Chondromalacia PatellaNCT07014787
Assessing the Effect of Different Grades of Chondromalacia on Static and Dynamic Balance Using Biodex Balance System
An observational study of Chondromalacia Patella, run by Cairo University at 1 site in Egypt.
Trial summary
The aim of this study is to investigate the effect of grades of chondromalacia on static and dynamic balance. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Chondromalacia Patella
- Type of treatment
- Injection or infusion
- How many people
- 100 participants
- Where
- 1 siteEgypt
- Study dates
- 5 Nov 2024to 15 Jun 2025
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: 100 patients, 80 with different grades of chondromalacia (Grade I, II, III, IV) with 20 participants in each group and 20 healthy participants in the control group will be recruited for the study.
Who may be able to join
- Age ranged from 18 to 40 years old
- groups include both males and females
- Patients with Grade I, II, III and IV chondromalacia: Confirmation of diagnosis by MRI
- BMI will be ranged from 19.0 to 29.0
- Patients with Unilateral or bilateral chondromalacia.
- Chronic cases for more than 3 months.
- Positive sign of Knee pain according to patellar Grind Test
Who cannot join
- patients have not undergone knee replacement.
- patients have not done Intra-articular injection in the affected knee for the past 3 months.
- Patients with rheumatoid arthritis or other inflammatory arthritis.
- Patients with Vestibular disorders or neurological conditions.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Faculty of physical therapy Cairo University
Giza, 12518
About this study
Official title: EFFECT OF GRADES OF CHONDROMALACIA ON STATIC AND DYNAMIC BALANCE: CROSS-SECTIONAL STUDY
The aim of this study is to investigate the effect of grades of chondromalacia on static and dynamic balance.
Read the detailed description
Chondromalacia patellae is a very common disorder which is characterized by softening, swelling, fraying, fissuring, and erosion of hyaline cartilage overlying the patella. Patellar chondromalacia could be observed as a cause of patellofemoral pain, as well as in patients with osteoarthritis, in patients with knee trauma, or even in asymptomatic patients.
Balance, as an essential function in human daily life and activities, can be defined as central nervous system input. Postural control can be divided into static balance and dynamic balance; static balance controls the oscillation amplitude of the body, and dynamic balance uses the body's internal and external information to analyze factors that influence the stability of interference (Such as walking, pushing and pulling),and to maintain postural control. The perfect combination of static and dynamic balance is key to normal activities of the human daily life.
100 patients, 80 with different grades of chondromalacia (Grade I, II, III, IV) with 20 participants in each group and 20 healthy participants in the control group will be recruited for the study to assess the effect of different chondromalacia grades on static and dynamic balance.
- Conditions
- Chondromalacia Patella
- Keywords
- Biodex balance system static and dynamic balance assessment of chondromalacia
- Medical subject headings
- Chondromalacia Patellae
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Control Group | Control group of 20 healthy patients Normal MRI Study | |
| grade I chondromalacia. | Experimental group of 20 patients with grade I chondromalacia Softening and swelling, intact surface Nearly normal (soft indentation and/or superficial fissures and cracks) Increased T2 signal intensity of morphologically normal cartilage | |
| grade II chondromalacia | Experimental group of 20 patients with grade II chondromalacia. Fragmentation and fissuring of articular cartilage affecting an area of less than 0.5 inches Abnormal (lesions extending to <50% of cartilage depth) A: Superficial partial-thickness cartilage defect <50% of total articular surface thickness B: Deep partial-thickness cartilage defect >50% of total articular surface thickness | |
| grade III chondromalacia | Experimental group of 20 patients with grade III chondromalacia Fragmentation and fissuring of articular cartilage affecting an area greater than 0.5 inches Severely abnormal (lesions extending >50% of cartilage depth, but not through subchondral bone) Full-thickness cartilage defect | |
| grade IV chondromalacia | Experimental group of 20 patients with grade IV chondromalacia Cartilage erosion to bone Lesions involving subchondral bone |
What is being measured
The primary outcome is the main question the study is designed to answer.
