Viral WartsPhase 4NCT07016360
Comparison of Efficacy of Topical Adaplene Gel Versus Crythotherapy in Recurrent Plantar Warts
A Phase 4 study testing Topical Adapalene Gel 0.1% and Topical Liquid Nitrogen application in people with Viral Warts, run by Khyber Teaching Hospital at 1 site in Pakistan.
Trial summary
This is a comparative study between two treatment options for skin viral infection. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Viral Warts
- What is being tested?
- Topical Adapalene Gel 0.1% and Topical Liquid Nitrogen application
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 98 participants
- Where
- 1 sitePakistan
- Study dates
- 15 Sep 2025to 15 Sep 2026
- Phase
- Phase 4
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- -
- Patients age limit 18-60 Years Patients with either gender (Male/Female) Patients with recurrent plantar warts
Who cannot join
- Pregnancy/lactation. Pt on topical or systemic therapy in last 6 months. On immunosuppressants. > 5 lesions. Pts with local secondary infections.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Khyber Teaching Hospital
Peshawar, Khyber Pakhtunkhwa, 25000
About this study
Official title: Comparison of Efficacy of Topical Adapalene Gel Versus Cryotherapy in Recurrent Plantar Warts
This is a comparative study between two treatment options for skin viral infection.
Read the detailed description
This is a comparative study between two treatment for viral infection in epidermal layer of skin that proliferates slowly forming thick, growths. This study will compare and evaluate the differences in efficacy between topical liquid nitrogen and topical retinoids.
- Conditions
- Viral Warts
- Being tested
- Topical Adapalene Gel 0.1%, Topical Liquid Nitrogen application
- Keywords
- Plantar warts, Topical adapalene gel, Cryotherapy
- Medical subject headings
- Warts
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Topical Adapalene Gel 0.1%Drug
Topical adapalene is a retinoid that helps in epidermal changes. Cryotherapy is a liquid nitrogen applied to affected parts for 6 months
Topical Liquid Nitrogen applicationProcedure or surgery
Liquid Nitrogen will be applied to affected parts.
| Study group | Role | What they receive |
|---|---|---|
| A | Experimental | Treated with Topical adapalene gel 0.1% Receives: Drug: Topical Adapalene Gel 0.1% |
| B | Experimental | Treated with liquid nitrogen over affected parts Receives: Procedure: Topical Liquid Nitrogen application |
What is being measured
The primary outcome is the main question the study is designed to answer.
Efficacy of Treatment
It will be defined through visual inspection by observing the complete clearance of the warts after 8 weeks administration of the treatment in both groups
Measured: 06 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2025
- Study start15 Sep 2025
- Primary completion15 Feb 2026
- Study completion15 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Viral WartsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 98 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Khyber Teaching Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Saba Naz, Khyber Teaching Hospital
- Investigators
- Saba Naz, MBBS, Principal investigator, Khyber Teaching Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07016360
- Sponsor's protocol ID
- 192/DME/KMC
- Status last verified
- Apr 2026
- First submitted
- 21 May 2025
- Last updated
- 29 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Patient's confidentiality may be breached
Study at a glance
From the registry record, last updated by the sponsor on 29 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Efficacy of Topical Adapalene Gel Versus Cryotherapy in Recurrent Plantar Warts
- ClinicalTrials.gov ID
- NCT07016360
- Acronym / sponsor ID
- 192/DME/KMC
- Conditions
- Viral Warts
- Keywords
- Plantar warts, Topical adapalene gel, Cryotherapy
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 98 participants (estimated)
- Lead sponsor
- Khyber Teaching HospitalUniversity, hospital or other
- Study start
- 15 Sep 2025 (actual)
- Primary completion
- 15 Feb 2026 (actual)
- Study completion
- 15 Sep 2026 (estimated)
- First posted
- 11 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a comparative study between two treatment options for skin viral infection.
Detailed description
This is a comparative study between two treatment for viral infection in epidermal layer of skin that proliferates slowly forming thick, growths. This study will compare and evaluate the differences in efficacy between topical liquid nitrogen and topical retinoids.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| A | Experimental | Drug: Topical Adapalene Gel 0.1%Treated with Topical adapalene gel 0.1% |
| B | Experimental | Procedure: Topical Liquid Nitrogen applicationTreated with liquid nitrogen over affected parts |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- -
- Patients age limit 18-60 Years Patients with either gender (Male/Female) Patients with recurrent plantar warts
Key exclusion criteria (1 listed)
- Pregnancy/lactation. Pt on topical or systemic therapy in last 6 months. On immunosuppressants. > 5 lesions. Pts with local secondary infections.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Topical Adapalene Gel 0.1%Topical adapalene is a retinoid that helps in epidermal changes. Cryotherapy is a liquid nitrogen applied to affected parts for 6 months | Drug | A |
| Topical Liquid Nitrogen applicationLiquid Nitrogen will be applied to affected parts. | Procedure or surgery | B |
Primary outcome
Efficacy of Treatment
Time frame: 06 months
It will be defined through visual inspection by observing the complete clearance of the warts after 8 weeks administration of the treatment in both groups
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Apr 2026.
- Individual participant dataSharing planned: No. Patient's confidentiality may be breached
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Saba Naz, MBBS principal investigator
Khyber Teaching Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing Topical Adapalene Gel 0.1% and Topical Liquid Nitrogen application in people with Viral Warts, run by Khyber Teaching Hospital at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 29 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Saba Naz, MBBS (+923209600115, sabikhattak477@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Efficacy of Treatment (time frame: 06 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Apr 2026.