower body musculoskeletal injuries recently (within the past 6 months)
- health conditions that may place risk to the individual such as those with respiratory issues, hypertension, chronic atrial fibrillation, valvular diseases, heart disease; or obstructive cardiomyopathy
- if taking pharmacological drugs, performance-enhancing drugs, recreational drugs, nutritional supplements, or smoked nicotine
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Aerobic exerciseAerobic exercise was done with and without neuromuscular electrical stimulation | Behavioural | Aerobic exercise alone, Aerobic exercise with neuromuscular electrical stimulation of the leg musculature |
Primary outcome
Oxygen consumption
Time frame: 20 minutes
L/min
7 secondary outcomes
Carbon dioxide production
Time frame: 20 minutes
Heart rate
Time frame: 20 minutes
Respiratory exchange ratio
Time frame: 20 minutes
Rating of perceived exertion
Time frame: 20 minutes
Kilocalories utilized
Time frame: 20 minutes
Carbohydrate utilized
Time frame: 20 minutes
Fats utilized
Time frame: 20 minutes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jun 2025.
- Individual participant dataSharing planned: Undecided. Will decide if asked by other investigators.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Aerobic exercise in people with Aerobic Exercise, run by University of Manitoba at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Oxygen consumption (time frame: 20 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jun 2025.