Measuring static and dynamic balance
Measuring static and dynamic balance using biodex balance system
Measured: up to four weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2025
- Study start5 Nov 2024
- Primary completion30 May 2025
- Study completion15 Jun 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chondromalacia PatellaStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Selwan Khaled Mahmoud, Cairo University
- Investigators
- Selwan Khaled Ayad, Teacher Assistant, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07014787
- Sponsor's protocol ID
- P.T.REC/012/005573
- Status last verified
- Jun 2025
- First submitted
- 3 Jun 2025
- Last updated
- 11 Jun 2025
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Jun 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- EFFECT OF GRADES OF CHONDROMALACIA ON STATIC AND DYNAMIC BALANCE: CROSS-SECTIONAL STUDY
- ClinicalTrials.gov ID
- NCT07014787
- Acronym / sponsor ID
- P.T.REC/012/005573
- Conditions
- Chondromalacia Patella
- Keywords
- Biodex balance system static and dynamic balance assessment of chondromalacia
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 5 Nov 2024 (actual)
- Primary completion
- 30 May 2025 (actual)
- Study completion
- 15 Jun 2025 (estimated)
- First posted
- 11 Jun 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate the effect of grades of chondromalacia on static and dynamic balance.
Detailed description
Chondromalacia patellae is a very common disorder which is characterized by softening, swelling, fraying, fissuring, and erosion of hyaline cartilage overlying the patella. Patellar chondromalacia could be observed as a cause of patellofemoral pain, as well as in patients with osteoarthritis, in patients with knee trauma, or even in asymptomatic patients.
Balance, as an essential function in human daily life and activities, can be defined as central nervous system input. Postural control can be divided into static balance and dynamic balance; static balance controls the oscillation amplitude of the body, and dynamic balance uses the body's internal and external information to analyze factors that influence the stability of interference (Such as walking, pushing and pulling),and to maintain postural control. The perfect combination of static and dynamic balance is key to normal activities of the human daily life.
100 patients, 80 with different grades of chondromalacia (Grade I, II, III, IV) with 20 participants in each group and 20 healthy participants in the control group will be recruited for the study to assess the effect of different chondromalacia grades on static and dynamic balance.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| Control Group | – | –Control group of 20 healthy patients Normal MRI Study |
| grade I chondromalacia. | – | –Experimental group of 20 patients with grade I chondromalacia Softening and swelling, intact surface Nearly normal (soft indentation and/or superficial fissures and cracks) Increased T2 signal intensity of morphologically normal cartilage |
| grade II chondromalacia | – | –Experimental group of 20 patients with grade II chondromalacia. Fragmentation and fissuring of articular cartilage affecting an area of less than 0.5 inches Abnormal (lesions extending to <50% of cartilage depth) A: Superficial partial-thickness cartilage defect <50% of total articular surface thickness B: Deep partial-thickness cartilage defect >50% of total articular surface thickness |
| grade III chondromalacia | – | –Experimental group of 20 patients with grade III chondromalacia Fragmentation and fissuring of articular cartilage affecting an area greater than 0.5 inches Severely abnormal (lesions extending >50% of cartilage depth, but not through subchondral bone) Full-thickness cartilage defect |
| grade IV chondromalacia | – | –Experimental group of 20 patients with grade IV chondromalacia Cartilage erosion to bone Lesions involving subchondral bone |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- 100 patients, 80 with different grades of chondromalacia (Grade I, II, III, IV) with 20 participants in each group and 20 healthy participants in the control group will be recruited for the study.
Key inclusion criteria (7 listed)
- Age ranged from 18 to 40 years old
- groups include both males and females
- Patients with Grade I, II, III and IV chondromalacia: Confirmation of diagnosis by MRI
- BMI will be ranged from 19.0 to 29.0
- Patients with Unilateral or bilateral chondromalacia.
Key exclusion criteria (4 listed)
- patients have not undergone knee replacement.
- patients have not done Intra-articular injection in the affected knee for the past 3 months.
- Patients with rheumatoid arthritis or other inflammatory arthritis.
- Patients with Vestibular disorders or neurological conditions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Measuring static and dynamic balance
Time frame: up to four weeks
Measuring static and dynamic balance using biodex balance system
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jun 2025.
Related trials for Chondromalacia Patella
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Sports Rehabilitation Therapy for Knee Joint Sports Injuries: A Case Study of Anterior Cruciate Ligament Injury and Patellar Chondromalacia
Anterior Cruciate Ligament Injury, Patellofemoral Pain Syndrome
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Selwan Khaled Ayad, Teacher Assistant principal investigator
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chondromalacia Patella, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Jun 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Selwan Khaled Ayad, teacher Assistant (+201064709563, selwan_kayad@outlook.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Measuring static and dynamic balance (time frame: up to four weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jun 2025.